Prostate Cancer (Adenocarcinoma)NCT07417475
Robot-Assisted Radical Prostatectomy: the HOOD Technique Versus Standard Anterior Reconstruction
A study testing Prostatectomy with anterior-posterior renconstruciton and Prostatectomy with HOOD techinque in people with Prostate Cancer (Adenocarcinoma), run by Araz Musaev at 1 site in Turkey (Türkiye).
Trial summary
This prospective, non-randomized cohort study included consecutive patients undergoing robotic-assisted laparoscopic radical prostatectomy (RARP) between January 2024 and January 2026 following ethics committee approval. Read more about this study
- Who is it for?
- Ages 40 to 75 years, men only
- Conditions the study is for
- Prostate Cancer (Adenocarcinoma)
- What is being tested?
- Prostatectomy with anterior-posterior renconstruciton and Prostatectomy with HOOD techinque
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 200 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jan 2024to 1 Jan 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 75 years
- Men only
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- life expectancy >10 years,
- clinically organ confined disease (cT1-cT2),
- biopsy ISUP GG ≤3,
- total serum prostate-specific antigen (PSA) ≤10 ng/ml
- normal preoperative continence and potency
Who cannot join
- high risk prosatate cancer
- cN1
- M1 prostate cancer (according to preoperative GA68 PSMA PET CT)
- pre-existing urinary incontinence,
- previous prostatic, urethral, bladder neck surgery
- neoadjuvant therapy
- prior pelvic radiotherapy
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Ankara Universtity School of medicine department of urology
Ankara
About this study
Official title: Early Functional Outcomes After Robot-Assisted Radical Prostatectomy: A Prospective Comparison of the HOOD Technique Versus Standard Anterior Reconstruction
This prospective, non-randomized cohort study included consecutive patients undergoing robotic-assisted laparoscopic radical prostatectomy (RARP) between January 2024 and January 2026 following ethics committee approval. Patients with clinically localized prostate cancer eligible for bilateral nerve-sparing surgery were enrolled. Two surgical techniques-anterior-posterior reconstruction (APR) and the HOOD technique-were compared. All procedures were performed by a single high-volume surgeon at a tertiary referral center. The primary endpoint was early urinary continence recovery, assessed at catheter removal and at 3, 6, and 12 weeks postoperatively. Secondary outcomes included postoperative complications, positive surgical margin rates, and early oncological outcomes.
- Conditions
- Prostate Cancer (Adenocarcinoma)
- Being tested
- Prostatectomy with anterior-posterior renconstruciton, Prostatectomy with HOOD techinque
- Keywords
- HOOD technique, Prostate cancer, Nerve-sparing
- Medical subject headings
- Prostatic Neoplasms, Adenocarcinoma
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Prostatectomy with anterior-posterior renconstrucitonProcedure or surgery
Prostatectomy with anterior-posterior reconstruction involves restoration of both the posterior musculofascial plate and the anterior periurethral support structures during vesicourethral anastomosis, aiming to re-establish normal pelvic anatomy and improve early postoperative urinary continence following radical prostatectomy.
Prostatectomy with HOOD techinqueProcedure or surgery
Prostatectomy with the HOOD (Hood technique) is a nerve-sparing approach in which the anterior periprostatic structures, including the detrusor apron and puboprostatic ligaments, are preserved to maintain anterior urethral support and neurovascular integrity, with the aim of improving early urinary continence and functional recovery after radical prostatectomy.
| Study group | Role | What they receive |
|---|---|---|
| HOOD technique | Experimental | Not described Receives: Procedure: Prostatectomy with HOOD techinque |
| Anterior-Posterior reconstruction | Active comparator | Not described Receives: Procedure: Prostatectomy with anterior-posterior renconstruciton |
What is being measured
The primary outcome is the main question the study is designed to answer.
Functional outcomes
The Urinary continance recovery rates at the catheter removal, and subsequently at 3 weeks , 6 weeks and 12 weeks after surgery.
Measured: 3 weeks , 6 weeks and 12 weeks after surgery.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Feb 2026
- Study start1 Jan 2024
- Primary completion1 Jan 2026
- Study completion1 Jan 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (8)Papers the sponsor has linked to this study.
- Other trials for Prostate Cancer (Adenocarcinoma)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 200 participants (actual)
Sponsor and investigators
- Lead sponsor
- Araz Musaev
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Araz Musaev, Ankara University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07417475
- Sponsor's protocol ID
- İ01-86-26
- Status last verified
- Feb 2026
- First submitted
- 11 Feb 2026
- Last updated
- 18 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Mandel A, Choudhary M, Tillu N, Maheshwari A, Kolanukuduru K, Wagaskar V, Tewari A. Hood Technique for Radical Prostatectomy. J Endourol. 2025 Mar;39(S1):S35-S38. doi: 10.1089/end.2024.0303.
