Dental Pulp NecrosispainNCT07386197
The Effect of Sealer Type and Obturation Technique on Postoperative Pain
A study testing Obturation of root canals in people with Dental Pulp Necrosis, run by Jordan University of Science and Technology at 1 site in Jordan.
Trial summary
Postoperative pain is an important consideration in endodontic treatment, and its incidence may be influenced by both obturation technique and sealer type. This study focused on molars to minimize anatomical variability and provide a consistent assessment of pain associated with different endodontic protocols. Read more about this study
- Who is it for?
- Ages 18 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Dental Pulp Necrosis
- What is being tested?
- Obturation of root canals
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 120 participants
- Where
- 1 siteJordan
- Study dates
- 7 Oct 2022to 2 Oct 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- both male and female patients within
- The age of 18-60 years old who required root canal treatment
- Either mandibular or maxillary molars with the diagnosis of either; necrotic pulp with asymptomatic apical periodontitis,
- Teeth with pulp extirpated ( previously initiated root canal treatment) regardless of the periapical status
Who cannot join
- Teeth diagnosed with irreversible pulpitis;
- Teeth with intracanal abberations or mishaps such as perforations, transportation, severe ledging , broken instruments, apical resorption or open apices;
- Teeth requiring posts;
- Any patient on long term steroid or any other medical condition that requires long term analgesic.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Effect of Sealer Type and Obturation Technique on Postoperative Pain of Root Canal Treated Teeth
Postoperative pain is an important consideration in endodontic treatment, and its incidence may be influenced by both obturation technique and sealer type. This study focused on molars to minimize anatomical variability and provide a consistent assessment of pain associated with different endodontic protocols.
This study aimed to evaluate the incidence and level of postoperative pain in molars treated with root canal therapy, in relation to the type of sealer and obturation technique used.
Read the detailed description
One hundred and twenty patients (aged 18-60 years; 63 males, 57 females) requiring root canal treatment of mandibular or maxillary molars will be included. Only teeth with necrotic pulp and asymptomatic apical periodontitis or previously extirpated pulp are considered. Patients will be randomly assigned to one of four groups (30 patients each): Group A-AH Plus resin sealer with cold lateral compaction (AH-CLC); Group B-AH Plus with warm vertical compaction (AH-WVC); Group C-TotalFill bioceramic sealer with single-cone technique (TF-SC); Group D-TotalFill HiFlow with warm vertical compaction (TF-WVC). Postoperative pain will be self-recorded using the Visual Analog Scale (VAS) and Verbal Rating Scale (VRS) at 6 hours, 1 day, 2 days, 3 days, and 1 week after treatment. Completed forms will be collected when patients returned for permanent coronal restoration. Analgesic use was also recorded. Data will analyzed using one way ANOVA and Chi square tests.
- Conditions
- Dental Pulp Necrosis
- Being tested
- Obturation of root canals
- Keywords
- Root canal treatment, Obturation, Sealer, Postoperative pain
- Medical subject headings
- Dental Pulp Necrosis, Bites and Stings, Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Obturation of root canalsProcedure or surgery
Also called Root canal filling with bioceramic sealers
filling of root canal using different materials of resin based or bioceramic based and cold lateral condensation or warm vertical condenstion techniques
| Study group | Role | What they receive |
|---|---|---|
| AH Plus resin sealer with cold lateral compaction | Active comparator | Obturation using cold lateral condensation and resin sealer Receives: Procedure: Obturation of root canals |
| AH Plus with warm vertical compaction | Active comparator | Obturation using warm vertical compaction and resin sealer Receives: Procedure: Obturation of root canals |
| TotalFill bioceramic sealer with single-cone technique | Active comparator | Obturation with single cone and bioceramic sealer Receives: Procedure: Obturation of root canals |
| TotalFill HiFlow with warm vertical compaction | Active comparator | Obturation with warm vertical compaction and bioceramic sealer Receives: Procedure: Obturation of root canals |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain level after obturation of root canals
The level of pain the patient will experience after obturation of the teeth using a visual analogue scale and a numerical scale from 0-10. Zero is the minimum and 10 is the maximum. The higher the score the worse it is, the best technique will have low scores of pain
Measured: 6 hours, 1 day, 2 days, 3 days and 1 week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Feb 2026
- Study start7 Oct 2022
- Primary completion28 Jul 2023
- Study completion2 Oct 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dental Pulp NecrosisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Patients will be randomly assigned into four treatment methods
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 120 participants (actual)
Sponsor and investigators
- Lead sponsor
- Jordan University of Science and Technology
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Ahmad Alhiyasat, PhD, Study chair, Jordan University of Science and Technology
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07386197
- Sponsor's protocol ID
- 313/2021
- Other IDs
- Deanship of Research
- Acronym
- pain
- Status last verified
- Jan 2026
- First submitted
- 15 Jan 2026
- Last updated
- 4 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Data will be shared upon reasonable request from the study principal
Study at a glance
From the registry record, last updated by the sponsor on 4 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Sealer Type and Obturation Technique on Postoperative Pain of Root Canal Treated Teeth
- ClinicalTrials.gov ID
- NCT07386197
- Acronym / sponsor ID
- pain / 313/2021
- Conditions
- Dental Pulp Necrosis
- Keywords
- Root canal treatment, Obturation, Sealer, Postoperative pain
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 120 participants (actual)
- Lead sponsor
- Jordan University of Science and TechnologyUniversity, hospital or other
- Study start
- 7 Oct 2022 (actual)
- Primary completion
- 28 Jul 2023 (actual)
- Study completion
- 2 Oct 2023 (actual)
- First posted
- 4 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Postoperative pain is an important consideration in endodontic treatment, and its incidence may be influenced by both obturation technique and sealer type. This study focused on molars to minimize anatomical variability and provide a consistent assessment of pain associated with different endodontic protocols.
