AzTrials
AzTrials

Coronary Artery Disease (CAD)NCT07392021

Effects of a Recovery-Promoting Program in Patients Undergoing CABG Surgery

A study testing Recovery Promotion Program for CABG patients and Standard Postoperative CABG Care in people with Coronary Artery Disease (CAD) and Coronary Artery Bypass Graft (CABG), run by Mahidol University at 1 site in Thailand.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record
Search all trials

Trial summary

Patients undergoing coronary artery bypass graft (CABG) surgery often experience physical limitations, psychological stress, and challenges during recovery after hospital discharge. Inadequate preparation and limited follow-up support may affect patients' confidence in self-care and overall recovery. Read more about this study

Who is it for?
Ages 20 years and older
What is being tested?
Recovery Promotion Program for CABG patients and Standard Postoperative CABG Care
Could I receive a placebo?
No, everyone receives an active treatment
How many people
60 participants
Where
1 siteThailand
Study dates
22 Aug 2025to 31 Aug 2026
Phase
Interventional
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 20 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Thai patients undergoing elective first-time on-pump coronary artery bypass graft (CABG) surgery alone or combined with valve surgery
  • If age >60 years, participants must pass cognitive screening using the 6-Item Cognitive Impairment Test (6-CIT)
  • New York Heart Association (NYHA) functional class I-III
  • Left ventricular ejection fraction (LVEF) >30%
  • Independent in activities of daily living and able to perform the 6-minute walk test (6MWT)

Who cannot join

  • Severe or acute comorbidities within 24 hours prior to surgery (e.g., chronic obstructive pulmonary disease, renal failure, acute myocardial infarction, severe arrhythmia)
  • Severe postoperative complications or unstable vital signs (e.g., major bleeding, significant arrhythmia, embolism, need for dialysis, extracorporeal membrane oxygenation)
  • Disability or limited ambulation or mobility assessed prior to hospital discharge
  • Failure of extubation within 3 days after surgery or requirement for reoperation

Trial locations and contacts

1 site in 1 country.

Thailand1 site

  • Rajavithi Hospital, Ministry of Public Health, Thailand

    Bangkok, Bangkok, 10400

Other trials in Thailand

About this study

Official title: The Effects of a Recovery-Promoting Program on Self-Efficacy, Quality of Recovery, and Clinical Outcomes in Patients Undergoing Coronary Artery Bypass Graft Surgery

Patients undergoing coronary artery bypass graft (CABG) surgery often experience physical limitations, psychological stress, and challenges during recovery after hospital discharge. Inadequate preparation and limited follow-up support may affect patients' confidence in self-care and overall recovery.

The purpose of this study is to evaluate the effects of a recovery-promoting program on self-efficacy, quality of recovery, and clinical outcomes in patients undergoing CABG surgery.

Read more

Participants will receive standard postoperative care. In addition, participants in the intervention group will receive a recovery-promoting program provided by nurses, which includes structured education, guidance on postoperative activity and symptom management, and follow-up support after discharge.

The study will assess changes in self-efficacy, quality of recovery, and selected clinical outcomes to compare recovery between participants who receive the recovery-promoting program and those who receive standard care.

Read the detailed description

Coronary artery bypass graft (CABG) surgery is a standard treatment for patients with advanced coronary artery disease. Although surgical outcomes have improved, patients frequently experience challenges during postoperative recovery, including reduced physical capacity, delayed functional recovery, psychological distress, and difficulties in self-management after hospital discharge. These challenges may contribute to prolonged recovery and suboptimal clinical outcomes.

Evidence-based approaches such as Cardiac Rehabilitation (CR) and Enhanced Recovery After Cardiac Surgery (ERAS) have been shown to support postoperative recovery. However, in routine clinical practice, the application of these approaches is often fragmented, and continuity of care after discharge remains limited. In particular, patients may receive insufficient guidance and support to enhance self-efficacy and confidence in managing recovery at home.

