Reproductive IssuesNCT07388797
Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy
An observational study of Reproductive Issues, run by Chinese University of Hong Kong at 1 site in China.
Trial summary
Hypotheses: We hypothesize that serum progesterone levels on the day of embryo transfer in HRT-FET cycles are positively associated with clinical pregnancy rates. Aims: To evaluate the relationship between serum progesterone levels on embryo transfer day and clinical pregnancy outcomes in frozen-thawed embryo transfer… Read more about this study
- Who is it for?
- Ages 18 to 42 years, women only
- Conditions the study is for
- Reproductive Issues
- How many people
- 370 participants
- Where
- 1 siteChina
- Study dates
- 20 Jan 2026to 31 Dec 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 42 years
- Women only
- No healthy volunteers
- Adult
Study population: All infertility patients undergoing FET at the Assisted Reproductive Technology Unit of the department of Obstetrics and Gynecology in the Prince of Wales Hospital
Who may be able to join
- Patients undergoing FET cycles
- Infertility patients aged >18 years old and < 42 years old
- BMI < 30 kg/m2
- Transfer of at least one good-quality embryo.
Who cannot join
- Severe endocrine disorders (e.g., thyroid dysfunction, premature ovarian failure).
- Severe uterine factors without treatment (severe endometriosis, extensive or subendometrial fibroid, uterine adherent, endometrial polyps)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
China1 site, 1 recruiting
- Recruiting
The Chinese University of Hong Kong
Hong Kong
Chung PW Pui Wah, Jacqueline, 35051537, jacquelinechung@cuhk.edu.hk
About this study
Official title: Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy in Frozen-thawed Embryo Transfer Cycles Using Hormone Replacement Therapy: a Prospective Observational Study
Hypotheses:
We hypothesize that serum progesterone levels on the day of embryo transfer in HRT-FET cycles are positively associated with clinical pregnancy rates.
Aims:
To evaluate the relationship between serum progesterone levels on embryo transfer day and clinical pregnancy outcomes in frozen-thawed embryo transfer cycles using hormone replacement therapy (HRT).
Primary outcome:
To compare the incidence of clinical pregnancy outcome in those infertility patients undergoing frozen embryo transfer with caterized Progesterone level on the day of embryo transfer
Secondary outcomes:
Biochemical pregnancy rate. Implantation rate. Early pregnancy loss rate. Ectopic pregnancy rate.
- Conditions
- Reproductive Issues
What is being measured
The primary outcome is the main question the study is designed to answer.
Clinical pregnancy rate (CPR)
Rate of clinical pregnancy outcome in subjects undergoing FET
Measured: 6 weeks of gestation and ultrasound scanning will be performed to confirm at least one gestational sac around 1 to 3 months after FET
Secondary outcomes (4)
Biochemical pregnancy rate
Rate of biochemical pregnancy outcome in subjects undergoing FET
Measured: Up to 12 weeks
Implantation rate
Rate of implantation in subjects undergoing FET
Measured: Up to 12 weeks
Early pregnancy loss rate
Rate of early pregnancy loss in subjects undergoing FET
Measured: Up to 12 weeks
Ectopic pregnancy rate
Rate of Ectopic pregnancy in subjects undergoing FET
Measured: Up to 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Feb 2026
- Study start20 Jan 2026
- Primary completion30 Jun 2028 (estimated)
- Study completion31 Dec 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Reproductive IssuesStudies of the same condition, open and under way.
- More trials run by Chinese University of Hong KongThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 370 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Chinese University of Hong Kong
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Chung Pui Wah Jacqueline, Chinese University of Hong Kong
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07388797
- Sponsor's protocol ID
- 2025.875
- Status last verified
- May 2026
- First submitted
- 29 Jan 2026
- Last updated
- 11 May 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 11 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy in Frozen-thawed Embryo Transfer Cycles Using Hormone Replacement Therapy: a Prospective Observational Study
- ClinicalTrials.gov ID
- NCT07388797
- Acronym / sponsor ID
- 2025.875
- Conditions
- Reproductive Issues
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 370 participants (estimated)
- Lead sponsor
- Chinese University of Hong KongUniversity, hospital or other
- Study start
- 20 Jan 2026 (actual)
- Primary completion
- 30 Jun 2028 (estimated)
- Study completion
- 31 Dec 2028 (estimated)
- First posted
- 5 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Hypotheses:
We hypothesize that serum progesterone levels on the day of embryo transfer in HRT-FET cycles are positively associated with clinical pregnancy rates.
Aims:
To evaluate the relationship between serum progesterone levels on embryo transfer day and clinical pregnancy outcomes in frozen-thawed embryo transfer cycles using hormone replacement therapy (HRT).
Primary outcome:
To compare the incidence of clinical pregnancy outcome in those infertility patients undergoing frozen embryo transfer with caterized Progesterone level on the day of embryo transfer
Secondary outcomes:
Biochemical pregnancy rate. Implantation rate. Early pregnancy loss rate. Ectopic pregnancy rate.
Study design
- Observational model
- Other
- Time perspective
- Prospective
Who may qualify
- Ages
- 18 to 42 years
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
- Study population
- All infertility patients undergoing FET at the Assisted Reproductive Technology Unit of the department of Obstetrics and Gynecology in the Prince of Wales Hospital
Key inclusion criteria (4 listed)
- Patients undergoing FET cycles
- Infertility patients aged >18 years old and < 42 years old
- BMI < 30 kg/m2
- Transfer of at least one good-quality embryo.
Key exclusion criteria (2 listed)
- Severe endocrine disorders (e.g., thyroid dysfunction, premature ovarian failure).
- Severe uterine factors without treatment (severe endometriosis, extensive or subendometrial fibroid, uterine adherent, endometrial polyps)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Clinical pregnancy rate (CPR)
Time frame: 6 weeks of gestation and ultrasound scanning will be performed to confirm at least one gestational sac around 1 to 3 months after FET
Rate of clinical pregnancy outcome in subjects undergoing FET
4 secondary outcomes
Biochemical pregnancy rate
Time frame: Up to 12 weeks
Implantation rate
Time frame: Up to 12 weeks
Early pregnancy loss rate
Time frame: Up to 12 weeks
Ectopic pregnancy rate
Time frame: Up to 12 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 May 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Reproductive Issues, run by Chinese University of Hong Kong at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 11 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Clinical pregnancy rate (CPR) (time frame: 6 weeks of gestation and ultrasound scanning will be performed to confirm at least one gestational sac around 1 to 3 months after FET). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 May 2026.