Healthy SubjectsNCT07409675
Development of a Clinical Photographic Atlas for Skin Aging Based on the Characterization of Facial Dermal Collagen Using LC-OCT Technology
An observational study of Healthy Subjects and Healthy Adult, run by Vichy Laboratoires at 1 site in France.
Trial summary
This is a single-center, single visit study conducted in healthy female subjects, aged 20 to 75 years inclusive meeting specific inclusion/exclusion criteria. The study is to develop a clinical photographic atlas to assess skin aging by studying the relationship between age, sun exposure and quantity of collagen… Read more about this study
- Who is it for?
- Ages 20 to 75 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Healthy Subjects, Healthy Adult
- What is being tested?
- LC-OCT acquisitions on the forehead, Perform standardized photographs using ColorFace and LC-OCT acquisitions on forehead
- Type of treatment
- Medical device
- How many people
- 250 participants
- Where
- 1 siteFrance
- Study dates
- 6 Nov 2024to 19 Feb 2025
- How long will I take part?
- 1 Day
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 75 years
- Women only
- Healthy volunteers accepted
- Adult, Older adult
Study population: Healthy female volunteers
Who may be able to join
- Subject having signed an Informed Consent Form (ICF) before any trial related activity is carried out;
- Healthy female subject aged 20 to 75 years inclusive at the time of signing the ICF;
- Subject with a phototype I to III on Fitzpatrick's scale;
- Subject who is willing to follow the study procedures and to complete the study course;
- Subject registered with Social Security in agreement with French law on study research.
Who cannot join
- Male subject;
- Female subject who is pregnant or who is breast feeding;
- Subject with current participation in any other interventional clinical study, based on interview of the subject;
- Subject with facial dermatitis, rosacea, acne, eczema, psoriasis, skin rashes, open lesions, vitiligo or viral conditions such as herpes labialis;
- Subject who has collagen vascular disease, a significant systemic disease, immunological problems or inflammatory skin conditions on the face;
- Subject who has had a face lift;
Show all 11Show fewer
- Subject has had a non-ablative and/or ablative laser procedure on the face in the past 3 months;
- Subject with a history of botulinum toxin or mesotherapy injections on the face within the last 6 months, or absorbable fillers injections (such as hyaluronic acid or autologous fat…) in the last 12 months or injectable implants (semi-permanent fillers) within the last 24 months;
- Subject having done a moderate to deep peeling or non-invasive rejuvenation techniques such as radiofrequency, ultrasound and lasers in the last 6 months;
- Subject having applied any cosmetic product (care cream, lotion, makeup) except usual cleansing products or any drug to her face on the day of the visit;
- Subject who has been deprived of their freedom by administrative or legal decision, or who is under care of a guardian or legal guardianship, or subject hospitalized in a medical or social establishment for any reason.
Trial locations and contacts
1 site in 1 country.
About this study
This is a single-center, single visit study conducted in healthy female subjects, aged 20 to 75 years inclusive meeting specific inclusion/exclusion criteria. The study is to develop a clinical photographic atlas to assess skin aging by studying the relationship between age, sun exposure and quantity of collagen measured non-invasively (LC-OCT). No product will be tested during the study.
Read the detailed description
Single-center, single visit study in healthy female subjects, aged 20 to 75 years inclusive meeting specific inclusion/exclusion criteria. The study is to develop a clinical photographic atlas to assess skin aging by studying the relationship between age, sun exposure and quantity of collagen measured non-invasively (LC-OCT). No product will be tested during the study.
