Chronic DiseaseADHER-EGNCT07375550
Determinants of Medication Non-Adherence Among Patients With Chronic Diseases in Egyptian Community Pharmacies
An observational study of Chronic Disease, run by Egyptian Chinese University at 1 site in Egypt.
Trial summary
Medication non-adherence among patients with chronic diseases is a major public health concern and is associated with poor disease control, increased complications, and higher healthcare costs. Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Chronic Disease
- How many people
- 261 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jan 2026to 1 Mar 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: The study population consists of adult patients aged 18 to 80 years who have been diagnosed with at least one chronic disease and are receiving long-term pharmacological treatment. Participants will be recruited from community pharmacy settings across multiple Egyptian cities Eligible patients are those attending participating community pharmacies during the study period and who are capable of understanding the study procedures and providing written informed consent. The study population reflects a real-world sample of patients managing chronic conditions in community pharmacy practice in Egypt.
Who may be able to join
- Adults aged 18 to 80 years.
- Diagnosed with at least one chronic disease requiring long-term pharmacological treatment.
- Currently receiving at least one prescribed medication for a chronic condition.
- Attending a participating community pharmacy during the study period.
- Able and willing to provide written informed consent.
Who cannot join
- Patients with cognitive impairment or mental conditions that limit their ability to understand the study procedures or complete the questionnaire.
- Patients who refuse or are unable to provide written informed consent.
- Patients who are acutely ill and unable to participate at the time of data collection.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Adherence Determinants of Medication Non-Adherence Among Patients With Chronic Diseases at Community Pharmacy Settings in Egypt: A Multicenter Cross-Sectional Study
Medication non-adherence among patients with chronic diseases is a major public health concern and is associated with poor disease control, increased complications, and higher healthcare costs. Community pharmacists play an important role in supporting patients' medication use through counseling and education; however, the determinants of medication non-adherence among patients attending community pharmacies in Egypt are not well characterized.
This multicenter, cross-sectional study aims to assess the prevalence of medication non-adherence and identify factors associated with non-adherence among adult Egyptian patients with chronic diseases attending community pharmacy settings. Medication adherence will be evaluated using the Adherence in Chronic Diseases Scale (ACDS), along with sociodemographic, clinical, and medication-related factors. The findings are expected to provide evidence to inform strategies for improving medication adherence and optimizing chronic disease management in community pharmacy practice in Egypt.
Read the detailed description
Chronic diseases represent a substantial burden on healthcare systems and require long-term pharmacological treatment to prevent complications and maintain optimal health outcomes. Effective management of these conditions relies heavily on patients' adherence to prescribed medication regimens. Medication non-adherence is common worldwide and is associated with disease progression, increased hospitalizations, reduced quality of life, and increased healthcare costs.
Community pharmacists are accessible healthcare professionals who are well positioned to support medication adherence through patient education, counseling, and follow-up. Despite this, medication non-adherence remains prevalent, and the factors contributing to non-adherence among patients with chronic diseases in Egypt have not been adequately studied. Sociodemographic characteristics, clinical factors, medication-related issues such as adverse effects, and the availability and quality of pharmacist counseling may all influence adherence behavior.
This study is designed as a multicenter, cross-sectional investigation conducted in community pharmacies across major Egyptian cities, including Cairo, Alexandria, and Giza. The study population includes adult patients aged 18 to 80 years who have been diagnosed with at least one chronic disease and are currently receiving pharmacological treatment for their condition.
Data will be collected using a structured, interviewer-administered questionnaire. Information gathered will include sociodemographic characteristics, clinical and medication history, and exposure to medication counseling. Medication adherence will be assessed using the Adherence in Chronic Diseases Scale (ACDS), a validated tool for evaluating adherence behaviors in patients with chronic conditions.
The primary outcome of the study is the prevalence of medication non-adherence among patients with chronic diseases attending community pharmacies. Secondary outcomes include identification of factors associated with medication non-adherence, such as medication side effects, patient-related characteristics, and pharmacist-provided counseling. Data analysis will be performed using SPSS software, with binary logistic regression applied to identify significant predictors of medication adherence. Statistical significance will be set at a p-value of less than 0.05.
