StrokeNCT07425756
taVNS Combined With TENS on Motor Function in Stroke
A study testing transcutaneous auricular vagus nerve stimulation, transcutaneous electrical nerve stimulation and task-oriented training in people with Stroke, run by The Hong Kong Polytechnic University at 1 site in Hong Kong.
Trial summary
the current study is a Blinded Randomised Controlled Trial investing the effectiveness of Combining Transcutaneous Vagus Nerve Stimulation with Peripheral Nerve Stimulation on Upper Limb Motor Function in People with Stroke Read more about this study
- Who is it for?
- Ages 50 to 75 years
- Conditions the study is for
- Stroke
- What is being tested?
- transcutaneous auricular vagus nerve stimulation, transcutaneous electrical nerve stimulation and task-oriented training
- Type of treatment
- Medical device
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 120 participants
- Where
- 1 siteHong Kong
- Study dates
- 1 Jan 2025to 1 Dec 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- aged 55 - 75 years old;
- diagnosed with stroke confirmed by magnetic resonance imaging or computed tomography for more than 6 months;
- had volitional control of the non-paretic arm and at least minimal antigravity movement in the paretic shoulder;
- had at least 5 degrees of wrist extension in the antigravity position;
- be able to communicate
Who cannot join
- had neurological disease other than stroke, e.g., Parkinson's disease or dementia;
- ongoing healthy condition, e.g., angina pectoris, pain, or arthritis;
- had any contraindications of taVNS (metal implants in the brain, history of seizure)
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Hong Kong1 site, 1 recruiting
- Recruiting
The Hong Kong Polytechnic University
Kowloon
Shamay Ng, PhD, +852 2766 4889, shamay.ng@polyu.edu.hk
Shamay Ng, PhD
About this study
Official title: Effect of Combining Transcutaneous Vagus Nerve Stimulation With Peripheral Nerve Stimulation on Upper Limb Motor Function in People With Stroke: A Single- Blinded Randomised Controlled Trial
the current study is a Blinded Randomised Controlled Trial investing the effectiveness of Combining Transcutaneous Vagus Nerve Stimulation with Peripheral Nerve Stimulation on Upper Limb Motor Function in People with Stroke
- Conditions
- Stroke
- Being tested
- transcutaneous auricular vagus nerve stimulation, sham transcutaneous auricular vagus nerve stimulation, transcutaneous electrical nerve stimulation, sham transcutaneous electrical nerve stimulation, task-oriented training
- Keywords
- stroke
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
transcutaneous auricular vagus nerve stimulationDevice
The left cymba conchae was selected as taVNS stimulation side. The taVNS was delivered by earphone-shaped stimulators for 30 minutes with the stimulation parameters as follows: 0.3-ms square pulses at 20 Hz for 30 seconds with a duty cycle of 1:1; and the intensity of the stimulation was individually adjusted according to the tolerance of participants
sham transcutaneous auricular vagus nerve stimulationDevice
The sham stimulation will be delivered with a shame model of the same device that used in the taVNS intervention. The interference of the device will display that the device is working normally while no electrical current output.
transcutaneous electrical nerve stimulationDevice
TENS will be delivered with commercial TENS machine. The stimulation parameters were as follows: continuous 0.2-ms square pulses at 100 Hz with the intensity adjusted according to the tolerance of each patient. Disposable surface electrodes of 5X5 cm2 were applied to stimulate the median nerve and the superficial radial nerve of both the affected and non-affected upper limbs. The placebo stimulation was delivered with a device that looked identical but had its internal electrical circuit disconnected.
sham transcutaneous electrical nerve stimulationDevice
The sham stimulation will be administered using a device that looks identical to the TENS device used in the TENS intervention. However, the internal electrical circuit of this device will be disconnected.
task-oriented trainingOther
A physiotherapist supervised the intervention and monitored individual progress. The task-oriented training aims to improve the motor recovery of the upper limbs through the systematic and repetitive movement of shoulder, elbow, forearm, wrist and fingers. The task-oriented training will be conducted in seating position with a table in front. Each training task will be repeated for 10 repetitions per set with 1 minute of rest between sets.The progressions are repositioning from gravity eliminate to against position, improve movement quality, increasing number of sets and shortening rest period.
