Intraoperative AwarenessNCT07396727
Subconscious Effects of Intraoperative Speech: Health Professionals' Perceptions
An observational study of Intraoperative Awareness and Anesthesia, General, run by Başakşehir Çam & Sakura City Hospital at 1 site in Turkey (Türkiye).
Trial summary
This observational, questionnaire-based study aims to evaluate health professionals' perceptions regarding the potential subconscious effects of intraoperative conversations on patients. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Intraoperative Awareness, Anesthesia, General, Consciousness
- What is being tested?
- Questionnaire / Survey
- How many people
- 251 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jan 2026to 2 Feb 2026
- How long will I take part?
- 1 Day
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Operating room health professionals in Turkey, including anesthesiologists, anesthesia residents, anesthesia technicians, surgeons, surgical residents, and operating room nurses. Participation is voluntary and limited to individuals aged 18 years and older who provide informed consent to complete the online questionnaire.
Who may be able to join
- Age 18 years or older
- Currently working in an operating room environment in Turkey (e.g., anesthesiologist, anesthesia resident, anesthesia technician, surgeon, surgical resident, operating room nurse)
- Access to the internet and ability to complete an online questionnaire
- Willingness to participate voluntarily and provide informed consent via the online form
Who cannot join
- Individuals younger than 18 years
- Healthcare personnel not directly working in the operating room environment.
- Participants who provide incomplete, misleading, or random responses in the questionnaire
- Individuals who do not provide informed consent at the beginning of the online survey
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Başakşehir Çam and Sakura City Hospital
Başakşehir, Istanbul, 34480
About this study
Official title: Health Professionals' Perceptions of the Subconscious Effects of Intraoperative Conversations in Patients: A Questionnaire-Based Study
This observational, questionnaire-based study aims to evaluate health professionals' perceptions regarding the potential subconscious effects of intraoperative conversations on patients. Although intraoperative awareness is rare, neuroscientific evidence suggests that unconscious perception of auditory stimuli under anesthesia may influence postoperative psychological outcomes. An anonymous 19-item online survey will be distributed to anesthesiologists, anesthesia residents, anesthesia technicians, surgeons, surgical residents, and operating room nurses across Turkey. Data will be collected via Google Forms, with voluntary participation and informed consent. Statistical analysis will include descriptive and comparative methods to assess differences across professional groups and experience levels.
Read the detailed description
Intraoperative awareness refers to conscious or subconscious perception during general anesthesia. Although its clinical incidence is rare, previous studies using EEG, fMRI, and neurocognitive methods have shown that auditory stimuli presented during anesthesia can leave subconscious traces and may influence postoperative psychological well-being, trust in healthcare, and anxiety levels.This study aims to explore health professionals' knowledge, awareness, and attitudes regarding the potential subconscious effects of intraoperative conversations. The research is designed as a multicenter, observational, cross-sectional, questionnaire-based study. A 19-item anonymous online survey will be distributed through professional networks, social media, and institutional mailing lists. Target participants include anesthesiologists, anesthesia residents, anesthesia technicians, surgeons, surgical residents, and operating room nurses actively working in operating rooms across Turkey. The primary objective is to evaluate the awareness level of healthcare professionals on the potential subconscious effects of intraoperative speech. Secondary objectives include identifying differences between professional groups, years of experience, and demographic factors. No intervention or treatment is involved, and no patient participation is required. Participation is voluntary and anonymous, with informed consent obtained at the beginning of the online survey. The anticipated sample size is a minimum of 150 participants to allow meaningful subgroup comparisons. Data will be collected via Google Forms and analyzed using SPSS software. Descriptive statistics, group comparisons (t-test, ANOVA, Mann-Whitney U, Kruskal-Wallis), and chi-square tests will be performed. If sufficient sample size is achieved, correlation and regression analyses may also be conducted. This study is expected to provide valuable insights into the level of professional awareness and ethical considerations regarding intraoperative communication, potentially contributing to the development of training strategies to reduce intraoperative awareness risks and improve patient safety.
