Sedation During GI EndoscopyNCT07423676
Comparison Between Two Drugs in Sedation of Upper GI Endoscopy
An observational study of Sedation During GI Endoscopy, run by Zagazig University.
Trial summary
The goal of this clinical trial is to compare time of sedation between two drugs administered to patients undergoing upper gastrointestinal endoscopy Primary outcome : Time of sedation : is the time to reach sedation score of 5 according to modified Ramsay sedation score starting from the time of injecting bolts dose… Read more about this study
- Who is it for?
- Ages 21 to 60 years
- Conditions the study is for
- Sedation During GI Endoscopy
- How many people
- 52 participants
- Where
- No sites listed yet
- Study dates
- 1 Mar 2026to 2 May 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 to 60 years
- All sexes
- Adult
Study population: Adult patients not more than 60 years old with BMI < 35 kg/m2
Who may be able to join
- Patient acceptance
- Adults aged 21-60 years.
- Both sexes
- BMI<35 kg/m2
- ASA physical status :I\& II
- Patients Undergoing Gastrointestinal endoscopy
- Duration <30mintues
Who cannot join
- • Known allergy to any of the study drugs
- Unstable Cardiovascular disease
- Moderate to severe respiratory diseases
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Ketamine - Dexmedetomidine(Ketodex) Versus Propofol -Midazolam for Sedation in Patients Undergoing Upper Gastrointestinal Endoscopy
The goal of this clinical trial is to compare time of sedation between two drugs administered to patients undergoing upper gastrointestinal endoscopy Primary outcome : Time of sedation : is the time to reach sedation score of 5 according to modified Ramsay sedation score starting from the time of injecting bolts dose of study drugs
Secondary outcome :
- Recovery time :is the time to reach score 2 of modified Ramsay sedation score starting from injecting bolus dose of study drugs .
- Hemodynamics (MAP,HR) \& oxygen saturation
- Drug side effects (nausea,vomitting,agitation)
- Endoscopist satisfaction
- Conditions
- Sedation During GI Endoscopy
- Keywords
- Sedation
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Ketamine dexmetamodine and propofol midazolam | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
Comparison between time of sedation between ketamine Dexametomidine and propofol midazolam in sedation of GI endoscopy
Time of sedation :is the time to reach sedation score of 5 according to modified Ramsay sedation score starting from the time of injecting bolts dose of study drugs
Measured: Baseline
Comparison time of sedation between ketamine Dexametomidine and propofol midazolam in sedation of GI endoscopy
Time of sedation:is the time to reach sedation score of 5 according to modified Ramsay sedation score starting from the time of injecting bolts dose of study drugs
Measured: Baseline
Comparison of time of sedation between ketamine Dexametomidine g
- Time of sedation :is the time to reach score 5 of modified Ramsay sedation score starting from injecting bolus dose of study drugs .
Measured: Basline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Feb 2026
- Study start1 Mar 2026 (estimated)
- Primary completion2 May 2026 (estimated)
- Study completion2 May 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Sedation During GI EndoscopyStudies of the same condition, open and under way.
- More trials run by Zagazig UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 52 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Zagazig University
- Sponsor type
- Other government
- Responsible party
- Sponsor
- Investigators
- Doaa Mohamed Farid, MD, Principal investigator, Doaa mohamed FaridRehab Abdalla Wahdan, MD, Study director, Rehab Abdalla WahdanOlfat Monium Abraham, MD, Principal investigator, Olfat abdelmonium Ebrahim
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07423676
- Sponsor's protocol ID
- Sedation in GI endoscopy
- Status last verified
- Feb 2026
- First submitted
- 14 Feb 2026
- Last updated
- 20 Feb 2026
- Results posted
- No
- Individual data sharing
- No
Publications
Rey JF. Sedation for upper gastrointestinal endoscopy: as much as possible, or without? Endoscopy. 1996 Mar;28(3):308-9. doi: 10.1055/s-2007-1005460. No abstract available.