PubMed 40100831Turkolmez K, Akpinar C, Kubilay E, Suer E. Retzius-Sparing vs Modified Anatomical Structure Preserving and Retzius-Repairing Robotic-Assisted Radical Prostatectomy: A Prospective Randomized Comparison on Functional Outcomes with a 1-Year Follow-Up. J Endourol. 2022 Sep;36(9):1214-1222. doi: 10.1089/end.2022.0073. Epub 2022 Jun 2.
PubMed 35546454Tewari AK, Bigelow K, Rao S, Takenaka A, El-Tabi N, Te A, Vaughan ED. Anatomic restoration technique of continence mechanism and preservation of puboprostatic collar: a novel modification to achieve early urinary continence in men undergoing robotic prostatectomy. Urology. 2007 Apr;69(4):726-31. doi: 10.1016/j.urology.2006.12.028.
PubMed 17445659Student V Jr, Vidlar A, Grepl M, Hartmann I, Buresova E, Student V. Advanced Reconstruction of Vesicourethral Support (ARVUS) during Robot-assisted Radical Prostatectomy: One-year Functional Outcomes in a Two-group Randomised Controlled Trial. Eur Urol. 2017 May;71(5):822-830. doi: 10.1016/j.eururo.2016.05.032. Epub 2016 Jun 6.
PubMed 27283216Porpiglia F, Bertolo R, Manfredi M, De Luca S, Checcucci E, Morra I, Passera R, Fiori C. Total Anatomical Reconstruction During Robot-assisted Radical Prostatectomy: Implications on Early Recovery of Urinary Continence. Eur Urol. 2016 Mar;69(3):485-95. doi: 10.1016/j.eururo.2015.08.005. Epub 2015 Aug 19.
PubMed 26297603Mather JS. Impossible direct laryngoscopy in achondroplasia. A case report. Anaesthesia. 1966 Apr;21(2):244-8. doi: 10.1111/j.1365-2044.1966.tb02607.x. No abstract available.
PubMed 5956576Heesakkers J, Farag F, Bauer RM, Sandhu J, De Ridder D, Stenzl A. Pathophysiology and Contributing Factors in Postprostatectomy Incontinence: A Review. Eur Urol. 2017 Jun;71(6):936-944. doi: 10.1016/j.eururo.2016.09.031. Epub 2016 Oct 6.
PubMed 27720536Cambio AJ, Evans CP. Minimising postoperative incontinence following radical prostatectomy: considerations and evidence. Eur Urol. 2006 Nov;50(5):903-13; discussion 913. doi: 10.1016/j.eururo.2006.08.009. Epub 2006 Aug 28.
PubMed 16956715
Study at a glance
From the registry record, last updated by the sponsor on 18 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Early Functional Outcomes After Robot-Assisted Radical Prostatectomy: A Prospective Comparison of the HOOD Technique Versus Standard Anterior Reconstruction
- ClinicalTrials.gov ID
- NCT07417475
- Acronym / sponsor ID
- İ01-86-26
- Conditions
- Prostate Cancer (Adenocarcinoma)
- Keywords
- HOOD technique, Prostate cancer, Nerve-sparing
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 200 participants (actual)
- Lead sponsor
- Araz MusaevUniversity, hospital or other
- Study start
- 1 Jan 2024 (actual)
- Primary completion
- 1 Jan 2026 (actual)
- Study completion
- 1 Jan 2026 (actual)
- First posted
- 18 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective, non-randomized cohort study included consecutive patients undergoing robotic-assisted laparoscopic radical prostatectomy (RARP) between January 2024 and January 2026 following ethics committee approval. Patients with clinically localized prostate cancer eligible for bilateral nerve-sparing surgery were enrolled. Two surgical techniques-anterior-posterior reconstruction (APR) and the HOOD technique-were compared. All procedures were performed by a single high-volume surgeon at a tertiary referral center. The primary endpoint was early urinary continence recovery, assessed at catheter removal and at 3, 6, and 12 weeks postoperatively. Secondary outcomes included postoperative complications, positive surgical margin rates, and early oncological outcomes.
