HemiplegiaDynamicNCT07386119
Investigation of the Effects of Vestibular Rehabilitation and Dynamic Neuromuscular
A study testing Conventional Exercise programs, Dynamic Neuromuscular Stabilization and Vestibular Rehabilitation Group in people with Hemiplegia and Vestibular Exercises, run by Istanbul Medipol University Hospital at 1 site in Turkey (Türkiye).
Trial summary
This study will aim to investigate the effects of vestibular rehabilitation, dynamic neuromuscular stabilization (DNS), and conservative rehabilitation exercises on balance and mobility in hemiplegic patients, and to compare the exercise programs with one another. Read more about this study
- Who is it for?
- Ages 18 to 60 years
- Conditions the study is for
- Hemiplegia, Vestibular Exercises, Physiotherapy and Rehabilitation
- What is being tested?
- Conventional Exercise programs, Dynamic Neuromuscular Stabilization and Vestibular Rehabilitation Group
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 45 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 17 Jan 2026to 5 Aug 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Being 18 years of age or older
- Having experienced at least one stroke and presenting with hemiplegic symptoms
- Having passed at least one year since the stroke even
- Scoring at least 24 points on the Mini-Mental State Examination (MMSE)
- Being able to walk independently for at least 30 meters without assistance
- Being able to comply with and participate in the exercise program
Who cannot join
- Individuals with chronic pulmonary and/or cardiac diseases
- Presence of uncontrolled hypertension
- Conditions accompanied by peripheral nerve injury or lower motor neuron disorders
- Presence of additional neurological disorders such as ataxia, dyskinesia, or dystonia
- Severe spasticity, peripheral lesions, pressure ulcers, marked muscle atrophy, obesity, skin irritation, or use of a cardiac pacemaker
- Presence of vestibular symptoms such as vertigo or dizziness
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Investigation of the Effects of Vestibular Rehabilitation and Dynamic Neuromuscular Stabilization Exercises on Balance and Mobility in Patients With Hemiplegia
This study will aim to investigate the effects of vestibular rehabilitation, dynamic neuromuscular stabilization (DNS), and conservative rehabilitation exercises on balance and mobility in hemiplegic patients, and to compare the exercise programs with one another. Evaluation tools include the Brunnstrom Motor Staging, Fugl-Meyer Upper Extremity Motor Function Scale, Modified Ashworth Scale, Mini-Mental State Examination, Berg Balance Scale, Stroke Impact Scale, and Timed Up and Go test.
Read the detailed description
This study will aim to investigate the effects of vestibular rehabilitation, dynamic neuromuscular stabilization (DNS), and conservative rehabilitation exercises on balance and mobility in hemiplegic patients, and to compare the exercise programs with one another. A total of 45 hemiplegic patients will enrolled and randomized into three groups: Conventional Exercise Group (CEG, n = 15), Dynamic Neuromuscular Stabilization Group (DNSG, n = 15), and Vestibular Rehabilitation Group (VRG, n = 15). Each group will be participated in specialized exercise programs twice a week for six weeks. All groups will be underwent assessments before and after treatment. Evaluation tools include the Brunnstrom Motor Staging, Fugl-Meyer Upper Extremity Motor Function Scale, Modified Ashworth Scale, Mini-Mental State Examination, Berg Balance Scale, Stroke Impact Scale, and Timed Up and Go test.
- Being tested
- Conventional Exercise programs, Dynamic Neuromuscular Stabilization, Vestibular Rehabilitation Group
- Keywords
- Hemiplegia, Vestibular Rehabilitation, Dynamic Neuromuscular Stabilization, Balance, Mobility
- Medical subject headings
- Hemiplegia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Conventional Exercise programsOther
This group participated in Conventional Exercise programs twice a week for six weeks.
Dynamic Neuromuscular StabilizationOther
This group participated in Dynamic Neuromuscular Stabilization Exercise programs twice a week for six weeks.
