Autism Spectrum DisorderDOMANCT07384819
Duration of Moment in Autism
A study testing Temporal Integration Window task and Attentional Blink task in people with Autism Spectrum Disorder, run by Hôpital le Vinatier at 2 sites in France.
Trial summary
This study investigates the temporal dynamics of perception and attention in children with Autism Spectrum Disorder (ASD), focusing on two key phenomena: the Temporal Integration Window (TIW) and the attentional blink. Read more about this study
- Who is it for?
- Ages 36 to 71 monthsHealthy volunteers can take part
- Conditions the study is for
- Autism Spectrum Disorder
- What is being tested?
- Temporal Integration Window task and Attentional Blink task
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 228 participants
- Where
- 2 sitesFrance
- Study dates
- 16 Feb 2026to 16 Aug 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 36 to 71 months
- All sexes
- Healthy volunteers accepted
- Child
Who may be able to join
- Children aged 3 or 5 years
- Either with a diagnosis of Autism Spectrum Disorder (ASD) or typically developing (neurotypical)
- No intellectual disability (per Mullen, Denver, or psychometric report)
- Normal or corrected vision and hearing
- Written informed consent from legal guardians
- Legal guardians affiliated to a French social security plan
- For ASD group only : classification as prototypical or non-prototypical based on clinical evaluation
Who cannot join
- Neurological disorder
- Parental or child refusal to participate
- For neurotypical children: developmental delay or psychiatric diagnosis
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
France2 sites
Baby lab - Institut des sciences cognitives Marc Jeannerod
Bron
Jean-Rémy HOCHMANN, PhD, +33 04 37 91 12 70, hochmann@isc.cnrs.fr
CEDA - Le Vinatier
Bron
Marie-Maude GEOFFRAY-CASSAR, PhD, +33426738530, Marie-Maude.GEOFFRAY-CASSAR@ch-le-vinatier.fr
About this study
Official title: Evaluation of Visual Perception Development in Autism: Duration of a Moment
This study investigates the temporal dynamics of perception and attention in children with Autism Spectrum Disorder (ASD), focusing on two key phenomena: the Temporal Integration Window (TIW) and the attentional blink. Using eye-tracking, 3- and 5-year-old children with ASD (prototypical or not) will be compared to age-matched neurotypical peers.
The investigators hypothesize that children with ASD exhibit shorter TIWs and attentional blinks, reflecting faster perceptual sampling and attentional processing. These characteristics may contribute to sensory hypersensitivity and difficulties in complex, unpredictable environments such as social situations. The protocol includes two experimental tasks.
Read the detailed description
The study is a multicenter research project that aims to investigate the temporal dynamics of visual perception and attention in children with Autism Spectrum Disorder (ASD), including both prototypical and non-prototypical subgroups. It compares these groups to age-matched neurotypical peers. The study focuses on two distinct cognitive phenomena:
Temporal Integration Window (TIW) : a pre-attentive perceptual mechanism that determines the time frame within which visual information is integrated into a unified percept. In typically developing adults, this window is estimated to be around 65 milliseconds. Prior research suggests that children with ASD may have a shorter TIW, indicating faster perceptual sampling.
Attentional Blink (AB) : a post-perceptual phenomenon reflecting limitations in attentional resources. When two targets are presented in rapid succession, the second target is often missed if it follows too closely after the first. The duration of the attentional blink is thought to decrease with age and maturation. Previous studies have shown that attentional blink is already present at 5 months of age and shortens during development.
The central hypothesis is that both TIW and AB durations might be shorter in children with ASD, reflecting faster perceptual and attentional processing. This accelerated dynamic could contribute to sensory hypersensitivity and difficulty coping with complex or unpredictable environments, such as those involving social stimuli.
A total of 228 children will participate, divided into six groups.
Each participant will complete two eye-tracking tasks during a single session lasting approximately one hour:
- The TIW task
- The Attentional Blink task
Developmental level is assessed using validated tools: the Mullen Scales of Early Learning, VINELAND-2 or the IDE questionnaire, depending on the child's group.
The study will also examine whether the prototypical ASD subgroup, as defined by clinical criteria shows distinct perceptual profiles, and whether age or developmental level influences temporal dynamics.
This study aims to better understand early perceptual and attentional processes in autism.
