FunctionalityNCT07410208
Effect of PRP With Physiotherapy on Shoulder Impingement
A study testing Platelet Rich Plasma (PRP), Conventional physiotherapy programme and IPRP-PT Study Protocol in people with Functionality and Shoulder Impingement Syndrome, run by Istinye University at 1 site in Turkey (Türkiye).
Trial summary
Background Shoulder impingement syndrome is the most common disorder of the shoulder. Study results on the effectiveness of treatment options are inconclusive and limited. Therefore, more evidence is needed for long-term results Objective To investigate the effectiveness of the ideal physiotherapy protocol (IPRP-PT)… Read more about this study
- Who is it for?
- Ages 30 to 65 years
- Conditions the study is for
- Functionality, Shoulder Impingement Syndrome, Platelet-Rich Plasma
- What is being tested?
- Platelet Rich Plasma (PRP), Conventional physiotherapy programme and IPRP-PT Study Protocol
- Type of treatment
- Pill or oral medicine, Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 54 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Jul 2019to 30 Jul 2020
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age between 30-65 years
- Diagnosis of stage I or II shoulder impingement syndrome
- Received one dose of PRP injection
- Referred for and seeking physical therapy
- Voluntary participation
- Ability to cooperate with the study procedures
Who cannot join
- Previous surgical treatment for shoulder impingement syndrome
- Presence of other orthopedic conditions (e.g., shoulder fractures)
- Presence of neuromuscular disease
- Presence of a pacemaker
- Pregnancy
Trial locations and contacts
1 site in 1 country.
About this study
Official title: The Effect of Combined PRP and Ideal Physiotherapy Program on Pain and Functionality in Shoulder Impingement Syndrome: A Randomized Controlled Trial
Background Shoulder impingement syndrome is the most common disorder of the shoulder. Study results on the effectiveness of treatment options are inconclusive and limited. Therefore, more evidence is needed for long-term results Objective To investigate the effectiveness of the ideal physiotherapy protocol (IPRP-PT) applied after platelet-rich plasma (PRP) injection on pain and functionality in patients with shoulder impingement syndrome, and to propose an alternative treatment protocol.
Methods The study was performed in 54 patients with shoulder impingement syndrome who were injected with PRP. Patients were randomly divided into two equal groups. For 21 days, the study group received IPRP-PT study protocol, conventional physiotherapy and home exercise programme, while the control group received only conventional physiotherapy programme. Normal range of motion, muscle strength and posture were assessed. In addition, short form Mc-gill (SF-MPQ), Visual Analogue Scale (VAS), Constant Murley Shoulder Score, Disabilities of the Arm, Shoulder and Hand Questionnaire (DASH), Functional Impairment Test-Hand and Neck/Shoulder/Arm (FIT-HaNSA), were used.
- Being tested
- Platelet Rich Plasma (PRP), Conventional physiotherapy programme, IPRP-PT Study Protocol
- Keywords
- Shoulder Impingement Syndrome, Platelet-Rich Plasma, Exercise, Pain, Functionality
- Medical subject headings
- Shoulder Impingement Syndrome, Motor Activity, Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Platelet Rich Plasma (PRP)Drug
All patients included in the study were educated about the correct posture in daily life, sleeping position, and the things to be followed to improve the quality of life.
In addition to 2 cc anticoagulant citrate dextrose withdrawn syringe, 20 cc of blood was taken by the nurse from the patients diagnosed with shoulder impingement syndrome. After the blood was transferred to a special PRP kit and centrifuged at 4000 rpm for 8-9 minutes, the platelet-rich plasma portion remaining at the top of the kit was taken into the syringe and applied to the 1/3 posterolateral 1/3 of the glenohumeral joint by the physician. After PRP injections, evaluations of the study and control groups were performed before and after 21 days of treatment. The study group received IPRP-PT study protocol, conventional physiotherapy and home exercises, while the control group received only conventional physiotherapy and home programme.
