PeriodontitisNCT07424300
Olfactory Function and Oral Malodor in Periodontitis Before and After Periodontal Therapy
A study testing Scaling and Root Planing (SRP) in people with Periodontitis and Olfactory Dysfunction, run by Batman University at 1 site in Turkey (Türkiye).
Trial summary
This prospective cohort study investigated the relationship between oral malodor and olfactory function in adults with generalized periodontitis. A total of 101 patients were evaluated before and after routine nonsurgical periodontal therapy. Read more about this study
- Who is it for?
- Ages 18 to 55 years
- Conditions the study is for
- Periodontitis, Olfactory Dysfunction, Halitosis
- What is being tested?
- Scaling and Root Planing (SRP)
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 101 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 3 Dec 2025to 20 Mar 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Adults aged 18-55 years
- Diagnosis of generalized periodontitis
- Complaint of halitosis
- At least 15 natural teeth
Who cannot join
- Self-reported smell loss or change within 2 weeks prior to baseline
- Antibiotic or anti-inflammatory drug use for more than 7 days within the previous 6 weeks
- Presence of upper respiratory tract infection
- Unrestored advanced dental caries
- History of COVID-19 infection
- Pregnancy
- Smoking was not an exclusion criterion.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Chemosensory Dysfunction and Oral Inflammation: A Prospective Interventional Study on Periodontitis and Post-Treatment Olfactory Recovery
This prospective cohort study investigated the relationship between oral malodor and olfactory function in adults with generalized periodontitis. A total of 101 patients were evaluated before and after routine nonsurgical periodontal therapy. Volatile sulfur compound (VSC) levels and psychophysical olfactory performance using the Sniffin' Sticks test (TDI score) were measured at baseline and one week after completion of three sessions of scaling and root planing (SRP). The study aimed to determine whether reduction of oral inflammation and halitosis is associated with improvement in olfactory performance.
Read the detailed description
Generalized periodontitis is a chronic inflammatory disease associated with increased production of volatile sulfur compounds (VSCs), contributing to halitosis. Elevated intraoral malodor may interfere with olfactory perception through masking effects and inflammatory mechanisms.
Participants diagnosed with generalized periodontitis and complaining of halitosis underwent routine nonsurgical periodontal therapy consisting of three sessions of scaling and root planing performed at one-week intervals. Olfactory function (threshold, discrimination, identification; total TDI score) and total VSC concentrations were assessed at baseline (prior to first session) and one week after completion of the third session.
The study evaluated changes in chemosensory function and halitosis parameters following periodontal therapy and analyzed correlations between baseline VSC levels and olfactory performance.
- Conditions
- Periodontitis, Olfactory Dysfunction, Halitosis
- Being tested
- Scaling and Root Planing (SRP)
- Medical subject headings
- Periodontitis, Halitosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Scaling and Root Planing (SRP)Procedure or surgery
Full-mouth non-surgical periodontal therapy consisting of scaling and root planing (SRP) performed using ultrasonic scalers and hand curettes. The therapy is administered over three sessions spanning three weeks to achieve thorough debridement of subgingival dysbiotic biofilm and calculus, alongside tongue cleaning instruction.
| Study group | Role | What they receive |
|---|---|---|
| Non-Surgical Periodontal Therapy | Experimental | All enrolled patients with generalized periodontitis receive non-surgical periodontal therapy consisting of full-mouth scaling and root planing (SRP) administered over three sessions across three weeks. Receives: Procedure: Scaling and Root Planing (SRP) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Total TDI Score
Change in psychophysical olfactory performance measured by the Sniffin' Sticks Test (Threshold-Discrimination-Identification composite score).
The Sniffin' Sticks Test total TDI score ranges from 1 to 48, calculated as the sum of:
- Odor Threshold (1-16).
- Odor Discrimination (0-16).
- Odor Identification (0-16).
Higher scores indicate better olfactory function.
Measured: Baseline to 1 week after completion of third SRP session (approximately 4 weeks total)
Change in Total Volatile Sulfur Compound (tVSC) Levels
Change in total volatile sulfur compound (tVSC) concentration measured using the OralChroma portable gas chromatograph device.
tVSC levels are reported in parts per billion (ppb). Higher values indicate greater halitosis severity (worse outcome).
Measured: Baseline to 1 week after completion of third SRP session
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Feb 2026
- Study start3 Dec 2025
- Primary completion20 Mar 2026
- Study completion20 Mar 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for PeriodontitisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- All participants diagnosed with generalized periodontitis received the identical intervention, which consisted of non-surgical periodontal therapy (full-mouth scaling and root planing) performed over three sessions. Pre-treatment baseline measurements were compared with post-treatment outcomes within the same single cohort.
- Masking
- None (open label)
- Enrolment
- 101 participants (actual)
Sponsor and investigators
- Lead sponsor
- Batman University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mustafa Baran, Batman University
- Investigators
- Mustafa Baran, Asst. Prof., Principal investigator, Batman University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07424300
- Sponsor's protocol ID
- 2024/08-03
- Status last verified
- Oct 2026
- First submitted
- 13 Feb 2026
- Last updated
- 20 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared due to privacy considerations and institutional data protection policies.
