Chronic Mechanical Neck PainNCT07403279
Sustained Natural Apophyseal Glides With and Without Integrated Neuromuscular Inhibition Technique in Neck Pain
A study testing Sustained Natural Apophyseal Glides, Integrated Neuromuscular Inhibition Technique and Standardized Physiotherapy Treatment in people with Chronic Mechanical Neck Pain, run by Riphah International University at 1 site in Pakistan.
Trial summary
The study was conducted to determine the effects of Sustained Natural Apophysial Glide with and without Integrated Neuromuscular Inhibition Technique on pain, range of motion and function in patients with chronic mechanical neck pain Read more about this study
- Who is it for?
- Ages 18 to 45 years
- Conditions the study is for
- Chronic Mechanical Neck Pain
- What is being tested?
- Sustained Natural Apophyseal Glides, Integrated Neuromuscular Inhibition Technique and Standardized Physiotherapy Treatment
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 44 participants
- Where
- 1 sitePakistan
- Study dates
- 18 Aug 2025to 18 Nov 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Age ranged from 18 to 45 years and both genders.
- Patient having neck-pain symptoms for more than 3 months duration.
- Spurling test, distraction test, upper limb tension test and shoulder abduction test negative upon assessment.
- The participants should have MTrPs in any one of these following cervical muscles which include levator scapulae, upper trapezius, splenius capitis and sternocleidomastoid muscles which may be active or latent.
- A score greater than twenty percent on NDI.
- Jump Sign when pressure is applied.
- Positive Simons criteria which contains following these 5 characteristics :(1) Pain on palpation (2) pain that is radiating (3) Tightened cord like structure in muscle fiber that is detectable upon palpation(4) Reduced Flexibility of that muscle (5) 'twitching response' on needling.
- Participants who described pain which is felt between spinous process of 1st thoracic vertebrae and superior nuchal line in posterior or posterolateral part of neck
Who cannot join
- Recent fracture, trauma (whiplash injury) and surgery in and around the shoulder and neck
- Neural disorders due to prolapsed intervertebral disc
- Carcinoma, Heart diseases, Metabolic disease in bone and joints
- Patients having history of osteoporosis, prolong steroid and analgesics use
- Unstable spine and open sores, Localized infection in neck
- Vertebrobasilar insufficiency.
- Cervical radiculopathy and myelopathy
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Sustained Natural Apophyseal Glides With and Without Integrated Neuromuscular Inhibition Technique on Pain, Range of Motion, and Function in Patients With Chronic Mechanical Neck Pain
The study was conducted to determine the effects of Sustained Natural Apophysial Glide with and without Integrated Neuromuscular Inhibition Technique on pain, range of motion and function in patients with chronic mechanical neck pain
- Conditions
- Chronic Mechanical Neck Pain
- Being tested
- Sustained Natural Apophyseal Glides, Integrated Neuromuscular Inhibition Technique, Standardized Physiotherapy Treatment
- Keywords
- Integrated Neuromuscular Inhibition Technique, Neck pain, Range of Motion, Sustained Natural Apophyseal Glides, Trigger points
- Medical subject headings
- Neck Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Sustained Natural Apophyseal GlidesOther
SNAGs were applied in three sets, with repetitions progressively increased from 6 to 10 over a period of four weeks, administered three times per week.
Integrated Neuromuscular Inhibition TechniqueOther
The integrated neuromuscular inhibition technique comprised three steps: ischemic compression, strain-counterstrain technique, and muscle energy technique. The technique was applied to the upper trapezius, levator scapulae, sternocleidomastoid, and splenius capitis muscles. Muscle selection was based on palpatory examination performed prior to each treatment session. Each treatment session lasted 10 minutes, during which all three steps were repeated three times within a single session. The intervention was delivered three times per week for four weeks, resulting in a total of 12 treatment sessions.
Standardized Physiotherapy TreatmentOther
Standardized physiotherapy included the application of an electrical hot pack at moderate intensity for 10 minutes. Transcutaneous electrical nerve stimulation (TENS) delivered in continuous mode at a frequency of 100 Hz for 15 minutes. Passive stretching was performed for cervical muscles prone to tightness, including the levator scapulae, sternocleidomastoid, upper trapezius, and scalene muscles, with a 30-second hold, three sets of ten repetitions, and a one-minute rest between sets. Scapular stabilization exercises, comprising shoulder shrugging and scapular retraction, were performed for 15 repetitions with a 6-second hold. Neck isometric exercises were repeated ten times with a 6-second hold. Cervical stabilization exercises were performed in two sets of ten repetitions per session, with each repetition held for ten seconds, a forty-second rest between repetitions, and a two-minute rest between sets.
