StrokeNCT07424105
Effect of Optokinetic Stimulation on Spatial Neglect and Postural Stability in Patients With Stroke
A study testing Optokinetic stimulation and Traditional therapy in people with Stroke, run by Cairo University at 1 site in Egypt.
Trial summary
The purpose of this study is to investigate the efficacy of optokinetic stimulation in stroke patients by examining its effects on spatial neglect, static balance, dynamic balance, and weight-bearing symmetry. Read more about this study
- Who is it for?
- Ages 50 to 65 years
- Conditions the study is for
- Stroke
- What is being tested?
- Optokinetic stimulation and Traditional therapy
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 30 participants
- Where
- 1 siteEgypt
- Study dates
- 20 Feb 2026to 15 May 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patient's age ranges from 50 to 65 years referred by neurologist.
- Patient's will be diagnosed as stroke in the subacute stage
- Patients will suffer from spatial neglect resulting from the stroke that screened by albert's test.
- Patients are medically stable and able to understand and follow instructions.
Who cannot join
- There is any previous neurological disability
- There is general unstable conditions, history of epilepsy, cardiac pacemakers
- There is sever cognitive disorder
- There is visual field deficit
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Nagwa Ibrahim Rehab, PhD contact
Egypt1 site
Nahda University
Banī Suwayf
Abeer Abdelmoghney Mohamed, M.Sc, +20 10 20139616, berrotheprof9@gmail.com
About this study
The purpose of this study is to investigate the efficacy of optokinetic stimulation in stroke patients by examining its effects on spatial neglect, static balance, dynamic balance, and weight-bearing symmetry.
Read the detailed description
In stroke patients the presence of spatial neglect predicts poor outcome in functional recovery, entailing a longer time of hospitalization, greater functional dependency, increased risk of falls and a long-term disability in Activities of Daily Living (ADL). This results in an overall increase of costs for the health system.
Spatial neglect patients' performance in self-care and household is usually compromised. Those patients had more problems in performing self-care and household tasks than non-spatially neglected patients. For example, spatial neglect patients forgot or could not find objects at one side when dressing or in the kitchen and had difficulty eating or using devices. VSN severity had a negative impact on the performance of ADL. Spatial neglect had a negative impact on walking and wheelchair navigation. Spatial neglect had a negative impact on exercise such as walking and jogging .
Patients with spatial neglect had an increased weight-bearing asymmetry favouring the non-paretic leg and increased mediolateral CoP excursions while standing. However, upright standing is an inherently more demanding posture owing to the height of the center of mass relative to the base of support.
Because of all those effects of spatial neglect on outcomes, it is a necessity to engage more neurological rehabilitative procedures focusing on neglect and its complications. One of the treatments used for neglect is optokinetic stimulation (OKS).
The vestibular apparatus is the primary organ of balance which is used mainly during motion when compared to somatosensation. Optokinetic stimulation is known to stimulate areas of the brain such as the brain stem and cerebellum that immediately process balance signals from the vestibular apparatus before they are transmitted to the cerebral cortex via the thalamus. Optokinetic chart stimulation has been reported to restore voluntary movement and mobility in an acute hemorrhagic stroke as well as restore postural control and independent mobility in an acute, ataxic, posterior temporal parietal ischemic stroke.
So, this study will be conducted to investigate the effect of optokinetic stimulation on neglect and balance measures in stroke patients rehabilitation.
- Conditions
- Stroke
- Being tested
- Optokinetic stimulation, Sham optokinetic stimulation, Traditional therapy
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Optokinetic stimulationOther
Patients will receive optokinetic stimulation (OKS) as an intervention for spatial neglect, based on observing moving visual stimuli to promote visual scanning of the neglected hemispace. With the patient properly positioned, the physiotherapist will apply virtual reality glasses supported by a mobile device displaying pre-prepared OKS videos. The videos will show vertical bars moving leftward at a fixed speed of 1 cm/s, with random color changes to maintain attention. Patients will be instructed to report each color change. OKS will be delivered in five 4-minute bouts separated by 1-minute rest intervals, totaling 20 minutes per session.
