Parial DenervationNCT07393061
Partial Wrist Denervation in Comminuted Articular Distal Radius Fractures
A study testing Partial Wrist Denervation in Comminuted articular Distal Radius Fractures in people with Parial Denervation and Fracture Disatl Radius, run by Assiut University at 1 site in Egypt.
Trial summary
the aim of Partial Wrist Denervation in Comminuted articular Distal Radius Fractures is to decrease incidence of chronic wrist pain follwing this type of fracture Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Parial Denervation, Fracture Disatl Radius
- What is being tested?
- Partial Wrist Denervation in Comminuted articular Distal Radius Fractures
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 56 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Jan 2026to 1 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Fracture Pattern: Acute, comminuted intra-articular distal radius fractures (AO/OTA Type C2 or C3).
- Surgical Context: Procedure performed as a primary adjunct during initial open reduction and internal fixation (ORIF).
- Exclusion Criteria:Active local infection over the surgical site.
- Compromised soft tissue envelope that precludes safe dissection.
- Vascular injury or compromise requiring repair.
- Pre-existing neurological deficit (e.g., complex regional pain syndrome, major peripheral nerve injury).
Who cannot join
None listed.
Trial locations and contacts
1 site in 1 country.
About this study
the aim of Partial Wrist Denervation in Comminuted articular Distal Radius Fractures is to decrease incidence of chronic wrist pain follwing this type of fracture
Read the detailed description
Distal radius fractures represent the most common fractures in adults showing an overall prevalence of 17.5 % with respect to all fractures. partial wrist denervation is an adjunctive procedure performed during initial fracture fixation to mitigate chronic pain by interrupting sensory innervation to the wrist joint. It targets the anterior interosseous nerve (AIN) and posterior interosseous nerve (PIN), which convey nociceptive signals from the radiocarpal and midcarpal joints.
Comminuted intra-articular distal radius fractures (AO/OTA Type C2/C3) often lead to post-traumatic arthritis due to articular incongruity and capsular damage. Denervation at the index procedure may reduce central sensitization and chronic pain by resecting afferent pain fibers, potentially improving postoperative rehabilitation and functional outcomes.
Acute comminuted intra-articular distal radius fractures (AO/OTA C2/C3) with high risk of post-traumatic arthritis (e.g., articular step-off >2 mm, severe fragmentation).
- Active individuals seeking motion preservation, those with high functional demands (e.g., athletes, laborers), or patients preferring a less invasive option than salvage procedures.
- Adjunct to primary fixation: Performed concurrently with volar locking plate (VLP) or dorsal plating.
- Conditions
- Parial Denervation, Fracture Disatl Radius
- Being tested
- Partial Wrist Denervation in Comminuted articular Distal Radius Fractures
- Keywords
- parital denervation, comminuted distal radius fractures, chronic wrist pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Partial Wrist Denervation in Comminuted articular Distal Radius FracturesProcedure or surgery
Partial Wrist Denervation in Comminuted articular Distal Radius Fractures through sme approach of the surgery
| Study group | Role | What they receive |
|---|---|---|
| parital wrist denervation | Other | Partial Wrist Denervation in Comminuted articular Distal Radius Fractures Receives: Procedure: Partial Wrist Denervation in Comminuted articular Distal Radius Fractures |
What is being measured
The primary outcome is the main question the study is designed to answer.
