Whole Body VibrationWBV-BMRNCT07386145
Frequency and Voluntary Contraction-Dependent Activation of Tonic Vibration Reflex and Bone Myoregulation Reflex
A study testing whole-body vibration in people with Whole Body Vibration, run by Istanbul Physical Medicine Rehabilitation Training and Research Hospital at 1 site in Turkey (Türkiye).
Trial summary
When vibration is applied, sensors inside the muscle send signals to the nervous system, leading to automatic muscle activation. In this research, vibration will be applied using different body postures (such as standing or semi-squatting) and different vibration frequencies to understand how body position and… Read more about this study
- Who is it for?
- Ages 20 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Whole Body Vibration
- What is being tested?
- whole-body vibration
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Dec 2025to 26 Jan 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Being between 20-40 years old
- Volunteering to participate in the research
Who cannot join
- Refusal to participate in the study
- Intolerance to whole-body vibration (WBV)
- History of vertigo
- Presence of malignant disease
- Presence of chronic systemic disease
- Pregnancy
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Istanbul Physical Therapy and Rehabilitation Training Research Hospital
Istanbul, Bahcelievler, 34180
About this study
Official title: Whole-Body Vibration in Rehabilitation: Frequency and Voluntary Contraction-Dependent Activation of Tonic Vibration Reflex and Bone Myoregulation Reflex
When vibration is applied, sensors inside the muscle send signals to the nervous system, leading to automatic muscle activation. In this research, vibration will be applied using different body postures (such as standing or semi-squatting) and different vibration frequencies to understand how body position and vibration intensity influence muscle responses. Muscle activity will be recorded using surface electrodes placed on the skin. All procedures are non-invasive, painless, and do not involve medication or surgery.
The goal of this study is to improve understanding of how whole-body vibration affects muscle and nerve function. The findings may contribute to future rehabilitation strategies
Read the detailed description
This study investigates how whole-body vibration (WBV) affects muscle reflex activity in healthy adults. Whole-body vibration will be delivered using a vibration platform that transmits mechanical oscillations through the lower limbs and trunk while participants maintain specific postures.
The primary objective is to examine how different vibration frequencies and different body postures influence reflex-related muscle activation. Secondary objectives include evaluating how vibration modifies neuromuscular excitability and the timing and magnitude of reflex responses.
Participants will be exposed to multiple experimental conditions across separate sessions. These conditions will include different postural tasks (such as upright standing and semi-squat) and different vibration frequencies, allowing comparison of how mechanical load distribution and sensory input alter reflex modulation. Each vibration application will last 15 seconds, and rest periods will be provided between trials to minimize fatigue and ensure measurement reliability.
Muscle activity will be recorded using surface electromyography (EMG) electrodes placed over the soleus muscle. Reflex responses under different postures and vibration frequencies will be recorded during vibration. Data processing and analysis will be performed offline after the experiment is completed.
This study is based on previous findings indicating that whole-body vibration can stimulate muscle spindle afferent receptors as well as osteocyte-related mechanoreceptors within bone tissue, thereby increasing afferent sensory input and transiently modulating spinal and supraspinal motor control mechanisms, including reflex excitability and motor unit recruitment patterns. By systematically varying posture and vibration frequency, the study aims to clarify how vibration-induced sensory input interacts with biomechanical and neural factors to shape reflex response behavior.
The findings obtained from this study are expected to contribute to a more effective and targeted use of whole-body vibration in neuromuscular training, balance rehabilitation, enhancement of movement performance, and support of bone health. Furthermore, the results are anticipated to provide a scientific basis for the development of optimized vibration-based intervention protocols that consider both neuromuscular and musculoskeletal effects in clinical and athletic settings.
