Healthy VolunteersNCT07383974
The Impact of 12 Week Retention of Nutrients on Skin and the Perception of Physical Health Status
A study testing Vitamin C & Green Tea Capsules + Multivitamin & Mineral Capsules Combination in people with Healthy Volunteers and Dietary Supplementation, run by ChinaNorm at 1 site in China.
Trial summary
This is a randomized, double-blind, placebo-controlled clinical trial exploring the effects of a 12-week dietary supplement regimen on skin condition and perceived overall health status. The study will involve 120 healthy Chinese adults aged 18 and above with low daily fruit and vegetable intake. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Healthy Volunteers, Dietary Supplementation, Skin Health
- What is being tested?
- Vitamin C & Green Tea Capsules + Multivitamin & Mineral Capsules Combination
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 120 participants
- Where
- 1 siteChina
- Study dates
- 3 Nov 2025to 2 Feb 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Chinese adults of Asian descent aged 18 and above;
- Daily fruit and vegetable intake < 240g (calculated based on the fruit and vegetable section of the food frequency questionnaire);
- S3 measurement index < 30000;
- Participants must possess basic Chinese reading comprehension and expression skills, and be able to independently complete questionnaire surveys;
- Voluntary participation in the test and signing of the informed consent form;
- Willingness to comply with all evaluation requirements.
Who cannot join
- Presence of open facial skin lesions, clearly visible scars, acne marks, etc.;
- Skin lesions, scars, or significant pigmentation on the hand measurement area;
- Symptoms of skin disease on the face or hand measurement areas;
- Having undergone medical aesthetic procedures within the last 6 months;
- Participation in other clinical trials involving product use within the last 3 months;
- Use of health supplements or nutritional supplements (e.g., vitamins, minerals) within the last 1 month;
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- Currently planning for pregnancy, pregnant, or lactating;
- Presence of any disease under current treatment;
- Any other health issues or chronic diseases that affect behavioral or cognitive abilities;
- Other iatrogenic reasons identified by experts or professionals that may affect the evaluation results.
- The S3 instrument refers to a Raman spectroscopy-based biophotonic scanner. The threshold for the S3 screening value is based on previously published literature, which indicated that participants with a daily fruit and vegetable intake of less than 240g had an average Raman spectroscopy biophotonic scanner score below 25,000. However, considering practical recruitment challenges, the inclusion criterion was set at < 30,000. The S3 device measures the Skin Carotenoid Index, a non-invasive biomarker reflecting skin carotenoid levels.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site, 1 recruiting
- Recruiting
Shanghai China-norm Quality Technical Service Co., Ltd.
Shanghai, Shanghai Municipality, 200072
Yanwen Jiang, 13501700841, jiangyanwen@china-norm.com
About this study
This is a randomized, double-blind, placebo-controlled clinical trial exploring the effects of a 12-week dietary supplement regimen on skin condition and perceived overall health status.
The study will involve 120 healthy Chinese adults aged 18 and above with low daily fruit and vegetable intake. Participants will be randomly assigned to one of two groups: one group will take a combination of Nu Skin's Vitamin C \& Green Tea Capsules and Multivitamin \& Mineral Capsules, while the other group will take a matching placebo.
Read more
The primary goal is to assess if the supplement combination improves skin health after 12 weeks, measured through specialized facial imaging (assessing spots, redness, evenness) and probe measurements (assessing elasticity, moisture, gloss). Secondary goals include evaluating changes in participants' self-perceived health status (via quality of life, fatigue, and digestive health questionnaires), psychological resilience, memory, and exploring a new method for measuring skin carotenoid levels.
This study is not intended to verify the approved health functions of the products but to explore the potential combined effects of antioxidant and nutritional supplementation on skin and general well-being.
- Being tested
- Vitamin C & Green Tea Capsules + Multivitamin & Mineral Capsules Combination, Placebo Combination (Matching)
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Vitamin C & Green Tea Capsules + Multivitamin & Mineral Capsules CombinationDietary supplement
Participants take a combination of active supplements-specifically, Vitamin C \& Green Tea Capsules and Multivitamin \& Mineral Capsules-orally twice daily.