- Conditions
- Healthy Subjects, Healthy Adult
- Being tested
- LC-OCT acquisitions on the forehead, Perform standardized photographs using ColorFace, LC-OCT acquisitions on forehead, Perform photo-shooting using smartphones
- Keywords
- skin aging, collagen, LC-OCT
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
LC-OCT acquisitions on the foreheadDiagnostic test
During the study visit, the investigator will for each subjects in
Group 1:
- Perform standardized photographs using the ColorFace
Group 2:
- Perform standardized photographs using the ColorFace
Group 3:
- Perform standardized photographs using the ColorFace
Group 4:
- Perform standardized photographs using the ColorFace
- Perform LC-OCT acquisitions on the forehead
Group 5:
- Perform standardized photographs using the ColorFace®;
- Perform LC-OCT acquisitions on the forehead
Perform standardized photographs using ColorFaceDevice
Photographs
LC-OCT acquisitions on foreheadDevice
Image acquisition
Perform photo-shooting using smartphonesDevice
photo from back and front camera pictures and selfie
| Study group | Role | What they receive |
|---|---|---|
| Group 1: 20-30 years | The subjects will attend one single visit during which standardized photographs of the face (front and 45° left and right sides), photo shooting with a smartphone (back and front captures), LC-OCT microscopy image acquisition will be realized. The subject will have also to answer a questionnaire. Receives: Diagnostic Test: LC-OCT acquisitions on the forehead; Device: Perform standardized photographs using ColorFace; Device: LC-OCT acquisitions on forehead; Device: Perform photo-shooting using smartphones | |
| Group 2: 31-40 years | The subjects will attend one single visit during which standardized photographs of the face (front and 45° left and right sides), photo shooting with a smartphone (back and front captures), LC-OCT microscopy image acquisition will be realized. The subject will have also to answer a questionnaire. Receives: Diagnostic Test: LC-OCT acquisitions on the forehead; Device: Perform standardized photographs using ColorFace; Device: LC-OCT acquisitions on forehead; Device: Perform photo-shooting using smartphones | |
| Group 3: 41-50 years | The subjects will attend one single visit during which standardized photographs of the face (front and 45° left and right sides), photo shooting with a smartphone (back and front captures), LC-OCT microscopy image acquisition will be realized. The subject will have also to answer a questionnaire. Receives: Diagnostic Test: LC-OCT acquisitions on the forehead; Device: Perform standardized photographs using ColorFace; Device: LC-OCT acquisitions on forehead; Device: Perform photo-shooting using smartphones | |
| Group 4: 51-60 years | The subjects will attend one single visit during which standardized photographs of the face (front and 45° left and right sides), photo shooting with a smartphone (back and front captures), LC-OCT microscopy image acquisition will be realized. The subject will have also to answer a questionnaire. Receives: Diagnostic Test: LC-OCT acquisitions on the forehead; Device: Perform standardized photographs using ColorFace; Device: LC-OCT acquisitions on forehead; Device: Perform photo-shooting using smartphones | |
| Group 5: 61-75 years | The subjects will attend one single visit during which standardized photographs of the face (front and 45° left and right sides), photo shooting with a smartphone (back and front captures), LC-OCT microscopy image acquisition will be realized. The subject will have also to answer a questionnaire. Receives: Diagnostic Test: LC-OCT acquisitions on the forehead; Device: Perform standardized photographs using ColorFace; Device: LC-OCT acquisitions on forehead; Device: Perform photo-shooting using smartphones |
What is being measured
The primary outcome is the main question the study is designed to answer.
Non-invasive tissue imaging: 3D imaging through Line-field Confocal Optical Coherence Tomography technology (LC-OCT) acquisitions
Line-field Confocal Optical Coherence Tomography technology (LC-OCT) provides a unique 3D imaging modality, allowing the user to switch from a histology-like vertical mode to confocal-like horizontal mode and to record a 3D stack of tissue volumes in situ. With this technique skin can be imaged in vivo in its native state without further preparation. The superficial dermis can be clearly imaged using a live vertical, live horizontal and 3D mode.
This assessment will be performed on the face (forehead) with the LC-OCT deepLive™ (DAMAE).
This non invasive image will helps to characterize and quantify new metrics of skin aging linked to the dermal fibers network (collagen and elastin) such as caracterisation of the density and length of dermis fibers during aging.
Measured: Day 1
Secondary outcomes (3)
Standardized photographs of the face (front and 45° left and right sides)
Standardized photographs of the face (front and 45° left and right sides) will be performed using the ColorFace (Newtone Technologies, Lyon, France). The ColorFace® has multiple lighting modes and can acquire up to 5 images in one setting from a user-definable shooting template without technician intervention.
Subjects will be photographed using the following modalities:
- Cross-polarized (polarizing filter angle: 90 degrees, no specular gloss on the skin surface and observation of color variations)
- Standard 60 (polarizing filter angle: 60 degrees, observation of skin relief such as wrinkles)
- No filter
- Parallel-Polarized (polarizing filter angle: 0 degrees, observation of skin relief such as pores)
- UV (observation of the pigmentation not visible to the naked eye). All the digital photographs will be identified by the protocol number, the SIN, the side photographed, the type of light used and anomyzed.
They serve for illustration purposes of visible signs during skin aging .
Measured: Day 1
Photo shooting
Photo shooting (Back and Front camera pictures) will be performed using an iPhone 15. Back camera pictures will be taken by a trained personnel and the front camera picture will be taken by the subject himself after a brief training by the study personnel.
