VibrationVIBMOTNCT07424066
Non-invasive Vibratory Stimulation of the Knee Muscles for the Improvement of the Somatosensory Input and Motor Performance
A study testing Vibratory stimulation in people with Vibration, run by University of Milano Bicocca at 1 site in Italy.
Trial summary
The goal of this interventional cross-sectional study is to evaluate motor responses to non-invasive vibratory stimulation applied to the hamstring muscle tendons in healthy individuals. Knee flexion and extension efforts, in both isometric and concentric contractions, will be tested. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Vibration
- What is being tested?
- Vibratory stimulation
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 35 participants
- Where
- 1 siteItaly
- Study dates
- 20 May 2025to 31 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age equal to or greater than 18 years.
Who cannot join
- Neurological disorders.
- Musculoskeletal injuries, including previous ones, that may compromise the execution of required movements.
- Cardiorespiratory disorders.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Italy1 site, 1 recruiting
- Recruiting
Istituto Auxologico Italiano, Clinica Capitanio
Milan, Milan, 20122
Stefano Scarano, Medical doctor, +3902619116717, s.scarano@auxologico.it
Cristiano Alessandro, Engineer, cristiano.alessandro@unimib.it
About this study
Official title: Stimolazione Vibratoria Non-invasiva Per il Miglioramento Del Ritorno Sensoriale e Della Performance Motoria in Atleti Con Lesione al Legamento Crociato Anteriore
The goal of this interventional cross-sectional study is to evaluate motor responses to non-invasive vibratory stimulation applied to the hamstring muscle tendons in healthy individuals. Knee flexion and extension efforts, in both isometric and concentric contractions, will be tested.
The investigators hypothesize that vibratory stimulation causes an increase in activity in the flexor muscles (hamstrings) and a decrease in the extensor muscles (quadriceps) of the knee in all motor tasks. It follows that during knee flexion (both concentric and isometric), vibratory stimulation should cause an increase in the distance between the angular trajectories of the knee obtained with and without vibratory stimulation (with a positive sign). The increased activity of the hamstring muscles would, in fact, contribute to increasing the velocity of the flexor movement. Conversely, during extensor movements (both concentric and isometric), vibratory stimulation should reduce the instantaneous velocity of the movement, therefore causing an increase in distance (with a negative sign) between the trajectories obtained with and without stimulation.
Participants will be tested using an isokinetic dynamometer and they will be asked to perform the following motor tasks in a random order: concentric knee flexion, concentric knee extension, isometric knee flexion, and isometric knee extension. The dominant limb will be tested, only. The assessment will be performed one time.
- Conditions
- Vibration
- Being tested
- Vibratory stimulation
- Keywords
- vibratory stimulation, muscle spindle, muscle contraction, spinal reflex, somatosensory system
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Vibratory stimulationDevice
A vibratory stimulator will be applied to the back of the dominant leg, at the level of the hamstring muscle tendons. The stimulator consists of two small vibrating boxes fixed to the leg by means of an elastic band.
| Study group | Role | What they receive |
|---|---|---|
| Healthy participants | Experimental | Healthy participants will perform motor tasks with the dominant lower limb, consisting in knee flexion and extension movements in isometric and concentric conditions. The motor tasks will be performed while a vibratory stimulation is applied to hamstring tendons (treatment) and without vibratory stimulation (control) to assess motor responses. Receives: Device: Vibratory stimulation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Knee angle
Maximum distance (in degrees) between the knee trajectory obtained with and without vibratory stimulation.
Measured: Day 1.
Surface electromyography (sEMG)
Difference in sEMG between the muscle activity with and without vibratory stimulation, for each muscle (i.e., Quadriceps, Hamstrings, and Plantarflexor muscles).