The study is observational and poses minimal risk to participants. Ethical approval will be obtained from the relevant local ethics committee, and the study will be conducted in accordance with applicable ethical guidelines. Written informed consent will be obtained from all participants prior to enrollment. Participant confidentiality will be maintained through anonymization of collected data.
The results of this study are expected to generate important local evidence on medication adherence among Egyptian patients with chronic diseases and to support the development of targeted interventions and policies aimed at enhancing medication adherence and improving health outcomes in community pharmacy settings.
- Conditions
- Chronic Disease
- Keywords
- Chronic Disease, Egypt, Community pharmacy, Medication Adherence
- Medical subject headings
- Chronic Disease, Medication Adherence
What is being measured
The primary outcome is the main question the study is designed to answer.
Prevalence of Medication Non-Adherence Among Patients with Chronic Diseases
Medication non-adherence will be assessed using the Adherence in Chronic Diseases Scale (ACDS), a validated questionnaire designed to evaluate patients' adherence behaviors toward prescribed medications for chronic conditions. The outcome will be expressed as the proportion of participants classified as non-adherent and adherent based on ACDS scoring, and analyzed in relation to sociodemographic and clinical factors.
Measured: Through study completion, an average of 1 month (cross-sectional assessment)
Secondary outcomes (1)
Determinants and Predictors of Medication Non-Adherence in Patients with Chronic Diseases
analysis will be used to identify significant predictors of medication non-adherence as measured by the Adherence in Chronic Diseases Scale (ACDS).
Measured: Through study completion, an average of 1 month (cross-sectional assessment)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Jan 2026
- Study start1 Jan 2026
- Primary completion1 Mar 2026
- Study completion1 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Chronic DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 261 participants (actual)
Sponsor and investigators
- Lead sponsor
- Egyptian Chinese University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Sarah Sabry Hashem Nafea, Egyptian Chinese University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07375550
- Sponsor's protocol ID
- 3
- Acronym
- ADHER-EG
- Status last verified
- Apr 2026
- First submitted
- 30 Dec 2025
- Last updated
- 21 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 21 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Adherence Determinants of Medication Non-Adherence Among Patients With Chronic Diseases at Community Pharmacy Settings in Egypt: A Multicenter Cross-Sectional Study
- ClinicalTrials.gov ID
- NCT07375550
- Acronym / sponsor ID
- ADHER-EG / 3
- Conditions
- Chronic Disease
- Keywords
- Chronic Disease, Egypt, Community pharmacy, Medication Adherence
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 261 participants (actual)
- Lead sponsor
- Egyptian Chinese UniversityUniversity, hospital or other
- Study start
- 1 Jan 2026 (actual)
- Primary completion
- 1 Mar 2026 (actual)
- Study completion
- 1 Mar 2026 (actual)
- First posted
- 29 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Medication non-adherence among patients with chronic diseases is a major public health concern and is associated with poor disease control, increased complications, and higher healthcare costs. Community pharmacists play an important role in supporting patients' medication use through counseling and education; however, the determinants of medication non-adherence among patients attending community pharmacies in Egypt are not well characterized.
This multicenter, cross-sectional study aims to assess the prevalence of medication non-adherence and identify factors associated with non-adherence among adult Egyptian patients with chronic diseases attending community pharmacy settings. Medication adherence will be evaluated using the Adherence in Chronic Diseases Scale (ACDS), along with sociodemographic, clinical, and medication-related factors. The findings are expected to provide evidence to inform strategies for improving medication adherence and optimizing chronic disease management in community pharmacy practice in Egypt.
Detailed description
Chronic diseases represent a substantial burden on healthcare systems and require long-term pharmacological treatment to prevent complications and maintain optimal health outcomes. Effective management of these conditions relies heavily on patients' adherence to prescribed medication regimens. Medication non-adherence is common worldwide and is associated with disease progression, increased hospitalizations, reduced quality of life, and increased healthcare costs.
