Metabolic Adaptation to High-Intensity Interval TrainingCAII-BASKETNCT07377851
Carbonic Anhydrase II Responses to Basketball-Specific High-Intensity Interval Training
A study testing Basketball-Specific High-Intensity Interval Training in people with Metabolic Adaptation to High-Intensity Interval Training, run by Karamanoğlu Mehmetbey University at 1 site in Turkey (Türkiye).
Trial summary
This study aims to examine whether erythrocyte carbonic anhydrase II can be used as a biological marker of metabolic adaptation to basketball-specific high-intensity interval training. Read more about this study
- Who is it for?
- Ages 18 to 30 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Metabolic Adaptation to High-Intensity Interval Training
- What is being tested?
- Basketball-Specific High-Intensity Interval Training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 24 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Nov 2025to 15 Jan 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy male and female basketball players aged 18 years or older
- Actively participating in regular basketball training at the time of the study
- Free from known cardiovascular, metabolic, or respiratory diseases
- No musculoskeletal injury that could limit participation in high-intensity exercise
- Willingness to participate in a basketball-specific high-intensity interval training program
- Ability to provide written informed consent
Who cannot join
- Presence of any diagnosed cardiovascular, metabolic, or respiratory disease
- Use of medications or supplements known to affect metabolic or acid-base balance
- Acute or chronic musculoskeletal injury within the previous three months
- Participation in another structured training or research intervention during the study period
- Failure to comply with the training protocol or assessment procedures
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Karamanoğlu Mehmetbey University, Faculty of Sport Sciences
Karaman, Karaman, 70200
About this study
Official title: Erythrocyte Carbonic Anhydrase II as a Marker of Metabolic Adaptation to Basketball-Specific High-Intensity Interval Training
This study aims to examine whether erythrocyte carbonic anhydrase II can be used as a biological marker of metabolic adaptation to basketball-specific high-intensity interval training. Carbonic anhydrase II is an enzyme involved in acid-base balance and carbon dioxide transport, and it may reflect physiological adaptations to intense exercise.
Healthy basketball players participated in a structured high-intensity interval training program designed to reflect the physical demands of basketball. Blood samples and performance-related measurements were collected before and after the training period to evaluate changes in erythrocyte carbonic anhydrase II levels and related metabolic responses.
The findings of this study are expected to improve the understanding of exercise-induced metabolic adaptations and to explore the potential use of erythrocyte carbonic anhydrase II as a practical biomarker for monitoring training responses in basketball players.
Read the detailed description
This study was designed to investigate erythrocyte carbonic anhydrase II as a potential biomarker of metabolic adaptation to basketball-specific high-intensity interval training. Carbonic anhydrase II plays a key role in acid-base regulation and carbon dioxide transport, which are critical physiological processes during repeated high-intensity exercise.
Participants were healthy basketball players who completed a structured high-intensity interval training program reflecting the intermittent and high-demand nature of basketball activity. The training protocol consisted of repeated bouts of intense exercise interspersed with short recovery periods, consistent with established basketball-specific conditioning practices.
Blood samples were obtained at predefined time points to assess erythrocyte carbonic anhydrase II levels. These biochemical measurements were evaluated alongside selected performance and physiological indicators to characterize training-induced metabolic adaptations. All assessments were conducted under standardized conditions to minimize variability related to diet, hydration, and recent physical activity.
The study followed an observational pre-post design without clinical intervention beyond the prescribed training program. No experimental drugs or medical devices were used. Safety monitoring was conducted throughout the study period, and no serious adverse events were anticipated given the low-risk nature of the exercise protocol and the healthy status of the participants.
This study seeks to contribute to the growing body of research on exercise-related biomarkers by examining whether erythrocyte carbonic anhydrase II may provide practical insight into metabolic adaptation to sport-specific high-intensity training.
- Being tested
- Basketball-Specific High-Intensity Interval Training
- Keywords
- Carbonic Anhydrase II, Exercise Physiology, Metabolic Adaptation, High-Intensity Interval Training, Basketball Training
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Basketball-Specific High-Intensity Interval TrainingBehavioural
A structured basketball-specific high-intensity interval training program consisting of repeated bouts of intense exercise interspersed with short recovery periods, designed to induce metabolic adaptations.
| Study group | Role | What they receive |
|---|---|---|
| Basketball-Specific High-Intensity Interval Training | Experimental | Participants completed a basketball-specific high-intensity interval training program designed to induce metabolic adaptations. All participants were assigned to this single intervention arm and completed the same training protocol. Receives: Behavioral: Basketball-Specific High-Intensity Interval Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Erythrocyte Carbonic Anhydrase II Levels
The primary outcome is the change in erythrocyte carbonic anhydrase II levels measured before and after the basketball-specific high-intensity interval training program. Erythrocyte carbonic anhydrase II was assessed from blood samples as an indicator of metabolic adaptation to high-intensity exercise.
