Hypertension,EssentialENHANCeNCT07399912
Engaging Home-monitored Assessment to Navigate Clinical Decision-making
A study testing ENHANCe app and Teaching and training in people with Hypertension,Essential, run by SingHealth Polyclinics at 1 site in Singapore.
Trial summary
This study is testing a new app called ENHANCe, which is designed to help family doctors manage patients with high blood pressure using readings taken at home. Read more about this study
- Who is it for?
- Ages 21 years and older
- Conditions the study is for
- Hypertension,Essential
- What is being tested?
- ENHANCe app and Teaching and training
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 116 participants
- Where
- 1 siteSingapore
- Study dates
- 1 Oct 2025to 1 Oct 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- For primary care physicians:
- PCPs aged 21 years and above.
- Involved in the clinical management of patients with hypertension in the past six months.
- For patients:
- Patients aged 21 years and above
- Documentation of hypertension diagnosis in EMR
- Owns an HBP monitoring device
Who cannot join
- Documentation of dementia diagnosis in EMR
- Audio or visual impairments
- Hypertensive urgency or emergency
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Engaging Home-monitored Assessment to Navigate Clinical Decision-making -The ENHANCe Study
This study is testing a new app called ENHANCe, which is designed to help family doctors manage patients with high blood pressure using readings taken at home.
Read the detailed description
The researchers want to find out if the app is easy to use in everyday clinic settings, whether doctors find it helpful and are willing to use it, and if it helps improve care. The study will involve 16 doctors and 100 patients with high blood pressure, split into two groups at two clinics. One group will use the ENHANCe app, which can read blood pressure data from different sources-including handwritten notes-and give doctors advice based on that information. The other group will receive regular care without the app. Over six months, researchers will collect feedback from doctors through surveys and group discussions at the end of the study. They'll also track how many people complete the study, how long clinic visits take, whether doctors follow the app's advice, and how well patients' blood pressure is controlled. The goal is to see if the app can help doctors make faster, better decisions and improve health outcomes for people managing their blood pressure at home.
- Conditions
- Hypertension,Essential
- Being tested
- ENHANCe app, Teaching and training, Usual care
- Keywords
- Hypertension, Home blood pressure, Primary Care, Clinical decision support system
- Medical subject headings
- Essential Hypertension, Hypertension
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ENHANCe appDevice
ENHANCe app is a prototype; it is a smartphone based clinical decision support (CDS) tool to manage patients with hypertension using their home blood pressure. The app will scan patients' home BP records from paper or mobile phone, and provide a recommendation to the doctor on how to manage their blood pressure. The patient will not need to use the device during the study period. However, the recommendation from the ENHANCe app will be available to the doctor to manage your blood pressure during the study period if the patient is in the intervention group.
Teaching and trainingOther
All patients will have access to online educational resources throughout the study. After recruitment, they will receive a nurse-led education on HBP monitoring. The research team will train all primary care physicians (PCPs) on managing patients with hypertension using HBP records.
Usual careOther
Physicians manage patients using HBP records at their discretion
| Study group | Role | What they receive |
|---|---|---|
| Hypertension management using the Clinical Decision Support System | Experimental | All patients will have access to online educational resources throughout the study. After recruitment, they will receive a nurse-led education on HBP monitoring. The research team will train all primary care physicians (PCPs) on managing patients with hypertension using HBP records. The PCPs in the intervention group will be briefed on how the ENHANCe app works, and its recommendations. The ENHANCe app will be installed on designated mobile phones, and research staff will analyse HBP records during visits, documenting the output for PCPs to use. Based on the app's recommendations, patients will consult with intervention group PCPs 2-3 times throughout the study, with the last follow-up at 6 months. PCPs will complete a consult checklist after each visit. FGDs will be conducted with PCPs at the end of the study. The interviews will be recorded and transcribed for analysis. Receives: Device: ENHANCe app; Other: Teaching and training |
| Hypertension management as per usual care without a clinical decision support system | Other | All patients will have access to online educational resources throughout the study. After recruitment, they will receive a nurse-led education on HBP monitoring. The research team will train all primary care physicians (PCPs) on managing patients with hypertension using HBP records. Control group PCPs will manage patients using HBP records at their discretion, with a final follow-up scheduled at 6 months. PCPs will complete a consult checklist after each visit. Research staff will use the ENHANCe app to analyse BP diaries and document outcomes, but control group PCPs will not have access to the app or its results. Receives: Other: Teaching and training; Other: Usual care |
What is being measured
The primary outcome is the main question the study is designed to answer.
