MechanomyographyMMG versus AMGNCT07371377
The TOF3D Mechanomyograph. Evaluation of a New Device for Assessment of the Neuromuscular Block.
A study testing measurement of the time course of a neuromuscular block in people with Mechanomyography and Neuromuscular Blockade Monitoring, run by Klinikum Hersfeld-Rotenburg at 1 site in Germany.
Trial summary
In clinical anesthesiologic practice, most institutions use acceleromyography in order to assess the degree of a neuromuscular block. The aim of the present study is to assess a new device using mechanomyography. Until recently, this method was reserved for experimental settings. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Mechanomyography, Neuromuscular Blockade Monitoring
- What is being tested?
- measurement of the time course of a neuromuscular block
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 50 participants
- Where
- 1 siteGermany
- Study dates
- 9 Jan 2026to Jul 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- patients scheduled for surgery requiring general anesthesia with neuromuscular blocking agents
Who cannot join
- anticipated or known difficult airway
- increased risk for aspiration
- pregnancy
- neuromuscular disorders
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Germany1 site, 1 recruiting
- Recruiting
Department of Anesthesia and Intensive Care Medicine
Bad Hersfeld, 36251
Stefan Soltesz, Professor, 0049 173 3262086, stefan.soltesz@klinikum-hef.de
Stefan Soltesz, Professor
About this study
In clinical anesthesiologic practice, most institutions use acceleromyography in order to assess the degree of a neuromuscular block.
The aim of the present study is to assess a new device using mechanomyography. Until recently, this method was reserved for experimental settings. It seems to be able to work more precisely, and additionally, it offers the opportunity to use other stimulation patterns than acceleromyographic measurements.
The investigation is divided into two parts:
Part 1 compares the mechanomyograph directly with an acceleromyograph. In part 2, two mechanomyographs using different stimulation patterns are compared with each other.
- Being tested
- measurement of the time course of a neuromuscular block
- Keywords
- mechanomyography, tetanic fade
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
measurement of the time course of a neuromuscular blockDevice
a new device is compared to an established one.
| Study group | Role | What they receive |
|---|---|---|
| comparison of mechanomyograph and acceleromyograph | Other | Not described Receives: Device: measurement of the time course of a neuromuscular block |
| comparison of tetanic fade versus train of four ratio | Other | Not described Receives: Device: measurement of the time course of a neuromuscular block |
What is being measured
The primary outcome is the main question the study is designed to answer.
difference in time to recovery to a train of four ratio of 1,0.
difference in time to recovery to a train of four ratio of 1,0 measured by acceleromyography and mechanomyography, respectively
Measured: from enrollment to the end of anesthesiologic treatment at the day of surgery (2-3 weeks after enrollment)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Jan 2026
- Study start9 Jan 2026
- Primary completionDec 2026 (estimated)
- Study completionJul 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for MechanomyographyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Klinikum Hersfeld-Rotenburg
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07371377
- Sponsor's protocol ID
- MMG and TOF3D
- Acronym
- MMG versus AMG
- Status last verified
- Jan 2026
- First submitted
- 10 Jan 2026
- Last updated
- 27 Jan 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The TOF3D Mechanomyograph. Evaluation of a New Device for Assessment of the Neuromuscular Block.
- ClinicalTrials.gov ID
- NCT07371377
- Acronym / sponsor ID
- MMG versus AMG / MMG and TOF3D
- Keywords
- mechanomyography, tetanic fade
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Klinikum Hersfeld-RotenburgUniversity, hospital or other
- Study start
- 9 Jan 2026 (actual)
- Primary completion
- Dec 2026 (estimated)
- Study completion
- Jul 2027 (estimated)
- First posted
- 27 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In clinical anesthesiologic practice, most institutions use acceleromyography in order to assess the degree of a neuromuscular block.
The aim of the present study is to assess a new device using mechanomyography. Until recently, this method was reserved for experimental settings. It seems to be able to work more precisely, and additionally, it offers the opportunity to use other stimulation patterns than acceleromyographic measurements.
The investigation is divided into two parts:
Part 1 compares the mechanomyograph directly with an acceleromyograph. In part 2, two mechanomyographs using different stimulation patterns are compared with each other.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| comparison of mechanomyograph and acceleromyograph | Other | Device: measurement of the time course of a neuromuscular block |
| comparison of tetanic fade versus train of four ratio | Other | Device: measurement of the time course of a neuromuscular block |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- patients scheduled for surgery requiring general anesthesia with neuromuscular blocking agents
Key exclusion criteria (4 listed)
- anticipated or known difficult airway
- increased risk for aspiration
- pregnancy
- neuromuscular disorders
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| measurement of the time course of a neuromuscular blocka new device is compared to an established one. | Device | comparison of mechanomyograph and acceleromyograph, comparison of tetanic fade versus train of four ratio |
Primary outcome
difference in time to recovery to a train of four ratio of 1,0.
Time frame: from enrollment to the end of anesthesiologic treatment at the day of surgery (2-3 weeks after enrollment)
difference in time to recovery to a train of four ratio of 1,0 measured by acceleromyography and mechanomyography, respectively
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Jan 2026.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing measurement of the time course of a neuromuscular block in people with Mechanomyography and Neuromuscular Blockade Monitoring, run by Klinikum Hersfeld-Rotenburg at 1 site in Germany.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 27 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Germany. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Stefan Soltesz, Professor (0049 6621 88 922775, stefan.soltesz@klinikum-hef.de), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
difference in time to recovery to a train of four ratio of 1,0. (time frame: from enrollment to the end of anesthesiologic treatment at the day of surgery (2-3 weeks after enrollment)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Jan 2026; AzTrials last refreshed its copy on 8 Nov 2026.