Conventional physiotherapy programmeOther
It was applied once a day for 21 days to 54 patients included in the study. Ultrasound; Enraf Nonius Sonopuls692V® device was applied around the glenohumeral joint with an average treatment dose of 3 MHz, N 1.5 w/cm² and 8 minutes. Transcutaneous Electrical Nerve Stimulation (TENS); Enraf Nonius Sonopuls 692V® device was applied to the glenohumeral joint with a frequency between 60-120 Hz and a transition time of 50-100 µsec for 20 min. Hot Pack; It was applied to the glenohumeral joint for 20 minutes (Kuhn, 2009; Kul and Ugur, 2019; Walsh, Howe, Johnson, and Sluka, 2009).
IPRP-PT Study ProtocolOther
IPRP-PT study protocol was applied in addition to conventional physiotherapy for 21 days in 27 patients who underwent PRP injection in our study group. The exercises were performed once a day with a physiotherapist and twice a day at home. The exercises performed were as follows; posterior capsule stretching; wand exercise; scapulatoracic (st), acromioclavicular (ac) and sternoclavicular (sc) joint mobilisation; GH joint posterior, anterior, inferior sliding; GH joint distraction; deep friction massage of the tendon of the supraspinatus muscle; kinesiological taping; isometric and isotonic strengthening exercises; proprioceptive neuromuscular facilitation exercises (pnf); closed kinetic ring and proprioception exercises
| Study group | Role | What they receive |
|---|---|---|
| Study group | Experimental | Not described Receives: Drug: Platelet Rich Plasma (PRP); Other: Conventional physiotherapy programme; Other: IPRP-PT Study Protocol |
| Control Group | Active comparator | Not described Receives: Drug: Platelet Rich Plasma (PRP); Other: Conventional physiotherapy programme |
What is being measured
The primary outcome is the main question the study is designed to answer.
Posture Assessment
Corbin posture scale was used. Postural scores obtained by looking laterally and posteriorly were summed and evaluated as (0-2: excellent, 3-4: very good, 5-7: good, 8-11: fair, 12≥ poor).
Measured: Baseline and Day 21
Range of Motion (ROM) Evaluation
Normal joint movements were assessed using a universal goniometer. Passive and active shoulder joint flexion, extension, abduction, internal rotation, and external rotation were evaluated.
Measured: Baseline and Day 21
Manual Muscle Test
During the manual muscle test, the patient was positioned appropriately for the muscle being evaluated. They were asked to actively perform the movement. The force generated by the muscle was evaluated by applying manual resistance. Muscle strength of the shoulder flexors, extensors, abductors, internal rotators, and external rotators was rated on a scale of 0-5 (no contraction 0, very weak 1, weak 2, moderate 3, good 4, and normal 5.
Measured: Baseline and Day 21
Secondary outcomes (4)
Disabilities of the Arm, Shoulder and Hand Questionnaire (DASH)
DASH consists of 3 parts. In all questions, the person marks the appropriate answer in the 5-point Likert system. At the end of the questionnaire, the sum of the marked items is divided by the number of marked items, subtracted by one, then multiplied by 25 and the DASH total score is found. According to the result of the questionnaire, a score between 0-100 is obtained from each section (0: no disability, 100: maximum disability).
Measured: Baseline and Day 21
Constant Murley Shoulder Score (CMS)
It is a functional test used to evaluate ROM, muscle strength and functional level of the shoulder joint. The total constant score is classified as best (90-100), good (80-90), moderate (70-79) and poor (<70).
Measured: Baseline and Day 21
Pain Assessment
Short-form Mc-Gill Pain Questionnaire (SF-MPQ) and Visual Analogue Scale (VAS). The SF-MPQ assesses the sensory, emotional and intensity of pain. A total of 15 determinant pain descriptions are included. Three pain scores (sensory, emotional and total pain rate) are obtained . VAS In order to evaluate the pain of the patient subjectively, the patient was asked to mark the shoulder pain intensity on the pain scale evaluated over 10 digits.
Measured: Baseline and Day 21
Functional Impairment Test-Hand and Neck/Shoulder/Arm (FIT-HaNSA)
FIT-HaNSA is a standard three-task test battery that assesses functional endurance involving repetitive lifting and overhead activities in the upper extremity. The tests simulate lifting and sustained shoulder movements performed at a controlled rate (60 beats/min). In the first two tasks, the participant carries three 1 kg objects one by one between shelves using their affected arm. The first task represents reaching activities performed at waist level, and the second task represents reaching activities performed at shoulder level. In the third task, the participant performs screw insertion and removal operations while holding both arms in an overhead position in an eye-level arrangement. Short rest periods are provided between tasks, and each task lasts a maximum of 300 seconds. The second at which the patient completes the test is evaluated and recorded.