| Study group | Role | What they receive |
|---|---|---|
| taVNS + TENS | Experimental | participate will received taVNS cominged with TENS Receives: Device: transcutaneous auricular vagus nerve stimulation; Device: transcutaneous electrical nerve stimulation; Other: task-oriented training |
| sham-taVNS + TENS | Sham comparator | participate will received sham-taVNS cominged with TENS Receives: Device: sham transcutaneous auricular vagus nerve stimulation; Device: transcutaneous electrical nerve stimulation; Other: task-oriented training |
| taVNS + sham-TENS | Sham comparator | participate will received taVNS cominged with sham-TENS Receives: Device: transcutaneous auricular vagus nerve stimulation; Device: sham transcutaneous electrical nerve stimulation; Other: task-oriented training |
| control training group | Active comparator | participate will receive exercise training only Receives: Other: task-oriented training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Fugl-Meyer assessment of upper extremity (FMA-UE)
The FMA-UE was used to assess motor impairment. It includes 33 items assessing movement, coordination, and reflex actions of the shoulder, elbow, forearm, wrist, and hand joints of the paretic arm. Each item consists of a 3-point scale (0, 1, and 2), with a total maximum score of 66.
Measured: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
Chinese version of brief memory and executive test (BMET)
The Chinese version of BMET will be used to assess cognitive function. It incorporates tests divided into two main categories: i) executive functioning and processing speed; and ii) orientation and memory. The initial performance of each item is converted to item score (0-2) and the total score (0-16) was used for statistical analysis, where a higher score indicates better general cognitive function.
Measured: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
Secondary outcomes (8)
Jacket test
The jacket test will be used to assess the upper limb proficiency in putting on and removing a long-sleeved jacket. The participants will be required to put on a long-sleeved coat completely, so that it was straight on their shoulders, and then to remove it completely, while maintaining a standing position. The time taken to complete the task was recorded.
Measured: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
Motor Activity Log (MAL)
The motor activity log (MAL) will be used to assess the ADLs. The MAL has 30 items including object manipulation and upper limb gross activities. Each item is in both quality of movement and amount of movement on a 6-point Likert scale (0-5). The total scale ranges from 0 to 150 with higher score indicate better ADL.
Measured: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
Capabilities of upper extremity test (CUE-T)
The CUE-T will be used to assess the upper limb function capacity. It consists of 19 unilateral and bilateral upper limb tasks. Depending on the item, scoring is based on performance of the task, the number of repetitions of the task, or time to complete the task. Raw scores are converted to a 5-point scale (0-4). Total score ranges from 0 to 120 with higher score indicate greater functional capacity. Affected side or unaffected side scores can be obtained by adding the score of the unilateral items on each side
Measured: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
Hand grip strength
The K-Grip hand-hold dynamometer (K-Grip, kinvent biomecanique, Montpellier, France) will be used for hand grip measurement. The participants will be seated in a comfortable chair with arm support and elbow in 90° flexion. Participants will be asked to make a maximal effort for at least 5 s with verbal encouragement. There were three trials for both side and the average value will be used for statistical analysis.
Measured: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
Pinch grip strength
The electronic Jamar pinch gauge will be used to measure the later pinch grip strength. The participants will be seated in a comfortable chair with arm support and elbow in 90° flexion. Participants will be asked to make a maximal effort for at least 5 s with verbal encouragement. There will be three trials for both side and the average value will be used for statistical analysis.
Measured: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
Capabilities of upper extremity-questionnaire (CUE-Q)
The CUE-Q will be used to assess the self-prospective functional limitation. It consists of 32 for unilateral and bilateral upper limb use, addressing areas of reaching and lifting, pulling, and pushing, wrist actions, and hand and finger actions. The responses are given on a 5-point Likert scale representing self-perceived difficulty in performing the action. Total score ranges from 0 to 160 with higher score indicate lesser functional limitation.
Measured: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
Stroke impact scale (SIS)
The SIS will be used to assess the quality of life. The SIS comprises 59 items covers eight domains of quality of life and an extra question on stroke recovery. Each item is rated on a 5-point Likert scale in terms of the difficulty in completing each item. The summative scores are generated for each domain, ranging from 0 to 100.
Measured: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
Community integration measure(CIM)
The Chinese version of CIM will be used to assess individuals' perceptions of community integration. It is a 10-item questionnaire with each item rated on a 5-point Likert scale, yielding a total score that ranges from 10 to 50. Higher scores indicate a better degree of perceived community integration.
