Diabetic Foot Ulcer (DFU)NCT07373327
Vinegar vs Normal Saline Dressing for Diabetic Foot Ulcers
A study testing Vinegar Dressing and Normal Saline Dressing in people with Diabetic Foot Ulcer (DFU), run by University of Health Sciences Lahore.
Trial summary
This study is investigating the effectiveness of two different types of wound dressings in treating diabetic foot ulcers (DFUs), a common complication of diabetes that can be difficult to heal. Read more about this study
- Who is it for?
- Ages 20 to 65 years
- Conditions the study is for
- Diabetic Foot Ulcer (DFU)
- What is being tested?
- Vinegar Dressing and Normal Saline Dressing
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 84 participants
- Where
- No sites listed yet
- Study dates
- 4 Feb 2026to 1 Aug 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age: 20 to 65 years.
- Gender: Both male and female participants are included.
- Condition: Patients with Grade 3 and 4 infected diabetic foot ulcers (DFU) according to the Wagner classification.
Who cannot join
- Wagner Grades 1, 2, 5, and 6 diabetic foot ulcers.
- History of Radiotherapy.
- History of Chemotherapy.
- Use of Steroids.
- Use of Immunosuppressive drugs.
- Allergy to vinegar.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: A Randomized Clinical Trial to Compare the Efficacy of Vinegar Dressing Versus Normal Saline Dressing in the Treatment of Diabetic Foot Ulcers
This study is investigating the effectiveness of two different types of wound dressings in treating diabetic foot ulcers (DFUs), a common complication of diabetes that can be difficult to heal. The study will compare the use of vinegar dressings to normal saline (saltwater) dressings to see which one helps heal the wound faster and more effectively.
People with diabetic foot ulcers often struggle with infections and slow healing. The goal of this study is to determine if vinegar, a simple and affordable treatment, works better than saline in improving wound healing and reducing infections. The study will measure how quickly the wound heals, how much dead tissue is removed, and whether the bacteria in the wound disappear.
This study will involve patients with infected diabetic foot ulcers. Participants will be randomly assigned to receive either vinegar or saline dressing. The results will help determine the best and most cost-effective treatment for diabetic foot ulcers, potentially making it easier for patients to access better care.
- Conditions
- Diabetic Foot Ulcer (DFU)
- Being tested
- Vinegar Dressing, Normal Saline Dressing
- Medical subject headings
- Diabetic Foot
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Vinegar DressingOther
In this arm, participants will receive a dressing made by soaking gauze in a vinegar solution. The solution will be prepared by adding one tablespoon of plain white vinegar to a cup of normal saline. The gauze will be applied to the wound in a wet-to-dry manner, twice daily, until the wound is fully healed or cultured negative. The goal is to assess the effectiveness of vinegar in promoting wound healing, reducing infection, and removing necrotic tissue.
Normal Saline DressingOther
In this arm, participants will receive a dressing using normal saline (saltwater). The wound will be washed with normal saline and dressed in a wet-to-dry manner, twice daily, until the wound is fully healed or cultured negative. This arm will serve as the control group, with the goal of comparing the outcomes of saline dressing to vinegar dressing in terms of wound healing, bacterial infection reduction, and necrotic tissue removal.
| Study group | Role | What they receive |
|---|---|---|
| Vinegar Dressing | Experimental | Not described Receives: Other: Vinegar Dressing |
| Normal Saline Dressing | Active comparator | Not described Receives: Other: Normal Saline Dressing |
What is being measured
The primary outcome is the main question the study is designed to answer.
Rate of Negative Cultures
Definition: The proportion of participants whose wound cultures become negative (no bacterial growth) by the end of the treatment period (e.g., 3 weeks or 8 weeks).
Measurement: The swab cultures will be taken weekly, and the presence or absence of bacterial infection will be recorded until the wound is culture-negative.
Rationale: This outcome is crucial as it directly measures the effectiveness of vinegar dressing in reducing wound infection compared to normal saline dressing.