Sham optokinetic stimulationOther
A static image consisting of black-and-white vertical bars will be projected for patients in this group. The bars will undergo random color changes similar to those used in the intervention group; however, no movement will be present.
Traditional therapyOther
All participants in both groups will receive a selected physical therapy program for 30 min per session to enhance balance for 10 weeks.
| Study group | Role | What they receive |
|---|---|---|
| Optokinetic stimulation + Traditional therapy | Experimental | Patients in this group will receive optokinetic stimulation and traditional therapy, twice weekly over a period of 10 weeks. Receives: Other: Optokinetic stimulation; Other: Traditional therapy |
| Sham optokinetic stimulation + Traditional therapy | Sham comparator | Patients in this group will receive sham optokinetic stimulation and traditional therapy, twice weekly over a period of 10 weeks. Receives: Other: Sham optokinetic stimulation; Other: Traditional therapy |
What is being measured
The primary outcome is the main question the study is designed to answer.
Albert test
It is the test used for screening of unilateral spatial neglect .the examiner asked to cross all the lines. The more un crossed lines the worst degree of spatial neglect.
Measured: 10 weeks
Catherine bergego scale (CGS)
It is a 4 point scale used to indicate the severity of neglect .the total score out of 30 . the higher scores indicate the more severe the spatial neglect
Measured: 10 weeks
Secondary outcomes (3)
Limit of stability (LOS)
It measures the examiner ability to shift center of gravity in eight directions. Lower scores indicated lower abilities to maintain dynamic balance.
Measured: 10 weeks
The Modified clinical test of sensory interaction on balance (m CTSIB)
It measures sensory integration and its effect on stability and static balance. The higher scores indicates higher control.
Measured: 10 weeks
Center of pressure
It examiner would maintain his center of pressure in the center of illustrated figure on the screen of HUMAC system . the longer the patient can maintain static balance the more control and stability patient has.
Measured: 10 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Feb 2026
- Study start20 Feb 2026 (estimated)
- Primary completion5 May 2026 (estimated)
- Study completion15 May 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for StrokeStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 30 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Abeer Abdelmoghney Mohamed, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07424105
- Sponsor's protocol ID
- P.T.REC/012/005508
- Status last verified
- Feb 2026
- First submitted
- 14 Feb 2026
- Last updated
- 20 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Optokinetic Stimulation on Spatial Neglect and Postural Stability in Patients With Stroke
- ClinicalTrials.gov ID
- NCT07424105
- Acronym / sponsor ID
- P.T.REC/012/005508
- Conditions
- Stroke
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 30 participants (estimated)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 20 Feb 2026 (estimated)
- Primary completion
- 5 May 2026 (estimated)
- Study completion
- 15 May 2026 (estimated)
- First posted
- 20 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to investigate the efficacy of optokinetic stimulation in stroke patients by examining its effects on spatial neglect, static balance, dynamic balance, and weight-bearing symmetry.
Detailed description
In stroke patients the presence of spatial neglect predicts poor outcome in functional recovery, entailing a longer time of hospitalization, greater functional dependency, increased risk of falls and a long-term disability in Activities of Daily Living (ADL). This results in an overall increase of costs for the health system.
Spatial neglect patients' performance in self-care and household is usually compromised. Those patients had more problems in performing self-care and household tasks than non-spatially neglected patients. For example, spatial neglect patients forgot or could not find objects at one side when dressing or in the kitchen and had difficulty eating or using devices. VSN severity had a negative impact on the performance of ADL. Spatial neglect had a negative impact on walking and wheelchair navigation. Spatial neglect had a negative impact on exercise such as walking and jogging .
Patients with spatial neglect had an increased weight-bearing asymmetry favouring the non-paretic leg and increased mediolateral CoP excursions while standing. However, upright standing is an inherently more demanding posture owing to the height of the center of mass relative to the base of support.
