Solid TumorsPhase 2NCT07415031
A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies
A Phase 2 study testing Adagrasib, Pembrolizumab and Cetuximab in people with Solid Tumors, run by Mirati Therapeutics Inc. at 101 sites in 21 countries.
Trial summary
This is an open-label, solid tumor, continuation, rollover trial which enrolls participants from ongoing BMS parent studies that evaluated adagrasib (MRTX849, BMS-986503) either as monotherapy or in combination with other cancer therapies in patients with non-small cell lung cancer (NSCLC), colorectal cancer (CRC) and… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Solid Tumors
- What is being tested?
- Adagrasib, Pembrolizumab and Cetuximab
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 170 participants
- Where
- 101 sitesin 21 countries
- Study dates
- 6 May 2026to 16 Feb 2028
- Phase
- Phase 2
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Participant is eligible to receive continued study treatment as per the parent study, and/or investigator assessed clinical benefit.
- Individuals with assigned female sex at birth (AFSB) must have documented proof that they are not of childbearing potential. IOCBP participants who are sexually active must agree to follow the instructions for method(s) of contraception and included in the ICF.
Who cannot join
- Participant is not eligible for study treatment per the parent study eligibility criteria.
- Participants who have completed treatment with the study drugs, progressed on prior study treatment, or discontinued study treatment due to toxicity in the parent study are not eligible to receive study drug in this study.
- Participants not receiving clinical benefit from parent study drug as assessed by the investigator.
- Other protocol defined inclusion/exclusion criteria applies.
Trial locations and contacts
101 sites in 21 countries. Contact the study team or a site near you to ask about taking part.
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com contact
First line of the email MUST contain NCT # and Site #. contact
101 sites in 21 countries
France18 sites, 17 recruiting
- Recruiting
ICO Papin
Angers, Maine-et-Loire, 49055
Frederic Bigot, Site 0032, 33241352700
- Recruiting
Chu Jean Minjoz
Besançon, Doubs, 25000
Elodie Klajer, Site 0091, 33381479999
- Recruiting
Hospices Civils de Lyon - Hopital Louis Pradel
Bron, Rhône, 69677
Michael Duruisseaux, Site 0090, 33427857700
- Recruiting
Centre Hospitalier Intercommunal de Créteil
Créteil, 94010
Gaelle Rousseau-Bussac, Site 0085, 33157022102
- Recruiting
L Hopital Nord Ouest
Gleizé, Rhône, 69400
LIONEL FALCHERO, Site 0075, +33642346915
- Recruiting
Chu Grenoble Alpes
La Tronche, Isère, 38700
Denis Moro-Sibilot, Site 0065, 33476765467
- Recruiting
Assistance Publique Hôpitaux de Marseille - Hôpital Nord
Marseille, 13915
PASCALE TOMASINI, Site 0059, +33491965901
- Recruiting
Centre Hospitalier Universitaire de Nice - Hopital Pasteur
Nice, Alpes-Maritimes, 06000
Jacques Boutros, Site 0076, 0492037767
- Recruiting
Centre Antoine-Lacassagne
Nice, Alpes-Maritimes, 06189
Victoria ferrari, Site 0086, 0492031324
- Recruiting
Groupe hospitalier Paris saint Joseph
Paris, Île-de-France Region, 75014
Charles Naltet, Site 0061, 33144123752
- Recruiting
CHU Bordeaux Haut-Leveque
Pessac, Aquitaine, 33600
Remi Veillon, Site 0103, 33557656338
- Withdrawn
Local Institution - 0051
Poitiers, Vienne, 86021
- Recruiting
