AdherenceNCT07415109
Improving LDL-C Levels Through Temporal Self-regulation Theory-based, Personality-tailored Health Messages
A study testing General Message and Personalized Message in people with Adherence and Preventive Health Services, run by National University Health System, Singapore at 1 site in Singapore.
Trial summary
The study is meant to run parallel to the larger study, RESET. The goal of this study is to to evaluate the effectiveness of a once-off general and personality-tailored text message on GP consultation among RESET participants identified to have high LDL-C. Read more about this study
- Who is it for?
- Ages 21 to 65 years
- Conditions the study is for
- Adherence, Preventive Health Services
- What is being tested?
- General Message and Personalized Message
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 3,000 participants
- Where
- 1 siteSingapore
- Study dates
- 25 Nov 2025to Nov 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- New participants of RESET who have given consent to be contacted for future studies
- ≥21 years old
Who cannot join
- are not able to read, write or communicate in English
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Singapore1 site, 1 recruiting
- Recruiting
National University of Singapore
Singapore, 117599
About this study
Official title: Improving LDL-C Levels Through Temporal Self-regulation Theory-based, Personality-tailored Health Messages: A Three-Arm Randomized Controlled Trial
The study is meant to run parallel to the larger study, RESET. The goal of this study is to to evaluate the effectiveness of a once-off general and personality-tailored text message on GP consultation among RESET participants identified to have high LDL-C. The main question it aims to answer is:
Will participants exposed to personality tailored advice have a higher adherence to GP consultation compared to the participants in the control group?
Read more
Researchers will compare a personalized message to a general message (with no personalization according to patients personality type) and control group to see if the messages increase adherence.
Participants are required to complete two questionnaires: one before and one after they receive their RESET results.
- Conditions
- Adherence, Preventive Health Services
- Being tested
- General Message, Personalized Message
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
General MessageBehavioural
The intervention will consist of messages and infographics embedded in participants' return of results (ROR) emails within the RESET study. Each participant will receive the ROR alongside the intervention once, at the time their results are sent. No repeat messages will be delivered.
The general health message will include indications for lipid therapy, benefits of lipid-lowering medications, common side effects, risks of non-adherence, and an infographic on diet and lifestyle modification based on ACE lipid management guidance. The infographic will be included in the same ROR email.
Personalized MessageBehavioural
The intervention will consist of messages and infographics embedded in participants' return of results (ROR) emails within the RESET study. Each participant will receive the ROR alongside the intervention once, at the time their results are sent. No repeat messages will be delivered.
The message will include the personality-tailored message with the same core content as the general message, including indications for lipid therapy, benefits of lipid-lowering medications, common side effects, risks of non-adherence, and an infographic on diet and lifestyle modification based on ACE lipid management guidance. An infographic will be included in the same ROR email. This message will contain an added component framed according to conscientiousness and neuroticism scores, as these traits are strong predictors of health behaviours. Scores will be derived from baseline BFI-44 results.
| Study group | Role | What they receive |
|---|---|---|
| Personality-Tailored Message | Experimental | Not described Receives: Behavioral: Personalized Message |
| General Message | Active comparator | Not described Receives: Behavioral: General Message |
| Control | No intervention | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
Intention to adopt a healthier diet
A 3-item, 7-point Likert scale assessing participants' intention to adopt a healthier diet. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to adopt a healthier diet.
Measured: From enrollment to 3 months after results have been returned.
Intention to engage in Physical Activity
A 3-item, 7-point Likert scale assessing participants' intention to engage in physical activity. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to engage in physical activity.
Measured: From enrollment to 3 months after results have been returned.
Intention to visit a General Practitioner
A 3-item, 7-point Likert scale assessing participants' intention to visit a general practitioner. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to visit a general practitioner.
