Obsessive-Compulsive Disorder (OCD)NCT07419009
Feasibility of Modulating Cognitive Control in OCD
A study testing continuous theta-burst transcranial magnetic stimulation (cTBS) in people with Obsessive-Compulsive Disorder (OCD), run by Dartmouth-Hitchcock Medical Center.
Trial summary
This study tests out procedures to look at whether a type of brain stimulation called transcranial magnetic stimulation impacts flexible shifts in behavior in obsessive-compulsive disorder (OCD). Read more about this study
- Who is it for?
- Ages 18 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Obsessive-Compulsive Disorder (OCD)
- What is being tested?
- continuous theta-burst transcranial magnetic stimulation (cTBS)
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 12 participants
- Where
- No sites listed yet
- Study dates
- 1 Nov 2026to 30 Sep 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Current primary DSM-5 OCD diagnosis and current Y-BOCS total score of ≥16 (OCD group, only) or no current diagnosis of an emotional disorder, and no known history of OCD, PTSD, anxiety disorder(s), or recurrent major depressive disorder (Healthy participant group, only)
- 18-60 years of age
- ability to speak, read, write, and understand English sufficiently well to complete study procedures and provide informed consent
- psychotherapy and/or psychiatric medication use remain stable for 6 weeks prior to study entry
Who cannot join
- Presence of current psychiatric diagnosis (healthy control group, only)
- active substance use disorder
- history of mania or hypomania, or lifetime presence of significant psychotic symptoms
- active suicidal or homicidal ideation
- use of medications known to reduce seizure threshold (e.g., stimulants)
- organic brain disease or injury representing a contraindication to TMS
- any health problems that would interfere with safe and/or practical study participation, including contraindications to TMS (e.g., seizure disorder, presence of metal hardware that would come in close contact with the discharging coil)
- current pregnancy or planning to become pregnant during the study period
About this study
Official title: Evaluating Frontal Pole as a Window to Modulation of Cognitive Control in OCD
This study tests out procedures to look at whether a type of brain stimulation called transcranial magnetic stimulation impacts flexible shifts in behavior in obsessive-compulsive disorder (OCD). This study examines whether study procedures are feasible and acceptable to people participating in the study, but does not determine whether this type of brain stimulation causes changes.
- Conditions
- Obsessive-Compulsive Disorder (OCD)
- Being tested
- continuous theta-burst transcranial magnetic stimulation (cTBS)
- Medical subject headings
- Obsessive-Compulsive Disorder
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
continuous theta-burst transcranial magnetic stimulation (cTBS)Device
3 consecutive daily sessions of cTBS
| Study group | Role | What they receive |
|---|---|---|
| Obsessive-compulsive disorder (OCD) | Other | Not described Receives: Device: continuous theta-burst transcranial magnetic stimulation (cTBS) |
| Healthy Adult Participants | Other | Not described Receives: Device: continuous theta-burst transcranial magnetic stimulation (cTBS) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Rate of enrollment
Percent of screened participants who are determined to be eligible and enrolled.
Measured: At study enrollment
Secondary outcomes (2)
Rates of visit completion
Percent (%) of enrolled participants completing each study visit
Measured: From enrollment to date of post-TMS study visit (approximately 1 week)
Peak cTBS intensity tolerated
Average of peak intensity (up to target intensity) tolerated during cTBS sessions
Measured: From enrollment to end of TMS sessions (approximately 1 week)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Feb 2026
- Study start1 Nov 2026 (estimated)
- Primary completion30 Sep 2027 (estimated)
- Study completion30 Sep 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Obsessive-Compulsive Disorder (OCD)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 12 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Dartmouth-Hitchcock Medical Center
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Sarah.L.Garnaat, Dartmouth-Hitchcock Medical Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07419009
- Sponsor's protocol ID
- STUDY02003117
- Status last verified
- May 2026
- First submitted
- 6 Feb 2026
- Last updated
- 2 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 2 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluating Frontal Pole as a Window to Modulation of Cognitive Control in OCD
- ClinicalTrials.gov ID
- NCT07419009
- Acronym / sponsor ID
- STUDY02003117
- Conditions
- Obsessive-Compulsive Disorder (OCD)
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 12 participants (estimated)
- Lead sponsor
- Dartmouth-Hitchcock Medical CenterUniversity, hospital or other
- Study start
- 1 Nov 2026 (estimated)
- Primary completion
- 30 Sep 2027 (estimated)
- Study completion
- 30 Sep 2027 (estimated)
- First posted
- 18 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study tests out procedures to look at whether a type of brain stimulation called transcranial magnetic stimulation impacts flexible shifts in behavior in obsessive-compulsive disorder (OCD). This study examines whether study procedures are feasible and acceptable to people participating in the study, but does not determine whether this type of brain stimulation causes changes.
Study design
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Obsessive-compulsive disorder (OCD) | Other | Device: continuous theta-burst transcranial magnetic stimulation (cTBS) |
| Healthy Adult Participants | Other | Device: continuous theta-burst transcranial magnetic stimulation (cTBS) |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Current primary DSM-5 OCD diagnosis and current Y-BOCS total score of ≥16 (OCD group, only) or no current diagnosis of an emotional disorder, and no known history of OCD, PTSD, anxiety disorder(s), or recurrent major depressive disorder (Healthy participant group, only)
- 18-60 years of age
- ability to speak, read, write, and understand English sufficiently well to complete study procedures and provide informed consent
- psychotherapy and/or psychiatric medication use remain stable for 6 weeks prior to study entry
Key exclusion criteria (8 listed)
- Presence of current psychiatric diagnosis (healthy control group, only)
- active substance use disorder
- history of mania or hypomania, or lifetime presence of significant psychotic symptoms
- active suicidal or homicidal ideation
- use of medications known to reduce seizure threshold (e.g., stimulants)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| continuous theta-burst transcranial magnetic stimulation (cTBS)3 consecutive daily sessions of cTBS | Device | Healthy Adult Participants, Obsessive-compulsive disorder (OCD) |
Primary outcome
Rate of enrollment
Time frame: At study enrollment
Percent of screened participants who are determined to be eligible and enrolled.
2 secondary outcomes
Rates of visit completion
Time frame: From enrollment to date of post-TMS study visit (approximately 1 week)
Peak cTBS intensity tolerated
Time frame: From enrollment to end of TMS sessions (approximately 1 week)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Oct 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
A study testing continuous theta-burst transcranial magnetic stimulation (cTBS) in people with Obsessive-Compulsive Disorder (OCD), run by Dartmouth-Hitchcock Medical Center.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 2 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Rate of enrollment (time frame: At study enrollment). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Oct 2026.