AzTrials
AzTrials

OverweightPhase 3ENLIGHTEN-6NCT07392190

A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

A Phase 3 study testing Eloralintide in people with Overweight and Obesity, run by Eli Lilly and Company at 185 sites in 14 countries.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record
Search all trials

Trial summary

The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo in participants with persistent obesity or overweight, with or without type 2 diabetes, and on stable incretin background therapy. Participation in the study will last about 80 weeks. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Overweight, Obesity
What is being tested?
Eloralintide
Type of treatment
Injection or infusion
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
900 participants
Where
185 sitesin 14 countries
Study dates
10 Feb 2026to Jul 2028
Phase
Phase 3
Are there results?
Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Are on stable incretin therapy at screening
  • With persistent obesity or overweight defined as:
  • ≥30 kg/m2 OR
  • ≥27 kg/m2 with at least one existing obesity related complication at screening:
  • hypertension
  • dyslipidemia
Show all 10Show fewer
  • obstructive sleep apnea
  • cardiovascular disease (for example, ischemic cardiovascular disease, New York Heart Association Functional Class I-III heart failure), or
  • type 2 diabetes
  • Have a stable body weight (<5% body weight change) at screening

Who cannot join

  • Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed >1 year before screening)
  • Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
  • Have type 1 diabetes
  • Have taken any of the following antihyperglycemic medications within 90 days before screening:
  • dipeptidyl peptidase-4 (DPP-4) inhibitors
  • amylin analogs
Show all 14Show fewer
  • insulin
  • Have had within 90 days prior to screening:
  • heart attack
  • stroke
  • coronary artery revascularization
  • unstable angina, or
  • hospitalization due to congestive heart failure
  • Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure

Trial locations and contacts

185 sites in 14 countries. Contact the study team or a site near you to ask about taking part.

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or contact

317-615-4559

LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact contact

clinical_inquiry_hub@lilly.com

185 sites in 14 countries

United States58 sites, 58 recruiting

  • JEM Research Institute

    Atlantis, Florida, 33462

    561-968-2933

    David Halpert

    Recruiting

  • Birmingham Clinical Research

    Birmingham, Alabama, 35209

    205-870-4343

    Nova Law

    Recruiting

  • Brigham and Women's Hospital Diabetes Program

    Boston, Massachusetts, 02115

    617-732-4245

    Vanita Aroda

    Recruiting

  • New England Research Associates, LLC

    Bridgeport, Connecticut, 06606

    203-374-9816

    Ilja Hulinsky

    Recruiting

  • University of North Carolina Medical Center

    Chapel Hill, North Carolina, 27514

    984-974-3004

    Klara Klein

    Recruiting

  • Clinical Research Professionals

    Chesterfield, Missouri, 63005

    636-220-1200

    Timothy Jennings

    Recruiting

  • Great Lakes Clinical Trials - Ravenswood

    Chicago, Illinois, 60640

    773-275-3500 Ext 162

    Rupal Trivedi

    Recruiting

  • CTI Clinical Research Center

    Cincinnati, Ohio, 45212

    513-721-3868

    Robert Wagner

    Recruiting

  • Centennial Medical Group

    Columbia, Maryland, 21045

    410-730-3399

    Rajiv Dua

    Recruiting

  • UT Southwestern Medical Center

    Dallas, Texas, 75390

    Amy Shah

    Recruiting

  • AMR Clinical

    Doral, Florida, 33172

    Abid Chaudhry

    Recruiting

  • Teak Research Consults - Dunwoody

    Dunwoody, Georgia, 30338

    470-403-4755

    Aakar Thaker

    Recruiting

  • Northeast Research Institute (NERI)