- Conditions
- Intraoperative Awareness, Anesthesia, General, Consciousness
- Being tested
- Questionnaire / Survey
- Keywords
- Anesthesia, General, Intraoperative Awareness, Consciousness, Health Personnel, Operating Rooms
- Medical subject headings
- Intraoperative Awareness
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Questionnaire / SurveyOther
An anonymous, structured 19-item online questionnaire (Google Forms) administered to operating room health professionals, including anesthesiologists, anesthesia residents, anesthesia technicians, surgeons, surgical residents, and operating room nurses. The survey collects demographic information, awareness, attitudes, and perceptions regarding the potential subconscious effects of intraoperative conversations.
| Study group | Role | What they receive |
|---|---|---|
| Operating Room Health Professionals | Anesthesiologists, anesthesia residents, anesthesia technicians, surgeons, surgical residents, and operating room nurses working actively in operating rooms across Turkey. Receives: Other: Questionnaire / Survey |
What is being measured
The primary outcome is the main question the study is designed to answer.
Awareness and Perceptions of Health Professionals Regarding Subconscious Effects of Intraoperative Conversations
Evaluated through responses to a 19-item anonymous online questionnaire. Measured parameters include knowledge of intraoperative awareness, beliefs about subconscious auditory perception under anesthesia, and attitudes toward ethical and professional considerations. Responses are assessed using Likert scales, categorical questions, and descriptive statistics.
Measured: At survey completion (single time point) during the 1-month data collection period
Secondary outcomes (3)
Differences in Awareness Across Professional Groups
The evaluation was based on responses to a 19-item anonymous online survey. Comparison of perceptions regarding patient awareness during anesthesia among anesthesiologists, anesthesia assistants, anesthesia technicians, surgeons, surgical assistants, and operating room nurses.
Measured: At survey completion (single time point) during the 1-month data collection period
Correlation between Age and Awareness/Professional Attitude Score
Association between participant age (years) and the composite awareness/professional attitude score measured by the online questionnaire.
Measured: At survey completion (single time point) during the 1-month data collection period
Support for Training and Ethical Guidelines
Evaluated through responses to a 19-item anonymous online questionnaire. Proportion of participants endorsing the need for training programs and ethical standards addressing intraoperative communication.
Measured: At survey completion (single time point) during the 1-month data collection period
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Feb 2026
- Study start1 Jan 2026
- Primary completion2 Feb 2026
- Study completion2 Feb 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for Intraoperative AwarenessStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 251 participants (actual)
- Target duration
- 1 Day
Sponsor and investigators
- Lead sponsor
- Başakşehir Çam & Sakura City Hospital
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Emine OZCAN, Başakşehir Çam & Sakura City Hospital
- Investigators
- Emine Ozcan, MD, Principal investigator, Başakşehir Çam & Sakura City Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07396727
- Sponsor's protocol ID
- AWAKE2025
- Status last verified
- Feb 2026
- First submitted
- 26 Sep 2025
- Last updated
- 9 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: The study collects anonymous survey responses only. No individual participant data (IPD) will be shared.
Publications
Fu VX, Sleurink KJ, Janssen JC, Wijnhoven BPL, Jeekel J, Klimek M. Perception of auditory stimuli during general anesthesia and its effects on patient outcomes: a systematic review and meta-analysis. Can J Anaesth. 2021 Aug;68(8):1231-1253. doi: 10.1007/s12630-021-02015-0. Epub 2021 May 19.
PubMed 34013463Kim KM, Bang JY, Choi BM, Noh GJ. Assessment of explicit and implicit memories during remimazolam anaesthesia using the process dissociation procedure: A prospective cohort study. Eur J Anaesthesiol. 2023 Nov 1;40(11):833-840. doi: 10.1097/EJA.0000000000001904. Epub 2023 Sep 25.
PubMed 37747426Han L, Purger DA, Eagleman SL, Halpern CH, Buch V, Gaston SM, Razavi B, Meador K, Drover DR. Deep learning models using intracranial and scalp EEG for predicting sedation level during emergence from anaesthesia. BJA Open. 2024 Oct 12;12:100347. doi: 10.1016/j.bjao.2024.100347. eCollection 2024 Dec.
PubMed 40018289Jang H, Mashour GA, Hudetz AG, Huang Z. Measuring the dynamic balance of integration and segregation underlying consciousness, anesthesia, and sleep. bioRxiv [Preprint]. 2024 Apr 15:2024.04.12.589265. doi: 10.1101/2024.04.12.589265.
