OSA - Obstructive Sleep ApneaNCT07376343
Comparative Study of CPAP Predictive Equations and In-laboratory Manual Titration in Thai Patients With Obstructive Sleep Apnea
An observational study of OSA - Obstructive Sleep Apnea, run by Thammasat University at 2 sites in Thailand.
Trial summary
The goal of this observational study is to compare predictive equations for continuous positive airway pressure (CPAP) with in-laboratory manual titration in patients with obstructive sleep apnea (OSA). Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- OSA - Obstructive Sleep Apnea
- What is being tested?
- Sleep test and Predictive equations of continuous positive airway pressure (CPAP)
- How many people
- 150 participants
- Where
- 2 sitesThailand
- Study dates
- 1 Feb 2026to 31 Dec 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients aged 18 years or older with suspected OSA
Who may be able to join
- Suspected OSA
- Undergoing an in-laboratory sleep study
Who cannot join
- No indication for in-laboratory manual CPAP titration
- Failure to determine an optimal CPAP pressure during in-laboratory manual CPAP titration
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Thailand2 sites, 2 recruiting
- Recruiting
Faculty of Medicine, Thammasat University
Pathum Thani, 12120
Narongkorn Saiphoklang, MD, +6629269794, M_narongkorn@hotmail.com
Apiwat Pugongchai, MSc, +6629269142, pu.apiwat@gmail.com
- Recruiting
Narongkorn Saiphoklang
Pathum Thani, 12120
Narongkorn Saiphoklang, MD, +6629269794, M_narongkorn@hotmail.com
Apiwat Pugongchai, MSc, +6629269142, pu.apiwat@gmail.com
About this study
The goal of this observational study is to compare predictive equations for continuous positive airway pressure (CPAP) with in-laboratory manual titration in patients with obstructive sleep apnea (OSA).
The main question the study aims to answer is:
Which CPAP predictive equation best predicts the optimal CPAP pressure in OSA patients in Thailand? Participants will undergo an in-laboratory sleep study.
Read the detailed description
This study is a cross-sectional study involving Thai patients aged 18 years or older with suspected obstructive sleep apnea (OSA). Participants will undergo an in-laboratory sleep study. During the study, sleep technicians will use CPAP predictive equations to estimate the optimal CPAP pressure.
- Conditions
- OSA - Obstructive Sleep Apnea
- Being tested
- Sleep test, Predictive equations of continuous positive airway pressure (CPAP)
- Keywords
- OSA, obstructive sleep apnea, CPAP, continuous positive airway pressure, equation, Thailand, sleep test, polysomnography
- Medical subject headings
- Sleep Apnea, Obstructive
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Sleep testDiagnostic test
Type 1 polysomnography will be performed in the Sleep Center of Thammasat (SCENT).
Predictive equations of continuous positive airway pressure (CPAP)Other
CPAP predictive equations will be selected based on evidence from reliable studies.
| Study group | Role | What they receive |
|---|---|---|
| Obstructive sleep apnea (OSA) | Patients aged 18 years or older with OSA Receives: Diagnostic Test: Sleep test; Other: Predictive equations of continuous positive airway pressure (CPAP) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Accuracy of CPAP equations in predicting the optimal pressure in OSA patients
Sensitivity and specificity (%) of CPAP equations in predicting the optimal pressure in OSA patients
Measured: At baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Jan 2026
- Study start1 Feb 2026
- Primary completion31 Oct 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (11)Papers the sponsor has linked to this study.
- Other trials for OSA - Obstructive Sleep ApneaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 150 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Thammasat University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Narongkorn Saiphoklang, MD, Thammasat University
- Investigators
- Narongkorn Saiphoklang, Principal investigator, Thammasat University Faculty of Medicine
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07376343
- Sponsor's protocol ID
- TUH-EC-OO-0-031/68
- Status last verified
- Apr 2026
- First submitted
- 17 Jan 2026
- Last updated
- 17 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: IPD and documents will be available for sharing immediately after publication for a period of 2 years.
Publications
Lin IF, Chuang ML, Liao YF, Chen NH, Li HY. Predicting effective continuous positive airway pressure in Taiwanese patients with obstructive sleep apnea syndrome. J Formos Med Assoc. 2003 Apr;102(4):215-21.
PubMed 12833183Chuang ML, Lin IF, Vintch JR, Liao YF. Predicting continuous positive airway pressure from a modified split-night protocol in moderate to severe obstructive sleep apnea-hypopnea syndrome. Intern Med. 2008;47(18):1585-92. doi: 10.2169/internalmedicine.47.1107. Epub 2008 Sep 16.
PubMed 18797117Luo J, Xiao S, Qiu Z, Song N, Luo Y. Comparison of manual versus automatic continuous positive airway pressure titration and the development of a predictive equation for therapeutic continuous positive airway pressure in Chinese patients with obstructive sleep apnoea. Respirology. 2013 Apr;18(3):528-33. doi: 10.1111/resp.12014.