    Fleming Island, Florida, 32003

    904-541-8225

    Senan Sultan

    Recruiting

  • Center for Advanced Research & Education

    Gainesville, Georgia, 30501

    770-534-5154

    Angela Ritter

    Recruiting

  • Medication Management

    Greensboro, North Carolina, 27401

    336-763-6968

    James Franklin

    Recruiting

  • Juno Research

    Houston, Texas, 77040

    713-779-5494

    Damaris Vega

    Recruiting

  • Family First Medical Center

    Idaho Falls, Idaho, 83404

    208-552-7700

    Flint Packer

    Recruiting

  • Irvine Clinical Research

    Irvine, California, 92614

    949-753-1663

    Elly Lee

    Recruiting

  • Jacksonville Center for Clinical Research

    Jacksonville, Florida, 32216

    904-730-0101

    Alpa Patel

    Recruiting

  • Activian Clinical Research

    Kingwood, Texas, 77339

    832-969-3401

    Martin Basaldua

    Recruiting

  • Scripps Whittier Diabetes Institute

    La Jolla, California, 92037

    858-824-5352

    Athena Philis-Tsimikas

    Recruiting

  • EndoTrials Center for Clinical Research

    La Mesa, California, 91942

    619-460-2626

    Darius Schneider

    Not yet recruiting

  • AMR Clinical

    Lexington, Kentucky, 40509

    Peter Akpunonu

    Recruiting

  • Care Access - Lima

    Lima, Ohio, 45805

    Jimmy Alele

    Recruiting

  • New Horizon Research Center

    Miami, Florida, 33165

    305-226-3933

    Lazaro Nunez

    Recruiting

  • Texas Valley Clinical Research (TVCR) - Mission

    Mission, Texas, 78572

    Alejandro Gonzalez Campos

    Recruiting

  • Synergy Groups Medical LLC - Missouri City

    Missouri City, Texas, 77459

    832-532-4210

    Deirdre McMullen

    Recruiting

  • IMA Clinical Research Monroe-Main

    Monroe, Louisiana, 71201

    318-737-1098

    Mark Napoli

    Recruiting

  • Carteret Medical Group

    Morehead City, North Carolina, 28557

    252-499-8623

    Mary Lawrence

    Recruiting

  • Trial Management Associates

    Myrtle Beach, South Carolina, 29572

    843-994-7655

    Donald Eagerton

    Not yet recruiting

  • Yale University School of Medicine

    New Haven, Connecticut, 06519

    203-785-7421

    Ania Jastreboff

    Recruiting

  • NYU Langone Health

    New York, New York, 10016

    212-263-3166

    Holly Lofton

    Recruiting

  • Weill Cornell Medical College

    New York, New York, 10021

    646-962-2111

    Louis Aronne

    Recruiting

  • IMA Clinical Research Manhattan

    New York, New York, 10036

    Eli Shalenberg

    Recruiting

  • RIO Clinical Trials - Phoenix

    Phoenix, Arizona, 85016

    480-966-7882

    Kenneth Steil

    Recruiting

  • Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18)

    Pittsburgh, Pennsylvania, 15236

    412-650-6155

    Bryce Palchick

    Recruiting

  • Peninsula Research Associates

    Rolling Hills Estates, California, 90274

    310-265-1623

    Lawrence Sher

    Recruiting

  • Care Access - Sacramento

    Sacramento, California, 95831

    925-734-2331

    Francisco Garcia

    Not yet recruiting

  • St Johns Center for Clinical Research

    Saint Augustine, Florida, 32086

    904-209-0043

    Ameeth Vedre

    Recruiting

  • IMA Clinical Research San Antonio

    San Antonio, Texas, 78229

    210-692-7157

    Priscilla Thomas

    Recruiting

  • Endeavor Clinical Trials

    San Antonio, Texas, 78240

    518-428-6859

    Nitendra Agarwal

    Recruiting

  • Artemis Institute for Clinical Research

    San Diego, California, 92123

    858-278-3647

    Stacey Layle

    Recruiting

  • Southern California Clinical Research

    Santa Ana, California, 92701

    714-474-2173

    Wayne Ho

    Recruiting

  • Headlands Research - Scottsdale

    Scottsdale, Arizona, 85260

    480-725-8708

    Benjamin Clark

    Recruiting

  • Consano Clinical Research, LLC

    Shavano Park, Texas, 78231

    210-545-4900

    Michelle Welch

    Recruiting

  • Great Lakes Research Institute

    Southfield, Michigan, 48075

    248-864-5242

    Derrick Williamson

    Recruiting

  • Revive Research Institute, Inc.