- Conditions
- Autism Spectrum Disorder
- Being tested
- Temporal Integration Window task, Attentional Blink task
- Keywords
- autism, Prototypical autism, Temporal Integration Window, Attentional Blink, Eye-tracking, Visual perception, Infant development
- Medical subject headings
- Autism Spectrum Disorder, Autistic Disorder
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Temporal Integration Window taskBehavioural
The TIW task involves alternating visual displays (integration and segmentation trials) across four inter-stimulus intervals (ISI: 16, 32, 83, 116 ms). This task allows estimation of the participant's perceptual integration threshold.
Attentional Blink taskBehavioural
The Attentional Blink task presents rapid sequences of images (including two targets and distractors), measuring the minimum time delay required for both targets to be detected. Three different T1-T2 intervals are tested.
| Study group | Role | What they receive |
|---|---|---|
| Neurotypical 3-year-olds | Other | 3-year-old children without a neurodevelopmental disorder Receives: Behavioral: Temporal Integration Window task; Behavioral: Attentional Blink task |
| Neurotypical 5-year-olds | Other | 5-year-old children without a neurodevelopmental disorder Receives: Behavioral: Temporal Integration Window task; Behavioral: Attentional Blink task |
| Prototypical ASD 3-year-olds | Experimental | 3-year-old children with a diagnosis of ASD and prototypical characteristics Receives: Behavioral: Temporal Integration Window task; Behavioral: Attentional Blink task |
| Prototypical ASD 5-year-olds | Experimental | 5-year-old children with a diagnosis of ASD and prototypical characteristics Receives: Behavioral: Temporal Integration Window task; Behavioral: Attentional Blink task |
| Non-prototypical ASD 3-year-olds | Experimental | 3-year-old children with a diagnosis of ASD but not prototypical characteristics Receives: Behavioral: Temporal Integration Window task; Behavioral: Attentional Blink task |
| Non-prototypical ASD 5-year-olds | Experimental | 5-year-old children with a diagnosis of ASD but not prototypical characteristics Receives: Behavioral: Temporal Integration Window task; Behavioral: Attentional Blink task |
What is being measured
The primary outcome is the main question the study is designed to answer.
Temporal dynamics of perception
The Temporal Integration Window (TIW) is defined as the shortest interval between two displays that can be integrated into a single percept
Measured: Baseline
Temporal dynamics of attention
The Attentional Blink duration, defined as the minimal delay between two target stimuli that allows detection of both.
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Feb 2026
- Study start16 Feb 2026 (estimated)
- Primary completion16 Aug 2028 (estimated)
- Study completion16 Aug 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Autism Spectrum DisorderStudies of the same condition, open and under way.
- More trials run by Hôpital le VinatierThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 228 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Hôpital le Vinatier
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07384819
- Sponsor's protocol ID
- 2025-A02488-41
- Acronym
- DOMA
- Status last verified
- Feb 2026
- First submitted
- 27 Jan 2026
- Last updated
- 5 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 5 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Visual Perception Development in Autism: Duration of a Moment
- ClinicalTrials.gov ID
- NCT07384819
- Acronym / sponsor ID
- DOMA / 2025-A02488-41
- Conditions
- Autism Spectrum Disorder
- Keywords
- autism, Prototypical autism, Temporal Integration Window, Attentional Blink, Eye-tracking, Visual perception, Infant development
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 228 participants (estimated)
- Lead sponsor
- Hôpital le VinatierUniversity, hospital or other
- Study start
- 16 Feb 2026 (estimated)
- Primary completion
- 16 Aug 2028 (estimated)
- Study completion
- 16 Aug 2028 (estimated)
- First posted
- 3 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study investigates the temporal dynamics of perception and attention in children with Autism Spectrum Disorder (ASD), focusing on two key phenomena: the Temporal Integration Window (TIW) and the attentional blink. Using eye-tracking, 3- and 5-year-old children with ASD (prototypical or not) will be compared to age-matched neurotypical peers.
The investigators hypothesize that children with ASD exhibit shorter TIWs and attentional blinks, reflecting faster perceptual sampling and attentional processing. These characteristics may contribute to sensory hypersensitivity and difficulties in complex, unpredictable environments such as social situations. The protocol includes two experimental tasks.
Detailed description
The study is a multicenter research project that aims to investigate the temporal dynamics of visual perception and attention in children with Autism Spectrum Disorder (ASD), including both prototypical and non-prototypical subgroups. It compares these groups to age-matched neurotypical peers. The study focuses on two distinct cognitive phenomena:
Temporal Integration Window (TIW) : a pre-attentive perceptual mechanism that determines the time frame within which visual information is integrated into a unified percept. In typically developing adults, this window is estimated to be around 65 milliseconds. Prior research suggests that children with ASD may have a shorter TIW, indicating faster perceptual sampling.