The end results PAIN will be assessed according to mayo clinc wrist score
mayo clinc wrist score its a clincal reported outcome measure designed to assess function and pain of the wrist follwing surgery the score is bassed on 100 points divided into four equally weighted categories the final score places the wrist into outcome category total score 90/100 is excellent while below 65 is poor
Measured: 2 weeks, 6 weeks, 3 months, 6 months..and 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted6 Feb 2026
- Study start1 Jan 2026
- Primary completion1 Jan 2027 (estimated)
- Study completion1 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Parial DenervationStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- observational
- Masking
- None (open label)
- Enrolment
- 56 participants (actual)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Momen Moustafa, Assiut University
- Investigators
- walyd ryad saleh, professor of orthopedics, Study director, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07393061
- Sponsor's protocol ID
- denervation in fracture radius
- Status last verified
- Jan 2026
- First submitted
- 22 Jan 2026
- Last updated
- 6 Feb 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: will wait till we see the result
Study at a glance
From the registry record, last updated by the sponsor on 6 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Partial Wrist Denervation in Comminuted Articular Distal Radius Fractures
- ClinicalTrials.gov ID
- NCT07393061
- Acronym / sponsor ID
- denervation in fracture radius
- Conditions
- Parial Denervation, Fracture Disatl Radius
- Keywords
- parital denervation, comminuted distal radius fractures, chronic wrist pain
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 56 participants (actual)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 1 Jan 2026 (actual)
- Primary completion
- 1 Jan 2027 (estimated)
- Study completion
- 1 Jan 2027 (estimated)
- First posted
- 6 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
the aim of Partial Wrist Denervation in Comminuted articular Distal Radius Fractures is to decrease incidence of chronic wrist pain follwing this type of fracture
Detailed description
Distal radius fractures represent the most common fractures in adults showing an overall prevalence of 17.5 % with respect to all fractures. partial wrist denervation is an adjunctive procedure performed during initial fracture fixation to mitigate chronic pain by interrupting sensory innervation to the wrist joint. It targets the anterior interosseous nerve (AIN) and posterior interosseous nerve (PIN), which convey nociceptive signals from the radiocarpal and midcarpal joints.
Comminuted intra-articular distal radius fractures (AO/OTA Type C2/C3) often lead to post-traumatic arthritis due to articular incongruity and capsular damage. Denervation at the index procedure may reduce central sensitization and chronic pain by resecting afferent pain fibers, potentially improving postoperative rehabilitation and functional outcomes.
Acute comminuted intra-articular distal radius fractures (AO/OTA C2/C3) with high risk of post-traumatic arthritis (e.g., articular step-off >2 mm, severe fragmentation).
- Active individuals seeking motion preservation, those with high functional demands (e.g., athletes, laborers), or patients preferring a less invasive option than salvage procedures.
- Adjunct to primary fixation: Performed concurrently with volar locking plate (VLP) or dorsal plating.
Study design
- Primary purpose
- Prevention
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- observational
| Arm | Type | Receives |
|---|---|---|
| parital wrist denervation | Other | Procedure: Partial Wrist Denervation in Comminuted articular Distal Radius FracturesPartial Wrist Denervation in Comminuted articular Distal Radius Fractures |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Fracture Pattern: Acute, comminuted intra-articular distal radius fractures (AO/OTA Type C2 or C3).
- Surgical Context: Procedure performed as a primary adjunct during initial open reduction and internal fixation (ORIF).
- Exclusion Criteria:Active local infection over the surgical site.
- Compromised soft tissue envelope that precludes safe dissection.
- Vascular injury or compromise requiring repair.
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Partial Wrist Denervation in Comminuted articular Distal Radius FracturesPartial Wrist Denervation in Comminuted articular Distal Radius Fractures through sme approach of the surgery | Procedure or surgery | parital wrist denervation |
Primary outcome
The end results PAIN will be assessed according to mayo clinc wrist score
Time frame: 2 weeks, 6 weeks, 3 months, 6 months..and 1 year
mayo clinc wrist score its a clincal reported outcome measure designed to assess function and pain of the wrist follwing surgery the score is bassed on 100 points divided into four equally weighted categories the final score places the wrist into outcome category total score 90/100 is excellent while below 65 is poor
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Feb 2026.
- Related InfoLink provided by the sponsor.
- Individual participant dataSharing planned: Undecided. will wait till we see the result
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
walyd ryad saleh, professor of orthopedics study director
Assiut University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Partial Wrist Denervation in Comminuted articular Distal Radius Fractures in people with Parial Denervation and Fracture Disatl Radius, run by Assiut University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 6 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The end results PAIN will be assessed according to mayo clinc wrist score (time frame: 2 weeks, 6 weeks, 3 months, 6 months..and 1 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Feb 2026.