    Southfield, Michigan, 48075

    248-829-3103

    Syed Raza

    Recruiting

  • Cotton O'Neil Diabetes & Endocrinology

    Topeka, Kansas, 66606

    785-354-9591

    susan brian

    Recruiting

  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

    Troy, Michigan, 48098

    248-312-0025

    Neil Fraser

    Recruiting

  • Novak Clinical Research - Tucson - North La Cholla Boulevard

    Tucson, Arizona, 85741

    Thili Kulatilake

    Recruiting

  • University Clinical Investigators, Inc.

    Tustin, California, 92780

    714-734-7944

    Joanna Van

    Recruiting

  • MedVadis Research Corporation

    Waltham, Massachusetts, 02451

    617-744-1310

    David DiBenedetto

    Recruiting

  • Chase Medical Research, LLC

    Waterbury, Connecticut, 06708

    203-419-4420

    Joseph Soufer

    Recruiting

  • Texas Valley Clinical Research

    Weslaco, Texas, 78596

    956-431-8090

    Eduardo Luna

    Recruiting

  • Iowa Diabetes and Endocrinology Research Center

    West Des Moines, Iowa, 50266

    Amy Keller

    Recruiting

  • Metabolic Research Institute, Inc.

    West Palm Beach, Florida, 33401

    561-802-3060

    Barry Horowitz, MD

    Recruiting

  • Accellacare - Wilmington - 1917 Tradd Court

    Wilmington, North Carolina, 28401

    910-799-5500

    John Parker

    Recruiting

  • Medrasa Clinical Research

    Wylie, Texas, 75098

    469-449-3645

    Tanvir Ahmad

    Recruiting

Other trials in United States

China22 sites, 22 recruiting

  • The First Hospital of Jilin University

    Changchun, 130021

    15843081103

    Guixia Wang

    Not yet recruiting

  • The Second Hospital of Jilin University

    Changchun, 130041

    Hanqing Cai

    Recruiting

  • The Second Xiangya Hospital of Central South University

    Changsha, 410011

    Xia Li

    Recruiting

  • Sichuan Provincial People's Hospital

    Chengdu, 610072

    Limin Tian

    Recruiting

  • West China Hospital Sichuan University

    Chengdu, 610041

    18980601658

    zhenmei an

    Recruiting

  • 2nd Affiliated Hospital Chongqing Medical Universi

    Chongqing, 400000

    13594028475

    Dongfang Liu

    Not yet recruiting

  • Zhujiang Hospital

    Guangzhou, 510280

    Jia Sun

    Recruiting

  • The Affiliated Hospital of Guizhou Medical University

    Guiyang, 550004

    Miao Zhang

    Recruiting

  • The Second People's Hospital of Hefei

    Hefei, 230011

    86-13956099720

    Jun Ye

    Recruiting

  • Huzhou Central Hospital

    Huzhou, 313000

    Shunbin Li

    Recruiting

  • Jinan Central Hospital

    Jinan, 250013

    Nianrong Mi

    Not yet recruiting

  • The First Affiliated Hospital of Henan University of Science &Technology

    Luoyang Shi, 471023

    13653880139

    Hongwei Jiang

    Recruiting

  • Affiliated Hospital of Luzhou Medical College

    Luzhou, 646000

    Qin Wan

    Recruiting

  • Jiangxi Provincial People's Hospital

    Nanchang, 330038

    13767035719

    Zongyou Cheng

    Recruiting

  • Nanjing First Hospital

    Nanjing, 210006

    15366136156

    Qian Li

    Recruiting

  • Zhongda Hospital Southeast University

    Nanjing, 210009

    Ling Li

    Recruiting

  • The Second Affiliated Hospital of Nanjing Medical University

    Nanjing, 210011

    18951762960

    Yibing Lu

    Recruiting

  • Ningbo First Hospital

    Ningbo, 315010

    13757426626

    Li Li

    Recruiting

  • Zhongshan Hospital,Fudan University

    Shanghai, 200032

    13651913857

    Xiaoying Li

    Not yet recruiting

  • The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University

    Wenzhou, 315100

    13806542929

    Chaoming Wu

