Pulmonary NodulesNCT07389889
Percutaneous Robotic Navigation Microwave Ablation Versus CT-guided Microwave Ablation in the Treatment of Pulmonary Nodules With Ground-glass Opacity
A study testing Robot and CT scan in people with Pulmonary Nodules and Ground-glass Opacity, run by Fujian Medical University Union Hospital.
Trial summary
1. To compare the precision of robot-guided microwave ablation and CT-guided microwave ablation in the treatment of ground-glass nodules. 2. To evaluate the safety of robot-assisted microwave ablation and CT-guided microwave ablation in the treatment of ground-glass nodules. 3. Read more about this study
- Who is it for?
- Ages 18 to 85 years
- Conditions the study is for
- Pulmonary Nodules, Ground-glass Opacity
- What is being tested?
- Robot and CT scan
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 116 participants
- Where
- No sites listed yet
- Study dates
- 1 Feb 2026to 1 Feb 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 85 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Aged 18 to 85 years
- Nodules measuring 3-30mm with ground-glass opacities constituting ≥75% of the lesion
- Preoperative clinical evaluation confirming no hilar or mediastinal lymph node metastasis and no distant metastasis
- Patients diagnosed as stage IA primary peripheral lung cancer according to the UICC 8th TNM staging system, and with one of the following conditions:
- cannot undergo surgical resection due to poor cardiopulmonary function or advanced age (ii) refusing or unwilling to undergo surgical resection (iii) with newly developed or residual pulmonary nodules after early-stage primary lung cancer surgery (iv) with unilateral lung disease who cannot undergo unilateral surgical resection (v)with multiple primary lung cancers unsuitable for surgical resection
- Preoperative ECOG physical status score is 0/1
- ASA score is I-III
- Patients voluntarily participate in this study and sign the informed consent form
Who cannot join
- Smoking cessation duration <2 weeks
- Lesions adjacent to pulmonary artery-vein main trunks
- Lesions near the hilum or adjacent to lobar bronchi
- Pregnancy or lactation status
- Severe mental disorders
- History of other malignancies within 5 years
Show all 11Show fewer
- Unstable angina or myocardial infarction within 6 months with coronary angiography showing severe stenosis of major coronary branches
- Cerebral infarction or hemorrhage within 6 months
- Continuous systemic corticosteroid therapy within 1 month
- Patients or their authorized persons who do not wish to comply with the study protocol
- Patients with other investigator-assessed ineligibility for the trial
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Percutaneous Robotic Navigation Microwave Ablation Versus CT-guided Microwave Ablation in the Treatment of Pulmonary Nodules With Ground-glass Opacity: A Prospective Randomized Controlled Trial
- To compare the precision of robot-guided microwave ablation and CT-guided microwave ablation in the treatment of ground-glass nodules.
- To evaluate the safety of robot-assisted microwave ablation and CT-guided microwave ablation in the treatment of ground-glass nodules.
- Explore the application potential of robot navigation microwave ablation technology in the treatment of pulmonary nodules.
- Conditions
- Pulmonary Nodules, Ground-glass Opacity
- Being tested
- Robot, CT scan
- Keywords
- ggo
- Medical subject headings
- Multiple Pulmonary Nodules
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
RobotProcedure or surgery
Microwave ablation guided by Robot or CT
CT scanProcedure or surgery
CT
| Study group | Role | What they receive |
|---|---|---|
| Group A: Experimental group: Microwave ablation under robot navigation | Active comparator | Microwave ablation under robot navigation Receives: Procedure: Robot |
| Group B: CT-guided microwave ablation | Sham comparator | Not described Receives: Procedure: CT scan |
What is being measured
The primary outcome is the main question the study is designed to answer.
Accuracy of puncture
The proportion of patients who are successfully punctured to the target pulmonary nodule on the first attempt of puncture among all patients; whether the puncture is successful is validated by CT scan.
Measured: 24 month
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Feb 2026
- Study start1 Feb 2026 (estimated)
- Primary completion1 Feb 2028 (estimated)
- Study completion1 Feb 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Pulmonary NodulesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 116 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Fujian Medical University Union Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07389889
- Sponsor's protocol ID
- union TC1
- Status last verified
- Dec 2025
- First submitted
- 10 Dec 2025
- Last updated
- 5 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 5 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Percutaneous Robotic Navigation Microwave Ablation Versus CT-guided Microwave Ablation in the Treatment of Pulmonary Nodules With Ground-glass Opacity: A Prospective Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07389889
- Acronym / sponsor ID
- union TC1
- Conditions
- Pulmonary Nodules, Ground-glass Opacity
- Keywords
- ggo
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 116 participants (estimated)
- Lead sponsor
- Fujian Medical University Union HospitalUniversity, hospital or other
- Study start
- 1 Feb 2026 (estimated)
- Primary completion
- 1 Feb 2028 (estimated)
- Study completion
- 1 Feb 2029 (estimated)
- First posted
- 5 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
- To compare the precision of robot-guided microwave ablation and CT-guided microwave ablation in the treatment of ground-glass nodules.
- To evaluate the safety of robot-assisted microwave ablation and CT-guided microwave ablation in the treatment of ground-glass nodules.
- Explore the application potential of robot navigation microwave ablation technology in the treatment of pulmonary nodules.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group A: Experimental group: Microwave ablation under robot navigation | Active comparator | Procedure: RobotMicrowave ablation under robot navigation |
| Group B: CT-guided microwave ablation | Sham comparator | Procedure: CT scan |
Who may qualify
- Ages
- 18 to 85 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Aged 18 to 85 years
- Nodules measuring 3-30mm with ground-glass opacities constituting ≥75% of the lesion
- Preoperative clinical evaluation confirming no hilar or mediastinal lymph node metastasis and no distant metastasis
- Patients diagnosed as stage IA primary peripheral lung cancer according to the UICC 8th TNM staging system, and with one of the following conditions:
- Preoperative ECOG physical status score is 0/1
Key exclusion criteria (11 listed)
- Smoking cessation duration <2 weeks
- Lesions adjacent to pulmonary artery-vein main trunks
- Lesions near the hilum or adjacent to lobar bronchi
- Pregnancy or lactation status
- Severe mental disorders
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| RobotMicrowave ablation guided by Robot or CT | Procedure or surgery | Group A: Experimental group: Microwave ablation under robot navigation |
| CT scanCT | Procedure or surgery | Group B: CT-guided microwave ablation |
Primary outcome
Accuracy of puncture
Time frame: 24 month
The proportion of patients who are successfully punctured to the target pulmonary nodule on the first attempt of puncture among all patients; whether the puncture is successful is validated by CT scan.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Feb 2026.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing Robot and CT scan in people with Pulmonary Nodules and Ground-glass Opacity, run by Fujian Medical University Union Hospital.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 5 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Shuliang Zhang (+86 15806024509, 670627941@qq.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Accuracy of puncture (time frame: 24 month). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Feb 2026.