Placebo Combination (Matching)Dietary supplement
Participants take a matching placebo combination (identical in appearance and taste to the active supplements) orally twice daily
| Study group | Role | What they receive |
|---|---|---|
| Supplement Combination Group | Experimental | Not described Receives: Dietary Supplement: Vitamin C & Green Tea Capsules + Multivitamin & Mineral Capsules Combination |
| Placebo Control Group | Placebo comparator | Not described Receives: Dietary Supplement: Placebo Combination (Matching) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Facial Image Capture VISIA-7
Measured: Imaging sessions are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks)
Skin Elasticity Test Probe Cutometer
Measured: Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks)
Skin Gloss Measurement Glossmeter
Measured: Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Skin Moisture Content Corneometer
Measured: Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks)
Skin Hemoglobin Measurement Mexameter MX18 (Courage & Khazaka, Germany)
Measured: Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Skin Moisture Loss Meter Vapometer (Delfin, Finland)
Measured: Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Skin Carotenoid Index
Measured: Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Secondary outcomes (5)
Skin Condition Survey
This survey assesses participants' subjective perception of their skin condition over the past month. It consists of two parts: 1) The Fitzpatrick Skin Typing Questionnaire determines the participant's skin type (I-VI) based on genetic predisposition, tanning ability, and sun reaction. 2) The Skin Status Self-Assessment uses a 100mm visual analog scale for participants to rate various aspects of their skin, including photo-damage (acute and chronic), brightness, glossiness, smoothness, hydration, pore appearance, evenness, softness, elasticity, overall wrinkles, appearance, plumpness, firmness, and spots.
Measured: The scales and questionnaires are administered at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Physical Health and Life Status Survey
This comprehensive survey evaluates participants' perceived physical health and quality of life over the past month. It incorporates five validated instruments: the SF-36 Health Survey, the Frequency of Physical Discomfort Questionnaire, the Gastrointestinal Discomfort Symptoms Questionnaire , the Population-Based Visual Fatigue Scale, and the TCM Constitution Classification and Determination Self-Assessment Table .
Measured: The survey is administered at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Psychological State and Memory Level
This component measures participants' subjective psychological state and memory function over the past month. It uses two main instruments: 1) The Brief Resilience Scale (BRS) assesses the ability to bounce back from stress and adversity (psychological resilience). 2) The Multifactorial Memory Questionnaire (MMQ) is divided into three subscales evaluating memory satisfaction/ability (Contentment), frequency of memory failures (Ability), and the use of compensatory strategies (Strategy).
Measured: The assessment is conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Self-Evaluation Questionnaire
This questionnaire is specifically designed for participants to subjectively evaluate the effects of the product intervention. It assesses perceived improvements in areas such as energy levels, overall health status, immune function, recovery speed from illness, quality of life, and the product's contribution to long-term health using a Likert scale.
Measured: This questionnaire is administered only at follow-up visits: T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Height and Weight Measurement BMI
Body Mass Index (BMI) is calculated from height and weight measurements to assess weight status and changes over the intervention period.
Measured: Measurements are conducted at T0 (baseline, upon enrollment) and T12w (12 weeks).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Feb 2026
- Study start3 Nov 2025
- Primary completion2 Feb 2026 (estimated)
- Study completion2 Feb 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy VolunteersStudies of the same condition, open and under way.
- More trials run by ChinaNormThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 120 participants (estimated)
Sponsor and investigators
- Lead sponsor
- ChinaNorm
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07383974
- Sponsor's protocol ID
- W25002003
- Status last verified
- Jan 2026
- First submitted
- 19 Jan 2026
- Last updated
- 3 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Impact of 12 Week Retention of Nutrients on Skin and the Perception of Physical Health Status
- ClinicalTrials.gov ID
- NCT07383974
- Acronym / sponsor ID
- W25002003
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 120 participants (estimated)
- Lead sponsor
- ChinaNormIndustry (pharma, biotech, devices)
- Study start
- 3 Nov 2025 (actual)
- Primary completion
- 2 Feb 2026 (estimated)
- Study completion
- 2 Feb 2026 (estimated)
- First posted
- 3 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a randomized, double-blind, placebo-controlled clinical trial exploring the effects of a 12-week dietary supplement regimen on skin condition and perceived overall health status.