Attentional Blink (AB) : a post-perceptual phenomenon reflecting limitations in attentional resources. When two targets are presented in rapid succession, the second target is often missed if it follows too closely after the first. The duration of the attentional blink is thought to decrease with age and maturation. Previous studies have shown that attentional blink is already present at 5 months of age and shortens during development.
The central hypothesis is that both TIW and AB durations might be shorter in children with ASD, reflecting faster perceptual and attentional processing. This accelerated dynamic could contribute to sensory hypersensitivity and difficulty coping with complex or unpredictable environments, such as those involving social stimuli.
A total of 228 children will participate, divided into six groups.
Each participant will complete two eye-tracking tasks during a single session lasting approximately one hour:
- The TIW task
- The Attentional Blink task
Developmental level is assessed using validated tools: the Mullen Scales of Early Learning, VINELAND-2 or the IDE questionnaire, depending on the child's group.
The study will also examine whether the prototypical ASD subgroup, as defined by clinical criteria shows distinct perceptual profiles, and whether age or developmental level influences temporal dynamics.
This study aims to better understand early perceptual and attentional processes in autism.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 6
| Arm | Type | Receives |
|---|---|---|
| Neurotypical 3-year-olds | Other | Behavioral: Temporal Integration Window task, Behavioral: Attentional Blink task3-year-old children without a neurodevelopmental disorder |
| Neurotypical 5-year-olds | Other | Behavioral: Temporal Integration Window task, Behavioral: Attentional Blink task5-year-old children without a neurodevelopmental disorder |
| Prototypical ASD 3-year-olds | Experimental | Behavioral: Temporal Integration Window task, Behavioral: Attentional Blink task3-year-old children with a diagnosis of ASD and prototypical characteristics |
| Prototypical ASD 5-year-olds | Experimental | Behavioral: Temporal Integration Window task, Behavioral: Attentional Blink task5-year-old children with a diagnosis of ASD and prototypical characteristics |
| Non-prototypical ASD 3-year-olds | Experimental | Behavioral: Temporal Integration Window task, Behavioral: Attentional Blink task3-year-old children with a diagnosis of ASD but not prototypical characteristics |
| Non-prototypical ASD 5-year-olds | Experimental | Behavioral: Temporal Integration Window task, Behavioral: Attentional Blink task5-year-old children with a diagnosis of ASD but not prototypical characteristics |
Who may qualify
- Ages
- 36 to 71 months
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child
Key inclusion criteria (7 listed)
- Children aged 3 or 5 years
- Either with a diagnosis of Autism Spectrum Disorder (ASD) or typically developing (neurotypical)
- No intellectual disability (per Mullen, Denver, or psychometric report)
- Normal or corrected vision and hearing
- Written informed consent from legal guardians
Key exclusion criteria (3 listed)
- Neurological disorder
- Parental or child refusal to participate
- For neurotypical children: developmental delay or psychiatric diagnosis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Temporal Integration Window taskThe TIW task involves alternating visual displays (integration and segmentation trials) across four inter-stimulus intervals (ISI: 16, 32, 83, 116 ms). This task allows estimation of the participant's perceptual integration threshold. | Behavioural | Neurotypical 3-year-olds, Neurotypical 5-year-olds, Non-prototypical ASD 3-year-olds, Non-prototypical ASD 5-year-olds, Prototypical ASD 3-year-olds, Prototypical ASD 5-year-olds |
| Attentional Blink taskThe Attentional Blink task presents rapid sequences of images (including two targets and distractors), measuring the minimum time delay required for both targets to be detected. Three different T1-T2 intervals are tested. | Behavioural | Neurotypical 3-year-olds, Neurotypical 5-year-olds, Non-prototypical ASD 3-year-olds, Non-prototypical ASD 5-year-olds, Prototypical ASD 3-year-olds, Prototypical ASD 5-year-olds |
Primary outcome
Temporal dynamics of perception
Time frame: Baseline
The Temporal Integration Window (TIW) is defined as the shortest interval between two displays that can be integrated into a single percept
Temporal dynamics of attention
Time frame: Baseline
The Attentional Blink duration, defined as the minimal delay between two target stimuli that allows detection of both.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Feb 2026.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Temporal Integration Window task and Attentional Blink task in people with Autism Spectrum Disorder, run by Hôpital le Vinatier at 2 sites in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 5 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Sara DOCHEZ (+33437915364, sara.dochez@ch-le-vinatier.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Temporal dynamics of perception (time frame: Baseline). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Feb 2026.