- Conditions
- Whole Body Vibration
- Being tested
- whole-body vibration
- Keywords
- whole-body vibration, bone myoregulation reflex, tonic vibration reflex, muscle spindle, osteocyte, vibration, reflex latency
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
whole-body vibrationDevice
Participants will receive whole-body vibration using a vibration platform under different frequency and posture conditions. Vibration will be applied in short bouts (e.g., 15 seconds per trial) with rest periods between trials to minimize fatigue. Reflex and muscle activity responses will be recorded during vibration using surface electromyography (EMG)
| Study group | Role | What they receive |
|---|---|---|
| Low-Frequency WBV - Upright Posture | Experimental | Participants will receive whole-body vibration at low frequencies (30, 32, 34, 36 Hz) while standing in an upright posture. Each vibration bout will last 15 seconds, with rest periods between trials. Soleus muscle activity will be recorded using surface electromyography during vibration. Receives: Device: whole-body vibration |
| Low-Frequency WBV - Semi-Squat Posture | Experimental | Participants will receive whole-body vibration at low frequencies while maintaining a semi-squat posture. Each vibration bout will last 15 seconds, with rest periods between trials. Soleus muscle activity will be recorded using surface electromyography during vibration. Receives: Device: whole-body vibration |
| High-Frequency WBV - Upright Posture | Experimental | Participants receive whole-body vibration at high frequency (40, 42, 44, 46 Hz) in an upright posture. Vibration will be applied in 15-second bouts with rest intervals.Soleus muscle activity will be recorded using surface electromyography during vibration. Receives: Device: whole-body vibration |
| High-Frequency WBV - Semi-Squat Posture | Experimental | Participants will receive whole-body vibration at high frequencies while standing in a semi-squat posture. Each vibration exposure will last 15 seconds, with rest intervals between trials. Soleus muscle activity will be recorded using surface electromyography during vibration. Receives: Device: whole-body vibration |
What is being measured
The primary outcome is the main question the study is designed to answer.
Latency of the soleus reflex during whole-body vibration
The primary outcome measure is the latency of the soleus reflex activated by whole-body vibration (WBV). Reflex latency will be calculated using a cumulative averaging method. The vibration stimulus will be recorded via an accelerometer mounted on the vibration platform (LIS344ALH; ±6 g; ECOPACK®, Mansfield, TX, USA). The onset of the mechanical stimulus and the onset of the reflex response will be identified using cumulative averaging. Reflex latency will be defined as the time interval between the onset of the mechanical stimulus and the onset of the reflex response detected on surface electromyography (EMG), and will be expressed in milliseconds (ms).
Measured: Day 1 (During a single experimental session)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Feb 2026
- Study start15 Dec 2025
- Primary completion25 Jan 2026
- Study completion26 Jan 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Whole Body VibrationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- This is a crossover interventional study in which each participant is exposed to multiple whole-body vibration conditions with different frequencies and postures.
- Masking
- None (open label)
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Lead sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Nida dogan, Istanbul Physical Medicine Rehabilitation Training and Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07386145
- Sponsor's protocol ID
- ND 2025-79
- Acronym
- WBV-BMR
- Status last verified
- Feb 2026
- First submitted
- 28 Jan 2026
- Last updated
- 18 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 18 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Whole-Body Vibration in Rehabilitation: Frequency and Voluntary Contraction-Dependent Activation of Tonic Vibration Reflex and Bone Myoregulation Reflex
- ClinicalTrials.gov ID
- NCT07386145
- Acronym / sponsor ID
- WBV-BMR / ND 2025-79
- Conditions
- Whole Body Vibration
- Keywords
- whole-body vibration, bone myoregulation reflex, tonic vibration reflex, muscle spindle, osteocyte, vibration, reflex latency
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research HospitalOther government
- Study start
- 15 Dec 2025 (actual)
- Primary completion
- 25 Jan 2026 (actual)
- Study completion
- 26 Jan 2026 (actual)
- First posted
- 4 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
When vibration is applied, sensors inside the muscle send signals to the nervous system, leading to automatic muscle activation. In this research, vibration will be applied using different body postures (such as standing or semi-squatting) and different vibration frequencies to understand how body position and vibration intensity influence muscle responses. Muscle activity will be recorded using surface electrodes placed on the skin. All procedures are non-invasive, painless, and do not involve medication or surgery.
The goal of this study is to improve understanding of how whole-body vibration affects muscle and nerve function. The findings may contribute to future rehabilitation strategies
Detailed description
This study investigates how whole-body vibration (WBV) affects muscle reflex activity in healthy adults. Whole-body vibration will be delivered using a vibration platform that transmits mechanical oscillations through the lower limbs and trunk while participants maintain specific postures.
The primary objective is to examine how different vibration frequencies and different body postures influence reflex-related muscle activation. Secondary objectives include evaluating how vibration modifies neuromuscular excitability and the timing and magnitude of reflex responses.
Participants will be exposed to multiple experimental conditions across separate sessions. These conditions will include different postural tasks (such as upright standing and semi-squat) and different vibration frequencies, allowing comparison of how mechanical load distribution and sensory input alter reflex modulation. Each vibration application will last 15 seconds, and rest periods will be provided between trials to minimize fatigue and ensure measurement reliability.