Centre Hospitalier de Cornouaille Quimper - Concarneau
Quimper, 29000
Romain Corre, Site 0058, 33899282481
- Not yet recruiting
Local Institution - 0063
Saint-Herblain, Loire-Atlantique, 44800
Site 0063
- Recruiting
Institut de Cancérologie de l'Ouest
Saint-Herblain, Loire-Atlantique, 44805
Sandrine Hiret, Site 0050, 33240679978
- Recruiting
Hôpital d'Instruction des Armées Bégin
Saint-Mandé, 94160
Hugo PICCHI, Site 0078, +33631841829
- Recruiting
Nouvel Hôpital Civil (NHC)
Strasbourg, Alsace, 67091
Celine Mascaux, Site 0074, 0033369550644
- Recruiting
Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau
Tours, 37032
Thierry Lecomte, Site 0077, 33218370522
United States17 sites, 13 recruiting
- Recruiting
Texas Oncology-Bedford
Bedford, Texas, 76022
Kartik Konduri, Site 0117, 214-370-1000
- Recruiting
Southern California Permanente Medical Group
Bellflower, California, 90706
Gary Buchschacher, Site 0016, 000-000-0000
- Recruiting
PeaceHealth St. Joseph Medical Center
Bellingham, Washington, 98225
Navdeep Sangha, Site 0013, 323-783-5752
- Withdrawn
Local Institution - 0092
Boston, Massachusetts, 00215
- Active, not recruiting
Local Institution - 0080
Boston, Massachusetts, 02215
- Recruiting
Texas Oncology - Baylor Charles A. Sammons Cancer Center
Dallas, Texas, 75246
Kartik Konduri, Site 0118, 214-370-1000
- Recruiting
Oncology Associates Of Oregon, Pc
Eugene, Oregon, 97401
Jeff Porter Sharman, Site 0004, 888-542-2525
- Recruiting
The West Clinic, PLLC dba West Cancer Center
Germantown, Tennessee, 38138
Ramakrishna Battini, Site 0023, 901-683-0055
- Recruiting
Texas Oncology - DFW
Grapevine, Texas, 76051
Kartik Konduri, Site 0002, 214-370-1000
- Recruiting
MemorialCare - Long Beach Medical Center
Long Beach, California, 90806
Nilesh Vora, Site 0082, 562-997-4070
- Withdrawn
Local Institution - 0003
Newark, Delaware, 19713
- Recruiting
Nebraska Cancer Specialists
Omaha, Nebraska, 68114
Mary Wells, Site 0036, 531-329-3667
- Withdrawn
Local Institution - 0005
Phoenix, Arizona, 85054
- Recruiting
Mayo Clinic in Rochester, Minnesota
Rochester, Minnesota, 55905
Konstantinos Leventakos, Site 0017, 507-284-2511
- Recruiting
Metro-Minnesota Community Oncology Research Consortium (MMCORC)
Saint Paul, Minnesota, 55101
Yan Ji, Site 0073
- Recruiting
Florida Cancer Specialists - North
St. Petersburg, Florida, 33701
Maen Hussein, Site 0001, 727-216-1143
- Recruiting
Cancer Center of Kansas
Wichita, Kansas, 67208
Shaker Dakhil, Site 0112, 316-262-4467
Spain14 sites, 14 recruiting
- Recruiting
CHUAC-Complejo Hospitalario Universitario A Coruña
A Coruña, A Coruña [La Coruña], 15006
Maria Garcia Campelo, Site 0007, 34981178353
- Recruiting
Institut Catala d'Oncologia-Hospital Germans Trias i Pujol
Badalona, Barcelona, 08916
Enric Carcereny, Site 0006, 34934978925
- Recruiting
Hospital Universitari Dexeus
Barcelona, Barcelona [Barcelona], 08028
ANDRES AGUILAR, Site 0010, +34935460135
- Recruiting
Hospital Universitari Vall d'Hebron
Barcelona, Barcelona [Barcelona], 08035
Nuria Pardo Aranda, Site 0029, 0034932746085
- Recruiting
Hospital Universitario Reina Sofia
Córdoba, 14004
Maria Jose Ortiz Morales, Site 0027, 34635325317
- Recruiting
Hospital Universitario Ramón y Cajal
Madrid, Madrid, Comunidad de, 28034
Pilar Garrido Lopez, Site 0024, (+34)913368263
- Recruiting
Hospital General Universitario Gregorio Marañon
Madrid, 28007
Antonio Calles Blanco, Site 0083, +34915868115
- Recruiting
Hospital Universitario Fundacion Jimenez Diaz