Measured: Baseline( week 0) and post training (week 8)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Jan 2026
- Study start1 Nov 2025
- Primary completion10 Jan 2026
- Study completion15 Jan 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Metabolic Adaptation to High-Intensity Interval TrainingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 24 participants (actual)
Sponsor and investigators
- Lead sponsor
- Karamanoğlu Mehmetbey University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Recep Soslu, Karamanoğlu Mehmetbey University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07377851
- Sponsor's protocol ID
- 03-2023/02
- Acronym
- CAII-BASKET
- Status last verified
- Jan 2026
- First submitted
- 22 Jan 2026
- Last updated
- 30 Jan 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Erythrocyte Carbonic Anhydrase II as a Marker of Metabolic Adaptation to Basketball-Specific High-Intensity Interval Training
- ClinicalTrials.gov ID
- NCT07377851
- Acronym / sponsor ID
- CAII-BASKET / 03-2023/02
- Keywords
- Carbonic Anhydrase II, Exercise Physiology, Metabolic Adaptation, High-Intensity Interval Training, Basketball Training
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 24 participants (actual)
- Lead sponsor
- Karamanoğlu Mehmetbey UniversityUniversity, hospital or other
- Study start
- 1 Nov 2025 (actual)
- Primary completion
- 10 Jan 2026 (actual)
- Study completion
- 15 Jan 2026 (actual)
- First posted
- 30 Jan 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to examine whether erythrocyte carbonic anhydrase II can be used as a biological marker of metabolic adaptation to basketball-specific high-intensity interval training. Carbonic anhydrase II is an enzyme involved in acid-base balance and carbon dioxide transport, and it may reflect physiological adaptations to intense exercise.
Healthy basketball players participated in a structured high-intensity interval training program designed to reflect the physical demands of basketball. Blood samples and performance-related measurements were collected before and after the training period to evaluate changes in erythrocyte carbonic anhydrase II levels and related metabolic responses.
The findings of this study are expected to improve the understanding of exercise-induced metabolic adaptations and to explore the potential use of erythrocyte carbonic anhydrase II as a practical biomarker for monitoring training responses in basketball players.
Detailed description
This study was designed to investigate erythrocyte carbonic anhydrase II as a potential biomarker of metabolic adaptation to basketball-specific high-intensity interval training. Carbonic anhydrase II plays a key role in acid-base regulation and carbon dioxide transport, which are critical physiological processes during repeated high-intensity exercise.
Participants were healthy basketball players who completed a structured high-intensity interval training program reflecting the intermittent and high-demand nature of basketball activity. The training protocol consisted of repeated bouts of intense exercise interspersed with short recovery periods, consistent with established basketball-specific conditioning practices.
Blood samples were obtained at predefined time points to assess erythrocyte carbonic anhydrase II levels. These biochemical measurements were evaluated alongside selected performance and physiological indicators to characterize training-induced metabolic adaptations. All assessments were conducted under standardized conditions to minimize variability related to diet, hydration, and recent physical activity.
The study followed an observational pre-post design without clinical intervention beyond the prescribed training program. No experimental drugs or medical devices were used. Safety monitoring was conducted throughout the study period, and no serious adverse events were anticipated given the low-risk nature of the exercise protocol and the healthy status of the participants.
This study seeks to contribute to the growing body of research on exercise-related biomarkers by examining whether erythrocyte carbonic anhydrase II may provide practical insight into metabolic adaptation to sport-specific high-intensity training.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Basketball-Specific High-Intensity Interval Training | Experimental | Behavioral: Basketball-Specific High-Intensity Interval TrainingParticipants completed a basketball-specific high-intensity interval training program designed to induce metabolic adaptations. All participants were assigned to this single intervention arm and completed the same training protocol. |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Healthy male and female basketball players aged 18 years or older
- Actively participating in regular basketball training at the time of the study
- Free from known cardiovascular, metabolic, or respiratory diseases
- No musculoskeletal injury that could limit participation in high-intensity exercise
- Willingness to participate in a basketball-specific high-intensity interval training program
Key exclusion criteria (5 listed)
- Presence of any diagnosed cardiovascular, metabolic, or respiratory disease
- Use of medications or supplements known to affect metabolic or acid-base balance
- Acute or chronic musculoskeletal injury within the previous three months
- Participation in another structured training or research intervention during the study period
- Failure to comply with the training protocol or assessment procedures
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Basketball-Specific High-Intensity Interval TrainingA structured basketball-specific high-intensity interval training program consisting of repeated bouts of intense exercise interspersed with short recovery periods, designed to induce metabolic adaptations. | Behavioural | Basketball-Specific High-Intensity Interval Training |
Primary outcome
Change in Erythrocyte Carbonic Anhydrase II Levels
Time frame: Baseline( week 0) and post training (week 8)
The primary outcome is the change in erythrocyte carbonic anhydrase II levels measured before and after the basketball-specific high-intensity interval training program. Erythrocyte carbonic anhydrase II was assessed from blood samples as an indicator of metabolic adaptation to high-intensity exercise.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Jan 2026.
- Individual participant dataSharing planned: No
Related trials for Metabolic Adaptation to High-Intensity Interval Training
Recruiting
Rehabilitation With Exercise-Based Intervention for Nonalcoholic Chronic Hepatic Esteatosis
Metabolic Adaptation to High-Intensity Interval Training, Metabolic Associated-dysfunction Steatotic Liver Disease (MASLD)
Recruiting
Redox Status and Exercise Training-induced Adaptations
Overweight (BMI > 25), Obesity
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Basketball-Specific High-Intensity Interval Training in people with Metabolic Adaptation to High-Intensity Interval Training, run by Karamanoğlu Mehmetbey University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Erythrocyte Carbonic Anhydrase II Levels (time frame: Baseline( week 0) and post training (week 8)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Jan 2026.