PubMed 23145885Wu MF, Hsu JY, Huang WC, Shen GH, Wang JM, Wen CY, Chang KM. Should sleep laboratories have their own predictive formulas for continuous positive airway pressure for patients with obstructive sleep apnea syndrome? J Chin Med Assoc. 2014 Jun;77(6):283-9. doi: 10.1016/j.jcma.2014.02.015. Epub 2014 Apr 14.
PubMed 24731756Pang F, Deng W, Huang J, Guo Y, Lin M, Zhang X, Liu J. Prediction of Optimal Positive Airway Pressure in Chinese Patients With Obstructive Sleep Apnea. Clin Respir J. 2024 Dec;18(12):e70047. doi: 10.1111/crj.70047.
PubMed 39716408Choi JH, Kim EJ, Kim KW, Choi J, Kwon SY, Lee HM, Kim TH, Lee SH, Shin C, Lee SH. Optimal continuous positive airway pressure level in korean patients with obstructive sleep apnea syndrome. Clin Exp Otorhinolaryngol. 2010 Dec;3(4):207-11. doi: 10.3342/ceo.2010.3.4.207. Epub 2010 Dec 22.
PubMed 21217962Lee GH, Kim MJ, Lee EM, Kim CS, Lee SA. Prediction of optimal CPAP pressure and validation of an equation for Asian patients with obstructive sleep apnea. Respir Care. 2013 May;58(5):810-5. doi: 10.4187/respcare.01860.
PubMed 23051618Sarma L, Putti N, Alias K, Chilana M. Determination of equation for estimating continuous positive airway pressure in patients with obstructive sleep apnea for the Indian population. Lung India. 2020 Sep-Oct;37(5):411-414. doi: 10.4103/lungindia.lungindia_322_19.
PubMed 32883901Bamagoos AA, Alshaynawi SA, Gari AS, Badawi AM, Alhiniah MH, Alshahrani AA, Rajab RR, Bahaj RK, Alhejaili F, Wali SO. Optimal positive airway pressure requirement and polysomnography indices of obstructive sleep apnea severity in the Saudi population. Ann Thorac Med. 2023 Jan-Mar;18(1):31-38. doi: 10.4103/atm.atm_183_22. Epub 2023 Jan 25.
PubMed 36968331Ebben MR, Narizhnaya M, Krieger AC. A new predictive model for continuous positive airway pressure in the treatment of obstructive sleep apnea. Sleep Breath. 2017 May;21(2):435-442. doi: 10.1007/s11325-016-1436-7. Epub 2016 Nov 22.
PubMed 27878543Saiphoklang N, Leelasittikul K, Pugongchai A. Prediction of optimal continuous positive airway pressure in Thai patients with obstructive sleep apnea. Sci Rep. 2021 Jul 6;11(1):13935. doi: 10.1038/s41598-021-93554-5.
PubMed 34230571
Study at a glance
From the registry record, last updated by the sponsor on 17 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Study of CPAP Predictive Equations and In-laboratory Manual Titration in Thai Patients With Obstructive Sleep Apnea
- ClinicalTrials.gov ID
- NCT07376343
- Acronym / sponsor ID
- TUH-EC-OO-0-031/68
- Conditions
- OSA - Obstructive Sleep Apnea
- Keywords
- OSA, obstructive sleep apnea, CPAP, continuous positive airway pressure, equation, Thailand, sleep test, polysomnography
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 150 participants (estimated)
- Lead sponsor
- Thammasat UniversityUniversity, hospital or other
- Study start
- 1 Feb 2026 (actual)
- Primary completion
- 31 Oct 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 29 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this observational study is to compare predictive equations for continuous positive airway pressure (CPAP) with in-laboratory manual titration in patients with obstructive sleep apnea (OSA).
The main question the study aims to answer is:
Which CPAP predictive equation best predicts the optimal CPAP pressure in OSA patients in Thailand? Participants will undergo an in-laboratory sleep study.
Detailed description
This study is a cross-sectional study involving Thai patients aged 18 years or older with suspected obstructive sleep apnea (OSA). Participants will undergo an in-laboratory sleep study. During the study, sleep technicians will use CPAP predictive equations to estimate the optimal CPAP pressure.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Obstructive sleep apnea (OSA) | – | Diagnostic Test: Sleep test, Other: Predictive equations of continuous positive airway pressure (CPAP)Patients aged 18 years or older with OSA |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients aged 18 years or older with suspected OSA
Key inclusion criteria (2 listed)
- Suspected OSA
- Undergoing an in-laboratory sleep study
Key exclusion criteria (2 listed)
- No indication for in-laboratory manual CPAP titration
- Failure to determine an optimal CPAP pressure during in-laboratory manual CPAP titration
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Sleep testType 1 polysomnography will be performed in the Sleep Center of Thammasat (SCENT). | Diagnostic test | Obstructive sleep apnea (OSA) |
| Predictive equations of continuous positive airway pressure (CPAP)CPAP predictive equations will be selected based on evidence from reliable studies. | Other | Obstructive sleep apnea (OSA) |
Primary outcome
Accuracy of CPAP equations in predicting the optimal pressure in OSA patients
Time frame: At baseline
Sensitivity and specificity (%) of CPAP equations in predicting the optimal pressure in OSA patients
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Apr 2026.
