Smoking &Amp; Tobacco CessationNCT07375459
Community-based Mobile-assisted Brief Intervention for Smoking Cessation
A study testing Brief cessation advice + self-help booklet, Opt-out referral and Mobile chat messaging in people with Smoking &Amp; Tobacco Cessation, run by National University of Singapore at 1 site in Singapore.
Trial summary
The goal of this pilot trial is to evaluate the feasibility of a mobile-assisted brief intervention for smoking cessation in community-based individuals in Singapore. Specific aims include: 1. To assess how many eligible individuals accept the invitation to participate in the trial 2. Read more about this study
- Who is it for?
- Ages 21 to 80 yearsHealthy volunteers can take part
- Conditions the study is for
- Smoking &Amp; Tobacco Cessation
- What is being tested?
- Brief cessation advice + self-help booklet, Opt-out referral and Mobile chat messaging
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- 1 siteSingapore
- Study dates
- 4 Feb 2026to 31 Mar 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 to 80 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Aged 21 to 80 years
- Smoked at least one cigarette daily
- Able to communicate and read in English or Chinese
- Own a smartphone with WhatsApp installed
Who cannot join
- Exposed to any smoking cessation treatment in the past 3 months
- Pregnant women
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Mobile-assisted Brief Intervention for Smoking Cessation in Community-based Setting: a Pilot Randomised Controlled Trial
The goal of this pilot trial is to evaluate the feasibility of a mobile-assisted brief intervention for smoking cessation in community-based individuals in Singapore. Specific aims include:
- To assess how many eligible individuals accept the invitation to participate in the trial
- To assess the retention of the participants through 6 months after treatment initiation
- To assess the acceptability of the intervention in terms of participants' engagement and ratings
- To examine the intervention effect on abstinence outcomes
Participants will be randomly assigned to either the intervention group or control group and followed for 6 months from randomisation.
- Conditions
- Smoking &Amp; Tobacco Cessation
- Being tested
- Brief cessation advice + self-help booklet, Opt-out referral, Mobile chat messaging
- Keywords
- mHealth, WhatsApp, smoking cessation, chat-based intervention, Singapore
- Medical subject headings
- Smoking, Tobacco Use Cessation, Smoking Cessation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Brief cessation advice + self-help bookletBehavioural
Participants will receive brief cessation advice following the AWARD (ask, warn, advise, refer, do-it-again) model and a 24-page self-help booklet.
Opt-out referralBehavioural
Research personnel will assist the participant in signing up for the I Quit Programme to receive additional cessation support, unless they decline
Mobile chat messagingBehavioural
Participants will receive personalised chat-based support delivered by a live counsellor for 3 months via WhatsApp. The message will incorporate behaviour change techniques for smoking cessation and mindfulness principles to strengthen participants' capacity to quit smoking.
| Study group | Role | What they receive |
|---|---|---|
| Mobile-assisted brief intervention | Experimental | Not described Receives: Behavioral: Brief cessation advice + self-help booklet; Behavioral: Opt-out referral; Behavioral: Mobile chat messaging |
| Brief advice | Active comparator | Not described Receives: Behavioral: Brief cessation advice + self-help booklet |
What is being measured
The primary outcome is the main question the study is designed to answer.
