Auricular Vagus Nerve StimulationNCT07371676
Effects of Vagus Nerve Stimulation on the Autonomic Nervous System
A study testing Stimulation in people with Auricular Vagus Nerve Stimulation and Transcutaneous, run by Istanbul Gelisim University at 1 site in Turkey (Türkiye).
Trial summary
The aim of this study is to determine the effect of vagus nerve stimulation, applied after running exercise, on recovery and fatigue in healthy young adults. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Auricular Vagus Nerve Stimulation, Transcutaneous, Recovery
- What is being tested?
- Stimulation
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 17 Sep 2024to 5 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Being healthy between the ages of 18-35
- Volunteering to participate in the study
- Signing the voluntary consent form
- Being in the inactive category according to the International Physical Activity Questionnaire
Who cannot join
- Having a regular exercise habit
- Being in the very minimally active or active category according to the International Physical Activity Survey
- Presence of any chronic disease and medication use for this condition
- History and treatment of current respiratory system disease
- History and treatment of current cardiac system disease
- History and treatment of current hearing system disease
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Acute Effects of Post-Exercise Vagus Nerve Stimulation on the Autonomic Nervous System and Recovery in Healthy Young Adults
The aim of this study is to determine the effect of vagus nerve stimulation, applied after running exercise, on recovery and fatigue in healthy young adults.
- Conditions
- Auricular Vagus Nerve Stimulation, Transcutaneous, Recovery
- Being tested
- Stimulation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
StimulationDevice
Recovery in athletes through vagus nerve stimulation
| Study group | Role | What they receive |
|---|---|---|
| Vagus nerve stimulation group | Experimental | Not described Receives: Device: Stimulation |
| Control Group | No intervention | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
Assessment of the autonomic nervous system.
Using heart rate variability (HRV) measurements recorded
Measured: Periprocedural
Secondary outcomes (1)
Lactic acid concentrate indicator
Measured: Periprocedural
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Jan 2026
- Study start17 Sep 2024
- Primary completion6 May 2025
- Study completion5 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Auricular Vagus Nerve StimulationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- Istanbul Gelisim University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07371676
- Sponsor's protocol ID
- 19.04.2024/05
- Status last verified
- Dec 2025
- First submitted
- 29 Dec 2025
- Last updated
- 28 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Kim AY, Marduy A, de Melo PS, Gianlorenco AC, Kim CK, Choi H, Song JJ, Fregni F. Safety of transcutaneous auricular vagus nerve stimulation (taVNS): a systematic review and meta-analysis. Sci Rep. 2022 Dec 21;12(1):22055. doi: 10.1038/s41598-022-25864-1.
PubMed 36543841Ackland GL, Patel ABU, Miller S, Gutierrez Del Arroyo A, Thirugnanasambanthar J, Ravindran JI, Schroth J, Boot J, Caton L, Mein CA, Abbott TEF, Gourine AV. Non-invasive vagus nerve stimulation and exercise capacity in healthy volunteers: a randomized trial. Eur Heart J. 2025 May 2;46(17):1634-1644. doi: 10.1093/eurheartj/ehaf037.
PubMed 39969124Hatik SH, Arslan M, Demirbilek O, Ozden AV. The effect of transcutaneous auricular vagus nerve stimulation on cycling ergometry and recovery in healthy young individuals. Brain Behav. 2023 Dec;13(12):e3332. doi: 10.1002/brb3.3332. Epub 2023 Nov 16.
PubMed 37974551Erturk C, Mutus R. Post-exercise auricular vagus nerve stimulation modulates autonomic and recovery responses in physically inactive young adults: a randomized controlled trial. Sci Rep. 2026 Apr 2;16(1):15814. doi: 10.1038/s41598-026-47143-z.
PubMed 41927730
Study at a glance
From the registry record, last updated by the sponsor on 28 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Acute Effects of Post-Exercise Vagus Nerve Stimulation on the Autonomic Nervous System and Recovery in Healthy Young Adults
- ClinicalTrials.gov ID
- NCT07371676
- Acronym / sponsor ID
- 19.04.2024/05
- Conditions
- Auricular Vagus Nerve Stimulation, Transcutaneous, Recovery
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- Istanbul Gelisim UniversityUniversity, hospital or other
- Study start
- 17 Sep 2024 (actual)
- Primary completion
- 6 May 2025 (actual)
- Study completion
- 5 Dec 2025 (actual)
- First posted
- 28 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to determine the effect of vagus nerve stimulation, applied after running exercise, on recovery and fatigue in healthy young adults.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Vagus nerve stimulation group | Experimental | Device: Stimulation |
| Control Group | No intervention | – |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Being healthy between the ages of 18-35
- Volunteering to participate in the study
- Signing the voluntary consent form
- Being in the inactive category according to the International Physical Activity Questionnaire
Key exclusion criteria (6 listed)
- Having a regular exercise habit
- Being in the very minimally active or active category according to the International Physical Activity Survey
- Presence of any chronic disease and medication use for this condition
- History and treatment of current respiratory system disease
- History and treatment of current cardiac system disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| StimulationRecovery in athletes through vagus nerve stimulation | Device | Vagus nerve stimulation group |
Primary outcome
Assessment of the autonomic nervous system.
Time frame: Periprocedural
Using heart rate variability (HRV) measurements recorded
1 secondary outcome
Lactic acid concentrate indicator
Time frame: Periprocedural
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Jan 2026.
- Background: PubMed 36543841Kim AY, Marduy A, de Melo PS, Gianlorenco AC, Kim CK, Choi H, Song JJ, Fregni F. Safety of transcutaneous auricular vagus nerve stimulation (taVNS): a systematic review and meta-analysis. Sci Rep. 2022 Dec 21;12(1):22055. doi: 10.1038/s41598-022-25864-1.
- Background: PubMed 39969124Ackland GL, Patel ABU, Miller S, Gutierrez Del Arroyo A, Thirugnanasambanthar J, Ravindran JI, Schroth J, Boot J, Caton L, Mein CA, Abbott TEF, Gourine AV. Non-invasive vagus nerve stimulation and exercise capacity in healthy volunteers: a randomized trial. Eur Heart J. 2025 May 2;46(17):1634-1644. doi: 10.1093/eurheartj/ehaf037.
- Background: PubMed 37974551Hatik SH, Arslan M, Demirbilek O, Ozden AV. The effect of transcutaneous auricular vagus nerve stimulation on cycling ergometry and recovery in healthy young individuals. Brain Behav. 2023 Dec;13(12):e3332. doi: 10.1002/brb3.3332. Epub 2023 Nov 16.
- Derived from this study: PubMed 41927730Erturk C, Mutus R. Post-exercise auricular vagus nerve stimulation modulates autonomic and recovery responses in physically inactive young adults: a randomized controlled trial. Sci Rep. 2026 Apr 2;16(1):15814. doi: 10.1038/s41598-026-47143-z.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Stimulation in people with Auricular Vagus Nerve Stimulation and Transcutaneous, run by Istanbul Gelisim University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 28 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Assessment of the autonomic nervous system. (time frame: Periprocedural). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07371676, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Jan 2026; AzTrials last refreshed its copy on 7 Nov 2026.