This study aims to evaluate the effects of a recovery-promoting program on self-efficacy, quality of recovery, and clinical outcomes in patients undergoing CABG surgery. The recovery-promoting program integrates key components of CR and ERAS principles and is delivered by nurses using a structured approach. The intervention includes pre-discharge education, guidance on postoperative activity and symptom management, and follow-up support after discharge through a tele-nursing platform. This approach is designed to enhance patients' engagement in recovery and support continuity of care beyond hospital discharge.

A quasi-experimental design is used to compare outcomes between patients receiving standard postoperative care and those receiving the recovery-promoting program in addition to standard care. Eligible patients are assigned to either a control group or an experimental group according to the study protocol. Data are collected at predefined time points to evaluate changes in self-efficacy, quality of recovery, and selected clinical outcomes.

Self-efficacy and quality of recovery are assessed using validated instruments, while clinical outcomes are obtained from clinical records and routine assessments. The primary focus of the study is to examine differences between groups over time and to explore the potential role of a structured, nurse-led recovery-promoting program in supporting postoperative recovery following CABG surgery.

The findings of this study are expected to contribute to evidence supporting integrated recovery strategies and tele-nursing approaches in postoperative cardiac care and may inform the development of structured nursing interventions to improve recovery outcomes in patients undergoing CABG surgery.

Being tested
Recovery Promotion Program for CABG patients, Standard Postoperative CABG Care
Keywords
Coronary Artery Bypass Graft, Quality of Recovery, Enhanced Recovery After Cardiac Surgery, Self-Efficacy, Cardiac Rehabilitation, Pulmonary Function, Functional Capacity
Medical subject headings
Coronary Artery Disease

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Recovery Promotion Program for CABG patientsBehavioural

    An integrated recovery promotion program combining Cardiac Rehabilitation (CR) and Enhanced Recovery After Cardiac Surgery (ERAS) principles. The intervention is delivered by trained nurses and physiotherapists and consists of three phases: (1) preoperative phase including patient education, breathing exercises, and psychological preparation; (2) postoperative in-hospital phase including early mobilization, pulmonary rehabilitation, symptom monitoring, and individualized guidance; and (3) post-discharge phase including weekly follow-up, self-management support, and remote monitoring via LINE Official Account for six weeks. The program is designed to enhance self-efficacy, promote functional recovery, and reduce postoperative complications following CABG.

  • Standard Postoperative CABG CareOther

    Standard postoperative care for patients undergoing coronary artery bypass grafting (CABG) according to Rajavithi Hospital protocols. Care includes routine medical and nursing care, postoperative monitoring, physiotherapy, medication management, discharge education, and scheduled follow-up without the structured integrated CR-ERAS program or tele-nursing support.

Study groups in NCT07392021
Study groupRoleWhat they receive
Recovery Promotion Program for CABG patientsExperimentalParticipants in this arm receive an integrated recovery promotion program combining Cardiac Rehabilitation (CR) and Enhanced Recovery After Cardiac Surgery (ERAS) in addition to standard postoperative care. The program includes structured education, early mobilization, breathing exercises, symptom monitoring, and self-management support delivered by nurses through in-hospital sessions and a LINE Official Account after discharge. The intervention aims to enhance self-efficacy, promote functional recovery, and reduce postoperative complications following coronary artery bypass grafting (CABG).
Receives: Behavioral: Recovery Promotion Program for CABG patients
Standard CABG CareActive comparatorParticipants in this arm receive standard postoperative care according to hospital protocols for patients undergoing coronary artery bypass grafting (CABG). This includes routine medical and nursing care, usual postoperative monitoring, discharge education, and follow-up appointments without the structured integrated Cardiac Rehabilitation and ERAS program or LINE-based support.
Receives: Other: Standard Postoperative CABG Care

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Quality of Recovery after CABG.