Vestibular Rehabilitation GroupOther
This group participated in Vestibular Rehabilitation programs twice a week for six weeks.
| Study group | Role | What they receive |
|---|---|---|
| Group 1: Conventional Exercise Group | Experimental | Conventional Exercise will be conducted in this group Receives: Other: Conventional Exercise programs |
| Group 2: Dynamic Neuromuscular Stabilization Group | Experimental | Dynamic Neuromuscular Stabilization exercises will be done in this group Receives: Other: Dynamic Neuromuscular Stabilization |
| Group 3: Vestibular Rehabilitation Group | Experimental | Vestibular Rehabilitation will be conducted in this group Receives: Other: Vestibular Rehabilitation Group |
What is being measured
The primary outcome is the main question the study is designed to answer.
The Fugl-Meyer Assessment of Upper Extremity
It is a standardized, stroke-specific, performance-based outcome measure used in clinical trials to evaluate motor recovery of the upper limb. It assesses movement, coordination, and reflex activity of the shoulder, elbow, forearm, wrist, and hand, providing a quantitative measure of motor impairment and recovery over time. The maximum score for the arm section is 36. During the finger-to-nose test, coordination and speed of movement are evaluated out of 6 points, while tremor, dysmetria, and speed of movement in the upper extremity are also examined in detail.
Measured: From the beginning of treatment to the end of the 6th week
Modified Ashworth Scale (MAS)
It is a widely used clinical outcome measure in clinical trials to assess spasticity by grading the resistance encountered during passive muscle stretching. The joint is passively moved with repetitive and rapid movements, and the joint's resistance to these movements is scored.
Measured: From the beginning of treatment to the end of the 6th week
Mini-Mental State Examination (MMSE)
It is a brief, standardized cognitive screening tool used in clinical trials to assess global cognitive function, including orientation, attention, memory, language, and visuospatial abilities. The total score ranges from 0 to 30, with higher scores indicating better cognitive performance. Scores of 24-30 indicate normal cognition, 18-23 mild cognitive impairment, and ≤17 moderate to severe cognitive impairment.
Measured: From the beginning of treatment to the end of the 6th week
Berg Balance Scale (BBS)
This is a 14-item scale that assesses a patient's ability to maintain balance for a specific period during static and various functional movements. The scoring system ranges from 0 to 4, with 0 meaning "cannot" and 4 meaning "can do independently," and the maximum total score is 56. A total score between 0-20 indicates a high risk of falls; between 21-40 indicates a moderate risk of falls; and between 41-56 indicates a low risk of falls.
Measured: From the beginning of treatment to the end of the 6th week
Stroke Impact Scale (SIS)
It is a stroke-specific, patient-reported outcome measure widely used in clinical trials to evaluate the perceived impact of stroke on multiple domains of health-related quality of life. Based on the obtained score, 0 indicates no recovery, whereas 100 represents complete recovery.
Measured: From the beginning of treatment to the end of the 6th week
Timed Up and Go (TUG)
The test is a simple and widely used functional mobility assessment in clinical trials. It measures the time required for an individual to stand up from a chair, walk 3 meters, turn around, walk back, and sit down. Shorter completion times indicate better functional mobility and balance, and the test is commonly used to assess fall risk and mobility limitations.
Measured: From the beginning of treatment to the end of the 6th week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Feb 2026
- Study start17 Jan 2026
- Primary completion1 Mar 2026
- Study completion5 Aug 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for HemiplegiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 45 participants (actual)
Sponsor and investigators
- Lead sponsor
- Istanbul Medipol University Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, merve yilmaz menek, Istanbul Medipol University Hospital
- Investigators
- MERVE YILMAZ MENEK, Principal investigator, Medipol University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07386119
- Sponsor's protocol ID
- E-10840098-202.3.02-3748
- Acronym
- Dynamic
- Status last verified
- Aug 2026
- First submitted
- 28 Jan 2026
- Last updated
- 6 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data (IPD) will be made available to other researchers upon reasonable request, if deemed necessary.