These photos will serve for grading facial aging: Comparing the clinical assessments made by three dermatologists with those obtained by an AI-based scoring system that analyses selfie pictures.
Measured: Day 1
Questionnaire
Subjects will be asked to complete a self-assessment questionnaire about their lifestyle habits in order to assess the link between lifestyle habits and aging.
Measured: Day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Feb 2026
- Study start6 Nov 2024
- Primary completion19 Feb 2025
- Study completion19 Feb 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy SubjectsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Other
- Enrolment
- 250 participants (actual)
- Target duration
- 1 Day
Sponsor and investigators
- Lead sponsor
- Vichy Laboratoires
- Sponsor type
- Industry (pharma, biotech, devices)
- Collaborators
- Centre de Pharmacologie Clinique Applique a la Dermatologie
- Responsible party
- Sponsor
- Investigators
- Catherine QUEILLE-ROUSSEL, MD, Principal investigator, CPCAD, Hôpital l'Archet 2
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07409675
- Sponsor's protocol ID
- VCY24-008
- Status last verified
- Feb 2026
- First submitted
- 26 Jan 2026
- Last updated
- 13 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 13 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Development of a Clinical Photographic Atlas for Skin Aging Based on the Characterization of Facial Dermal Collagen Using LC-OCT Technology
- ClinicalTrials.gov ID
- NCT07409675
- Acronym / sponsor ID
- VCY24-008
- Conditions
- Healthy Subjects, Healthy Adult
- Keywords
- skin aging, collagen, LC-OCT
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 250 participants (actual)
- Lead sponsor
- Vichy LaboratoiresIndustry (pharma, biotech, devices)
- Collaborators
- Centre de Pharmacologie Clinique Applique a la Dermatologie
- Study start
- 6 Nov 2024 (actual)
- Primary completion
- 19 Feb 2025 (actual)
- Study completion
- 19 Feb 2025 (actual)
- First posted
- 13 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a single-center, single visit study conducted in healthy female subjects, aged 20 to 75 years inclusive meeting specific inclusion/exclusion criteria. The study is to develop a clinical photographic atlas to assess skin aging by studying the relationship between age, sun exposure and quantity of collagen measured non-invasively (LC-OCT). No product will be tested during the study.
Detailed description
Single-center, single visit study in healthy female subjects, aged 20 to 75 years inclusive meeting specific inclusion/exclusion criteria. The study is to develop a clinical photographic atlas to assess skin aging by studying the relationship between age, sun exposure and quantity of collagen measured non-invasively (LC-OCT). No product will be tested during the study.
Study design
- Observational model
- Cohort
- Time perspective
- Other
- Target follow-up
- 1 Day
- Number of arms
- 5
| Arm | Type | Receives |
|---|---|---|
| Group 1: 20-30 years | – | Diagnostic Test: LC-OCT acquisitions on the forehead, Device: Perform standardized photographs using ColorFace, Device: LC-OCT acquisitions on forehead, Device: Perform photo-shooting using smartphonesThe subjects will attend one single visit during which standardized photographs of the face (front and 45° left and right sides), photo shooting with a smartphone (back and front captures), LC-OCT microscopy image acquisition will be realized. The subject will have also to answer a questionnaire. |
| Group 2: 31-40 years | – | Diagnostic Test: LC-OCT acquisitions on the forehead, Device: Perform standardized photographs using ColorFace, Device: LC-OCT acquisitions on forehead, Device: Perform photo-shooting using smartphonesThe subjects will attend one single visit during which standardized photographs of the face (front and 45° left and right sides), photo shooting with a smartphone (back and front captures), LC-OCT microscopy image acquisition will be realized. The subject will have also to answer a questionnaire. |
| Group 3: 41-50 years | – | Diagnostic Test: LC-OCT acquisitions on the forehead, Device: Perform standardized photographs using ColorFace, Device: LC-OCT acquisitions on forehead, Device: Perform photo-shooting using smartphonesThe subjects will attend one single visit during which standardized photographs of the face (front and 45° left and right sides), photo shooting with a smartphone (back and front captures), LC-OCT microscopy image acquisition will be realized. The subject will have also to answer a questionnaire. |
| Group 4: 51-60 years | – | Diagnostic Test: LC-OCT acquisitions on the forehead, Device: Perform standardized photographs using ColorFace, Device: LC-OCT acquisitions on forehead, Device: Perform photo-shooting using smartphonesThe subjects will attend one single visit during which standardized photographs of the face (front and 45° left and right sides), photo shooting with a smartphone (back and front captures), LC-OCT microscopy image acquisition will be realized. The subject will have also to answer a questionnaire. |
| Group 5: 61-75 years | – | Diagnostic Test: LC-OCT acquisitions on the forehead, Device: Perform standardized photographs using ColorFace, Device: LC-OCT acquisitions on forehead, Device: Perform photo-shooting using smartphonesThe subjects will attend one single visit during which standardized photographs of the face (front and 45° left and right sides), photo shooting with a smartphone (back and front captures), LC-OCT microscopy image acquisition will be realized. The subject will have also to answer a questionnaire. |
Who may qualify
- Ages
- 20 to 75 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Healthy female volunteers
Key inclusion criteria (5 listed)
- Subject having signed an Informed Consent Form (ICF) before any trial related activity is carried out;
- Healthy female subject aged 20 to 75 years inclusive at the time of signing the ICF;
- Subject with a phototype I to III on Fitzpatrick's scale;
- Subject who is willing to follow the study procedures and to complete the study course;
- Subject registered with Social Security in agreement with French law on study research.