    Quality of recovery will be assessed using the Quality of Recovery-15 (QoR-15) questionnaire, a validated postoperative recovery instrument consisting of 15 items with a total score ranging from 0 to 150. The questionnaire assesses physical comfort, emotional state, psychological support, and physical independence. Higher scores indicate better postoperative recovery.

    Measured: up to 8 weeks after surgery

Secondary outcomes (4)

  1. Self Efficacy

    Self-efficacy refers to the patient's confidence in managing recovery-related behaviors following coronary artery bypass graft surgery. It will be assessed using the Cardiac Self-Efficacy Scale, a validated questionnaire that measures confidence in managing cardiac symptoms and maintaining functional activities. Total scores range from 0 to 56, with higher scores indicating greater perceived cardiac self-efficacy.

    Measured: Preoperative, baseline; within 2 weeks prior to surgery and immediately prior to surgery

  2. Functional capacity

    Functional capacity will be assessed using the 6-Minute Walk Test (6MWT), which measures the distance walked in meters on a flat surface over six minutes. Greater walking distance indicates better functional capacity and postoperative recovery following coronary artery bypass graft surgery.

    Measured: up to 8 weeks after surgery.

  3. Pulmonary Function

    Pulmonary function will be assessed using Peak Expiratory Flow Rate (PEFR), measured in liters per minute. PEFR reflects airway function and respiratory muscle performance and is commonly used to evaluate postoperative pulmonary recovery following coronary artery bypass graft surgery. Higher PEFR values indicate better pulmonary function.

    Measured: Baseline (preoperative, at initial patient assessment); perioperative period (at hospital admission); at hospital discharge (postoperative day 7).

  4. Duration of mechanical ventilation

    Duration of mechanical ventilation will be measured as the total number of hours from initiation of postoperative mechanical ventilation until successful extubation. This outcome reflects early postoperative respiratory recovery following coronary artery bypass graft surgery. Shorter duration indicates better respiratory recovery.

    Measured: Perioperative period.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted6 Feb 2026
  2. Study start22 Aug 2025
  3. Primary completion31 Jul 2026 (estimated)
  4. Study completion31 Aug 2026 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Non-randomised
Intervention model
Parallel groups
Model description
This study uses a parallel-group design comparing two groups of patients undergoing coronary artery bypass graft surgery. Participants in the control group receive standard postoperative care, while participants in the experimental group receive a recovery-promoting program in addition to standard care. Outcomes are assessed and compared between groups at predefined time points.
Masking
None (open label)
Enrolment
60 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07392021
Sponsor's protocol ID
COA.No.MURA2025/476, 148/2568
Other IDs
TCTR20250915012
Status last verified
Feb 2026
First submitted
21 Jan 2026
Last updated
6 Feb 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No: Individual participant data will not be shared due to ethical and confidentiality considerations.

Publications

  • Bandura A. Self-efficacy: toward a unifying theory of behavioral change. Psychol Rev. 1977 Mar;84(2):191-215. doi: 10.1037//0033-295x.84.2.191. No abstract available.

    PubMed 847061

  • Narayanan LT, Hamid SRGS. Incentive spirometry inspiratory capacity changes and predictors after open heart surgery: a 5-day prospective study. Med J Malaysia. 2020 May;75(3):226-234.

    PubMed 32467537

  • Brown TM, Pack QR, Aberegg E, Brewer LC, Ford YR, Forman DE, Gathright EC, Khadanga S, Ozemek C, Thomas RJ; American Heart Association Exercise, Cardiac Rehabilitation and Secondary Prevention Committee of the Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Lifestyle and Cardiometabolic Health; and Council on Quality of Care and Outcomes Research. Core Components of Cardiac Rehabilitation Programs: 2024 Update: A Scientific Statement From the American Heart Association and the American Association of Cardiovascular and Pulmonary Rehabilitation. Circulation. 2024 Oct 29;150(18):e328-e347. doi: 10.1161/CIR.0000000000001289. Epub 2024 Sep 24.