Madrid, 28040
Manuel Domine Gomez, Site 0015, 34915504800
- Recruiting
Hospital Universitario 12 De Octubre
Madrid, 28041
Maria Zurera Berjaga, Site 0062, 34976765746
- Recruiting
H.R.U Málaga - Hospital General
Málaga, 29011
María Vanesa Gutierrez Calderon, Site 0018, 34951308130
- Recruiting
Hospital Universitari Son Espases
Palma, Balears [Baleares], 07120
Aitor Azkarate, Site 0011, 0000000000
- Recruiting
Clinica Universidad de Navarra
Pamplona, Navarre, 31008
Miguel Fernández de Sanmamed Gutiérrez, Site 0009, 34948255400
- Recruiting
Hospital Universitario Virgen Macarena
Seville, 41009
David Vicente Baz, Site 0008, 34955008932
- Recruiting
Hospital Clinico de Valencia
Valencia, Valenciana, Comunitat, 46010
Valentina Gambardella, Site 0084, 34961973500
China13 sites
- Withdrawn
Local Institution - 0037
Beijing, Beijing Municipality, 100142
- Withdrawn
Local Institution - 0038
Changsha, Hunan, 410031
- Withdrawn
Local Institution - 0040
Chengdu, Sichuan, 610041
- Withdrawn
Local Institution - 0044
Hangzhou, Zhejiang, 310022
- Withdrawn
Local Institution - 0039
Jinan, Shandong, 250117
- Withdrawn
Local Institution - 0047
Linyi, Shandong, 276000
- Withdrawn
Local Institution - 0048
Nanchang, Jiangxi, 330006
- Withdrawn
Local Institution - 0046
Nanjing, Jiangsu, 210012
- Withdrawn
Local Institution - 0043
Shanghai, Shanghai Municipality, 200032
- Withdrawn
Local Institution - 0049
Shenyang, Liaoning, 110001
- Withdrawn
Local Institution - 0041
Xi'an, 710061
- Withdrawn
Local Institution - 0045
Xiamen, Fujian, 361003
- Withdrawn
Local Institution - 0042
Zhengzhou, Henan, 450008
Italy10 sites, 10 recruiting
- Recruiting
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
Bologna, 40138
Francesco Gelsomino, Site 0053, +390512142203
- Recruiting
Azienda Ospedaliera Universitaria Careggi
Florence, Tuscany, 50134
Lorenzo Antonuzzo, Site 0054, 00390557947298
- Recruiting
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
Meldola, Emilia-Romagna, 47014
Angelo Delmonte, Site 0052, 390543739100
- Recruiting
Istituto Europeo di Oncologia IRCCS
Milan, 20141
Antonio Passaro, Site 0021, +390257489482
- Recruiting
Istituto Europeo di Oncologia IRCCS
Milan, 20141
Maria Zampino, Site 0107, 0257489258
- Recruiting
Azienda Ospedaliero-Universitaria San Luigi Gonzaga
Orbassano, Piedmont, 10043
Silvia Novello, Site 0020, 390119026322
- Recruiting
AO Santa Maria della Misericordia
Perugia, Umbria, 06132
Giulio Metro, Site 0026, 39755784185
- Recruiting
Azienda Sanitaria Territoriale Pesaro Urbino (AST PU)
Pesaro, Pesaro E Urbino, 61122
Rita Chiari, Site 0079, +390755783688
- Recruiting
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
Roma, 00168
Emilio Bria, Site 0031, +390458128124
- Recruiting
Istituto Nazionale Tumori Regina Elena
Rome, Roma, 00144
Federico Cappuzzo, Site 0019, +390586223189
Netherlands4 sites, 3 recruiting
- Recruiting
Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL)
Amsterdam, North Holland, 1066 CX
Willemijn Theelen, Site 0034, 06-xxxxxxxx
- Withdrawn
Local Institution - 0056
Breda, North Brabant, 4818 CK
- Recruiting
Ziekenhuis St. Jansdal
Harderwijk, 3844 DG
L.N. Boom, Site 0035, 0031341463504
- Recruiting
St. Antonius Ziekenhuis, locatie Utrecht
Utrecht, 3543 AZ
E. (Lisanne) Kastelijn, Site 0071
Greece3 sites, 3 recruiting
- Recruiting
Alexandra General Hospital of Athens
Athens, Attikí, 115 28
Michalis Liontos, Site 0081, 306977009490
- Recruiting
Metropolitan Hospital