Muscle activity will be recorded using surface electromyography (EMG) electrodes placed over the soleus muscle. Reflex responses under different postures and vibration frequencies will be recorded during vibration. Data processing and analysis will be performed offline after the experiment is completed.
This study is based on previous findings indicating that whole-body vibration can stimulate muscle spindle afferent receptors as well as osteocyte-related mechanoreceptors within bone tissue, thereby increasing afferent sensory input and transiently modulating spinal and supraspinal motor control mechanisms, including reflex excitability and motor unit recruitment patterns. By systematically varying posture and vibration frequency, the study aims to clarify how vibration-induced sensory input interacts with biomechanical and neural factors to shape reflex response behavior.
The findings obtained from this study are expected to contribute to a more effective and targeted use of whole-body vibration in neuromuscular training, balance rehabilitation, enhancement of movement performance, and support of bone health. Furthermore, the results are anticipated to provide a scientific basis for the development of optimized vibration-based intervention protocols that consider both neuromuscular and musculoskeletal effects in clinical and athletic settings.
Study design
- Primary purpose
- Other
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 4
- Model description
- This is a crossover interventional study in which each participant is exposed to multiple whole-body vibration conditions with different frequencies and postures.
| Arm | Type | Receives |
|---|---|---|
| Low-Frequency WBV - Upright Posture | Experimental | Device: whole-body vibrationParticipants will receive whole-body vibration at low frequencies (30, 32, 34, 36 Hz) while standing in an upright posture. Each vibration bout will last 15 seconds, with rest periods between trials. Soleus muscle activity will be recorded using surface electromyography during vibration. |
| Low-Frequency WBV - Semi-Squat Posture | Experimental | Device: whole-body vibrationParticipants will receive whole-body vibration at low frequencies while maintaining a semi-squat posture. Each vibration bout will last 15 seconds, with rest periods between trials. Soleus muscle activity will be recorded using surface electromyography during vibration. |
| High-Frequency WBV - Upright Posture | Experimental | Device: whole-body vibrationParticipants receive whole-body vibration at high frequency (40, 42, 44, 46 Hz) in an upright posture. Vibration will be applied in 15-second bouts with rest intervals.Soleus muscle activity will be recorded using surface electromyography during vibration. |
| High-Frequency WBV - Semi-Squat Posture | Experimental | Device: whole-body vibrationParticipants will receive whole-body vibration at high frequencies while standing in a semi-squat posture. Each vibration exposure will last 15 seconds, with rest intervals between trials. Soleus muscle activity will be recorded using surface electromyography during vibration. |
Who may qualify
- Ages
- 20 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Being between 20-40 years old
- Volunteering to participate in the research
Key exclusion criteria (6 listed)
- Refusal to participate in the study
- Intolerance to whole-body vibration (WBV)
- History of vertigo
- Presence of malignant disease
- Presence of chronic systemic disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| whole-body vibrationParticipants will receive whole-body vibration using a vibration platform under different frequency and posture conditions. Vibration will be applied in short bouts (e.g., 15 seconds per trial) with rest periods between trials to minimize fatigue. Reflex and muscle activity responses will be recorded during vibration using surface electromyography (EMG) | Device | High-Frequency WBV - Semi-Squat Posture, High-Frequency WBV - Upright Posture, Low-Frequency WBV - Semi-Squat Posture, Low-Frequency WBV - Upright Posture |
Primary outcome
Latency of the soleus reflex during whole-body vibration
Time frame: Day 1 (During a single experimental session)
The primary outcome measure is the latency of the soleus reflex activated by whole-body vibration (WBV). Reflex latency will be calculated using a cumulative averaging method. The vibration stimulus will be recorded via an accelerometer mounted on the vibration platform (LIS344ALH; ±6 g; ECOPACK®, Mansfield, TX, USA). The onset of the mechanical stimulus and the onset of the reflex response will be identified using cumulative averaging. Reflex latency will be defined as the time interval between the onset of the mechanical stimulus and the onset of the reflex response detected on surface electromyography (EMG), and will be expressed in milliseconds (ms).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Feb 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing whole-body vibration in people with Whole Body Vibration, run by Istanbul Physical Medicine Rehabilitation Training and Research Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 18 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Latency of the soleus reflex during whole-body vibration (time frame: Day 1 (During a single experimental session)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Feb 2026.