Key exclusion criteria (11 listed)
- Male subject;
- Female subject who is pregnant or who is breast feeding;
- Subject with current participation in any other interventional clinical study, based on interview of the subject;
- Subject with facial dermatitis, rosacea, acne, eczema, psoriasis, skin rashes, open lesions, vitiligo or viral conditions such as herpes labialis;
- Subject who has collagen vascular disease, a significant systemic disease, immunological problems or inflammatory skin conditions on the face;
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| LC-OCT acquisitions on the foreheadDuring the study visit, the investigator will for each subjects in Group 1: - Perform standardized photographs using the ColorFace Group 2: - Perform standardized photographs using the ColorFace Group 3: - Perform standardized photographs using the ColorFace Group 4: * Perform standardized photographs using the ColorFace * Perform LC-OCT acquisitions on the forehead Group 5: * Perform standardized photographs using the ColorFace®; * Perform LC-OCT acquisitions on the forehead | Diagnostic test | Group 1: 20-30 years, Group 2: 31-40 years, Group 3: 41-50 years, Group 4: 51-60 years, Group 5: 61-75 years |
| Perform standardized photographs using ColorFacePhotographs | Device | Group 1: 20-30 years, Group 2: 31-40 years, Group 3: 41-50 years, Group 4: 51-60 years, Group 5: 61-75 years |
| LC-OCT acquisitions on foreheadImage acquisition | Device | Group 1: 20-30 years, Group 2: 31-40 years, Group 3: 41-50 years, Group 4: 51-60 years, Group 5: 61-75 years |
| Perform photo-shooting using smartphonesphoto from back and front camera pictures and selfie | Device | Group 1: 20-30 years, Group 2: 31-40 years, Group 3: 41-50 years, Group 4: 51-60 years, Group 5: 61-75 years |
Primary outcome
Non-invasive tissue imaging: 3D imaging through Line-field Confocal Optical Coherence Tomography technology (LC-OCT) acquisitions
Time frame: Day 1
Line-field Confocal Optical Coherence Tomography technology (LC-OCT) provides a unique 3D imaging modality, allowing the user to switch from a histology-like vertical mode to confocal-like horizontal mode and to record a 3D stack of tissue volumes in situ. With this technique skin can be imaged in vivo in its native state without further preparation. The superficial dermis can be clearly imaged using a live vertical, live horizontal and 3D mode. This assessment will be performed on the face (forehead) with the LC-OCT deepLive™ (DAMAE). This non invasive image will helps to characterize and quantify new metrics of skin aging linked to the dermal fibers network (collagen and elastin) such as caracterisation of the density and length of dermis fibers during aging.
3 secondary outcomes
Standardized photographs of the face (front and 45° left and right sides)
Time frame: Day 1
Photo shooting
Time frame: Day 1
Questionnaire
Time frame: Day 1
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Feb 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Catherine QUEILLE-ROUSSEL, MD principal investigator
CPCAD, Hôpital l'Archet 2
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Healthy Subjects and Healthy Adult, run by Vichy Laboratoires at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Non-invasive tissue imaging: 3D imaging through Line-field Confocal Optical Coherence Tomography technology (LC-OCT) acquisitions (time frame: Day 1). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Feb 2026.