Measured: From enrollment to 8 weeks after treatment initiation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Jan 2026
- Study start4 Feb 2026 (estimated)
- Primary completion10 Jul 2026 (estimated)
- Study completion1 Aug 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Diabetic Foot Ulcer (DFU)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 84 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Health Sciences Lahore
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Dr. MIAN MUHAMMAD BILAL, University of Health Sciences Lahore
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07373327
- Sponsor's protocol ID
- Exp133
- Status last verified
- Jan 2026
- First submitted
- 13 Jan 2026
- Last updated
- 28 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 28 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Randomized Clinical Trial to Compare the Efficacy of Vinegar Dressing Versus Normal Saline Dressing in the Treatment of Diabetic Foot Ulcers
- ClinicalTrials.gov ID
- NCT07373327
- Acronym / sponsor ID
- Exp133
- Conditions
- Diabetic Foot Ulcer (DFU)
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 84 participants (estimated)
- Lead sponsor
- University of Health Sciences LahoreUniversity, hospital or other
- Study start
- 4 Feb 2026 (estimated)
- Primary completion
- 10 Jul 2026 (estimated)
- Study completion
- 1 Aug 2026 (estimated)
- First posted
- 28 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is investigating the effectiveness of two different types of wound dressings in treating diabetic foot ulcers (DFUs), a common complication of diabetes that can be difficult to heal. The study will compare the use of vinegar dressings to normal saline (saltwater) dressings to see which one helps heal the wound faster and more effectively.
People with diabetic foot ulcers often struggle with infections and slow healing. The goal of this study is to determine if vinegar, a simple and affordable treatment, works better than saline in improving wound healing and reducing infections. The study will measure how quickly the wound heals, how much dead tissue is removed, and whether the bacteria in the wound disappear.
This study will involve patients with infected diabetic foot ulcers. Participants will be randomly assigned to receive either vinegar or saline dressing. The results will help determine the best and most cost-effective treatment for diabetic foot ulcers, potentially making it easier for patients to access better care.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Vinegar Dressing | Experimental | Other: Vinegar Dressing |
| Normal Saline Dressing | Active comparator | Other: Normal Saline Dressing |
Who may qualify
- Ages
- 20 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Age: 20 to 65 years.
- Gender: Both male and female participants are included.
- Condition: Patients with Grade 3 and 4 infected diabetic foot ulcers (DFU) according to the Wagner classification.
Key exclusion criteria (6 listed)
- Wagner Grades 1, 2, 5, and 6 diabetic foot ulcers.
- History of Radiotherapy.
- History of Chemotherapy.
- Use of Steroids.
- Use of Immunosuppressive drugs.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Vinegar DressingIn this arm, participants will receive a dressing made by soaking gauze in a vinegar solution. The solution will be prepared by adding one tablespoon of plain white vinegar to a cup of normal saline. The gauze will be applied to the wound in a wet-to-dry manner, twice daily, until the wound is fully healed or cultured negative. The goal is to assess the effectiveness of vinegar in promoting wound healing, reducing infection, and removing necrotic tissue. | Other | Vinegar Dressing |
| Normal Saline DressingIn this arm, participants will receive a dressing using normal saline (saltwater). The wound will be washed with normal saline and dressed in a wet-to-dry manner, twice daily, until the wound is fully healed or cultured negative. This arm will serve as the control group, with the goal of comparing the outcomes of saline dressing to vinegar dressing in terms of wound healing, bacterial infection reduction, and necrotic tissue removal. | Other | Normal Saline Dressing |
Primary outcome
Rate of Negative Cultures
Time frame: From enrollment to 8 weeks after treatment initiation
Definition: The proportion of participants whose wound cultures become negative (no bacterial growth) by the end of the treatment period (e.g., 3 weeks or 8 weeks). Measurement: The swab cultures will be taken weekly, and the presence or absence of bacterial infection will be recorded until the wound is culture-negative. Rationale: This outcome is crucial as it directly measures the effectiveness of vinegar dressing in reducing wound infection compared to normal saline dressing.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Jan 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing Vinegar Dressing and Normal Saline Dressing in people with Diabetic Foot Ulcer (DFU), run by University of Health Sciences Lahore.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 28 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Dr. MIAN MUHAMMAD BILAL Principal Investigator (03451110281, drbilal279@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Rate of Negative Cultures (time frame: From enrollment to 8 weeks after treatment initiation). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Jan 2026.