Because of all those effects of spatial neglect on outcomes, it is a necessity to engage more neurological rehabilitative procedures focusing on neglect and its complications. One of the treatments used for neglect is optokinetic stimulation (OKS).
The vestibular apparatus is the primary organ of balance which is used mainly during motion when compared to somatosensation. Optokinetic stimulation is known to stimulate areas of the brain such as the brain stem and cerebellum that immediately process balance signals from the vestibular apparatus before they are transmitted to the cerebral cortex via the thalamus. Optokinetic chart stimulation has been reported to restore voluntary movement and mobility in an acute hemorrhagic stroke as well as restore postural control and independent mobility in an acute, ataxic, posterior temporal parietal ischemic stroke.
So, this study will be conducted to investigate the effect of optokinetic stimulation on neglect and balance measures in stroke patients rehabilitation.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Optokinetic stimulation + Traditional therapy | Experimental | Other: Optokinetic stimulation, Other: Traditional therapyPatients in this group will receive optokinetic stimulation and traditional therapy, twice weekly over a period of 10 weeks. |
| Sham optokinetic stimulation + Traditional therapy | Sham comparator | Other: Sham optokinetic stimulation, Other: Traditional therapyPatients in this group will receive sham optokinetic stimulation and traditional therapy, twice weekly over a period of 10 weeks. |
Who may qualify
- Ages
- 50 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Patient's age ranges from 50 to 65 years referred by neurologist.
- Patient's will be diagnosed as stroke in the subacute stage
- Patients will suffer from spatial neglect resulting from the stroke that screened by albert's test.
- Patients are medically stable and able to understand and follow instructions.
Key exclusion criteria (4 listed)
- There is any previous neurological disability
- There is general unstable conditions, history of epilepsy, cardiac pacemakers
- There is sever cognitive disorder
- There is visual field deficit
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Optokinetic stimulationPatients will receive optokinetic stimulation (OKS) as an intervention for spatial neglect, based on observing moving visual stimuli to promote visual scanning of the neglected hemispace. With the patient properly positioned, the physiotherapist will apply virtual reality glasses supported by a mobile device displaying pre-prepared OKS videos. The videos will show vertical bars moving leftward at a fixed speed of 1 cm/s, with random color changes to maintain attention. Patients will be instructed to report each color change. OKS will be delivered in five 4-minute bouts separated by 1-minute rest intervals, totaling 20 minutes per session. | Other | Optokinetic stimulation + Traditional therapy |
| Sham optokinetic stimulationA static image consisting of black-and-white vertical bars will be projected for patients in this group. The bars will undergo random color changes similar to those used in the intervention group; however, no movement will be present. | Other | Sham optokinetic stimulation + Traditional therapy |
| Traditional therapyAll participants in both groups will receive a selected physical therapy program for 30 min per session to enhance balance for 10 weeks. | Other | Optokinetic stimulation + Traditional therapy, Sham optokinetic stimulation + Traditional therapy |
Primary outcome
Albert test
Time frame: 10 weeks
It is the test used for screening of unilateral spatial neglect .the examiner asked to cross all the lines. The more un crossed lines the worst degree of spatial neglect.
Catherine bergego scale (CGS)
Time frame: 10 weeks
It is a 4 point scale used to indicate the severity of neglect .the total score out of 30 . the higher scores indicate the more severe the spatial neglect
3 secondary outcomes
Limit of stability (LOS)
Time frame: 10 weeks
The Modified clinical test of sensory interaction on balance (m CTSIB)
Time frame: 10 weeks
Center of pressure
Time frame: 10 weeks
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Feb 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Nagwa Ibrahim Rehab, PhD contact
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Optokinetic stimulation and Traditional therapy in people with Stroke, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 20 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Abeer Abdelmoghney Mohamed, M.Sc (+20 10 20139616, berrotheprof9@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Albert test (time frame: 10 weeks). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Feb 2026.