PubMed 38659759Ozcan E. Operating Room Professionals' Awareness of Possible Unconscious Auditory Perception During General Anesthesia: A Cross-Sectional Survey Study. Anesthesiol Res Pract. 2026 Jul 14;2026:9936739. doi: 10.1155/anrp/9936739. eCollection 2026.
PubMed 42453645
Study at a glance
From the registry record, last updated by the sponsor on 9 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Health Professionals' Perceptions of the Subconscious Effects of Intraoperative Conversations in Patients: A Questionnaire-Based Study
- ClinicalTrials.gov ID
- NCT07396727
- Acronym / sponsor ID
- AWAKE2025
- Conditions
- Intraoperative Awareness, Anesthesia, General, Consciousness
- Keywords
- Anesthesia, General, Intraoperative Awareness, Consciousness, Health Personnel, Operating Rooms
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 251 participants (actual)
- Lead sponsor
- Başakşehir Çam & Sakura City HospitalOther government
- Study start
- 1 Jan 2026 (actual)
- Primary completion
- 2 Feb 2026 (actual)
- Study completion
- 2 Feb 2026 (actual)
- First posted
- 9 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This observational, questionnaire-based study aims to evaluate health professionals' perceptions regarding the potential subconscious effects of intraoperative conversations on patients. Although intraoperative awareness is rare, neuroscientific evidence suggests that unconscious perception of auditory stimuli under anesthesia may influence postoperative psychological outcomes. An anonymous 19-item online survey will be distributed to anesthesiologists, anesthesia residents, anesthesia technicians, surgeons, surgical residents, and operating room nurses across Turkey. Data will be collected via Google Forms, with voluntary participation and informed consent. Statistical analysis will include descriptive and comparative methods to assess differences across professional groups and experience levels.
Detailed description
Intraoperative awareness refers to conscious or subconscious perception during general anesthesia. Although its clinical incidence is rare, previous studies using EEG, fMRI, and neurocognitive methods have shown that auditory stimuli presented during anesthesia can leave subconscious traces and may influence postoperative psychological well-being, trust in healthcare, and anxiety levels.This study aims to explore health professionals' knowledge, awareness, and attitudes regarding the potential subconscious effects of intraoperative conversations. The research is designed as a multicenter, observational, cross-sectional, questionnaire-based study. A 19-item anonymous online survey will be distributed through professional networks, social media, and institutional mailing lists. Target participants include anesthesiologists, anesthesia residents, anesthesia technicians, surgeons, surgical residents, and operating room nurses actively working in operating rooms across Turkey. The primary objective is to evaluate the awareness level of healthcare professionals on the potential subconscious effects of intraoperative speech. Secondary objectives include identifying differences between professional groups, years of experience, and demographic factors. No intervention or treatment is involved, and no patient participation is required. Participation is voluntary and anonymous, with informed consent obtained at the beginning of the online survey. The anticipated sample size is a minimum of 150 participants to allow meaningful subgroup comparisons. Data will be collected via Google Forms and analyzed using SPSS software. Descriptive statistics, group comparisons (t-test, ANOVA, Mann-Whitney U, Kruskal-Wallis), and chi-square tests will be performed. If sufficient sample size is achieved, correlation and regression analyses may also be conducted. This study is expected to provide valuable insights into the level of professional awareness and ethical considerations regarding intraoperative communication, potentially contributing to the development of training strategies to reduce intraoperative awareness risks and improve patient safety.
Study design
- Observational model
- Other
- Time perspective
- Cross-sectional
- Target follow-up
- 1 Day
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Operating Room Health Professionals | – | Other: Questionnaire / SurveyAnesthesiologists, anesthesia residents, anesthesia technicians, surgeons, surgical residents, and operating room nurses working actively in operating rooms across Turkey. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Operating room health professionals in Turkey, including anesthesiologists, anesthesia residents, anesthesia technicians, surgeons, surgical residents, and operating room nurses. Participation is voluntary and limited to individuals aged 18 years and older who provide informed consent to complete the online questionnaire.