Study at a glance
From the registry record, last updated by the sponsor on 20 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Chemosensory Dysfunction and Oral Inflammation: A Prospective Interventional Study on Periodontitis and Post-Treatment Olfactory Recovery
- ClinicalTrials.gov ID
- NCT07424300
- Acronym / sponsor ID
- 2024/08-03
- Conditions
- Periodontitis, Olfactory Dysfunction, Halitosis
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 101 participants (actual)
- Lead sponsor
- Batman UniversityUniversity, hospital or other
- Study start
- 3 Dec 2025 (actual)
- Primary completion
- 20 Mar 2026 (actual)
- Study completion
- 20 Mar 2026 (actual)
- First posted
- 20 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective cohort study investigated the relationship between oral malodor and olfactory function in adults with generalized periodontitis. A total of 101 patients were evaluated before and after routine nonsurgical periodontal therapy. Volatile sulfur compound (VSC) levels and psychophysical olfactory performance using the Sniffin' Sticks test (TDI score) were measured at baseline and one week after completion of three sessions of scaling and root planing (SRP). The study aimed to determine whether reduction of oral inflammation and halitosis is associated with improvement in olfactory performance.
Detailed description
Generalized periodontitis is a chronic inflammatory disease associated with increased production of volatile sulfur compounds (VSCs), contributing to halitosis. Elevated intraoral malodor may interfere with olfactory perception through masking effects and inflammatory mechanisms.
Participants diagnosed with generalized periodontitis and complaining of halitosis underwent routine nonsurgical periodontal therapy consisting of three sessions of scaling and root planing performed at one-week intervals. Olfactory function (threshold, discrimination, identification; total TDI score) and total VSC concentrations were assessed at baseline (prior to first session) and one week after completion of the third session.
The study evaluated changes in chemosensory function and halitosis parameters following periodontal therapy and analyzed correlations between baseline VSC levels and olfactory performance.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- All participants diagnosed with generalized periodontitis received the identical intervention, which consisted of non-surgical periodontal therapy (full-mouth scaling and root planing) performed over three sessions. Pre-treatment baseline measurements were compared with post-treatment outcomes within the same single cohort.
| Arm | Type | Receives |
|---|---|---|
| Non-Surgical Periodontal Therapy | Experimental | Procedure: Scaling and Root Planing (SRP)All enrolled patients with generalized periodontitis receive non-surgical periodontal therapy consisting of full-mouth scaling and root planing (SRP) administered over three sessions across three weeks. |
Who may qualify
- Ages
- 18 to 55 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Adults aged 18-55 years
- Diagnosis of generalized periodontitis
- Complaint of halitosis
- At least 15 natural teeth
Key exclusion criteria (7 listed)
- Self-reported smell loss or change within 2 weeks prior to baseline
- Antibiotic or anti-inflammatory drug use for more than 7 days within the previous 6 weeks
- Presence of upper respiratory tract infection
- Unrestored advanced dental caries
- History of COVID-19 infection
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Scaling and Root Planing (SRP)Full-mouth non-surgical periodontal therapy consisting of scaling and root planing (SRP) performed using ultrasonic scalers and hand curettes. The therapy is administered over three sessions spanning three weeks to achieve thorough debridement of subgingival dysbiotic biofilm and calculus, alongside tongue cleaning instruction. | Procedure or surgery | Non-Surgical Periodontal Therapy |
Primary outcome
Change in Total TDI Score
Time frame: Baseline to 1 week after completion of third SRP session (approximately 4 weeks total)
Change in psychophysical olfactory performance measured by the Sniffin' Sticks Test (Threshold-Discrimination-Identification composite score). The Sniffin' Sticks Test total TDI score ranges from 1 to 48, calculated as the sum of: * Odor Threshold (1-16). * Odor Discrimination (0-16). * Odor Identification (0-16). Higher scores indicate better olfactory function.
Change in Total Volatile Sulfur Compound (tVSC) Levels
Time frame: Baseline to 1 week after completion of third SRP session
Change in total volatile sulfur compound (tVSC) concentration measured using the OralChroma portable gas chromatograph device. tVSC levels are reported in parts per billion (ppb). Higher values indicate greater halitosis severity (worse outcome).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Oct 2026.
- Individual participant dataSharing planned: No. Individual participant data will not be shared due to privacy considerations and institutional data protection policies.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Mustafa Baran, Asst. Prof. principal investigator
Batman University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Scaling and Root Planing (SRP) in people with Periodontitis and Olfactory Dysfunction, run by Batman University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 20 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Total TDI Score (time frame: Baseline to 1 week after completion of third SRP session (approximately 4 weeks total)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Oct 2026; AzTrials last refreshed its copy on 1 Nov 2026.