| Study group | Role | What they receive |
|---|---|---|
| Sustained Natural Apophyseal Glides With Integrated Neuromuscular Inhibition Technique | Experimental | Not described Receives: Other: Sustained Natural Apophyseal Glides; Other: Integrated Neuromuscular Inhibition Technique; Other: Standardized Physiotherapy Treatment |
| Sustained Natural Apophyseal Glides | Active comparator | Not described Receives: Other: Sustained Natural Apophyseal Glides; Other: Standardized Physiotherapy Treatment |
What is being measured
The primary outcome is the main question the study is designed to answer.
Numeric Pain Rating Scale
Numeric Pain Rating Scale is utilized to evaluate pain.This is a scale between 0 and 10 where 0 denotes no pain and 10 denotes the worst pain whereas 1-3 denotes mild pain 4-6 denotes moderate pain and 7-10 denotes severe pain.
Measured: From enrollment to end of treatment at 4th weeks
Secondary outcomes (7)
Neck Disability Index
The Neck Disability Index is a self-reported questionnaire used to assess neck-related functional disability. It consists of 10 items addressing pain intensity, personal care, lifting, reading, headaches, concentration, work, driving, sleeping, and recreation. Each item is scored on a 6-point scale (0-5), with a total score ranging from 0 to 50, where higher scores indicate greater disability. Scores are categorized as no disability (0-4), mild disability (5-14), moderate disability (15-24), severe disability (25-34), and complete disability (≥35).
Measured: From enrollment to the end of treatment at 4th weeks
Range of Motion Cervical Spine (Flexion)
Changes in cervical spine flexion range of motion at baseline and 4th week of intervention was measured using goniometer
Measured: From enrollment to the end of treatment at 4th week.
Range of Motion Cervical Spine (Extension)
Changes in cervical spine extension range of motion at baseline and 4th week of intervention was measured using goniometer.
Measured: From enrollment to the end of treatment at 4th week
Range of Motion Cervical Spine (Lateral Flexion) Right Side
Changes in cervical spine lateral flexion on right side range of motion at baseline and 4th week of intervention was measured using goniometer.
Measured: From enrollment to the end of treatment at 4th week
Range of Motion Cervical Spine (Lateral Flexion) Left Side
Changes in cervical spine lateral flexion on left side range of motion at baseline and 4th week of intervention was measured using goniometer.
Measured: From enrollment to the end of treatment at 4th week
Range of Motion Cervical Spine (Rotation) Right Side
Changes in cervical spine rotation on right side range of motion at baseline and 4th week of intervention was measured using goniometer
Measured: From enrollment to the end of treatment at 4th week
Range of Motion Cervical Spine (Rotation) Left Side
Changes in cervical spine rotation on left side range of motion at baseline and 4th week of intervention was measured using goniometer
Measured: From enrollment to the end of treatment at 4th week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Feb 2026
- Study start18 Aug 2025
- Primary completion18 Nov 2025
- Study completion18 Nov 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (14)Papers the sponsor has linked to this study.
- Other trials for Chronic Mechanical Neck PainStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 44 participants (actual)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Syed Shakil ur Rehman, Ph.D, Principal investigator, Riphah International Universirty
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07403279
- Sponsor's protocol ID
- REC/RCR & AHS/24/0175
- Status last verified
- Feb 2026
- First submitted
- 4 Feb 2026
- Last updated
- 11 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Abd El-Azeim A, Grase M. Efficacy of Mulligan on electromyography activation of cervical muscles in mechanical neck pain: randomised experimental trial. Physiotherapy Quarterly. 2023;31(4):7-14.
Shelke A, B AP, M GB, Kumaran SD, G PR. Immediate effect of craniocervical flexion exercise and Mulligan mobilisation in patients with mechanical neck pain - A randomised clinical trial. Hong Kong Physiother J. 2023 Dec;43(2):137-147. doi: 10.1142/S1013702523500154. Epub 2023 Jun 21.
PubMed 37583921Ali Ismail AM, Abd El-Azeim AS, El-Sayed Felaya EE. Integrated neuromuscular inhibition technique versus spray and stretch technique in neck pain patients with upper trapezius trigger points: a randomized clinical trial. J Man Manip Ther. 2024 Apr;32(2):141-149. doi: 10.1080/10669817.2023.2192899. Epub 2023 Mar 23.