Attiki, 18547
Helena Linardou, Site 0022, 302104809852
- Recruiting
Theagenio Hospital
Thessaloniki, Kentrikí Makedonía, 540 07
THEODORA TSIOUDA, Site 0087, 00306932466411
Israel3 sites, 3 recruiting
- Recruiting
Bnai Zion Medical Center
Haifa, 31048
Abed Agbarya, Site 0119, 9720543101186359359
- Recruiting
Shaare Zedek Medical Center
Jerusalem, Jerusalem, 9103102
Nir Peled, Site 0055, 97205870406206555727
- Recruiting
Tel Aviv Sourasky Medical Center - Oncology - Hematology/Oncology
Tel Aviv, 6423906
Ofer Merimsky, Site 0106, 97236974907
South Korea3 sites, 3 recruiting
- Recruiting
National Cancer Center
Goyang-si, Kyǒnggi-do, 10408
Beung-Chul Ahn, Site 0069, 82222288133
- Recruiting
Severance Hospital, Yonsei University Health System
Seoul, Seoul-teukbyeolsi [Seoul], 03722
Han Sang Kim, Site 0068, 82222241583
- Recruiting
Samsung Medical Center
Seoul, 06351
Se-Hoon Lee, Site 0070, 82-2-3410-1132
United Kingdom3 sites, 3 recruiting
- Recruiting
University Hospitals Birmingham NHS Foundation Trust - Heartlands Hospital
Birmingham, B9 5SS
Shobhit Baijal, Site 0113, +44 121 627 5774
- Recruiting
Leicester Royal Infirmary-HOPE Clinical Trials Unit
Leicester, LE1 5WW
Samreen Ahmed, Site 0114, 0116 258 5998
- Recruiting
Guy's & St Thomas' NHS Foundation Trust
London, London, City of, SE1 9RT
Alexandros Georgiou, Site 0115, +44 20 7188 5368
Brazil2 sites, 2 recruiting
- Recruiting
ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO-Clinical Oncology
São Paulo, 01246000
Camila Moniz, Site 0108, 55-11-99644-6112
- Recruiting
Fundacao Antonio Prudente - AC Camargo Cancer Center
São Paulo, 01508-010
Helano Freitas, Site 0111, 5511945544480
Hungary2 sites, 2 recruiting
- Recruiting
Orszagos Koranyi Pulmonologiai Intezet
Budapest, 1121
Gyula Ostoros, Site 0089, 3613913213
- Recruiting
Orszagos Onkologiai Intezet
Budapest, 1122
Tunde Nagy, Site 0067, 3612248600
Australia1 site
- Withdrawn
Local Institution - 0093
St Leonards, New South Wales, 2065
Belgium1 site, 1 recruiting
- Recruiting
AZ Maria Middelares
Ghent, 9000
Paul Germonpre, Site 0033, 3292468400
Canada1 site, 1 recruiting
- Recruiting
BC Cancer - Vancouver
Vancouver, British Columbia, V5Z 4E6
Janessa Laskin, Site 0072, 111-111-1111
Germany1 site, 1 recruiting
- Recruiting
Klinikum Neuperlach
München, 81737
Stefan Boeck, Site 0012
Japan1 site, 1 recruiting
- Recruiting
Ehime University Hospital
Tōon, Ehime, 791-0295
Shoichiro Yamamoto, Site 0110, +81-90-2789-2188
Poland1 site, 1 recruiting
- Recruiting
Uniwersyteckie Centrum Kliniczne-Early Clinical Trials Unit
Gdansk, 80-214
Rafal Dziadziuszko, Site 0102, 48585844571
Portugal1 site, 1 recruiting
- Recruiting
Instituto Português de Oncologia de Lisboa Francisco Gentil
Lisbon, Lisbon District, 1099-023
Telma Sequeira, Site 0014, 914000669
Singapore1 site, 1 recruiting
- Recruiting
National Cancer Centre Singapore
Singapore, 168583
Qingqing Dawn Chong, Site 0088, 654368625
About this study
Official title: Solid Tumor Study for Long Term Treatment of Cancer Patients Who Have Participated in BMS Parent Studies Investigating Adagrasib (BMS-986503)
This is an open-label, solid tumor, continuation, rollover trial which enrolls participants from ongoing BMS parent studies that evaluated adagrasib (MRTX849, BMS-986503) either as monotherapy or in combination with other cancer therapies in patients with non-small cell lung cancer (NSCLC), colorectal cancer (CRC) and other advanced solid tumors.