Measured: 3 months after results have been returned.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Feb 2026
- Study start25 Nov 2025
- Primary completionJan 2028 (estimated)
- Study completionNov 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AdherenceStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 3,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National University Health System, Singapore
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Jocelyn Chew, National University Health System, Singapore
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07415109
- Sponsor's protocol ID
- NUS-IRB-2025-334
- Status last verified
- Apr 2026
- First submitted
- 11 Feb 2026
- Last updated
- 13 Apr 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 13 Apr 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Improving LDL-C Levels Through Temporal Self-regulation Theory-based, Personality-tailored Health Messages: A Three-Arm Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07415109
- Acronym / sponsor ID
- NUS-IRB-2025-334
- Conditions
- Adherence, Preventive Health Services
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 3,000 participants (estimated)
- Lead sponsor
- National University Health System, SingaporeUniversity, hospital or other
- Study start
- 25 Nov 2025 (actual)
- Primary completion
- Jan 2028 (estimated)
- Study completion
- Nov 2028 (estimated)
- First posted
- 17 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study is meant to run parallel to the larger study, RESET. The goal of this study is to to evaluate the effectiveness of a once-off general and personality-tailored text message on GP consultation among RESET participants identified to have high LDL-C. The main question it aims to answer is:
Will participants exposed to personality tailored advice have a higher adherence to GP consultation compared to the participants in the control group?
Researchers will compare a personalized message to a general message (with no personalization according to patients personality type) and control group to see if the messages increase adherence.
Participants are required to complete two questionnaires: one before and one after they receive their RESET results.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Personality-Tailored Message | Experimental | Behavioral: Personalized Message |
| General Message | Active comparator | Behavioral: General Message |
| Control | No intervention | – |
Who may qualify
- Ages
- 21 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- New participants of RESET who have given consent to be contacted for future studies
- ≥21 years old
Key exclusion criteria (1 listed)
- are not able to read, write or communicate in English
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| General MessageThe intervention will consist of messages and infographics embedded in participants' return of results (ROR) emails within the RESET study. Each participant will receive the ROR alongside the intervention once, at the time their results are sent. No repeat messages will be delivered. The general health message will include indications for lipid therapy, benefits of lipid-lowering medications, common side effects, risks of non-adherence, and an infographic on diet and lifestyle modification based on ACE lipid management guidance. The infographic will be included in the same ROR email. | Behavioural | General Message |
| Personalized MessageThe intervention will consist of messages and infographics embedded in participants' return of results (ROR) emails within the RESET study. Each participant will receive the ROR alongside the intervention once, at the time their results are sent. No repeat messages will be delivered. The message will include the personality-tailored message with the same core content as the general message, including indications for lipid therapy, benefits of lipid-lowering medications, common side effects, risks of non-adherence, and an infographic on diet and lifestyle modification based on ACE lipid management guidance. An infographic will be included in the same ROR email. This message will contain an added component framed according to conscientiousness and neuroticism scores, as these traits are strong predictors of health behaviours. Scores will be derived from baseline BFI-44 results. | Behavioural | Personality-Tailored Message |
Primary outcome
Intention to adopt a healthier diet
Time frame: From enrollment to 3 months after results have been returned.
A 3-item, 7-point Likert scale assessing participants' intention to adopt a healthier diet. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to adopt a healthier diet.
Intention to engage in Physical Activity
Time frame: From enrollment to 3 months after results have been returned.
A 3-item, 7-point Likert scale assessing participants' intention to engage in physical activity. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to engage in physical activity.
Intention to visit a General Practitioner
Time frame: 3 months after results have been returned.
A 3-item, 7-point Likert scale assessing participants' intention to visit a general practitioner. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to visit a general practitioner.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 Apr 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing General Message and Personalized Message in people with Adherence and Preventive Health Services, run by National University Health System, Singapore at 1 site in Singapore.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 13 Apr 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Singapore. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Jocelyn Chew (+6565168687, dbi-lab@nus.edu.sg), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Intention to adopt a healthier diet (time frame: From enrollment to 3 months after results have been returned.). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Apr 2026.