    Not yet recruiting

  • The Central Hospital of Wuhan

    Wuhan, 430014

    Zhongjing Wang

    Recruiting

  • Xianyang Hospital of Yan'an University

    Xianyang, 712000

    18391081568

    Fang Wang

    Not yet recruiting

Other trials in China

Israel17 sites, 17 recruiting

  • Emek Medical Center

    Afula, 1834111

    97246495139

    Lee Goldstein

    Not yet recruiting

  • Clalit Health Services - Atlit

    Atlit, 3032301

    04-9842020

    Elie Haddad

    Not yet recruiting

  • Soroka Medical Center

    Beersheba, 8410101

    972-8-6403896

    Idit Liberty

    Not yet recruiting

  • Hillel Yaffe Medical Center

    Hadera, 3810101

    04-7744931

    Irit Hochberg

    Not yet recruiting

  • Rambam Health Care Campus

    Haifa, 3109601

    972-4-7771606

    Sagit Zolotov

    Not yet recruiting

  • Edith Wolfson Medical Center

    Holon, 5810001

    972-35028392

    Orit Twito

    Not yet recruiting

  • Hadassah Medical Center

    Jerusalem, 9112001

    +972-507874590

    Gil Leibowitz

    Not yet recruiting

  • Meir Medical Center

    Kfar Saba, 4428164

    972-97472559

    Victor Vishlitzky

    Not yet recruiting

  • Maccabi health care services - Qiryat Motzkin

    Kiryat Motzkin, 2642435

    +97248781555

    Afif Nakhleh

    Not yet recruiting

  • Laniado Hospital

    Netanya, 4244914

    +97298609325

    Mark Niven

    Not yet recruiting

  • Rabin Medical Center - Hasharon Campus

    Petah Tikva, 4937211

    972-3-9372429

    Dror Dicker

    Not yet recruiting

  • Rabin Medical Center

    Petah Tikva, 4941492

    +97239377183

    Idit Dotan

    Not yet recruiting

  • Sheba Medical Center

    Ramat Gan, 5262100

    97235302021

    Gabriella Segal Lieberman

    Not yet recruiting

  • Kaplan Medical Center

    Rehovot, 7610001

    9729441895

    Viviana Ostrovsky

    Not yet recruiting

  • Clalit Health Services - Sakhnin Community Clinic

    Sakhnin, 3081000

    97246745729

    Mahmud Darawsha

    Not yet recruiting

  • Diabetes Medical Center

    Tel Aviv, 51549

    97236900333

    Maya Ish Shalom

    Not yet recruiting

  • Sourasky Medical Center

    Tel Aviv, 6423906

    97236973415

    Yael Sofer

    Not yet recruiting

Other trials in Israel

Japan11 sites, 11 recruiting

  • The Institute of Medical Science, Asahi Life Foundation

    Chūōku, 103-0002

    81120023812

    Yukiko Onishi

    Recruiting

  • Rinku General Medical Center

    Izumisano, 598-8577

    81120023812

    Tomoko Otsuki

    Recruiting

  • Kanto Rosai Hospital

    Kawasaki, 211-8510

    81120023812

    Yoshio Nagai

    Recruiting

  • Kimitsu Chuo Hospital

    Kisarazu, 292-8535

    81120023812

    Ryoichi Ishibashi

    Recruiting

  • Kure Medical Center

    Kure, 737-0023

    81120023812

    Mitsunobu Kubota

    Recruiting

  • Takeda General Hospital - Kyoto

    Kyoto, 601-1495

    81120023812

    KIminori Hosoda

    Recruiting

  • Mikannohana Clinic, Diabetes, Endocrinology and Metabolism

    Matsuyama, 7900034

    81120023812

    Tetsuji Niiya

    Recruiting

  • Kansai Electric Power Hospital

    Osaka, 553-0003

    81120023812

    Yoshiyuki Hamamoto

    Recruiting

  • Manda Memorial Hospital

    Sapporo, 060-0062

    81120023812

    Masahiko Kato

    Recruiting

  • Shimonoseki Medical Center

    Shimonoseki, 750-0061

    81120023812

    Kaoru Noda

    Recruiting

  • Japanese Red Cross Society - Wakayama Medical Center

    Wakayama, 640-8558

    81120023812

    Shizuka Kaneko

    Recruiting

Other trials in Japan

Australia10 sites, 10 recruiting

  • Emeritus Research

    Botany, 2019

    Paul Bird

    Recruiting