Publications
Yoon HS, Cha YJ, You JSH. Effects of dynamic core-postural chain stabilization on diaphragm movement, abdominal muscle thickness, and postural control in patients with subacute stroke: A randomized control trial. NeuroRehabilitation. 2020;46(3):381-389. doi: 10.3233/NRE-192983.
PubMed 32250328
Study at a glance
From the registry record, last updated by the sponsor on 6 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigation of the Effects of Vestibular Rehabilitation and Dynamic Neuromuscular Stabilization Exercises on Balance and Mobility in Patients With Hemiplegia
- ClinicalTrials.gov ID
- NCT07386119
- Acronym / sponsor ID
- Dynamic / E-10840098-202.3.02-3748
- Keywords
- Hemiplegia, Vestibular Rehabilitation, Dynamic Neuromuscular Stabilization, Balance, Mobility
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 45 participants (actual)
- Lead sponsor
- Istanbul Medipol University HospitalUniversity, hospital or other
- Study start
- 17 Jan 2026 (actual)
- Primary completion
- 1 Mar 2026 (actual)
- Study completion
- 5 Aug 2026 (actual)
- First posted
- 4 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will aim to investigate the effects of vestibular rehabilitation, dynamic neuromuscular stabilization (DNS), and conservative rehabilitation exercises on balance and mobility in hemiplegic patients, and to compare the exercise programs with one another. Evaluation tools include the Brunnstrom Motor Staging, Fugl-Meyer Upper Extremity Motor Function Scale, Modified Ashworth Scale, Mini-Mental State Examination, Berg Balance Scale, Stroke Impact Scale, and Timed Up and Go test.
Detailed description
This study will aim to investigate the effects of vestibular rehabilitation, dynamic neuromuscular stabilization (DNS), and conservative rehabilitation exercises on balance and mobility in hemiplegic patients, and to compare the exercise programs with one another. A total of 45 hemiplegic patients will enrolled and randomized into three groups: Conventional Exercise Group (CEG, n = 15), Dynamic Neuromuscular Stabilization Group (DNSG, n = 15), and Vestibular Rehabilitation Group (VRG, n = 15). Each group will be participated in specialized exercise programs twice a week for six weeks. All groups will be underwent assessments before and after treatment. Evaluation tools include the Brunnstrom Motor Staging, Fugl-Meyer Upper Extremity Motor Function Scale, Modified Ashworth Scale, Mini-Mental State Examination, Berg Balance Scale, Stroke Impact Scale, and Timed Up and Go test.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Group 1: Conventional Exercise Group | Experimental | Other: Conventional Exercise programsConventional Exercise will be conducted in this group |
| Group 2: Dynamic Neuromuscular Stabilization Group | Experimental | Other: Dynamic Neuromuscular StabilizationDynamic Neuromuscular Stabilization exercises will be done in this group |
| Group 3: Vestibular Rehabilitation Group | Experimental | Other: Vestibular Rehabilitation GroupVestibular Rehabilitation will be conducted in this group |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Being 18 years of age or older
- Having experienced at least one stroke and presenting with hemiplegic symptoms
- Having passed at least one year since the stroke even
- Scoring at least 24 points on the Mini-Mental State Examination (MMSE)
- Being able to walk independently for at least 30 meters without assistance
Key exclusion criteria (6 listed)
- Individuals with chronic pulmonary and/or cardiac diseases
- Presence of uncontrolled hypertension
- Conditions accompanied by peripheral nerve injury or lower motor neuron disorders
- Presence of additional neurological disorders such as ataxia, dyskinesia, or dystonia
- Severe spasticity, peripheral lesions, pressure ulcers, marked muscle atrophy, obesity, skin irritation, or use of a cardiac pacemaker
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Conventional Exercise programsThis group participated in Conventional Exercise programs twice a week for six weeks. | Other | Group 1: Conventional Exercise Group |
| Dynamic Neuromuscular StabilizationThis group participated in Dynamic Neuromuscular Stabilization Exercise programs twice a week for six weeks. | Other | Group 2: Dynamic Neuromuscular Stabilization Group |
| Vestibular Rehabilitation GroupThis group participated in Vestibular Rehabilitation programs twice a week for six weeks. | Other | Group 3: Vestibular Rehabilitation Group |
Primary outcome
The Fugl-Meyer Assessment of Upper Extremity
Time frame: From the beginning of treatment to the end of the 6th week
It is a standardized, stroke-specific, performance-based outcome measure used in clinical trials to evaluate motor recovery of the upper limb. It assesses movement, coordination, and reflex activity of the shoulder, elbow, forearm, wrist, and hand, providing a quantitative measure of motor impairment and recovery over time. The maximum score for the arm section is 36. During the finger-to-nose test, coordination and speed of movement are evaluated out of 6 points, while tremor, dysmetria, and speed of movement in the upper extremity are also examined in detail.