PubMed 36951194Lytras DE, Sykaras EI, Christoulas KI, Myrogiannis IS, Kellis E. Effects of Exercise and an Integrated Neuromuscular Inhibition Technique Program in the Management of Chronic Mechanical Neck Pain: A Randomized Controlled Trial. J Manipulative Physiol Ther. 2020 Feb;43(2):100-113. doi: 10.1016/j.jmpt.2019.03.011. Epub 2020 May 30.
PubMed 32482433Ozlu O, Sahin M. The effect of mulligan mobilization technique application in addition to conventional physiotherapy on pain and joint range of motion in people with neck pain. J Bodyw Mov Ther. 2024 Jul;39:225-230. doi: 10.1016/j.jbmt.2024.02.009. Epub 2024 Mar 5.
PubMed 38876630Ferdinand R, Kohilavani S. TO COMPARE THE EFFECTIVENESS OF INTEGRATED NEUROMUSCULAR INHIBITION TECHNIQUE VERSUS BOWEN TECHNIQUE ON UPPER TRAPEZIUS TRIGGER POINT IN SUBJECTS WITH MECHANICAL NECK PAIN
Dhami H, Kaur J, Kaur M. Comparison of Integrated Neuromuscular Inhibition Technique versus Myofascial Release of Upper Trapezius on Neck Range of Motion and Dysfunction in Individuals with Nonspecific Neck Pain. Indian Journal of Physiotherapy & Occupational Therapy. 2022;16(4).
Abhilash P. Comparison between immediate effect of integrated neuromuscular inhibition technique and active release technique on chronic neck pain and upper trapezius trigger points. 2024.
Thakur R, Mande P, Lokwani M. Effectiveness of Integrated Neuromuscular Inhibition Technique and Instrument Assisted Soft Tissue Mobilisation in the Management of Upper Trapezius Myofascial Trigger Points. Indian Journal of Physiotherapy & Occupational Therapy. 2022;16(4).
Shaukat S, Kiran Q, Hanif A, Saleem I, Paracha MS, Batool T. Role of Integrated Neuromuscular Inhibition Technique in Managing Upper Trapezius Trigger Points in Non-Specific Neck Pain: A Randomized Controlled Trial. Journal of Health, Wellness, and Community Research. 2025:e51-e.
Tank KD, Choksi P, Makwana P. To study the effect of muscle energy technique versus mulligan snags on pain, range of motion and functional disability for individuals with mechanical neck pain: a comparative study. Int J Physiother Res. 2018;6(1):2582-87.
Kocaman H, Yıldız NT, Canlı M, Alkan H. COMPARISON OF THE EFFECTS OF MULLIGAN MOBILIZATION TECHNIQUE COMBINED WITH CERVICAL STABILIZATION EXERCISES WITH THE EFFECTS OF CERVICAL STABILIZATION EXERCISES ALONE IN CHRONIC NECK PAIN: RANDOMIZED CONTROLLED STUDY. Karya Journal of Health Science. 2023;4(3):227-34.
Malik SZ, Haider R, Razzaq A, Rehman AU, Zahra S. Comparison of MET and Mulligan Mobilization Snags in Reducing Neck Pain and Improving Functional Activities in Chronic Mechanical Neck Pain Patients. Journal of Health, Wellness and Community Research. 2025:e567-e.
Naz S, Jamali N, Iftikhar A, Nawaz H, Iqbal T, Ghafoor F. Compare the Effectiveness of Mulligan (Nags & Snags) and McKenzie (Self-Stretching) On Improving the Pain and Functional Ability in Patient with Chronic Neck Pain: Effectiveness of Mulligan and McKenzie in Patient with Chronic Neck Pain. Pakistan Journal of Health Sciences. 2023:47-52
Study at a glance
From the registry record, last updated by the sponsor on 11 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Sustained Natural Apophyseal Glides With and Without Integrated Neuromuscular Inhibition Technique on Pain, Range of Motion, and Function in Patients With Chronic Mechanical Neck Pain
- ClinicalTrials.gov ID
- NCT07403279
- Acronym / sponsor ID
- REC/RCR & AHS/24/0175
- Conditions
- Chronic Mechanical Neck Pain
- Keywords
- Integrated Neuromuscular Inhibition Technique, Neck pain, Range of Motion, Sustained Natural Apophyseal Glides, Trigger points
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 44 participants (actual)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 18 Aug 2025 (actual)
- Primary completion
- 18 Nov 2025 (actual)
- Study completion
- 18 Nov 2025 (actual)
- First posted
- 11 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study was conducted to determine the effects of Sustained Natural Apophysial Glide with and without Integrated Neuromuscular Inhibition Technique on pain, range of motion and function in patients with chronic mechanical neck pain
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Sustained Natural Apophyseal Glides With Integrated Neuromuscular Inhibition Technique | Experimental | Other: Sustained Natural Apophyseal Glides, Other: Integrated Neuromuscular Inhibition Technique, Other: Standardized Physiotherapy Treatment |
| Sustained Natural Apophyseal Glides | Active comparator | Other: Sustained Natural Apophyseal Glides, Other: Standardized Physiotherapy Treatment |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (8 listed)
- Age ranged from 18 to 45 years and both genders.
