Knee OsteoarthritisNCT07386977
Knee Joint Position Sense in Knee Osteoarthritis
An observational study of Knee Osteoarthritis and Gonarthrosis, run by Lokman Hekim University at 1 site in Turkey (Türkiye).
Trial summary
The aim of this study was to compare knee joint position sense between sitting with visual input and prone without visual input in individuals with knee osteoarthritis. Read more about this study
- Who is it for?
- Ages 40 to 80 years
- Conditions the study is for
- Knee Osteoarthritis, Gonarthrosis
- How many people
- 58 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Mar 2025to 30 Dec 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Participants diagnosed with knee osteoarthritis according to Kellgren-Lawrence grades 1-3 were included in the study.
Who may be able to join
- Age between 40 and 80 years,
- A confirmed diagnosis of knee osteoarthritis,
- Absence of any health condition that could interfere with the measurement procedures.
Who cannot join
- Refusal to participate in the study,
- Presence of a diagnosed neurological disorder that could affect the measurements,
- Presence of cardiopulmonary instability that could influence the measurements,
- History of knee-related trauma within the past year,
- Receipt of physiotherapy or rehabilitation treatment within the past year,
- History of knee-related surgery,
- Inability to follow verbal instructions due to insufficient cognitive function.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Knee Joint Position Sense Under Different Testing Conditions in Individuals With Knee Osteoarthritis
The aim of this study was to compare knee joint position sense between sitting with visual input and prone without visual input in individuals with knee osteoarthritis.
Read the detailed description
Knee proprioception plays a critical role in joint stability, movement control, and the accurate perception and reproduction of joint position. In individuals with knee osteoarthritis (OA), alterations in joint structures, mechanoreceptor function, pain, and sensorimotor control may compromise joint position sense and increase errors during active joint position reproduction. However, proprioceptive performance is not solely determined by disease-related changes and may also be influenced by the conditions under which proprioception is assessed.
Both visual input and body position may influence proprioceptive performance. Visual information can provide additional sensory cues that support joint position estimation, whereas the absence of visual information may increase reliance on somatosensory and proprioceptive afferent input. Body position may also modify proprioceptive performance by altering gravitational demands, muscle activation patterns, joint loading, and sensory information arising from muscles and periarticular structures. Therefore, differences in joint position reproduction between testing conditions may reflect the combined influence of visual and positional factors rather than the isolated contribution of either factor.
Despite the clinical relevance of knee joint position sense, it remains unclear whether proprioceptive performance obtained under different visual and positional testing conditions is comparable and whether the response to these conditions differs between individuals with and without knee OA. Examining these condition-dependent differences may contribute to a better understanding of how proprioceptive assessment protocols influence measured joint position sense and may facilitate the interpretation and standardization of proprioceptive assessments.
Accordingly, the primary aim of this study was to compare absolute angular error during active knee joint position reproduction from 90° to 30° of knee flexion between individuals with and without knee OA under two different testing conditions: sitting with visual input and prone without visual input. A secondary aim was to investigate whether age and pain intensity were associated with proprioceptive error in individuals with knee OA.
- Conditions
- Knee Osteoarthritis, Gonarthrosis
- Keywords
- knee osteoarthritis, proprioception, angular error, joint position sense, gonarthrosis
- Medical subject headings
- Osteoarthritis, Knee
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Knee Osteoarthritis Group | Participants diagnosed with knee osteoarthritis. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Proprioception Measurement
During the measurement, the inclinometer was positioned over the proximal one-third of the fibula, with its axis aligned with the knee joint line, and secured using a strap. Measurements were performed in both the prone and sitting positions. Participants were instructed to actively move their knee from 90° of flexion toward the target position of 30° of flexion. Upon reaching the perceived target position, participants maintained the position for 5 seconds before returning to the starting position. Each measurement was repeated three times, with a 1-minute rest interval between trials. A 2-minute rest period was provided between the two testing positions to allow participants to change position and rest.
Measured: through study completion, an average of 2 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Feb 2026
- Study start1 Mar 2025
- Primary completion30 Sep 2026 (estimated)
- Study completion30 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Knee OsteoarthritisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 58 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Lokman Hekim University
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Seda BAKTIR, Lokman Hekim University
- Investigators
- ZAHİDE SEDA BAKTIR DOĞAN, Assist. Prof, Principal investigator, Lokman Hekim University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07386977
- Sponsor's protocol ID
- LHU-FTR-ZSBD-04
- Status last verified
- Oct 2026
- First submitted
- 28 Jan 2026
- Last updated
- 7 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: We are planning not to share this data not to declare the data of our participants with any third group.
