Tooth AvulsionAPnanotecnologNCT07371130
Therapeutic Wavelength Nanotechnology Devices in Alveolar Preservation
A study testing Socket Preservation in people with Tooth Avulsion and Tooth Crown Fracture, run by University of Bari Aldo Moro.
Trial summary
After tooth extraction, a progressive alveolar bone resorption is observed. Alveolar ridge preservation consists of placing a biomaterial within the extraction socket and covering it with a membrane. Read more about this study
- Who is it for?
- Ages 21 to 80 yearsHealthy volunteers can take part
- Conditions the study is for
- Tooth Avulsion, Tooth Crown Fracture
- What is being tested?
- Socket Preservation
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- No sites listed yet
- Study dates
- 15 Feb 2026to 1 May 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 to 80 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Adults in good general health
- Indication for tooth extraction in sites planned for delayed implant placement
- Inability to place immediate post-extraction implants due to insufficient residual bone to ensure primary stability
- Extraction sockets presenting absence of the buccal (vestibular) bone wall
- Signed informed consent
Who cannot join
- Systemic conditions affecting bone healing
- Uncontrolled periodontal disease
- Smoking >10 cigarettes/day
- Pregnancy or lactation
- Use of medications interfering with bone metabolism
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Evaluation of Low-Intensity Therapeutic Wavelength Nanotechnology Devices in Alveolar Preservation: A Clinical Trial
After tooth extraction, a progressive alveolar bone resorption is observed. Alveolar ridge preservation consists of placing a biomaterial within the extraction socket and covering it with a membrane.
This procedure helps limit physiological bone resorption, making the soft and hard tissue profile of the edentulous site more prosthetically favorable.
Read the detailed description
After tooth extraction, a progressive remodeling process occurs that is often associated with significant alveolar bone resorption, particularly in sites with compromised bony walls. Alveolar ridge preservation is a surgical procedure aimed at minimizing this physiological resorption by placing grafting materials within the extraction socket and protecting them with a barrier membrane.
In the present protocol, the socket is filled with a xenogeneic bone graft enriched with hyaluronic acid, which enhances biological activity by promoting angiogenesis, cell migration, and early wound healing. The grafted site is then covered with a dermal matrix membrane, providing mechanical protection, stabilization of the biomaterial, and guided tissue regeneration.
In one study group, in addition to the surgical procedure, postoperative biostimulation using low-intensity photonic nanotechnology is applied. This adjunctive therapy is intended to enhance cellular metabolism, modulate inflammation, and accelerate both soft and hard tissue healing. The combined approach aims to preserve alveolar volume more effectively, improve the quality of regenerated tissues, and create a more favorable prosthetic environment for subsequent implant rehabilitation.
- Conditions
- Tooth Avulsion, Tooth Crown Fracture
- Being tested
- Socket Preservation
- Keywords
- alveolar ridge preservation, alveolar preservation, bone loss, bone preservation
- Medical subject headings
- Tooth Avulsion, Bone Diseases, Metabolic
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Socket PreservationProcedure or surgery
After atraumatic tooth extraction, the socket is filled with a xenogeneic bone graft enriched with hyaluronic acid, which enhances biological activity by promoting angiogenesis, cell migration, and early wound healing. The grafted site is then covered with a dermal matrix membrane, providing mechanical protection, stabilization of the biomaterial, and guided tissue regeneration.
| Study group | Role | What they receive |
|---|---|---|
| Traditional Alveolar Preservation | Active comparator | The socket is filled with a xenogeneic bone graft enriched with hyaluronic acid and dermal membrane Receives: Procedure: Socket Preservation |
| therapeutic wavelengths Alveolar Preservation | Experimental | Therapeutic wavelengths are applied as part of the alveolar preservation protocol. The extraction socket is filled with a xenogeneic bone graft enriched with hyaluronic acid and subsequently covered with a dermal membrane to support healing and tissue regeneration. Receives: Procedure: Socket Preservation |
What is being measured
The primary outcome is the main question the study is designed to answer.
VAS
Postoperative pain assessment using the Visual Analog Scale (VAS) (1-10)
Measured: 1 day , 3 days , 7 days ,14 days
Analgesic consumption
recorded as the number of ibuprofen 400 mg tablets taken
Measured: 7 days
Secondary outcomes (1)
Histological Evaluation
- Prior to implant placement, a CBCT scan will be performed to assess alveolar bone volume and morphology.
- During implant site preparation, a bone core biopsy will be harvested using a trephine bur.
