Proprioceptive DisordersNCT07420608
Targeted Ankle Proprioceptive Training Improves Balance, Gait, and Functional Mobility in Chronic Stroke Survivors
A study testing Gait training in people with Proprioceptive Disorders and Balance; Distorted, run by Iqra National University at 1 site in Pakistan.
Trial summary
Stroke is a leading cause of long-term disability, with balance and gait deficits affecting >80% of survivors and increasing fall risk. Emerging evidence links ankle proprioceptive impairment-particularly inversion/eversion acuity-to these deficits, often bilateral and central in origin. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Proprioceptive Disorders, Balance; Distorted, Stroke Sequelae
- What is being tested?
- Gait training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 140 participants
- Where
- 1 sitePakistan
- Study dates
- 1 Jan 2023to 31 Dec 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Clinical diagnosis of chronic ischemic/hemorrhagic stroke (≥12 months post-stroke)
- Moderate-to-severe lower extremity impairment (Fugl-Meyer LE ≤28 or NIHSS motor leg ≥2)
- Documented ankle proprioceptive deficit (AMEDA AUC <0.7)
Who cannot join
- Acute medical issues (e.g., uncontrolled hypertension)
- Severe cognitive impairment (MMSE <24)
- Exercise contraindications
- Concurrent conflicting trials
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Targeted Ankle Proprioceptive Training Improves Balance, Gait, and Functional Mobility in Chronic Stroke Survivors: A Multicenter Randomized Controlled Trial With Longitudinal Follow Up
Stroke is a leading cause of long-term disability, with balance and gait deficits affecting >80% of survivors and increasing fall risk. Emerging evidence links ankle proprioceptive impairment-particularly inversion/eversion acuity-to these deficits, often bilateral and central in origin. Cross-sectional studies show strong associations, but causality, temporal progression, and intervention efficacy (especially in severe/non-ambulatory cases) remain unproven. This trial tests a targeted proprioceptive protocol against standard care.
Read the detailed description
Objectives: Primary: To evaluate the causal effect of 12-week targeted ankle proprioceptive training on weight-bearing ankle proprioception (AMEDA) in chronic stroke survivors.
Secondary: To assess effects on balance (Berg Balance Scale), gait speed (10m walk test), mobility (Timed Up and Go, Functional Ambulation Category), lower extremity motor function (Fugl-Meyer), and sustainability at 6-month follow-up. To describe longitudinal proprioceptive changes in a subsample from acute to chronic stages.
- Being tested
- Gait training
- Keywords
- stroke, stroke sequelae
- Medical subject headings
- Somatosensory Disorders, Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Gait trainingOther
Both groups: 12 weeks, 3 sessions/week × 60 min, supervised. Intervention Group (n=70): Progressive targeted ankle proprioceptive training
| Study group | Role | What they receive |
|---|---|---|
| Phase 1 (Weeks 1-4) | Active comparator | Robotic-assisted sensory discrimination (inversion/eversion, plantar/dorsiflexion; reduce angles, remove visual feedback). Receives: Other: Gait training |
| Phase 2 (Weeks 5-8) | Active comparator | Functional weight-bearing challenges (e.g., balance boards, textured surfaces, dynamic tasks). Receives: Other: Gait training |
| Phase 3 (Weeks 9-12) | Active comparator | Advanced integration (e.g., gait with proprioceptive cues, dual task) Receives: Other: Gait training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Primary outcome
Active Movement Extent Discrimination Apparatus for measuring propioceptive acuity
Measured: post-12 weeks, 6-month follow-up. Longitudinal subsample assessed from acute (<1 month) to chronic.
Secondary outcomes (1)
Secondary outcome
Berg Balance Scale for assessment of static balance and fall risk.
Measured: post-12 weeks, 6-month follow-up. Longitudinal subsample assessed from acute (<1 month) to chronic.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Feb 2026
- Study start1 Jan 2023
- Primary completion31 Dec 2024
- Study completion31 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Proprioceptive DisordersStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Multicenter, parallel-group, randomized controlled trial (RCT) with 1:1 allocation, assessor-blinded, intention-to-treat analysis. Includes a longitudinal observational subsample for acute-to-chronic proprioceptive changes.
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 140 participants (actual)
Sponsor and investigators
- Lead sponsor
- Iqra National University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Muslim khan, Iqra National University
- Investigators
- Ayman Abdullah Alhammad, Study director, Taibah University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07420608
- Sponsor's protocol ID
- Ref#: INU/REHAB/XC94
- Status last verified
- Feb 2026
- First submitted
- 4 Feb 2026
- Last updated
- 19 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Ethical concerns underlying data sharing will be adhered too
Publications
Khan M, Alhammad AA, Alghadier M, Alnasser SM, Alanazi AB, AlAidarous HAA, Moustafa EBS, Sharahily MA, Amri MI, Muteesasira E. Targeted ankle proprioceptive training improves balance, gait, and functional mobility in chronic stroke survivors: a multicenter randomized controlled trial with longitudinal follow-up. J Neuroeng Rehabil. 2026 May 29. doi: 10.1186/s12984-026-02031-5. Online ahead of print.