- Results publication: PubMed 12833183Lin IF, Chuang ML, Liao YF, Chen NH, Li HY. Predicting effective continuous positive airway pressure in Taiwanese patients with obstructive sleep apnea syndrome. J Formos Med Assoc. 2003 Apr;102(4):215-21.
- Results publication: PubMed 18797117Chuang ML, Lin IF, Vintch JR, Liao YF. Predicting continuous positive airway pressure from a modified split-night protocol in moderate to severe obstructive sleep apnea-hypopnea syndrome. Intern Med. 2008;47(18):1585-92. doi: 10.2169/internalmedicine.47.1107. Epub 2008 Sep 16.
- Results publication: PubMed 23145885Luo J, Xiao S, Qiu Z, Song N, Luo Y. Comparison of manual versus automatic continuous positive airway pressure titration and the development of a predictive equation for therapeutic continuous positive airway pressure in Chinese patients with obstructive sleep apnoea. Respirology. 2013 Apr;18(3):528-33. doi: 10.1111/resp.12014.
- Results publication: PubMed 24731756Wu MF, Hsu JY, Huang WC, Shen GH, Wang JM, Wen CY, Chang KM. Should sleep laboratories have their own predictive formulas for continuous positive airway pressure for patients with obstructive sleep apnea syndrome? J Chin Med Assoc. 2014 Jun;77(6):283-9. doi: 10.1016/j.jcma.2014.02.015. Epub 2014 Apr 14.
- Results publication: PubMed 39716408Pang F, Deng W, Huang J, Guo Y, Lin M, Zhang X, Liu J. Prediction of Optimal Positive Airway Pressure in Chinese Patients With Obstructive Sleep Apnea. Clin Respir J. 2024 Dec;18(12):e70047. doi: 10.1111/crj.70047.
- Results publication: PubMed 21217962Choi JH, Kim EJ, Kim KW, Choi J, Kwon SY, Lee HM, Kim TH, Lee SH, Shin C, Lee SH. Optimal continuous positive airway pressure level in korean patients with obstructive sleep apnea syndrome. Clin Exp Otorhinolaryngol. 2010 Dec;3(4):207-11. doi: 10.3342/ceo.2010.3.4.207. Epub 2010 Dec 22.
- Results publication: PubMed 23051618Lee GH, Kim MJ, Lee EM, Kim CS, Lee SA. Prediction of optimal CPAP pressure and validation of an equation for Asian patients with obstructive sleep apnea. Respir Care. 2013 May;58(5):810-5. doi: 10.4187/respcare.01860.
- Results publication: PubMed 32883901Sarma L, Putti N, Alias K, Chilana M. Determination of equation for estimating continuous positive airway pressure in patients with obstructive sleep apnea for the Indian population. Lung India. 2020 Sep-Oct;37(5):411-414. doi: 10.4103/lungindia.lungindia_322_19.
- Results publication: PubMed 36968331Bamagoos AA, Alshaynawi SA, Gari AS, Badawi AM, Alhiniah MH, Alshahrani AA, Rajab RR, Bahaj RK, Alhejaili F, Wali SO. Optimal positive airway pressure requirement and polysomnography indices of obstructive sleep apnea severity in the Saudi population. Ann Thorac Med. 2023 Jan-Mar;18(1):31-38. doi: 10.4103/atm.atm_183_22. Epub 2023 Jan 25.
- Results publication: PubMed 27878543Ebben MR, Narizhnaya M, Krieger AC. A new predictive model for continuous positive airway pressure in the treatment of obstructive sleep apnea. Sleep Breath. 2017 May;21(2):435-442. doi: 10.1007/s11325-016-1436-7. Epub 2016 Nov 22.
- Results publication: PubMed 34230571Saiphoklang N, Leelasittikul K, Pugongchai A. Prediction of optimal continuous positive airway pressure in Thai patients with obstructive sleep apnea. Sci Rep. 2021 Jul 6;11(1):13935. doi: 10.1038/s41598-021-93554-5.
- Individual participant dataSharing planned: Yes. IPD and documents will be available for sharing immediately after publication for a period of 2 years.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Narongkorn Saiphoklang principal investigator
Thammasat University Faculty of Medicine
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of OSA - Obstructive Sleep Apnea, run by Thammasat University at 2 sites in Thailand.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 17 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Thailand. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Narongkorn Saiphoklang, MD (+6629269794, M_narongkorn@hotmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Accuracy of CPAP equations in predicting the optimal pressure in OSA patients (time frame: At baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07376343, which also lists 11 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Apr 2026.