  • Box Hill Hospital

    Box Hill, 3128

    Ming Li Yee

    Recruiting

  • Royal Brisbane and Women's Hospital

    Brisbane, 4029

    +61736468111

    Donald McLeod

    Recruiting

  • Emeritus Research

    Camberwell, 3124

    Sam Francis

    Recruiting

  • Barwon Health

    Geelong, 3220

    Kay Hau (Aaron) Choy

    Recruiting

  • Austin Health - Repatriation Hospital

    Heidelberg West, 3081

    0394962160

    Elif Ekinci

    Recruiting

  • AIM Research

    Merewether, 2291

    +61 2 4963 2323

    Claire Morbey

    Recruiting

  • Southern Adelaide Diabetes & Endocrine Services

    Oaklands Park, 5046

    0874258693

    Jui Ho

    Recruiting

  • Royal North Shore Hospital

    St Leonards, 2065

    Sarah Glastras

    Recruiting

  • Innovate Clinical Research

    Waitara, 2077

    Rachel Graham

    Recruiting

Other trials in Australia

India10 sites

  • Motilal Nehru Medical College Hospital

    Allahabād, 211002

    Suspended

  • Life Care Hospital and Research Centre

    Bangalore, 560092

    Suspended

  • Madras Diabetes Research Foundation

    Chennai, 600086

    Suspended

  • Nizam's Institute of Medical Sciences

    Hyderabad, 500082

    Suspended

  • Eternal Heart Care Center and Research Institute

    Jaipur, 302020

    Suspended

  • Atmaram Child Care

    Kanpur, 208011

    Suspended

  • Shree Mahalaxmi DIATONE Institute

    Kolhāpur, 416001

    Suspended

  • Mysore Medical College

    Mysore, 570001

    Suspended

  • All India Institute of Medical Sciences (AIIMS) - Nagpur

    Nagpur, 441108

    Suspended

  • Nirmal Hospital Pvt Ltd.

    Surat, 395002

    Suspended

Other trials in India

Romania10 sites, 10 recruiting

  • Mariodiab Clinic

    Brasov, 500097

    40721203324

    Brindusa Cofaru

    Recruiting

  • C.M.D.T.A. Neomed

    Brasov, 500283

    0040762249010

    Liliana Marin

    Recruiting

  • Geea Medical Easy Diet

    Bucharest, 010627

    40314288633

    Georgeta Vacaru

    Recruiting

  • Centrul Medical NutriLife

    Bucharest, 013764

    0040212323445

    Marlena Pascu

    Recruiting

  • Gama Diamed

    Mangalia, 905500

    0040241740581

    Amalia Thury-Burileanu

    Recruiting

  • Diabdana

    Oradea, 410147

    004 0722 480 224

    Dana Cosma

    Recruiting

  • Clinica Korall

    Satu Mare, 440055

    40746013882

    Adriana Filimon

    Recruiting

  • Rinart Diab SRL

    Targoviste, 130168

    0040724372432

    Anca Nicoara

    Recruiting

  • SC Dentosim Queen SRL - Centrul Medical Diamed

    Târgu Mureş, 540098

    0040745641194

    Daniela Ciomos

    Recruiting

  • Cabinet Medical Dr.Geru

    Timișoara, 300288

    0723377127

    Polina Geru

    Recruiting

Other trials in Romania

Spain10 sites, 10 recruiting

  • Hospital San Rafael - La Coruña

    A Coruña, 15006

    655624017

    Alfonso Soto Gonzalez

    Recruiting

  • Centro Periférico de Especialidades Bola Azul

    Almería, 04009

    0034678510067

    Pedro Mezquita-Raya

    Recruiting

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035

    34697817352

    ANDREEA CIUDIN

    Recruiting

  • Instituto Gallego de Cirugía Ocular

    Ferrol, 15402

    Alma Maria Prieto tenreiro

    Recruiting

  • Clínica Juaneda

    Palma de Mallorca, 07014

    34 871 205256

    Santiago Tofe Povedano

    Recruiting

  • Hospital Universitario Quironsalud Madrid

    Pozuelo de Alarcón, 28223

    34914522000

    Esteban Jodar Gimeno

    Recruiting

  • Hospital Universitario Marqués de Valdecilla

    Santander, 39008

    34639659866

    Luis Vazquez Salvi

    Recruiting

  • Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)