PubMed 42216149
Study at a glance
From the registry record, last updated by the sponsor on 19 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Targeted Ankle Proprioceptive Training Improves Balance, Gait, and Functional Mobility in Chronic Stroke Survivors: A Multicenter Randomized Controlled Trial With Longitudinal Follow Up
- ClinicalTrials.gov ID
- NCT07420608
- Acronym / sponsor ID
- Ref#: INU/REHAB/XC94
- Keywords
- stroke, stroke sequelae
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 140 participants (actual)
- Lead sponsor
- Iqra National UniversityUniversity, hospital or other
- Study start
- 1 Jan 2023 (actual)
- Primary completion
- 31 Dec 2024 (actual)
- Study completion
- 31 Dec 2025 (actual)
- First posted
- 19 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Stroke is a leading cause of long-term disability, with balance and gait deficits affecting >80% of survivors and increasing fall risk. Emerging evidence links ankle proprioceptive impairment-particularly inversion/eversion acuity-to these deficits, often bilateral and central in origin. Cross-sectional studies show strong associations, but causality, temporal progression, and intervention efficacy (especially in severe/non-ambulatory cases) remain unproven. This trial tests a targeted proprioceptive protocol against standard care.
Detailed description
Objectives: Primary: To evaluate the causal effect of 12-week targeted ankle proprioceptive training on weight-bearing ankle proprioception (AMEDA) in chronic stroke survivors.
Secondary: To assess effects on balance (Berg Balance Scale), gait speed (10m walk test), mobility (Timed Up and Go, Functional Ambulation Category), lower extremity motor function (Fugl-Meyer), and sustainability at 6-month follow-up. To describe longitudinal proprioceptive changes in a subsample from acute to chronic stages.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
- Model description
- Multicenter, parallel-group, randomized controlled trial (RCT) with 1:1 allocation, assessor-blinded, intention-to-treat analysis. Includes a longitudinal observational subsample for acute-to-chronic proprioceptive changes.
| Arm | Type | Receives |
|---|---|---|
| Phase 1 (Weeks 1-4) | Active comparator | Other: Gait trainingRobotic-assisted sensory discrimination (inversion/eversion, plantar/dorsiflexion; reduce angles, remove visual feedback). |
| Phase 2 (Weeks 5-8) | Active comparator | Other: Gait trainingFunctional weight-bearing challenges (e.g., balance boards, textured surfaces, dynamic tasks). |
| Phase 3 (Weeks 9-12) | Active comparator | Other: Gait trainingAdvanced integration (e.g., gait with proprioceptive cues, dual task) |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Clinical diagnosis of chronic ischemic/hemorrhagic stroke (≥12 months post-stroke)
- Moderate-to-severe lower extremity impairment (Fugl-Meyer LE ≤28 or NIHSS motor leg ≥2)
- Documented ankle proprioceptive deficit (AMEDA AUC <0.7)
Key exclusion criteria (4 listed)
- Acute medical issues (e.g., uncontrolled hypertension)
- Severe cognitive impairment (MMSE <24)
- Exercise contraindications
- Concurrent conflicting trials
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Gait trainingBoth groups: 12 weeks, 3 sessions/week × 60 min, supervised. Intervention Group (n=70): Progressive targeted ankle proprioceptive training | Other | Phase 1 (Weeks 1-4), Phase 2 (Weeks 5-8), Phase 3 (Weeks 9-12) |
Primary outcome
Primary outcome
Time frame: post-12 weeks, 6-month follow-up. Longitudinal subsample assessed from acute (<1 month) to chronic.
Active Movement Extent Discrimination Apparatus for measuring propioceptive acuity
1 secondary outcome
Secondary outcome
Time frame: post-12 weeks, 6-month follow-up. Longitudinal subsample assessed from acute (<1 month) to chronic.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Feb 2026.
- Derived from this study: PubMed 42216149Khan M, Alhammad AA, Alghadier M, Alnasser SM, Alanazi AB, AlAidarous HAA, Moustafa EBS, Sharahily MA, Amri MI, Muteesasira E. Targeted ankle proprioceptive training improves balance, gait, and functional mobility in chronic stroke survivors: a multicenter randomized controlled trial with longitudinal follow-up. J Neuroeng Rehabil. 2026 May 29. doi: 10.1186/s12984-026-02031-5. Online ahead of print.
- data setLink provided by the sponsor.
- Individual participant dataSharing planned: No. Ethical concerns underlying data sharing will be adhered too
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ayman Abdullah Alhammad study director
Taibah University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Gait training in people with Proprioceptive Disorders and Balance; Distorted, run by Iqra National University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 19 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Primary outcome (time frame: post-12 weeks, 6-month follow-up. Longitudinal subsample assessed from acute (<1 month) to chronic.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07420608, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Feb 2026.