Community pharmacists are accessible healthcare professionals who are well positioned to support medication adherence through patient education, counseling, and follow-up. Despite this, medication non-adherence remains prevalent, and the factors contributing to non-adherence among patients with chronic diseases in Egypt have not been adequately studied. Sociodemographic characteristics, clinical factors, medication-related issues such as adverse effects, and the availability and quality of pharmacist counseling may all influence adherence behavior.
This study is designed as a multicenter, cross-sectional investigation conducted in community pharmacies across major Egyptian cities, including Cairo, Alexandria, and Giza. The study population includes adult patients aged 18 to 80 years who have been diagnosed with at least one chronic disease and are currently receiving pharmacological treatment for their condition.
Data will be collected using a structured, interviewer-administered questionnaire. Information gathered will include sociodemographic characteristics, clinical and medication history, and exposure to medication counseling. Medication adherence will be assessed using the Adherence in Chronic Diseases Scale (ACDS), a validated tool for evaluating adherence behaviors in patients with chronic conditions.
The primary outcome of the study is the prevalence of medication non-adherence among patients with chronic diseases attending community pharmacies. Secondary outcomes include identification of factors associated with medication non-adherence, such as medication side effects, patient-related characteristics, and pharmacist-provided counseling. Data analysis will be performed using SPSS software, with binary logistic regression applied to identify significant predictors of medication adherence. Statistical significance will be set at a p-value of less than 0.05.
The study is observational and poses minimal risk to participants. Ethical approval will be obtained from the relevant local ethics committee, and the study will be conducted in accordance with applicable ethical guidelines. Written informed consent will be obtained from all participants prior to enrollment. Participant confidentiality will be maintained through anonymization of collected data.
The results of this study are expected to generate important local evidence on medication adherence among Egyptian patients with chronic diseases and to support the development of targeted interventions and policies aimed at enhancing medication adherence and improving health outcomes in community pharmacy settings.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- The study population consists of adult patients aged 18 to 80 years who have been diagnosed with at least one chronic disease and are receiving long-term pharmacological treatment. Participants will be recruited from community pharmacy settings across multiple Egyptian cities Eligible patients are those attending participating community pharmacies during the study period and who are capable of understanding the study procedures and providing written informed consent. The study population reflects a real-world sample of patients managing chronic conditions in community pharmacy practice in Egypt.
Key inclusion criteria (5 listed)
- Adults aged 18 to 80 years.
- Diagnosed with at least one chronic disease requiring long-term pharmacological treatment.
- Currently receiving at least one prescribed medication for a chronic condition.
- Attending a participating community pharmacy during the study period.
- Able and willing to provide written informed consent.
Key exclusion criteria (3 listed)
- Patients with cognitive impairment or mental conditions that limit their ability to understand the study procedures or complete the questionnaire.
- Patients who refuse or are unable to provide written informed consent.
- Patients who are acutely ill and unable to participate at the time of data collection.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Prevalence of Medication Non-Adherence Among Patients with Chronic Diseases
Time frame: Through study completion, an average of 1 month (cross-sectional assessment)
Medication non-adherence will be assessed using the Adherence in Chronic Diseases Scale (ACDS), a validated questionnaire designed to evaluate patients' adherence behaviors toward prescribed medications for chronic conditions. The outcome will be expressed as the proportion of participants classified as non-adherent and adherent based on ACDS scoring, and analyzed in relation to sociodemographic and clinical factors.
1 secondary outcome
Determinants and Predictors of Medication Non-Adherence in Patients with Chronic Diseases
Time frame: Through study completion, an average of 1 month (cross-sectional assessment)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Apr 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Chronic Disease, run by Egyptian Chinese University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 21 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Prevalence of Medication Non-Adherence Among Patients with Chronic Diseases (time frame: Through study completion, an average of 1 month (cross-sectional assessment)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Apr 2026.