Liver TransplantationLiv (Liver)NCT07417423
Home-Based Exercise Education in Liver Transplant Recipients
A study testing Home-Based Exercise Education and Brochure-Based Exercise Education (Experimental) in people with Liver Transplantation and Fatigue, run by Hasan Kalyoncu University at 1 site in Turkey (Türkiye).
Trial summary
Liver transplant recipients often experience reduced physical activity levels, fatigue, and increased caregiver burden after transplantation. Structured home-based exercise education may help improve these outcomes. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Liver Transplantation, Fatigue, Physical Inactivity
- What is being tested?
- Home-Based Exercise Education and Brochure-Based Exercise Education (Experimental)
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 117 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 3 Oct 2024to 8 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adult liver transplant recipients
- Aged 18 years or older
- Clinically stable and cleared for participation in physical activity
- Able to understand and follow exercise instructions
- Provided written informed consent
Who cannot join
- Presence of severe cardiovascular, respiratory, or musculoskeletal conditions that contraindicate exercise
- Acute transplant rejection or severe post-transplant complications
- Cognitive impairment limiting participation
- Participation in another structured exercise program during the study period
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Inonu University Turgut Ozal Medical Center
Malatya, Gaziantep, 27010
About this study
Official title: The Effect of Brochure- and Video-Based Home Exercise Education on Physical Activity, Fatigue, and Caregiver Burden in Liver Transplant Recipients: A Randomized Controlled Trial
Liver transplant recipients often experience reduced physical activity levels, fatigue, and increased caregiver burden after transplantation. Structured home-based exercise education may help improve these outcomes. This study aims to evaluate the effects of brochure-based and video-based home exercise education programs on physical activity levels, fatigue, and caregiver burden in liver transplant recipients.
Participants are assigned to either a brochure-based exercise education group, a video-based exercise education group, or a control group receiving standard care. The primary objective is to determine whether structured home exercise education improves physical activity and reduces fatigue and caregiver burden compared to standard care.
Read the detailed description
Regular physical activity is essential for improving functional capacity and quality of life in liver transplant recipients. However, many recipients experience persistent fatigue, decreased physical activity levels, and increased caregiver burden after transplantation. Structured and accessible home-based exercise education may provide a practical approach to support long-term rehabilitation in this population.
This study evaluates the effectiveness of two different home-based exercise education methods: brochure-based education and video-based education. Participants receive standardized exercise recommendations designed to promote safe and gradual increases in physical activity. The intervention period includes structured follow-up and guidance to enhance adherence. A control group receives standard post-transplant care without structured exercise education.
Outcome measures include physical activity level, fatigue severity, and caregiver burden, assessed at predefined time points during the study period. The findings of this study may contribute to the development of accessible rehabilitation strategies for liver transplant recipients.
- Conditions
- Liver Transplantation, Fatigue, Physical Inactivity
- Being tested
- Home-Based Exercise Education, Brochure-Based Exercise Education (Experimental)
- Keywords
- Liver Transplantation, Donor, Exercise, Video Based Home Exercise
- Medical subject headings
- Fatigue, Sedentary Behavior, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Home-Based Exercise EducationBehavioural
Home-Based Exercise Education consists of structured guidance designed to promote safe and progressive physical activity in liver transplant recipients. The program includes recommendations regarding exercise type, frequency, duration, and intensity appropriate for the post-transplant period. Education is delivered either through a printed brochure or instructional video materials. The content focuses on aerobic and strengthening exercises that can be performed at home without specialized equipment. Participants are encouraged to follow the prescribed exercise recommendations throughout the study period.
Brochure-Based Exercise Education (Experimental)Behavioural
Participants receive structured home-based exercise education delivered through a printed brochure specifically developed for liver transplant recipients. The brochure includes written instructions and illustrations describing aerobic and strengthening exercises, along with recommendations for frequency, duration, intensity, and progression. The material is designed to enable participants to independently perform safe and gradual physical activity at home throughout the study period.
| Study group | Role | What they receive |
|---|---|---|
| Brochure-Based Exercise Education | Experimental | Participants receive structured home-based exercise education delivered through a printed brochure. The brochure includes information on safe physical activity, recommended exercises, frequency, intensity, and progression guidelines designed for liver transplant recipients. Receives: Behavioral: Brochure-Based Exercise Education (Experimental) |
| Video-Based Exercise Education | Experimental | Participants receive structured home-based exercise education delivered through instructional videos. The videos demonstrate recommended exercises, provide guidance on proper technique, frequency, intensity, and progression suitable for liver transplant recipients. Receives: Behavioral: Home-Based Exercise Education |
| Standard Care Control | No intervention | Participants receive standard post-transplant follow-up care without additional structured exercise education during the study period. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Physical Activity Level
International Physical Activity Questionnaire (IPAQ). Physical activity is expressed as MET-minutes per week calculated from activity intensity and duration. Scores range from 0 to >3000 MET-min/week, with higher values indicating higher physical activity level.
Measured: Baseline and end of intervention (8 weeks)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Feb 2026
- Study start3 Oct 2024
- Primary completion4 Sep 2025
- Study completion8 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Liver TransplantationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants are randomly assigned to one of three parallel groups: a brochure-based home exercise education group, a video-based home exercise education group, or a control group receiving standard care. Each participant remains in the assigned group throughout the study period, and outcomes are compared between groups.