- Conditions
- Solid Tumors
- Being tested
- Adagrasib, Pembrolizumab, Cetuximab, Pemetrexed, Docetaxel
- Keywords
- Adagrasib, KRAS G12C, KRAS, NSCLC, CRC, Krazati
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
AdagrasibDrug
Also called BMS-986503
Specified dose on specified days
PembrolizumabDrug
Specified dose on specified days
CetuximabDrug
Specified dose on specified days
PemetrexedDrug
Specified dose on specified days
DocetaxelDrug
Specified dose on specified days
IrinotecanDrug
Specified dose on specified days
LeucovorinDrug
Also called Folinic acid
Specified dose on specified days
OxaliplatinDrug
Specified dose on specified days
FluorouracilDrug
Specified dose on specified days
| Study group | Role | What they receive |
|---|---|---|
| Arm A1 | Experimental | Not described Receives: Drug: Adagrasib |
| Arm A2 | Experimental | Not described Receives: Drug: Adagrasib |
| Arm B1 | Experimental | Not described Receives: Drug: Adagrasib; Drug: Pembrolizumab |
| Arm B2 | Experimental | Not described Receives: Drug: Adagrasib; Drug: Pembrolizumab |
| Arm B3 | Experimental | Not described Receives: Drug: Adagrasib; Drug: Cetuximab |
| Arm B4 | Experimental | Not described Receives: Drug: Adagrasib; Drug: Pembrolizumab; Drug: Pemetrexed |
| Arm C1 | Experimental | Not described Receives: Drug: Pembrolizumab |
| Arm C2 | Experimental | Not described Receives: Drug: Docetaxel |
| Arm C3 | Experimental | Not described Receives: Drug: Irinotecan; Drug: Leucovorin; Drug: Fluorouracil |
| Arm C4 | Experimental | Not described Receives: Drug: Leucovorin; Drug: Oxaliplatin; Drug: Fluorouracil |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of Participants With Adverse Events (AEs)
Measured: Up to 90 days from last dose or study discontinuation
Number of Participants With AEs Leading to Treatment Discontinuation
Measured: Up to 90 days from last dose or study discontinuation
Number of Participants With Serious Adverse Events (SAEs)
Measured: Up to 90 days from last dose or study discontinuation
Number of Participants With AEs Leading to Death
Measured: Up to 90 days from last dose or study discontinuation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Feb 2026
- Study start6 May 2026
- Primary completion16 Feb 2028 (estimated)
- Study completion16 Feb 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Solid TumorsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 2
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 170 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Mirati Therapeutics Inc.
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Bristol-Myers Squibb, Study director, Bristol-Myers Squibb
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07415031
- Sponsor's protocol ID
- CA239-0071
- Other IDs
- EU CTR, WHO
- Status last verified
- Oct 2026
- First submitted
- 11 Feb 2026
- Last updated
- 27 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- Yes: BMS will provide access to individual anonymized participant data upon request from qualified researchers, and subject to certain criteria. Additional information regarding Bristol Myer Squibb's data sharing policy and process can be found at https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html
Study at a glance
From the registry record, last updated by the sponsor on 27 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Solid Tumor Study for Long Term Treatment of Cancer Patients Who Have Participated in BMS Parent Studies Investigating Adagrasib (BMS-986503)
- ClinicalTrials.gov ID
- NCT07415031
- Acronym / sponsor ID
- CA239-0071
- Conditions
- Solid Tumors
- Keywords
- Adagrasib, KRAS G12C, KRAS, NSCLC, CRC, Krazati
- Phase
- Phase 2
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 170 participants (estimated)
- Lead sponsor
- Mirati Therapeutics Inc.Industry (pharma, biotech, devices)
- Study start
- 6 May 2026 (actual)
- Primary completion
- 16 Feb 2028 (estimated)
- Study completion
- 16 Feb 2028 (estimated)
- First posted
- 17 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is an open-label, solid tumor, continuation, rollover trial which enrolls participants from ongoing BMS parent studies that evaluated adagrasib (MRTX849, BMS-986503) either as monotherapy or in combination with other cancer therapies in patients with non-small cell lung cancer (NSCLC), colorectal cancer (CRC) and other advanced solid tumors.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 10
| Arm | Type | Receives |
|---|---|---|
| Arm A1 | Experimental | Drug: Adagrasib |
| Arm A2 | Experimental | Drug: Adagrasib |
| Arm B1 | Experimental | Drug: Adagrasib, Drug: Pembrolizumab |
| Arm B2 | Experimental | Drug: Adagrasib, Drug: Pembrolizumab |
| Arm B3 | Experimental | Drug: Adagrasib, Drug: Cetuximab |
| Arm B4 | Experimental | Drug: Adagrasib, Drug: Pembrolizumab, Drug: Pemetrexed |
| Arm C1 | Experimental | Drug: Pembrolizumab |
| Arm C2 | Experimental | Drug: Docetaxel |
| Arm C3 | Experimental | Drug: Irinotecan, Drug: Leucovorin, Drug: Fluorouracil |
| Arm C4 | Experimental | Drug: Leucovorin, Drug: Oxaliplatin, Drug: Fluorouracil |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- Participant is eligible to receive continued study treatment as per the parent study, and/or investigator assessed clinical benefit.