Study design
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| HOOD technique | Experimental | Procedure: Prostatectomy with HOOD techinque |
| Anterior-Posterior reconstruction | Active comparator | Procedure: Prostatectomy with anterior-posterior renconstruciton |
Who may qualify
- Ages
- 40 to 75 years
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- life expectancy >10 years,
- clinically organ confined disease (cT1-cT2),
- biopsy ISUP GG ≤3,
- total serum prostate-specific antigen (PSA) ≤10 ng/ml
- normal preoperative continence and potency
Key exclusion criteria (7 listed)
- high risk prosatate cancer
- cN1
- M1 prostate cancer (according to preoperative GA68 PSMA PET CT)
- pre-existing urinary incontinence,
- previous prostatic, urethral, bladder neck surgery
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Prostatectomy with anterior-posterior renconstrucitonProstatectomy with anterior-posterior reconstruction involves restoration of both the posterior musculofascial plate and the anterior periurethral support structures during vesicourethral anastomosis, aiming to re-establish normal pelvic anatomy and improve early postoperative urinary continence following radical prostatectomy. | Procedure or surgery | Anterior-Posterior reconstruction |
| Prostatectomy with HOOD techinqueProstatectomy with the HOOD (Hood technique) is a nerve-sparing approach in which the anterior periprostatic structures, including the detrusor apron and puboprostatic ligaments, are preserved to maintain anterior urethral support and neurovascular integrity, with the aim of improving early urinary continence and functional recovery after radical prostatectomy. | Procedure or surgery | HOOD technique |
Primary outcome
Functional outcomes
Time frame: 3 weeks , 6 weeks and 12 weeks after surgery.
The Urinary continance recovery rates at the catheter removal, and subsequently at 3 weeks , 6 weeks and 12 weeks after surgery.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Feb 2026.
- Background: PubMed 40100831Mandel A, Choudhary M, Tillu N, Maheshwari A, Kolanukuduru K, Wagaskar V, Tewari A. Hood Technique for Radical Prostatectomy. J Endourol. 2025 Mar;39(S1):S35-S38. doi: 10.1089/end.2024.0303.
- Background: PubMed 35546454Turkolmez K, Akpinar C, Kubilay E, Suer E. Retzius-Sparing vs Modified Anatomical Structure Preserving and Retzius-Repairing Robotic-Assisted Radical Prostatectomy: A Prospective Randomized Comparison on Functional Outcomes with a 1-Year Follow-Up. J Endourol. 2022 Sep;36(9):1214-1222. doi: 10.1089/end.2022.0073. Epub 2022 Jun 2.
- Background: PubMed 17445659Tewari AK, Bigelow K, Rao S, Takenaka A, El-Tabi N, Te A, Vaughan ED. Anatomic restoration technique of continence mechanism and preservation of puboprostatic collar: a novel modification to achieve early urinary continence in men undergoing robotic prostatectomy. Urology. 2007 Apr;69(4):726-31. doi: 10.1016/j.urology.2006.12.028.
- Background: PubMed 27283216Student V Jr, Vidlar A, Grepl M, Hartmann I, Buresova E, Student V. Advanced Reconstruction of Vesicourethral Support (ARVUS) during Robot-assisted Radical Prostatectomy: One-year Functional Outcomes in a Two-group Randomised Controlled Trial. Eur Urol. 2017 May;71(5):822-830. doi: 10.1016/j.eururo.2016.05.032. Epub 2016 Jun 6.
- Background: PubMed 26297603Porpiglia F, Bertolo R, Manfredi M, De Luca S, Checcucci E, Morra I, Passera R, Fiori C. Total Anatomical Reconstruction During Robot-assisted Radical Prostatectomy: Implications on Early Recovery of Urinary Continence. Eur Urol. 2016 Mar;69(3):485-95. doi: 10.1016/j.eururo.2015.08.005. Epub 2015 Aug 19.
- Background: PubMed 5956576Mather JS. Impossible direct laryngoscopy in achondroplasia. A case report. Anaesthesia. 1966 Apr;21(2):244-8. doi: 10.1111/j.1365-2044.1966.tb02607.x. No abstract available.
- Background: PubMed 27720536Heesakkers J, Farag F, Bauer RM, Sandhu J, De Ridder D, Stenzl A. Pathophysiology and Contributing Factors in Postprostatectomy Incontinence: A Review. Eur Urol. 2017 Jun;71(6):936-944. doi: 10.1016/j.eururo.2016.09.031. Epub 2016 Oct 6.
- Background: PubMed 16956715Cambio AJ, Evans CP. Minimising postoperative incontinence following radical prostatectomy: considerations and evidence. Eur Urol. 2006 Nov;50(5):903-13; discussion 913. doi: 10.1016/j.eururo.2006.08.009. Epub 2006 Aug 28.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Prostatectomy with anterior-posterior renconstruciton and Prostatectomy with HOOD techinque in people with Prostate Cancer (Adenocarcinoma), run by Araz Musaev at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 18 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Functional outcomes (time frame: 3 weeks , 6 weeks and 12 weeks after surgery.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07417475, which also lists 8 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Feb 2026.