Measured: Baseline and Day 21
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Feb 2026
- Study start15 Jul 2019
- Primary completion20 Mar 2020
- Study completion30 Jul 2020
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for FunctionalityStudies of the same condition, open and under way.
- More trials run by Istinye UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 54 participants (actual)
Sponsor and investigators
- Lead sponsor
- Istinye University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hande Çağlıyan Erdoğan, Istinye University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07410208
- Sponsor's protocol ID
- Decision number 12
- Status last verified
- Apr 2026
- First submitted
- 21 Jan 2026
- Last updated
- 13 Apr 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Plan Description: Individual participant data will not be shared. Access Criteria: Data sharing is not planned due to ethical and confidentiality considerations.
Publications
Karakaya P, Varhan B, Cagliyan Erdogan H. Effectiveness of a Structured Post-Platelet Rich Plasma Rehabilitation Approach on Pain and Function in Subacromial Pain Syndrome: A Randomized Controlled Trial. Physiother Res Int. 2027 Jan;32(1):e70378. doi: 10.1002/pri.70378.
PubMed 42985783
Study at a glance
From the registry record, last updated by the sponsor on 13 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Combined PRP and Ideal Physiotherapy Program on Pain and Functionality in Shoulder Impingement Syndrome: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07410208
- Acronym / sponsor ID
- Decision number 12
- Keywords
- Shoulder Impingement Syndrome, Platelet-Rich Plasma, Exercise, Pain, Functionality
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 54 participants (actual)
- Lead sponsor
- Istinye UniversityUniversity, hospital or other
- Study start
- 15 Jul 2019 (actual)
- Primary completion
- 20 Mar 2020 (actual)
- Study completion
- 30 Jul 2020 (actual)
- First posted
- 13 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Background Shoulder impingement syndrome is the most common disorder of the shoulder. Study results on the effectiveness of treatment options are inconclusive and limited. Therefore, more evidence is needed for long-term results Objective To investigate the effectiveness of the ideal physiotherapy protocol (IPRP-PT) applied after platelet-rich plasma (PRP) injection on pain and functionality in patients with shoulder impingement syndrome, and to propose an alternative treatment protocol.
Methods The study was performed in 54 patients with shoulder impingement syndrome who were injected with PRP. Patients were randomly divided into two equal groups. For 21 days, the study group received IPRP-PT study protocol, conventional physiotherapy and home exercise programme, while the control group received only conventional physiotherapy programme. Normal range of motion, muscle strength and posture were assessed. In addition, short form Mc-gill (SF-MPQ), Visual Analogue Scale (VAS), Constant Murley Shoulder Score, Disabilities of the Arm, Shoulder and Hand Questionnaire (DASH), Functional Impairment Test-Hand and Neck/Shoulder/Arm (FIT-HaNSA), were used.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Study group | Experimental | Drug: Platelet Rich Plasma (PRP), Other: Conventional physiotherapy programme, Other: IPRP-PT Study Protocol |
| Control Group | Active comparator | Drug: Platelet Rich Plasma (PRP), Other: Conventional physiotherapy programme |
Who may qualify
- Ages
- 30 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Age between 30-65 years
- Diagnosis of stage I or II shoulder impingement syndrome
- Received one dose of PRP injection
- Referred for and seeking physical therapy
- Voluntary participation
Key exclusion criteria (5 listed)
- Previous surgical treatment for shoulder impingement syndrome
- Presence of other orthopedic conditions (e.g., shoulder fractures)
- Presence of neuromuscular disease
- Presence of a pacemaker