Response rate of participants
Participants agreeable to participate in the study
Measured: 6 months
Agreement with the CDSS recommendation among PCPs
Proportion of PCPs who agree with the CDSS recommendation in the two groups
Measured: 6 months
Withdrawal rate
Proportion of participants who withdrew
Measured: 6 months
Study completion rate
Proportion of participants who completed the intervention
Measured: 6 months
Adverse event rates
Proportion of adverse events reported in the two groups
Measured: 6 months
Consult duration
Consult time in the groups
Measured: 6 months
Ease of home blood pressure record assessment among PCPS
Ease of home blood pressure record assessment among PCPS in the two arms
Measured: 6 months
Secondary outcomes (2)
Proportion of CDSS recommendation followed by the PCPS
Proportion of ENHANCe recommendations followed by the PCPs among the two groups
Measured: 6 months
Blood pressure control status
Blood pressure control status among patients in the two groups
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Feb 2026
- Study start1 Oct 2025
- Primary completion1 Oct 2026 (estimated)
- Study completion1 Oct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Hypertension,EssentialStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Parallel Cluster RCT
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 116 participants (estimated)
Sponsor and investigators
- Lead sponsor
- SingHealth Polyclinics
- Sponsor type
- University, hospital or other
- Collaborators
- Nanyang Polytechnic
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07399912
- Sponsor's protocol ID
- 2024-4269-APP1
- Acronym
- ENHANCe
- Status last verified
- Sep 2025
- First submitted
- 28 Dec 2025
- Last updated
- 10 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: IPD will not be shared
Study at a glance
From the registry record, last updated by the sponsor on 10 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Engaging Home-monitored Assessment to Navigate Clinical Decision-making -The ENHANCe Study
- ClinicalTrials.gov ID
- NCT07399912
- Acronym / sponsor ID
- ENHANCe / 2024-4269-APP1
- Conditions
- Hypertension,Essential
- Keywords
- Hypertension, Home blood pressure, Primary Care, Clinical decision support system
- Study type
- Interventional
- Recruitment status
- Enrolling by invitation
- Enrolment
- 116 participants (estimated)
- Lead sponsor
- SingHealth PolyclinicsUniversity, hospital or other
- Collaborators
- Nanyang Polytechnic
- Study start
- 1 Oct 2025 (actual)
- Primary completion
- 1 Oct 2026 (estimated)
- Study completion
- 1 Oct 2026 (estimated)
- First posted
- 10 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is testing a new app called ENHANCe, which is designed to help family doctors manage patients with high blood pressure using readings taken at home.
Detailed description
The researchers want to find out if the app is easy to use in everyday clinic settings, whether doctors find it helpful and are willing to use it, and if it helps improve care. The study will involve 16 doctors and 100 patients with high blood pressure, split into two groups at two clinics. One group will use the ENHANCe app, which can read blood pressure data from different sources-including handwritten notes-and give doctors advice based on that information. The other group will receive regular care without the app. Over six months, researchers will collect feedback from doctors through surveys and group discussions at the end of the study. They'll also track how many people complete the study, how long clinic visits take, whether doctors follow the app's advice, and how well patients' blood pressure is controlled. The goal is to see if the app can help doctors make faster, better decisions and improve health outcomes for people managing their blood pressure at home.