    Seville, 41003

    + 34 954709183

    Alberto Aliaga Verdugo

    Recruiting

  • Hospital Quiron Infanta Luisa

    Seville, 41010

    670502836

    MARGARITA RIVAS FERNANDEZ

    Recruiting

  • Vithas Hospital Sevilla

    Seville, 41950

    658011529

    Cristobal Morales Portillo

    Recruiting

Other trials in Spain

Belgium9 sites, 9 recruiting

  • Imelda General Hospital

    Bonheiden, 2820

    003215505164

    Chris Vercammen

    Recruiting

  • Université Libre de Bruxelles - Hôpital Erasme

    Brussels, 1070

    Laurent Crenier

    Recruiting

  • Ziekenhuis Oost-Limburg, Campus St.-Jan

    Genk, 3600

    3289807250

    David Verhaert

    Recruiting

  • Jan Yperman Ziekenhuis

    Ieper, 8900

    +3257357270

    An Nollet

    Recruiting

  • AZ Groeninge Campus Kennedylaan

    Kortrijk, 8500

    003256633180

    Gerd Vanhaverbeke

    Recruiting

  • UZ Leuven

    Leuven, 3000

    3216346994

    Roman Vangoitsenhoven

    Recruiting

  • AZ Sint-Maarten

    Mechelen, 2800

    +3215892042

    Michel Vandenbroucke

    Recruiting

  • Meclinas

    Mechelen, 2800

    003215792797

    Julie Casaer

    Recruiting

  • Az Damiaan vzw

    Ostend, 8400

    059414160

    Marianne Kerrebrouck

    Recruiting

Other trials in Belgium

Taiwan9 sites, 9 recruiting

  • Chiayi Christian Hospital

    Chiayi City, 600

    886-5-2765041

    Chu-Kuang Chou

    Recruiting

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 807

    886-7-3121101 ext 7741

    Tsung-Hsien Lin

    Recruiting

  • Chang Gung Memorial Hospital at Kaohsiung

    Kaohsiung Niao Sung Dist, 83301

    +886912159389

    Jung-Fu Chen

    Recruiting

  • China Medical University Hospital

    Taichung, 404332

    886923832500

    Wen-Yuan Lin

    Recruiting

  • National Cheng Kung University Hospital

    Tainan, 704

    886 62353535 ext 3985

    Yi-Ching Yang

    Recruiting

  • National Taiwan University Hospital

    Taipei, 10002

    0223123456

    Chih-Yuan Wang

    Recruiting

  • Taipei Medical University Hospital

    Taipei, 110

    886-2-2737-2181 ext 8481

    Chun-Yao Huang

    Recruiting

  • Taipei Veterans General Hospital

    Taipei, 11217

    886228757516

    Chii-Min Hwu

    Recruiting

  • Chang Gung Medical Foundation-Linkou Branch

    Taoyuan, 333

    Chia-Hung Lin

    Recruiting

Other trials in Taiwan

Brazil7 sites, 7 recruiting

  • Quanta Diagnóstico e Terapia

    Curitiba, 80045170

    5541999736442

    Rosangela Rea

    Not yet recruiting

  • Centro de Diabetes Curitiba

    Curitiba, 80810-040

    554130231252

    LUCIANA PECHMANN

    Not yet recruiting

  • Private Practice - Dr.Miguel N. Hissa

    Fortaleza, 60430-350

    55 85 3214.6530

    Miguel Hissa

    Not yet recruiting

  • CPCLIN

    São Paulo, 01228-200

    551126303777

    Denise Franco

    Not yet recruiting

  • Hospital 9 De Julho

    São Paulo, 01409-901

    551131479432

    Layana Sandes Fraga

    Not yet recruiting

  • CEDOES

    Vitória, 29055450

    55 27 99933-3330

    Queulla Santos

    Not yet recruiting

  • Integral Pesquisa e Ensino

    Votuporanga, 15500-269

    55017997472217

    GRACIELLY DE SOUZA PANTANO

    Not yet recruiting

Other trials in Brazil

Mexico7 sites, 7 recruiting

  • Medical Center Metas

    Chihuahua City, 31110

    52 614 423 5956

    Luis Nevarez

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About this study

Official title: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Persistent Obesity or Overweight Treated With a Weekly Incretin, With and Without Type 2 Diabetes

The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo in participants with persistent obesity or overweight, with or without type 2 diabetes, and on stable incretin background therapy.