PubMed 8781797Sachdeva A, Bhalla A, Sood A, Duseja A, Gupta V. The effect of sedation during upper gastrointestinal endoscopy. Saudi J Gastroenterol. 2010 Oct-Dec;16(4):280-4. doi: 10.4103/1319-3767.70616.
PubMed 20871194
Study at a glance
From the registry record, last updated by the sponsor on 20 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Ketamine - Dexmedetomidine(Ketodex) Versus Propofol -Midazolam for Sedation in Patients Undergoing Upper Gastrointestinal Endoscopy
- ClinicalTrials.gov ID
- NCT07423676
- Acronym / sponsor ID
- Sedation in GI endoscopy
- Conditions
- Sedation During GI Endoscopy
- Keywords
- Sedation
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 52 participants (estimated)
- Lead sponsor
- Zagazig UniversityOther government
- Study start
- 1 Mar 2026 (estimated)
- Primary completion
- 2 May 2026 (estimated)
- Study completion
- 2 May 2026 (estimated)
- First posted
- 20 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to compare time of sedation between two drugs administered to patients undergoing upper gastrointestinal endoscopy Primary outcome : Time of sedation : is the time to reach sedation score of 5 according to modified Ramsay sedation score starting from the time of injecting bolts dose of study drugs
Secondary outcome :
- Recovery time :is the time to reach score 2 of modified Ramsay sedation score starting from injecting bolus dose of study drugs .
- Hemodynamics (MAP,HR) \& oxygen saturation
- Drug side effects (nausea,vomitting,agitation)
- Endoscopist satisfaction
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Ketamine dexmetamodine and propofol midazolam | – | – |
Who may qualify
- Ages
- 21 to 60 years
- Sex
- All
- Age groups
- Adult
- Study population
- Adult patients not more than 60 years old with BMI < 35 kg/m2
Key inclusion criteria (7 listed)
- Patient acceptance
- Adults aged 21-60 years.
- Both sexes
- BMI<35 kg/m2
- ASA physical status :I\& II
Key exclusion criteria (3 listed)
- • Known allergy to any of the study drugs
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Comparison between time of sedation between ketamine Dexametomidine and propofol midazolam in sedation of GI endoscopy
Time frame: Baseline
Time of sedation :is the time to reach sedation score of 5 according to modified Ramsay sedation score starting from the time of injecting bolts dose of study drugs
Comparison time of sedation between ketamine Dexametomidine and propofol midazolam in sedation of GI endoscopy
Time frame: Baseline
Time of sedation:is the time to reach sedation score of 5 according to modified Ramsay sedation score starting from the time of injecting bolts dose of study drugs
Comparison of time of sedation between ketamine Dexametomidine g
Time frame: Basline
• Time of sedation :is the time to reach score 5 of modified Ramsay sedation score starting from injecting bolus dose of study drugs .
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Feb 2026.
- Background: PubMed 8781797Rey JF. Sedation for upper gastrointestinal endoscopy: as much as possible, or without? Endoscopy. 1996 Mar;28(3):308-9. doi: 10.1055/s-2007-1005460. No abstract available.
- Background: PubMed 20871194Sachdeva A, Bhalla A, Sood A, Duseja A, Gupta V. The effect of sedation during upper gastrointestinal endoscopy. Saudi J Gastroenterol. 2010 Oct-Dec;16(4):280-4. doi: 10.4103/1319-3767.70616.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Doaa Mohamed Farid, MD principal investigator
Doaa mohamed Farid
Rehab Abdalla Wahdan, MD study director
Rehab Abdalla Wahdan
Olfat Monium Abraham, MD principal investigator
Olfat abdelmonium Ebrahim
Questions about this trial
What is this clinical trial studying?
An observational study of Sedation During GI Endoscopy, run by Zagazig University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 20 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Ahmed Esam Hamad, Register (+201095529439, tahawy188@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Comparison between time of sedation between ketamine Dexametomidine and propofol midazolam in sedation of GI endoscopy (time frame: Baseline). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07423676, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Feb 2026.