- The bone sample will undergo histological and histomorphometric analysis to evaluate:
- New bone formation
- Residual graft material
- Connective tissue percentage
Measured: 4- 6 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Jan 2026
- Study start15 Feb 2026 (estimated)
- Primary completion1 May 2026 (estimated)
- Study completion1 May 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Tooth AvulsionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Care provider
- Enrolment
- 20 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Bari Aldo Moro
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Giuseppe D'Albis, University of Bari Aldo Moro
- Investigators
- Giuseppe D'Albis, Dr., Principal investigator, University of Bari Aldo MoroDomenico Patarino, Dr., Principal investigator, Private PracticeSaverio Capodiferro, Prof. Dr., Study director, University of Bari Aldo Moro
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07371130
- Sponsor's protocol ID
- AlveolarPreservation
- Acronym
- APnanotecnolog
- Status last verified
- Feb 2026
- First submitted
- 18 Jan 2026
- Last updated
- 5 Feb 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Low-Intensity Therapeutic Wavelength Nanotechnology Devices in Alveolar Preservation: A Clinical Trial
- ClinicalTrials.gov ID
- NCT07371130
- Acronym / sponsor ID
- APnanotecnolog / AlveolarPreservation
- Conditions
- Tooth Avulsion, Tooth Crown Fracture
- Keywords
- alveolar ridge preservation, alveolar preservation, bone loss, bone preservation
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 20 participants (estimated)
- Lead sponsor
- University of Bari Aldo MoroUniversity, hospital or other
- Study start
- 15 Feb 2026 (estimated)
- Primary completion
- 1 May 2026 (estimated)
- Study completion
- 1 May 2026 (estimated)
- First posted
- 27 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
After tooth extraction, a progressive alveolar bone resorption is observed. Alveolar ridge preservation consists of placing a biomaterial within the extraction socket and covering it with a membrane.
This procedure helps limit physiological bone resorption, making the soft and hard tissue profile of the edentulous site more prosthetically favorable.
Detailed description
After tooth extraction, a progressive remodeling process occurs that is often associated with significant alveolar bone resorption, particularly in sites with compromised bony walls. Alveolar ridge preservation is a surgical procedure aimed at minimizing this physiological resorption by placing grafting materials within the extraction socket and protecting them with a barrier membrane.
In the present protocol, the socket is filled with a xenogeneic bone graft enriched with hyaluronic acid, which enhances biological activity by promoting angiogenesis, cell migration, and early wound healing. The grafted site is then covered with a dermal matrix membrane, providing mechanical protection, stabilization of the biomaterial, and guided tissue regeneration.
In one study group, in addition to the surgical procedure, postoperative biostimulation using low-intensity photonic nanotechnology is applied. This adjunctive therapy is intended to enhance cellular metabolism, modulate inflammation, and accelerate both soft and hard tissue healing. The combined approach aims to preserve alveolar volume more effectively, improve the quality of regenerated tissues, and create a more favorable prosthetic environment for subsequent implant rehabilitation.
Study design
- Primary purpose
- Prevention
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (care provider)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Traditional Alveolar Preservation | Active comparator | Procedure: Socket PreservationThe socket is filled with a xenogeneic bone graft enriched with hyaluronic acid and dermal membrane |
| therapeutic wavelengths Alveolar Preservation | Experimental | Procedure: Socket PreservationTherapeutic wavelengths are applied as part of the alveolar preservation protocol. The extraction socket is filled with a xenogeneic bone graft enriched with hyaluronic acid and subsequently covered with a dermal membrane to support healing and tissue regeneration. |
Who may qualify
- Ages
- 21 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Adults in good general health
- Indication for tooth extraction in sites planned for delayed implant placement
- Inability to place immediate post-extraction implants due to insufficient residual bone to ensure primary stability
- Extraction sockets presenting absence of the buccal (vestibular) bone wall
- Signed informed consent
Key exclusion criteria (5 listed)
- Systemic conditions affecting bone healing
- Uncontrolled periodontal disease
- Smoking >10 cigarettes/day
- Pregnancy or lactation
- Use of medications interfering with bone metabolism
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Socket PreservationAfter atraumatic tooth extraction, the socket is filled with a xenogeneic bone graft enriched with hyaluronic acid, which enhances biological activity by promoting angiogenesis, cell migration, and early wound healing. The grafted site is then covered with a dermal matrix membrane, providing mechanical protection, stabilization of the biomaterial, and guided tissue regeneration. | Procedure or surgery | Traditional Alveolar Preservation, therapeutic wavelengths Alveolar Preservation |
Primary outcome
VAS
Time frame: 1 day , 3 days , 7 days ,14 days
Postoperative pain assessment using the Visual Analog Scale (VAS) (1-10)
Analgesic consumption
Time frame: 7 days
recorded as the number of ibuprofen 400 mg tablets taken
1 secondary outcome
Histological Evaluation
Time frame: 4- 6 month
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Feb 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Giuseppe D'Albis, Dr. principal investigator
University of Bari Aldo Moro
Domenico Patarino, Dr. principal investigator
Private Practice
Saverio Capodiferro, Prof. Dr. study director
University of Bari Aldo Moro
Questions about this trial
What is this clinical trial studying?
A study testing Socket Preservation in people with Tooth Avulsion and Tooth Crown Fracture, run by University of Bari Aldo Moro.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 5 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Giuseppe D'Albis, Dr. (+393495103642, giuseppe.dalbis@uniba.it), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
VAS (time frame: 1 day , 3 days , 7 days ,14 days). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Feb 2026.