- Individuals with assigned female sex at birth (AFSB) must have documented proof that they are not of childbearing potential. IOCBP participants who are sexually active must agree to follow the instructions for method(s) of contraception and included in the ICF.
Key exclusion criteria (4 listed)
- Participant is not eligible for study treatment per the parent study eligibility criteria.
- Participants who have completed treatment with the study drugs, progressed on prior study treatment, or discontinued study treatment due to toxicity in the parent study are not eligible to receive study drug in this study.
- Participants not receiving clinical benefit from parent study drug as assessed by the investigator.
- Other protocol defined inclusion/exclusion criteria applies.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| AdagrasibAlso: BMS-986503Specified dose on specified days | Drug | Arm A1, Arm A2, Arm B1, Arm B2, Arm B3, Arm B4 |
| PembrolizumabSpecified dose on specified days | Drug | Arm B1, Arm B2, Arm B4, Arm C1 |
| CetuximabSpecified dose on specified days | Drug | Arm B3 |
| PemetrexedSpecified dose on specified days | Drug | Arm B4 |
| DocetaxelSpecified dose on specified days | Drug | Arm C2 |
| IrinotecanSpecified dose on specified days | Drug | Arm C3 |
| LeucovorinAlso: Folinic acidSpecified dose on specified days | Drug | Arm C3, Arm C4 |
| OxaliplatinSpecified dose on specified days | Drug | Arm C4 |
| FluorouracilSpecified dose on specified days | Drug | Arm C3, Arm C4 |
Primary outcome
Number of Participants With Adverse Events (AEs)
Time frame: Up to 90 days from last dose or study discontinuation
Number of Participants With AEs Leading to Treatment Discontinuation
Time frame: Up to 90 days from last dose or study discontinuation
Number of Participants With Serious Adverse Events (SAEs)
Time frame: Up to 90 days from last dose or study discontinuation
Number of Participants With AEs Leading to Death
Time frame: Up to 90 days from last dose or study discontinuation
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Oct 2026.
- BMS Clinical Trial InformationLink provided by the sponsor.
- BMS Clinical Trial Patient RecruitingLink provided by the sponsor.
- Individual participant dataSharing planned: Yes. BMS will provide access to individual anonymized participant data upon request from qualified researchers, and subject to certain criteria. Additional information regarding Bristol Myer Squibb's data sharing policy and process can be found at https://www.bms.com/researchers-and-partners/clinical-trials-and-research.html
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RecruitingObservational study
Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors
Malignant Solid Neoplasm
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com contact
First line of the email MUST contain NCT # and Site #. contact
Bristol-Myers Squibb study director
Bristol-Myers Squibb
101 sites in 21 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 2 study testing Adagrasib, Pembrolizumab and Cetuximab in people with Solid Tumors, run by Mirati Therapeutics Inc. at 101 sites in 21 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 27 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 101 sites in France, United States, Spain, China, Italy and 16 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact BMS Clinical Trials Contact Center www.BMSClinicalTrials.com (855-907-3286, Clinical.Trials@bms.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of Participants With Adverse Events (AEs) (time frame: Up to 90 days from last dose or study discontinuation). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Oct 2026.