- Patient having neck-pain symptoms for more than 3 months duration.
- Spurling test, distraction test, upper limb tension test and shoulder abduction test negative upon assessment.
- The participants should have MTrPs in any one of these following cervical muscles which include levator scapulae, upper trapezius, splenius capitis and sternocleidomastoid muscles which may be active or latent.
- A score greater than twenty percent on NDI.
Key exclusion criteria (7 listed)
- Recent fracture, trauma (whiplash injury) and surgery in and around the shoulder and neck
- Neural disorders due to prolapsed intervertebral disc
- Carcinoma, Heart diseases, Metabolic disease in bone and joints
- Patients having history of osteoporosis, prolong steroid and analgesics use
- Unstable spine and open sores, Localized infection in neck
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Sustained Natural Apophyseal GlidesSNAGs were applied in three sets, with repetitions progressively increased from 6 to 10 over a period of four weeks, administered three times per week. | Other | Sustained Natural Apophyseal Glides, Sustained Natural Apophyseal Glides With Integrated Neuromuscular Inhibition Technique |
| Integrated Neuromuscular Inhibition TechniqueThe integrated neuromuscular inhibition technique comprised three steps: ischemic compression, strain-counterstrain technique, and muscle energy technique. The technique was applied to the upper trapezius, levator scapulae, sternocleidomastoid, and splenius capitis muscles. Muscle selection was based on palpatory examination performed prior to each treatment session. Each treatment session lasted 10 minutes, during which all three steps were repeated three times within a single session. The intervention was delivered three times per week for four weeks, resulting in a total of 12 treatment sessions. | Other | Sustained Natural Apophyseal Glides With Integrated Neuromuscular Inhibition Technique |
| Standardized Physiotherapy TreatmentStandardized physiotherapy included the application of an electrical hot pack at moderate intensity for 10 minutes. Transcutaneous electrical nerve stimulation (TENS) delivered in continuous mode at a frequency of 100 Hz for 15 minutes. Passive stretching was performed for cervical muscles prone to tightness, including the levator scapulae, sternocleidomastoid, upper trapezius, and scalene muscles, with a 30-second hold, three sets of ten repetitions, and a one-minute rest between sets. Scapular stabilization exercises, comprising shoulder shrugging and scapular retraction, were performed for 15 repetitions with a 6-second hold. Neck isometric exercises were repeated ten times with a 6-second hold. Cervical stabilization exercises were performed in two sets of ten repetitions per session, with each repetition held for ten seconds, a forty-second rest between repetitions, and a two-minute rest between sets. | Other | Sustained Natural Apophyseal Glides, Sustained Natural Apophyseal Glides With Integrated Neuromuscular Inhibition Technique |
Primary outcome
Numeric Pain Rating Scale
Time frame: From enrollment to end of treatment at 4th weeks
Numeric Pain Rating Scale is utilized to evaluate pain.This is a scale between 0 and 10 where 0 denotes no pain and 10 denotes the worst pain whereas 1-3 denotes mild pain 4-6 denotes moderate pain and 7-10 denotes severe pain.
7 secondary outcomes
Neck Disability Index
Time frame: From enrollment to the end of treatment at 4th weeks
Range of Motion Cervical Spine (Flexion)
Time frame: From enrollment to the end of treatment at 4th week.
Range of Motion Cervical Spine (Extension)
Time frame: From enrollment to the end of treatment at 4th week
Range of Motion Cervical Spine (Lateral Flexion) Right Side
Time frame: From enrollment to the end of treatment at 4th week
Range of Motion Cervical Spine (Lateral Flexion) Left Side
Time frame: From enrollment to the end of treatment at 4th week
Range of Motion Cervical Spine (Rotation) Right Side
Time frame: From enrollment to the end of treatment at 4th week
Range of Motion Cervical Spine (Rotation) Left Side
Time frame: From enrollment to the end of treatment at 4th week
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Feb 2026.