    PubMed 39315436

  • Yang L, Kaye AD, Venakatesh AG, Green MS, Asgarian CD, Luedi MM, Liu H. Enhanced Recovery after Cardiac Surgery: An Update on Clinical Implications. Int Anesthesiol Clin. 2017 Fall;55(4):148-162. doi: 10.1097/AIA.0000000000000168. No abstract available.

    PubMed 28901988

  • McConnell G, Woltz P, Bradford WT, Ledford JE, Williams JB. Enhanced recovery after cardiac surgery program to improve patient outcomes. Nursing. 2018 Nov;48(11):24-31. doi: 10.1097/01.NURSE.0000546453.18005.3f.

    PubMed 30286030

  • Akowuah EF, Wagnild JM, Bardgett M, Prichard JG, Mathias A, Harrison SL, Ogundimu EO, Hancock HC, Maier RH; PREPs Trial investigators. A randomised controlled trial of prehabilitation in patients undergoing elective cardiac surgery. Anaesthesia. 2023 Sep;78(9):1120-1128. doi: 10.1111/anae.16072. Epub 2023 Jul 4.

    PubMed 37402352

  • Gibbison B, Pufulete M. Prehabilitation before cardiac surgery. Br J Anaesth. 2025 Jan;134(1):5-7. doi: 10.1016/j.bja.2024.11.001. Epub 2024 Nov 26.

    PubMed 39603851

  • Steinmetz C, Bjarnason-Wehrens B, Walther T, Schaffland TF, Walther C. Efficacy of Prehabilitation Before Cardiac Surgery: A Systematic Review and Meta-analysis. Am J Phys Med Rehabil. 2023 Apr 1;102(4):323-330. doi: 10.1097/PHM.0000000000002097. Epub 2022 Sep 23.

    PubMed 36149383

  • Kanejima Y, Shimogai T, Kitamura M, Ishihara K, Izawa KP. Effect of Early Mobilization on Physical Function in Patients after Cardiac Surgery: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2020 Sep 28;17(19):7091. doi: 10.3390/ijerph17197091.

    PubMed 32998202

  • Chen B, Xie G, Lin Y, Chen L, Lin Z, You X, Xie X, Dong D, Zheng X, Li D, Lin W. A systematic review and meta-analysis of the effects of early mobilization therapy in patients after cardiac surgery. Medicine (Baltimore). 2021 Apr 16;100(15):e25314. doi: 10.1097/MD.0000000000025314.

    PubMed 33847630

  • Borges MGB, Borges DL, Ribeiro MO, Lima LSS, Macedo KCM, Nina VJDS. Early Mobilization Prescription in Patients Undergoing Cardiac Surgery: Systematic Review. Braz J Cardiovasc Surg. 2022 May 2;37(2):227-238. doi: 10.21470/1678-9741-2021-0140.

    PubMed 35244377

  • Zhang Y, Chong JH, Harky A. Enhanced recovery after cardiac surgery and its impact on outcomes: A systematic review. Perfusion. 2022 Mar;37(2):162-174. doi: 10.1177/0267659121988957. Epub 2021 Jan 19.

    PubMed 33468017

Questions about this trial

What is this clinical trial studying?

A study testing Recovery Promotion Program for CABG patients and Standard Postoperative CABG Care in people with Coronary Artery Disease (CAD) and Coronary Artery Bypass Graft (CABG), run by Mahidol University at 1 site in Thailand.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 6 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Thailand. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Quality of Recovery after CABG. (time frame: up to 8 weeks after surgery). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07392021, which also lists 12 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Feb 2026.

AzTrials uses cookies for analytics and advertising. You can accept or reject them; the site works either way. Privacy Policy.

Free account

Keep searching with a free account

You’ve used your 3 free searches for this session. Log in or create a free AzTrials account to keep searching clinical trials and save the ones you want to follow.

Create a free accountLog in