Biochemically validated smoking abstinence rate
Defined as an exhaled carbon monoxide level of <5 parts per million or a negative salivary cotinine test (cut off 30ng/mL)
Measured: 6 months
Recruitment rate
Number of participants divided by the number of eligible subjects
Measured: 6 months
Retention rate
Number of participants completed the follow-up divided by the number of participants
Measured: 6 months
Secondary outcomes (8)
Self-reported 7-day point-prevalence smoking abstinence rate
Being completely smoke-free in the past 7 days
Measured: 3 months
Self-reported 7-day point-prevalence smoking abstinence rate
Being completely smoke-free in the past 7 days
Measured: 6 months
Self-reported smoking reduction rate
Smoking reduction by at least half of the baseline daily number of cigarettes in individuals who continue to smoke
Measured: 3 months
Self-reported smoking reduction rate
Smoking reduction by at least half of the baseline daily number of cigarettes in individuals who continue to smoke
Measured: 6 months
Self-reported quit attempt rate
Serious quit attempt that lasted 24 hours or longer
Measured: 3 months
Self-reported quit attempt rate
Serious quit attempt that lasted 24 hours or longer
Measured: 6 months
Smoking cessation service use rate
Use of any smoking cessation service during the follow-up period
Measured: 3 months
Smoking cessation service use rate
Use of any smoking cessation service during the follow-up period
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Jan 2026
- Study start4 Feb 2026
- Primary completion31 Dec 2026 (estimated)
- Study completion31 Mar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Smoking &Amp; Tobacco CessationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National University of Singapore
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, LUK Tzu Tsun, National University of Singapore
- Investigators
- Tzu Tsun Luk, PhD, RN, Principal investigator, National University of Singapore
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07375459
- Sponsor's protocol ID
- NUS-IRB-2025-690
- Status last verified
- Jul 2026
- First submitted
- 22 Jan 2026
- Last updated
- 16 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Mobile-assisted Brief Intervention for Smoking Cessation in Community-based Setting: a Pilot Randomised Controlled Trial
- ClinicalTrials.gov ID
- NCT07375459
- Acronym / sponsor ID
- NUS-IRB-2025-690
- Conditions
- Smoking &Amp; Tobacco Cessation
- Keywords
- mHealth, WhatsApp, smoking cessation, chat-based intervention, Singapore
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- National University of SingaporeUniversity, hospital or other
- Study start
- 4 Feb 2026 (actual)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 31 Mar 2027 (estimated)
- First posted
- 29 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this pilot trial is to evaluate the feasibility of a mobile-assisted brief intervention for smoking cessation in community-based individuals in Singapore. Specific aims include:
- To assess how many eligible individuals accept the invitation to participate in the trial
- To assess the retention of the participants through 6 months after treatment initiation
- To assess the acceptability of the intervention in terms of participants' engagement and ratings
- To examine the intervention effect on abstinence outcomes
Participants will be randomly assigned to either the intervention group or control group and followed for 6 months from randomisation.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Mobile-assisted brief intervention | Experimental | Behavioral: Brief cessation advice + self-help booklet, Behavioral: Opt-out referral, Behavioral: Mobile chat messaging |
| Brief advice | Active comparator | Behavioral: Brief cessation advice + self-help booklet |
Who may qualify
- Ages
- 21 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Aged 21 to 80 years
- Smoked at least one cigarette daily
- Able to communicate and read in English or Chinese
- Own a smartphone with WhatsApp installed
Key exclusion criteria (2 listed)
- Exposed to any smoking cessation treatment in the past 3 months
- Pregnant women
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Brief cessation advice + self-help bookletParticipants will receive brief cessation advice following the AWARD (ask, warn, advise, refer, do-it-again) model and a 24-page self-help booklet. | Behavioural | Brief advice, Mobile-assisted brief intervention |
| Opt-out referralResearch personnel will assist the participant in signing up for the I Quit Programme to receive additional cessation support, unless they decline | Behavioural | Mobile-assisted brief intervention |
| Mobile chat messagingParticipants will receive personalised chat-based support delivered by a live counsellor for 3 months via WhatsApp. The message will incorporate behaviour change techniques for smoking cessation and mindfulness principles to strengthen participants' capacity to quit smoking. | Behavioural | Mobile-assisted brief intervention |
Primary outcome
Biochemically validated smoking abstinence rate
Time frame: 6 months
Defined as an exhaled carbon monoxide level of <5 parts per million or a negative salivary cotinine test (cut off 30ng/mL)
Recruitment rate
Time frame: 6 months
Number of participants divided by the number of eligible subjects
Retention rate
Time frame: 6 months
Number of participants completed the follow-up divided by the number of participants
8 secondary outcomes
Self-reported 7-day point-prevalence smoking abstinence rate
Time frame: 3 months
Self-reported 7-day point-prevalence smoking abstinence rate
Time frame: 6 months
Self-reported smoking reduction rate
Time frame: 3 months
Self-reported smoking reduction rate
Time frame: 6 months
Self-reported quit attempt rate
Time frame: 3 months
Self-reported quit attempt rate
Time frame: 6 months
Smoking cessation service use rate
Time frame: 3 months
Smoking cessation service use rate
Time frame: 6 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Jul 2026.
- Individual participant dataSharing planned: No
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Tzu Tsun Luk, PhD, RN principal investigator
National University of Singapore
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Brief cessation advice + self-help booklet, Opt-out referral and Mobile chat messaging in people with Smoking &Amp; Tobacco Cessation, run by National University of Singapore at 1 site in Singapore.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 16 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Singapore. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Biochemically validated smoking abstinence rate (time frame: 6 months). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Jul 2026.