Study at a glance
From the registry record, last updated by the sponsor on 7 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Knee Joint Position Sense Under Different Testing Conditions in Individuals With Knee Osteoarthritis
- ClinicalTrials.gov ID
- NCT07386977
- Acronym / sponsor ID
- LHU-FTR-ZSBD-04
- Conditions
- Knee Osteoarthritis, Gonarthrosis
- Keywords
- knee osteoarthritis, proprioception, angular error, joint position sense, gonarthrosis
- Study type
- Observational
- Recruitment status
- Active, not recruiting
- Enrolment
- 58 participants (estimated)
- Lead sponsor
- Lokman Hekim UniversityOther government
- Study start
- 1 Mar 2025 (actual)
- Primary completion
- 30 Sep 2026 (estimated)
- Study completion
- 30 Dec 2026 (estimated)
- First posted
- 4 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study was to compare knee joint position sense between sitting with visual input and prone without visual input in individuals with knee osteoarthritis.
Detailed description
Knee proprioception plays a critical role in joint stability, movement control, and the accurate perception and reproduction of joint position. In individuals with knee osteoarthritis (OA), alterations in joint structures, mechanoreceptor function, pain, and sensorimotor control may compromise joint position sense and increase errors during active joint position reproduction. However, proprioceptive performance is not solely determined by disease-related changes and may also be influenced by the conditions under which proprioception is assessed.
Both visual input and body position may influence proprioceptive performance. Visual information can provide additional sensory cues that support joint position estimation, whereas the absence of visual information may increase reliance on somatosensory and proprioceptive afferent input. Body position may also modify proprioceptive performance by altering gravitational demands, muscle activation patterns, joint loading, and sensory information arising from muscles and periarticular structures. Therefore, differences in joint position reproduction between testing conditions may reflect the combined influence of visual and positional factors rather than the isolated contribution of either factor.
Despite the clinical relevance of knee joint position sense, it remains unclear whether proprioceptive performance obtained under different visual and positional testing conditions is comparable and whether the response to these conditions differs between individuals with and without knee OA. Examining these condition-dependent differences may contribute to a better understanding of how proprioceptive assessment protocols influence measured joint position sense and may facilitate the interpretation and standardization of proprioceptive assessments.
Accordingly, the primary aim of this study was to compare absolute angular error during active knee joint position reproduction from 90° to 30° of knee flexion between individuals with and without knee OA under two different testing conditions: sitting with visual input and prone without visual input. A secondary aim was to investigate whether age and pain intensity were associated with proprioceptive error in individuals with knee OA.
Study design
- Observational model
- Other
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Knee Osteoarthritis Group | – | –Participants diagnosed with knee osteoarthritis. |
Who may qualify
- Ages
- 40 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Participants diagnosed with knee osteoarthritis according to Kellgren-Lawrence grades 1-3 were included in the study.
Key inclusion criteria (3 listed)
- Age between 40 and 80 years,
- A confirmed diagnosis of knee osteoarthritis,
- Absence of any health condition that could interfere with the measurement procedures.
Key exclusion criteria (7 listed)
- Refusal to participate in the study,
- Presence of a diagnosed neurological disorder that could affect the measurements,
- Presence of cardiopulmonary instability that could influence the measurements,
- History of knee-related trauma within the past year,
- Receipt of physiotherapy or rehabilitation treatment within the past year,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Proprioception Measurement
Time frame: through study completion, an average of 2 year
During the measurement, the inclinometer was positioned over the proximal one-third of the fibula, with its axis aligned with the knee joint line, and secured using a strap. Measurements were performed in both the prone and sitting positions. Participants were instructed to actively move their knee from 90° of flexion toward the target position of 30° of flexion. Upon reaching the perceived target position, participants maintained the position for 5 seconds before returning to the starting position. Each measurement was repeated three times, with a 1-minute rest interval between trials. A 2-minute rest period was provided between the two testing positions to allow participants to change position and rest.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 7 Oct 2026.
- Individual participant dataSharing planned: No. We are planning not to share this data not to declare the data of our participants with any third group.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
ZAHİDE SEDA BAKTIR DOĞAN, Assist. Prof principal investigator
Lokman Hekim University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Knee Osteoarthritis and Gonarthrosis, run by Lokman Hekim University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 7 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Proprioception Measurement (time frame: through study completion, an average of 2 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Oct 2026.