Participation in the study will last about 80 weeks.

Conditions
Overweight, Obesity
Being tested
Eloralintide, Placebo
Keywords
Amylin receptor agonist
Medical subject headings
Overweight, Obesity

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • EloralintideDrug

    Also called LY3841136

    Administered SC

  • PlaceboDrug

    Administered SC

Study groups in NCT07392190
Study groupRoleWhat they receive
Eloralintide Dose 1ExperimentalParticipants will receive eloralintide subcutaneously (SC)
Receives: Drug: Eloralintide
Eloralintide Dose 2ExperimentalParticipants will receive eloralintide SC
Receives: Drug: Eloralintide
Eloralintide Dose 3ExperimentalParticipants will receive eloralintide SC
Receives: Drug: Eloralintide
Eloralintide Dose 4ExperimentalParticipants will receive eloralintide SC
Receives: Drug: Eloralintide
PlaceboPlacebo comparatorParticipants will receive placebo SC
Receives: Drug: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Percent Change from Baseline in Body Weight

    Measured: Baseline, Week 64

Secondary outcomes (15)

  1. Change from Baseline in Waist Circumference

    Measured: Baseline, Week 64

  2. Percent Change in Baseline in Triglycerides

    Measured: Baseline, Week 64

  3. Change from Baseline in Systolic Blood Pressure

    Measured: Baseline, Week 64

  4. Change from Baseline in Body Mass Index (BMI)

    Measured: Baseline, Week 64

  5. Change from Baseline in Fasting Glucose in Participants with Type 2 Diabetes at Baseline

    Measured: Baseline, Week 64

  6. Change from Baseline in Short Form-36 (SF-36 v2) Score

    Measured: Baseline, Week 64

  7. Change from Baseline in EQ-5D-5L Score

    Measured: Baseline, Week 64

  8. Change from Baseline in Control of Eating Questionnaire (CoEQ) Score

    Measured: Baseline, Week 64

  9. Achievement of Improved Categorical Shift in Patient Global Impression of Severity (PGIS) Physical Function Weight

    Measured: Baseline, Week 64

  10. Percent Change from Baseline in Fasting Insulin

    Measured: Baseline, Week 64

  11. Percent Change from Baseline in High Sensitivity C-Reactive Protein (hsCRP)

    Measured: Baseline, Week 64

  12. Change from Baseline in Estimated Glomerular Filtration Rate (eGFR)

    Measured: Baseline, Week 64

  13. Change in Medication Use

    Measured: Baseline through Week 64

  14. Pharmacokinetics (PK): Maximum Concentration at Steady State (Cmax,ss)

    Measured: Baseline through Week 64

  15. PK: Area Under the Concentration Versus Time Curve for One Dosing Interval at Steady State (AUC(0-ᴛ)ss)

    Measured: Baseline through Week 64

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted6 Feb 2026
  2. Study start10 Feb 2026
  3. Primary completionJun 2028 (estimated)
  4. Study completionJul 2028 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
900 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07392190
Sponsor's protocol ID
27743
Other IDs
J3R-MC-YDAL, 2025-523659-73-00, 2025
Acronym
ENLIGHTEN-6
Status last verified
Nov 2026
First submitted
30 Jan 2026
Last updated
4 Nov 2026
Results posted
No
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing Eloralintide in people with Overweight and Obesity, run by Eli Lilly and Company at 185 sites in 14 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 10 inclusion and 14 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: looking for participants now, as of the sponsor's last update on 4 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 185 sites in United States, China, Israel, Japan, Australia and 9 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

Contact Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or (317-615-4559, LillyTrials@Lilly.com), or a site near the patient. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Percent Change from Baseline in Body Weight (time frame: Baseline, Week 64). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07392190.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Nov 2026.

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