The study will involve 120 healthy Chinese adults aged 18 and above with low daily fruit and vegetable intake. Participants will be randomly assigned to one of two groups: one group will take a combination of Nu Skin's Vitamin C \& Green Tea Capsules and Multivitamin \& Mineral Capsules, while the other group will take a matching placebo.
The primary goal is to assess if the supplement combination improves skin health after 12 weeks, measured through specialized facial imaging (assessing spots, redness, evenness) and probe measurements (assessing elasticity, moisture, gloss). Secondary goals include evaluating changes in participants' self-perceived health status (via quality of life, fatigue, and digestive health questionnaires), psychological resilience, memory, and exploring a new method for measuring skin carotenoid levels.
This study is not intended to verify the approved health functions of the products but to explore the potential combined effects of antioxidant and nutritional supplementation on skin and general well-being.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, investigator)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Supplement Combination Group | Experimental | Dietary Supplement: Vitamin C & Green Tea Capsules + Multivitamin & Mineral Capsules Combination |
| Placebo Control Group | Placebo comparator | Dietary Supplement: Placebo Combination (Matching) |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Chinese adults of Asian descent aged 18 and above;
- Daily fruit and vegetable intake < 240g (calculated based on the fruit and vegetable section of the food frequency questionnaire);
- S3 measurement index < 30000;
- Participants must possess basic Chinese reading comprehension and expression skills, and be able to independently complete questionnaire surveys;
- Voluntary participation in the test and signing of the informed consent form;
Key exclusion criteria (11 listed)
- Presence of open facial skin lesions, clearly visible scars, acne marks, etc.;
- Skin lesions, scars, or significant pigmentation on the hand measurement area;
- Symptoms of skin disease on the face or hand measurement areas;
- Having undergone medical aesthetic procedures within the last 6 months;
- Participation in other clinical trials involving product use within the last 3 months;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Vitamin C & Green Tea Capsules + Multivitamin & Mineral Capsules CombinationParticipants take a combination of active supplements-specifically, Vitamin C \& Green Tea Capsules and Multivitamin \& Mineral Capsules-orally twice daily. | Dietary supplement | Supplement Combination Group |
| Placebo Combination (Matching)Participants take a matching placebo combination (identical in appearance and taste to the active supplements) orally twice daily | Dietary supplement | Placebo Control Group |
Primary outcome
Facial Image Capture VISIA-7
Time frame: Imaging sessions are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks)
Skin Elasticity Test Probe Cutometer
Time frame: Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks)
Skin Gloss Measurement Glossmeter
Time frame: Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Skin Moisture Content Corneometer
Time frame: Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks)
Skin Hemoglobin Measurement Mexameter MX18 (Courage & Khazaka, Germany)
Time frame: Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Skin Moisture Loss Meter Vapometer (Delfin, Finland)
Time frame: Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Skin Carotenoid Index
Time frame: Measurements are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
5 secondary outcomes
Skin Condition Survey
Time frame: The scales and questionnaires are administered at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Physical Health and Life Status Survey
Time frame: The survey is administered at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Psychological State and Memory Level
Time frame: The assessment is conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Self-Evaluation Questionnaire
Time frame: This questionnaire is administered only at follow-up visits: T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks).
Height and Weight Measurement BMI
Time frame: Measurements are conducted at T0 (baseline, upon enrollment) and T12w (12 weeks).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Feb 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Vitamin C & Green Tea Capsules + Multivitamin & Mineral Capsules Combination in people with Healthy Volunteers and Dietary Supplementation, run by ChinaNorm at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 3 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Yanwen Jiang (13501700841, jiangyanwen@china-norm.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Facial Image Capture VISIA-7 (time frame: Imaging sessions are conducted at T0 (baseline), T4w (4 weeks), T8w (8 weeks), and T12w (12 weeks)). The study lists 7 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Feb 2026.