- BackgroundAbd El-Azeim A, Grase M. Efficacy of Mulligan on electromyography activation of cervical muscles in mechanical neck pain: randomised experimental trial. Physiotherapy Quarterly. 2023;31(4):7-14.
- Background: PubMed 37583921Shelke A, B AP, M GB, Kumaran SD, G PR. Immediate effect of craniocervical flexion exercise and Mulligan mobilisation in patients with mechanical neck pain - A randomised clinical trial. Hong Kong Physiother J. 2023 Dec;43(2):137-147. doi: 10.1142/S1013702523500154. Epub 2023 Jun 21.
- Background: PubMed 36951194Ali Ismail AM, Abd El-Azeim AS, El-Sayed Felaya EE. Integrated neuromuscular inhibition technique versus spray and stretch technique in neck pain patients with upper trapezius trigger points: a randomized clinical trial. J Man Manip Ther. 2024 Apr;32(2):141-149. doi: 10.1080/10669817.2023.2192899. Epub 2023 Mar 23.
- Background: PubMed 32482433Lytras DE, Sykaras EI, Christoulas KI, Myrogiannis IS, Kellis E. Effects of Exercise and an Integrated Neuromuscular Inhibition Technique Program in the Management of Chronic Mechanical Neck Pain: A Randomized Controlled Trial. J Manipulative Physiol Ther. 2020 Feb;43(2):100-113. doi: 10.1016/j.jmpt.2019.03.011. Epub 2020 May 30.
- Background: PubMed 38876630Ozlu O, Sahin M. The effect of mulligan mobilization technique application in addition to conventional physiotherapy on pain and joint range of motion in people with neck pain. J Bodyw Mov Ther. 2024 Jul;39:225-230. doi: 10.1016/j.jbmt.2024.02.009. Epub 2024 Mar 5.
- BackgroundFerdinand R, Kohilavani S. TO COMPARE THE EFFECTIVENESS OF INTEGRATED NEUROMUSCULAR INHIBITION TECHNIQUE VERSUS BOWEN TECHNIQUE ON UPPER TRAPEZIUS TRIGGER POINT IN SUBJECTS WITH MECHANICAL NECK PAIN
- BackgroundDhami H, Kaur J, Kaur M. Comparison of Integrated Neuromuscular Inhibition Technique versus Myofascial Release of Upper Trapezius on Neck Range of Motion and Dysfunction in Individuals with Nonspecific Neck Pain. Indian Journal of Physiotherapy & Occupational Therapy. 2022;16(4).
- BackgroundAbhilash P. Comparison between immediate effect of integrated neuromuscular inhibition technique and active release technique on chronic neck pain and upper trapezius trigger points. 2024.
- BackgroundThakur R, Mande P, Lokwani M. Effectiveness of Integrated Neuromuscular Inhibition Technique and Instrument Assisted Soft Tissue Mobilisation in the Management of Upper Trapezius Myofascial Trigger Points. Indian Journal of Physiotherapy & Occupational Therapy. 2022;16(4).
- BackgroundShaukat S, Kiran Q, Hanif A, Saleem I, Paracha MS, Batool T. Role of Integrated Neuromuscular Inhibition Technique in Managing Upper Trapezius Trigger Points in Non-Specific Neck Pain: A Randomized Controlled Trial. Journal of Health, Wellness, and Community Research. 2025:e51-e.
- BackgroundTank KD, Choksi P, Makwana P. To study the effect of muscle energy technique versus mulligan snags on pain, range of motion and functional disability for individuals with mechanical neck pain: a comparative study. Int J Physiother Res. 2018;6(1):2582-87.
- BackgroundKocaman H, Yıldız NT, Canlı M, Alkan H. COMPARISON OF THE EFFECTS OF MULLIGAN MOBILIZATION TECHNIQUE COMBINED WITH CERVICAL STABILIZATION EXERCISES WITH THE EFFECTS OF CERVICAL STABILIZATION EXERCISES ALONE IN CHRONIC NECK PAIN: RANDOMIZED CONTROLLED STUDY. Karya Journal of Health Science. 2023;4(3):227-34.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Syed Shakil ur Rehman, Ph.D principal investigator
Riphah International Universirty
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Sustained Natural Apophyseal Glides, Integrated Neuromuscular Inhibition Technique and Standardized Physiotherapy Treatment in people with Chronic Mechanical Neck Pain, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 11 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Numeric Pain Rating Scale (time frame: From enrollment to end of treatment at 4th weeks). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07403279, which also lists 14 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Feb 2026.