This study aimed to evaluate the incidence and level of postoperative pain in molars treated with root canal therapy, in relation to the type of sealer and obturation technique used.
Detailed description
One hundred and twenty patients (aged 18-60 years; 63 males, 57 females) requiring root canal treatment of mandibular or maxillary molars will be included. Only teeth with necrotic pulp and asymptomatic apical periodontitis or previously extirpated pulp are considered. Patients will be randomly assigned to one of four groups (30 patients each): Group A-AH Plus resin sealer with cold lateral compaction (AH-CLC); Group B-AH Plus with warm vertical compaction (AH-WVC); Group C-TotalFill bioceramic sealer with single-cone technique (TF-SC); Group D-TotalFill HiFlow with warm vertical compaction (TF-WVC). Postoperative pain will be self-recorded using the Visual Analog Scale (VAS) and Verbal Rating Scale (VRS) at 6 hours, 1 day, 2 days, 3 days, and 1 week after treatment. Completed forms will be collected when patients returned for permanent coronal restoration. Analgesic use was also recorded. Data will analyzed using one way ANOVA and Chi square tests.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 4
- Model description
- Patients will be randomly assigned into four treatment methods
| Arm | Type | Receives |
|---|---|---|
| AH Plus resin sealer with cold lateral compaction | Active comparator | Procedure: Obturation of root canalsObturation using cold lateral condensation and resin sealer |
| AH Plus with warm vertical compaction | Active comparator | Procedure: Obturation of root canalsObturation using warm vertical compaction and resin sealer |
| TotalFill bioceramic sealer with single-cone technique | Active comparator | Procedure: Obturation of root canalsObturation with single cone and bioceramic sealer |
| TotalFill HiFlow with warm vertical compaction | Active comparator | Procedure: Obturation of root canalsObturation with warm vertical compaction and bioceramic sealer |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- both male and female patients within
- The age of 18-60 years old who required root canal treatment
- Either mandibular or maxillary molars with the diagnosis of either; necrotic pulp with asymptomatic apical periodontitis,
- Teeth with pulp extirpated ( previously initiated root canal treatment) regardless of the periapical status
Key exclusion criteria (4 listed)
- Teeth diagnosed with irreversible pulpitis;
- Teeth with intracanal abberations or mishaps such as perforations, transportation, severe ledging , broken instruments, apical resorption or open apices;
- Teeth requiring posts;
- Any patient on long term steroid or any other medical condition that requires long term analgesic.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Obturation of root canalsAlso: Root canal filling with bioceramic sealersfilling of root canal using different materials of resin based or bioceramic based and cold lateral condensation or warm vertical condenstion techniques | Procedure or surgery | AH Plus resin sealer with cold lateral compaction, AH Plus with warm vertical compaction, TotalFill HiFlow with warm vertical compaction, TotalFill bioceramic sealer with single-cone technique |
Primary outcome
Pain level after obturation of root canals
Time frame: 6 hours, 1 day, 2 days, 3 days and 1 week
The level of pain the patient will experience after obturation of the teeth using a visual analogue scale and a numerical scale from 0-10. Zero is the minimum and 10 is the maximum. The higher the score the worse it is, the best technique will have low scores of pain
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Feb 2026.
- Individual participant dataSharing planned: Yes. Data will be shared upon reasonable request from the study principal
Related trials for Dental Pulp Necrosis
Not yet recruiting
Post-operative Pain and Clinical Outcome After Single-cone Obturation With a Calcium Silicate-based Versus Epoxy Resin Sealer
Post Operative Pain, Acute, Irreversible Pulpitis (Toothache)
Not yet recruiting
PRP-Assisted Regenerative Endodontics Versus Conventional Root Canal Treatment in Mature Necrotic Teeth
Pulp Necrosis, Apical Periodontitis
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Clinical and Inflammatory Outcomes of Regenerative Endodontic Treatment Using Injectable Platelet-Rich Fibrin in Mature Necrotic Teeth With Chronic Apical Periodontitis.
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Conventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ahmad Alhiyasat, PhD study chair
Jordan University of Science and Technology
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Obturation of root canals in people with Dental Pulp Necrosis, run by Jordan University of Science and Technology at 1 site in Jordan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Jordan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain level after obturation of root canals (time frame: 6 hours, 1 day, 2 days, 3 days and 1 week). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Feb 2026.