Dental ImplantE-PRFNCT07412535
Extended Platelet Rich Fibrin or Hyaluronate Enriched Xenografts for Horizontal Ridge Augmentation Via Subperiosteal Tunneling
A study testing bovine bone mixed with hyaluronate and bovine bone mixed with E-PEF in people with Dental Implant, run by Mansoura University at 1 site in Egypt.
Trial summary
Extended platelet rich fibrin or hyaluronate enriched xenografts will be used for horizontal maxillary ridge augmentation via subperiosteal tunneling to allow placement of dental implants six months later. Read more about this study
- Who is it for?
- Ages 18 to 45 years
- Conditions the study is for
- Dental Implant
- What is being tested?
- bovine bone mixed with hyaluronate and bovine bone mixed with E-PEF
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 34 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Mar 2024to 1 Oct 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- a maxillary anterior or premolar narrow ridge (width 3-6 mm), and adequate bone height (>8 mm), seeking horizontal augmentation \& dental implant rehabilitation
Who cannot join
- systemic contraindications to surgery, local infection, untreated periodontal disease, heavy smoking, or pregnancy.
Trial locations and contacts
1 site in 1 country.
About this study
Extended platelet rich fibrin or hyaluronate enriched xenografts will be used for horizontal maxillary ridge augmentation via subperiosteal tunneling to allow placement of dental implants six months later.
- Conditions
- Dental Implant
- Being tested
- bovine bone mixed with hyaluronate, bovine bone mixed with E-PEF
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
bovine bone mixed with hyaluronateCombination product
cerabone plus will be inserted as a graft material via subperiosteal tunneling of thin maxilla
bovine bone mixed with E-PEFCombination product
bovine bone mixed with E-PEF will be inserted as a graft material via subperiosteal tunneling of thin maxilla
| Study group | Role | What they receive |
|---|---|---|
| Hyaluronate Group | Active comparator | Horizontal maxillary augmentation via subperiosteal tunneling using bovine bone and hyaluronate Receives: Combination Product: bovine bone mixed with hyaluronate |
| Extended Platelet Rich Fibrin Group | Experimental | horizontal maxillary augmentation via subperiosteal tunneling using bovine bone and extended platelet rich fibrin Receives: Combination Product: bovine bone mixed with E-PEF |
What is being measured
The primary outcome is the main question the study is designed to answer.
horizontal bone gain measurement
CBCT will be used to measure horizontal bone width of the surgical site (in mm) at 3 points: at level of the crest, 2 mm and 6mm apical to the crest.
Measured: 6months, 12 months
Secondary outcomes (1)
bone density measurement
Bone density will be assessed in HU by CBCT by using on demand 3D program
Measured: 6 months, 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Feb 2026
- Study start1 Mar 2024
- Primary completion1 Oct 2024
- Study completion1 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dental ImplantStudies of the same condition, open and under way.
- More trials run by Mansoura UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 34 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mansoura University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Noha Ahmed Mansour, Mansoura University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07412535
- Sponsor's protocol ID
- R.25.12.94
- Acronym
- E-PRF
- Status last verified
- Feb 2026
- First submitted
- 14 Jan 2026
- Last updated
- 17 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 17 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Extended Platelet Rich Fibrin or Hyaluronate Enriched Xenografts for Horizontal Ridge Augmentation Via Subperiosteal Tunneling
- ClinicalTrials.gov ID
- NCT07412535
- Acronym / sponsor ID
- E-PRF / R.25.12.94
- Conditions
- Dental Implant
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 34 participants (actual)
- Lead sponsor
- Mansoura UniversityUniversity, hospital or other
- Study start
- 1 Mar 2024 (actual)
- Primary completion
- 1 Oct 2024 (actual)
- Study completion
- 1 Oct 2025 (actual)
- First posted
- 17 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Extended platelet rich fibrin or hyaluronate enriched xenografts will be used for horizontal maxillary ridge augmentation via subperiosteal tunneling to allow placement of dental implants six months later.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Hyaluronate Group | Active comparator | Combination Product: bovine bone mixed with hyaluronateHorizontal maxillary augmentation via subperiosteal tunneling using bovine bone and hyaluronate |
| Extended Platelet Rich Fibrin Group | Experimental | Combination Product: bovine bone mixed with E-PEFhorizontal maxillary augmentation via subperiosteal tunneling using bovine bone and extended platelet rich fibrin |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- a maxillary anterior or premolar narrow ridge (width 3-6 mm), and adequate bone height (>8 mm), seeking horizontal augmentation \& dental implant rehabilitation
Key exclusion criteria (1 listed)
- systemic contraindications to surgery, local infection, untreated periodontal disease, heavy smoking, or pregnancy.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| bovine bone mixed with hyaluronatecerabone plus will be inserted as a graft material via subperiosteal tunneling of thin maxilla | Combination product | Hyaluronate Group |
| bovine bone mixed with E-PEFbovine bone mixed with E-PEF will be inserted as a graft material via subperiosteal tunneling of thin maxilla | Combination product | Extended Platelet Rich Fibrin Group |
Primary outcome
horizontal bone gain measurement
Time frame: 6months, 12 months
CBCT will be used to measure horizontal bone width of the surgical site (in mm) at 3 points: at level of the crest, 2 mm and 6mm apical to the crest.
1 secondary outcome
bone density measurement
Time frame: 6 months, 12 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Feb 2026.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing bovine bone mixed with hyaluronate and bovine bone mixed with E-PEF in people with Dental Implant, run by Mansoura University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
horizontal bone gain measurement (time frame: 6months, 12 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Feb 2026.