- Pregnancy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Platelet Rich Plasma (PRP)All patients included in the study were educated about the correct posture in daily life, sleeping position, and the things to be followed to improve the quality of life. In addition to 2 cc anticoagulant citrate dextrose withdrawn syringe, 20 cc of blood was taken by the nurse from the patients diagnosed with shoulder impingement syndrome. After the blood was transferred to a special PRP kit and centrifuged at 4000 rpm for 8-9 minutes, the platelet-rich plasma portion remaining at the top of the kit was taken into the syringe and applied to the 1/3 posterolateral 1/3 of the glenohumeral joint by the physician. After PRP injections, evaluations of the study and control groups were performed before and after 21 days of treatment. The study group received IPRP-PT study protocol, conventional physiotherapy and home exercises, while the control group received only conventional physiotherapy and home programme. | Drug | Control Group, Study group |
| Conventional physiotherapy programmeIt was applied once a day for 21 days to 54 patients included in the study. Ultrasound; Enraf Nonius Sonopuls692V® device was applied around the glenohumeral joint with an average treatment dose of 3 MHz, N 1.5 w/cm² and 8 minutes. Transcutaneous Electrical Nerve Stimulation (TENS); Enraf Nonius Sonopuls 692V® device was applied to the glenohumeral joint with a frequency between 60-120 Hz and a transition time of 50-100 µsec for 20 min. Hot Pack; It was applied to the glenohumeral joint for 20 minutes (Kuhn, 2009; Kul and Ugur, 2019; Walsh, Howe, Johnson, and Sluka, 2009). | Other | Control Group, Study group |
| IPRP-PT Study ProtocolIPRP-PT study protocol was applied in addition to conventional physiotherapy for 21 days in 27 patients who underwent PRP injection in our study group. The exercises were performed once a day with a physiotherapist and twice a day at home. The exercises performed were as follows; posterior capsule stretching; wand exercise; scapulatoracic (st), acromioclavicular (ac) and sternoclavicular (sc) joint mobilisation; GH joint posterior, anterior, inferior sliding; GH joint distraction; deep friction massage of the tendon of the supraspinatus muscle; kinesiological taping; isometric and isotonic strengthening exercises; proprioceptive neuromuscular facilitation exercises (pnf); closed kinetic ring and proprioception exercises | Other | Study group |
Primary outcome
Posture Assessment
Time frame: Baseline and Day 21
Corbin posture scale was used. Postural scores obtained by looking laterally and posteriorly were summed and evaluated as (0-2: excellent, 3-4: very good, 5-7: good, 8-11: fair, 12≥ poor).
Range of Motion (ROM) Evaluation
Time frame: Baseline and Day 21
Normal joint movements were assessed using a universal goniometer. Passive and active shoulder joint flexion, extension, abduction, internal rotation, and external rotation were evaluated.
Manual Muscle Test
Time frame: Baseline and Day 21
During the manual muscle test, the patient was positioned appropriately for the muscle being evaluated. They were asked to actively perform the movement. The force generated by the muscle was evaluated by applying manual resistance. Muscle strength of the shoulder flexors, extensors, abductors, internal rotators, and external rotators was rated on a scale of 0-5 (no contraction 0, very weak 1, weak 2, moderate 3, good 4, and normal 5.
4 secondary outcomes
Disabilities of the Arm, Shoulder and Hand Questionnaire (DASH)
Time frame: Baseline and Day 21
Constant Murley Shoulder Score (CMS)
Time frame: Baseline and Day 21
Pain Assessment
Time frame: Baseline and Day 21
Functional Impairment Test-Hand and Neck/Shoulder/Arm (FIT-HaNSA)
Time frame: Baseline and Day 21
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Apr 2026.
- Derived from this study: PubMed 42985783Karakaya P, Varhan B, Cagliyan Erdogan H. Effectiveness of a Structured Post-Platelet Rich Plasma Rehabilitation Approach on Pain and Function in Subacromial Pain Syndrome: A Randomized Controlled Trial. Physiother Res Int. 2027 Jan;32(1):e70378. doi: 10.1002/pri.70378.
- Individual participant dataSharing planned: No. Plan Description: Individual participant data will not be shared. Access Criteria: Data sharing is not planned due to ethical and confidentiality considerations.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Platelet Rich Plasma (PRP), Conventional physiotherapy programme and IPRP-PT Study Protocol in people with Functionality and Shoulder Impingement Syndrome, run by Istinye University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Posture Assessment (time frame: Baseline and Day 21). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07410208, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Apr 2026.