Modified Ashworth Scale (MAS)
Time frame: From the beginning of treatment to the end of the 6th week
It is a widely used clinical outcome measure in clinical trials to assess spasticity by grading the resistance encountered during passive muscle stretching. The joint is passively moved with repetitive and rapid movements, and the joint's resistance to these movements is scored.
Mini-Mental State Examination (MMSE)
Time frame: From the beginning of treatment to the end of the 6th week
It is a brief, standardized cognitive screening tool used in clinical trials to assess global cognitive function, including orientation, attention, memory, language, and visuospatial abilities. The total score ranges from 0 to 30, with higher scores indicating better cognitive performance. Scores of 24-30 indicate normal cognition, 18-23 mild cognitive impairment, and ≤17 moderate to severe cognitive impairment.
Berg Balance Scale (BBS)
Time frame: From the beginning of treatment to the end of the 6th week
This is a 14-item scale that assesses a patient's ability to maintain balance for a specific period during static and various functional movements. The scoring system ranges from 0 to 4, with 0 meaning "cannot" and 4 meaning "can do independently," and the maximum total score is 56. A total score between 0-20 indicates a high risk of falls; between 21-40 indicates a moderate risk of falls; and between 41-56 indicates a low risk of falls.
Stroke Impact Scale (SIS)
Time frame: From the beginning of treatment to the end of the 6th week
It is a stroke-specific, patient-reported outcome measure widely used in clinical trials to evaluate the perceived impact of stroke on multiple domains of health-related quality of life. Based on the obtained score, 0 indicates no recovery, whereas 100 represents complete recovery.
Timed Up and Go (TUG)
Time frame: From the beginning of treatment to the end of the 6th week
The test is a simple and widely used functional mobility assessment in clinical trials. It measures the time required for an individual to stand up from a chair, walk 3 meters, turn around, walk back, and sit down. Shorter completion times indicate better functional mobility and balance, and the test is commonly used to assess fall risk and mobility limitations.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Aug 2026.
- Results publication: PubMed 32250328Yoon HS, Cha YJ, You JSH. Effects of dynamic core-postural chain stabilization on diaphragm movement, abdominal muscle thickness, and postural control in patients with subacute stroke: A randomized control trial. NeuroRehabilitation. 2020;46(3):381-389. doi: 10.3233/NRE-192983.
- Effects of dynamic core-postural chain stabilization on diaphragm movement, abdominal muscle thickness, and postural control in patients with subacute stroke: A randomized control trial. NeuroRehabilitationLink provided by the sponsor.
- Individual participant dataSharing planned: No. Individual participant data (IPD) will be made available to other researchers upon reasonable request, if deemed necessary.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
MERVE YILMAZ MENEK principal investigator
Medipol University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Conventional Exercise programs, Dynamic Neuromuscular Stabilization and Vestibular Rehabilitation Group in people with Hemiplegia and Vestibular Exercises, run by Istanbul Medipol University Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The Fugl-Meyer Assessment of Upper Extremity (time frame: From the beginning of treatment to the end of the 6th week). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07386119, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Aug 2026.