- Masking
- None (open label)
- Enrolment
- 117 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hasan Kalyoncu University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, İlker DEMİR, Hasan Kalyoncu University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07417423
- Sponsor's protocol ID
- 2024/117
- Acronym
- Liv (Liver)
- Status last verified
- Feb 2026
- First submitted
- 11 Feb 2026
- Last updated
- 25 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data (IPD) will not be shared due to institutional data protection policies and ethical restrictions. The informed consent obtained from participants did not include permission for public data sharing.
Study at a glance
From the registry record, last updated by the sponsor on 25 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Brochure- and Video-Based Home Exercise Education on Physical Activity, Fatigue, and Caregiver Burden in Liver Transplant Recipients: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07417423
- Acronym / sponsor ID
- Liv (Liver) / 2024/117
- Conditions
- Liver Transplantation, Fatigue, Physical Inactivity
- Keywords
- Liver Transplantation, Donor, Exercise, Video Based Home Exercise
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 117 participants (actual)
- Lead sponsor
- Hasan Kalyoncu UniversityUniversity, hospital or other
- Study start
- 3 Oct 2024 (actual)
- Primary completion
- 4 Sep 2025 (actual)
- Study completion
- 8 Dec 2025 (actual)
- First posted
- 18 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Liver transplant recipients often experience reduced physical activity levels, fatigue, and increased caregiver burden after transplantation. Structured home-based exercise education may help improve these outcomes. This study aims to evaluate the effects of brochure-based and video-based home exercise education programs on physical activity levels, fatigue, and caregiver burden in liver transplant recipients.
Participants are assigned to either a brochure-based exercise education group, a video-based exercise education group, or a control group receiving standard care. The primary objective is to determine whether structured home exercise education improves physical activity and reduces fatigue and caregiver burden compared to standard care.
Detailed description
Regular physical activity is essential for improving functional capacity and quality of life in liver transplant recipients. However, many recipients experience persistent fatigue, decreased physical activity levels, and increased caregiver burden after transplantation. Structured and accessible home-based exercise education may provide a practical approach to support long-term rehabilitation in this population.
This study evaluates the effectiveness of two different home-based exercise education methods: brochure-based education and video-based education. Participants receive standardized exercise recommendations designed to promote safe and gradual increases in physical activity. The intervention period includes structured follow-up and guidance to enhance adherence. A control group receives standard post-transplant care without structured exercise education.
Outcome measures include physical activity level, fatigue severity, and caregiver burden, assessed at predefined time points during the study period. The findings of this study may contribute to the development of accessible rehabilitation strategies for liver transplant recipients.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
- Model description
- Participants are randomly assigned to one of three parallel groups: a brochure-based home exercise education group, a video-based home exercise education group, or a control group receiving standard care. Each participant remains in the assigned group throughout the study period, and outcomes are compared between groups.
| Arm | Type | Receives |
|---|---|---|
| Brochure-Based Exercise Education | Experimental | Behavioral: Brochure-Based Exercise Education (Experimental)Participants receive structured home-based exercise education delivered through a printed brochure. The brochure includes information on safe physical activity, recommended exercises, frequency, intensity, and progression guidelines designed for liver transplant recipients. |
| Video-Based Exercise Education | Experimental | Behavioral: Home-Based Exercise EducationParticipants receive structured home-based exercise education delivered through instructional videos. The videos demonstrate recommended exercises, provide guidance on proper technique, frequency, intensity, and progression suitable for liver transplant recipients. |
| Standard Care Control | No intervention | –Participants receive standard post-transplant follow-up care without additional structured exercise education during the study period. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Adult liver transplant recipients
- Aged 18 years or older
- Clinically stable and cleared for participation in physical activity
- Able to understand and follow exercise instructions
- Provided written informed consent
Key exclusion criteria (4 listed)
- Presence of severe cardiovascular, respiratory, or musculoskeletal conditions that contraindicate exercise
- Acute transplant rejection or severe post-transplant complications
- Cognitive impairment limiting participation
- Participation in another structured exercise program during the study period
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Home-Based Exercise EducationHome-Based Exercise Education consists of structured guidance designed to promote safe and progressive physical activity in liver transplant recipients. The program includes recommendations regarding exercise type, frequency, duration, and intensity appropriate for the post-transplant period. Education is delivered either through a printed brochure or instructional video materials. The content focuses on aerobic and strengthening exercises that can be performed at home without specialized equipment. Participants are encouraged to follow the prescribed exercise recommendations throughout the study period. | Behavioural | Video-Based Exercise Education |
| Brochure-Based Exercise Education (Experimental)Participants receive structured home-based exercise education delivered through a printed brochure specifically developed for liver transplant recipients. The brochure includes written instructions and illustrations describing aerobic and strengthening exercises, along with recommendations for frequency, duration, intensity, and progression. The material is designed to enable participants to independently perform safe and gradual physical activity at home throughout the study period. | Behavioural | Brochure-Based Exercise Education |
Primary outcome
Physical Activity Level
Time frame: Baseline and end of intervention (8 weeks)
International Physical Activity Questionnaire (IPAQ). Physical activity is expressed as MET-minutes per week calculated from activity intensity and duration. Scores range from 0 to >3000 MET-min/week, with higher values indicating higher physical activity level.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Feb 2026.
- Individual participant dataSharing planned: No. Individual participant data (IPD) will not be shared due to institutional data protection policies and ethical restrictions. The informed consent obtained from participants did not include permission for public data sharing.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Home-Based Exercise Education and Brochure-Based Exercise Education (Experimental) in people with Liver Transplantation and Fatigue, run by Hasan Kalyoncu University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 25 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Physical Activity Level (time frame: Baseline and end of intervention (8 weeks)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Feb 2026.