Measured: Day 1.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Feb 2026
- Study start20 May 2025
- Primary completion31 Dec 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for VibrationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 35 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Milano Bicocca
- Sponsor type
- University, hospital or other
- Collaborators
- Istituto Auxologico Italiano
- Responsible party
- Sponsor
- Investigators
- Cristiano Alessandro, Engineering, Principal investigator, University of Milano Bicocca
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07424066
- Sponsor's protocol ID
- Prot. Nr. 138/25
- Acronym
- VIBMOT
- Status last verified
- Oct 2025
- First submitted
- 6 Feb 2026
- Last updated
- 20 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 20 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Stimolazione Vibratoria Non-invasiva Per il Miglioramento Del Ritorno Sensoriale e Della Performance Motoria in Atleti Con Lesione al Legamento Crociato Anteriore
- ClinicalTrials.gov ID
- NCT07424066
- Acronym / sponsor ID
- VIBMOT / Prot. Nr. 138/25
- Conditions
- Vibration
- Keywords
- vibratory stimulation, muscle spindle, muscle contraction, spinal reflex, somatosensory system
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 35 participants (estimated)
- Lead sponsor
- University of Milano BicoccaUniversity, hospital or other
- Collaborators
- Istituto Auxologico Italiano
- Study start
- 20 May 2025 (actual)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 20 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this interventional cross-sectional study is to evaluate motor responses to non-invasive vibratory stimulation applied to the hamstring muscle tendons in healthy individuals. Knee flexion and extension efforts, in both isometric and concentric contractions, will be tested.
The investigators hypothesize that vibratory stimulation causes an increase in activity in the flexor muscles (hamstrings) and a decrease in the extensor muscles (quadriceps) of the knee in all motor tasks. It follows that during knee flexion (both concentric and isometric), vibratory stimulation should cause an increase in the distance between the angular trajectories of the knee obtained with and without vibratory stimulation (with a positive sign). The increased activity of the hamstring muscles would, in fact, contribute to increasing the velocity of the flexor movement. Conversely, during extensor movements (both concentric and isometric), vibratory stimulation should reduce the instantaneous velocity of the movement, therefore causing an increase in distance (with a negative sign) between the trajectories obtained with and without stimulation.
Participants will be tested using an isokinetic dynamometer and they will be asked to perform the following motor tasks in a random order: concentric knee flexion, concentric knee extension, isometric knee flexion, and isometric knee extension. The dominant limb will be tested, only. The assessment will be performed one time.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Healthy participants | Experimental | Device: Vibratory stimulationHealthy participants will perform motor tasks with the dominant lower limb, consisting in knee flexion and extension movements in isometric and concentric conditions. The motor tasks will be performed while a vibratory stimulation is applied to hamstring tendons (treatment) and without vibratory stimulation (control) to assess motor responses. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Age equal to or greater than 18 years.
Key exclusion criteria (3 listed)
- Neurological disorders.
- Musculoskeletal injuries, including previous ones, that may compromise the execution of required movements.
- Cardiorespiratory disorders.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Vibratory stimulationA vibratory stimulator will be applied to the back of the dominant leg, at the level of the hamstring muscle tendons. The stimulator consists of two small vibrating boxes fixed to the leg by means of an elastic band. | Device | Healthy participants |
Primary outcome
Knee angle
Time frame: Day 1.
Maximum distance (in degrees) between the knee trajectory obtained with and without vibratory stimulation.
Surface electromyography (sEMG)
Time frame: Day 1.
Difference in sEMG between the muscle activity with and without vibratory stimulation, for each muscle (i.e., Quadriceps, Hamstrings, and Plantarflexor muscles).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Feb 2026.
- Individual participant dataSharing planned: Undecided
Related trials for Vibration
Active, not recruitingPhase 4
Effects of Sequential Therapy With Mexidol® (Intravenous) and Mexidol® FORTE 250 (Oral) on Functional Brain Activity Assessed by Functional Magnetic Resonance Imaging and Biochemical Parameters in Patients With Chronic Cerebral Ischemia: A Comparison of Patients With and Without Metabolic Disorders
Metabolic Abnormalities, Obesity & Overweight
Not yet recruiting
Smartphone Camera Measurement of Breathing-Related Heart Rate Variability Compared With ECG in Healthy Adults
Respiratory Sinus Arrhythmia, Heart Rate Variability
Not yet recruiting
Effects of Whole-Body Vibration and Cervical Stabilization With Core Stabilization in Young Adults With Non-Specific Low Back Pain
Nonspecific Low Back Pain
RecruitingPhase 4
Improving Morning Strength and Cognitive Performance Using Caffeine or Whole-body Vibration.
Vibration Therapy, Caffeine
Not yet recruiting
Stair Biomechanics and Vibration Study After ACLR
Anterior Cruciate Ligament Reconstruction (ACLR), Anterior Cruciate Ligament Injury
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Cristiano Alessandro, Engineering principal investigator
University of Milano Bicocca
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Vibratory stimulation in people with Vibration, run by University of Milano Bicocca at 1 site in Italy.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 20 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Italy. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Stefano Scarano, Medical Doctor (+3902619116717, s.scarano@auxologico.it), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Knee angle (time frame: Day 1.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Feb 2026.