Key inclusion criteria (4 listed)
- Age 18 years or older
- Currently working in an operating room environment in Turkey (e.g., anesthesiologist, anesthesia resident, anesthesia technician, surgeon, surgical resident, operating room nurse)
- Access to the internet and ability to complete an online questionnaire
- Willingness to participate voluntarily and provide informed consent via the online form
Key exclusion criteria (4 listed)
- Individuals younger than 18 years
- Healthcare personnel not directly working in the operating room environment.
- Participants who provide incomplete, misleading, or random responses in the questionnaire
- Individuals who do not provide informed consent at the beginning of the online survey
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Questionnaire / SurveyAn anonymous, structured 19-item online questionnaire (Google Forms) administered to operating room health professionals, including anesthesiologists, anesthesia residents, anesthesia technicians, surgeons, surgical residents, and operating room nurses. The survey collects demographic information, awareness, attitudes, and perceptions regarding the potential subconscious effects of intraoperative conversations. | Other | Operating Room Health Professionals |
Primary outcome
Awareness and Perceptions of Health Professionals Regarding Subconscious Effects of Intraoperative Conversations
Time frame: At survey completion (single time point) during the 1-month data collection period
Evaluated through responses to a 19-item anonymous online questionnaire. Measured parameters include knowledge of intraoperative awareness, beliefs about subconscious auditory perception under anesthesia, and attitudes toward ethical and professional considerations. Responses are assessed using Likert scales, categorical questions, and descriptive statistics.
3 secondary outcomes
Differences in Awareness Across Professional Groups
Time frame: At survey completion (single time point) during the 1-month data collection period
Correlation between Age and Awareness/Professional Attitude Score
Time frame: At survey completion (single time point) during the 1-month data collection period
Support for Training and Ethical Guidelines
Time frame: At survey completion (single time point) during the 1-month data collection period
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Feb 2026.
- Background: PubMed 34013463Fu VX, Sleurink KJ, Janssen JC, Wijnhoven BPL, Jeekel J, Klimek M. Perception of auditory stimuli during general anesthesia and its effects on patient outcomes: a systematic review and meta-analysis. Can J Anaesth. 2021 Aug;68(8):1231-1253. doi: 10.1007/s12630-021-02015-0. Epub 2021 May 19.
- Background: PubMed 37747426Kim KM, Bang JY, Choi BM, Noh GJ. Assessment of explicit and implicit memories during remimazolam anaesthesia using the process dissociation procedure: A prospective cohort study. Eur J Anaesthesiol. 2023 Nov 1;40(11):833-840. doi: 10.1097/EJA.0000000000001904. Epub 2023 Sep 25.
- Background: PubMed 40018289Han L, Purger DA, Eagleman SL, Halpern CH, Buch V, Gaston SM, Razavi B, Meador K, Drover DR. Deep learning models using intracranial and scalp EEG for predicting sedation level during emergence from anaesthesia. BJA Open. 2024 Oct 12;12:100347. doi: 10.1016/j.bjao.2024.100347. eCollection 2024 Dec.
- Background: PubMed 38659759Jang H, Mashour GA, Hudetz AG, Huang Z. Measuring the dynamic balance of integration and segregation underlying consciousness, anesthesia, and sleep. bioRxiv [Preprint]. 2024 Apr 15:2024.04.12.589265. doi: 10.1101/2024.04.12.589265.
- Derived from this study: PubMed 42453645Ozcan E. Operating Room Professionals' Awareness of Possible Unconscious Auditory Perception During General Anesthesia: A Cross-Sectional Survey Study. Anesthesiol Res Pract. 2026 Jul 14;2026:9936739. doi: 10.1155/anrp/9936739. eCollection 2026.
- Individual participant dataSharing planned: No. The study collects anonymous survey responses only. No individual participant data (IPD) will be shared.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Emine Ozcan, MD principal investigator
Başakşehir Çam & Sakura City Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Intraoperative Awareness and Anesthesia, General, run by Başakşehir Çam & Sakura City Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 9 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Awareness and Perceptions of Health Professionals Regarding Subconscious Effects of Intraoperative Conversations (time frame: At survey completion (single time point) during the 1-month data collection period). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07396727, which also lists 5 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Feb 2026.