Study design
- Primary purpose
- Health services research
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- Parallel Cluster RCT
| Arm | Type | Receives |
|---|---|---|
| Hypertension management using the Clinical Decision Support System | Experimental | Device: ENHANCe app, Other: Teaching and trainingAll patients will have access to online educational resources throughout the study. After recruitment, they will receive a nurse-led education on HBP monitoring. The research team will train all primary care physicians (PCPs) on managing patients with hypertension using HBP records. The PCPs in the intervention group will be briefed on how the ENHANCe app works, and its recommendations. The ENHANCe app will be installed on designated mobile phones, and research staff will analyse HBP records during visits, documenting the output for PCPs to use. Based on the app's recommendations, patients will consult with intervention group PCPs 2-3 times throughout the study, with the last follow-up at 6 months. PCPs will complete a consult checklist after each visit. FGDs will be conducted with PCPs at the end of the study. The interviews will be recorded and transcribed for analysis. |
| Hypertension management as per usual care without a clinical decision support system | Other | Other: Teaching and training, Other: Usual careAll patients will have access to online educational resources throughout the study. After recruitment, they will receive a nurse-led education on HBP monitoring. The research team will train all primary care physicians (PCPs) on managing patients with hypertension using HBP records. Control group PCPs will manage patients using HBP records at their discretion, with a final follow-up scheduled at 6 months. PCPs will complete a consult checklist after each visit. Research staff will use the ENHANCe app to analyse BP diaries and document outcomes, but control group PCPs will not have access to the app or its results. |
Who may qualify
- Ages
- 21 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- PCPs aged 21 years and above.
- Involved in the clinical management of patients with hypertension in the past six months.
- Patients aged 21 years and above
- Documentation of hypertension diagnosis in EMR
- Owns an HBP monitoring device
Key exclusion criteria (3 listed)
- Documentation of dementia diagnosis in EMR
- Audio or visual impairments
- Hypertensive urgency or emergency
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ENHANCe appENHANCe app is a prototype; it is a smartphone based clinical decision support (CDS) tool to manage patients with hypertension using their home blood pressure. The app will scan patients' home BP records from paper or mobile phone, and provide a recommendation to the doctor on how to manage their blood pressure. The patient will not need to use the device during the study period. However, the recommendation from the ENHANCe app will be available to the doctor to manage your blood pressure during the study period if the patient is in the intervention group. | Device | Hypertension management using the Clinical Decision Support System |
| Teaching and trainingAll patients will have access to online educational resources throughout the study. After recruitment, they will receive a nurse-led education on HBP monitoring. The research team will train all primary care physicians (PCPs) on managing patients with hypertension using HBP records. | Other | Hypertension management as per usual care without a clinical decision support system, Hypertension management using the Clinical Decision Support System |
| Usual carePhysicians manage patients using HBP records at their discretion | Other | Hypertension management as per usual care without a clinical decision support system |
Primary outcome
Response rate of participants
Time frame: 6 months
Participants agreeable to participate in the study
Agreement with the CDSS recommendation among PCPs
Time frame: 6 months
Proportion of PCPs who agree with the CDSS recommendation in the two groups
Withdrawal rate
Time frame: 6 months
Proportion of participants who withdrew
Study completion rate
Time frame: 6 months
Proportion of participants who completed the intervention
Adverse event rates
Time frame: 6 months
Proportion of adverse events reported in the two groups
Consult duration
Time frame: 6 months
Consult time in the groups
Ease of home blood pressure record assessment among PCPS
Time frame: 6 months
Ease of home blood pressure record assessment among PCPS in the two arms
2 secondary outcomes
Proportion of CDSS recommendation followed by the PCPS
Time frame: 6 months
Blood pressure control status
Time frame: 6 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Feb 2026.
- Individual participant dataSharing planned: No. IPD will not be shared
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing ENHANCe app and Teaching and training in people with Hypertension,Essential, run by SingHealth Polyclinics at 1 site in Singapore.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: enrolling by invitation, as of the sponsor's last update on 10 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Singapore. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Response rate of participants (time frame: 6 months). The study lists 7 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Feb 2026.