Measured: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Feb 2026
- Study start1 Jan 2025
- Primary completion1 Dec 2027 (estimated)
- Study completion1 Dec 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (9)Papers the sponsor has linked to this study.
- Other trials for StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 120 participants (estimated)
Sponsor and investigators
- Lead sponsor
- The Hong Kong Polytechnic University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Shamay Ng, Professor, Principal investigator, The Hong Kong Polytechnic University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07425756
- Sponsor's protocol ID
- 25-VNS-GRF-LJ
- Status last verified
- Jan 2026
- First submitted
- 6 Feb 2026
- Last updated
- 23 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Data can be requested based on reasonable request
Publications
Liu TW, Ng SS, Ng GY. Translation and initial validation of the Chinese (Cantonese) version of community integration measure for use in patients with chronic stroke. Biomed Res Int. 2014;2014:623836. doi: 10.1155/2014/623836. Epub 2014 Jun 4.
PubMed 24995317Vellone E, Savini S, Fida R, Dickson VV, Melkus GD, Carod-Artal FJ, Rocco G, Alvaro R. Psychometric evaluation of the Stroke Impact Scale 3.0. J Cardiovasc Nurs. 2015 May-Jun;30(3):229-41. doi: 10.1097/JCN.0000000000000145.
PubMed 24695074Oleson CV, Marino RJ. Responsiveness and concurrent validity of the revised capabilities of upper extremity-questionnaire (CUE-Q) in patients with acute tetraplegia. Spinal Cord. 2014 Aug;52(8):625-8. doi: 10.1038/sc.2014.77. Epub 2014 Jun 3.
PubMed 24891011Marino RJ, Kern SB, Leiby B, Schmidt-Read M, Mulcahey MJ. Reliability and validity of the capabilities of upper extremity test (CUE-T) in subjects with chronic spinal cord injury. J Spinal Cord Med. 2015 Jul;38(4):498-504. doi: 10.1179/2045772314Y.0000000272. Epub 2014 Oct 9.
PubMed 25297342Uswatte G, Taub E, Morris D, Light K, Thompson PA. The Motor Activity Log-28: assessing daily use of the hemiparetic arm after stroke. Neurology. 2006 Oct 10;67(7):1189-94. doi: 10.1212/01.wnl.0000238164.90657.c2.
PubMed 17030751Chen P, Lai CKY, Chung RCK, Ng SSM. The Jacket Test for assessing people with chronic stroke. Disabil Rehabil. 2017 Dec;39(25):2577-2583. doi: 10.1080/09638288.2016.1236413. Epub 2016 Oct 28.
PubMed 27793076Wolf SL, Catlin PA, Ellis M, Archer AL, Morgan B, Piacentino A. Assessing Wolf motor function test as outcome measure for research in patients after stroke. Stroke. 2001 Jul;32(7):1635-9. doi: 10.1161/01.str.32.7.1635.
PubMed 11441212Ren L, Wong T, Lai C, Ng S. Psychometric assessment of the translated and culturally adapted Chinese (Cantonese) of the brief memory and executive test in people with stroke. Eur J Phys Rehabil Med. 2025 Jun;61(3):401-410. doi: 10.23736/S1973-9087.25.08873-2. Epub 2025 May 13.
PubMed 40358471Fugl-Meyer AR, Jaasko L, Leyman I, Olsson S, Steglind S. The post-stroke hemiplegic patient. 1. a method for evaluation of physical performance. Scand J Rehabil Med. 1975;7(1):13-31.
PubMed 1135616
Study at a glance
From the registry record, last updated by the sponsor on 23 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Combining Transcutaneous Vagus Nerve Stimulation With Peripheral Nerve Stimulation on Upper Limb Motor Function in People With Stroke: A Single- Blinded Randomised Controlled Trial
- ClinicalTrials.gov ID
- NCT07425756
- Acronym / sponsor ID
- 25-VNS-GRF-LJ
- Conditions
- Stroke
- Keywords
- stroke
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 120 participants (estimated)
- Lead sponsor
- The Hong Kong Polytechnic UniversityUniversity, hospital or other
- Study start
- 1 Jan 2025 (actual)
- Primary completion
- 1 Dec 2027 (estimated)
- Study completion
- 1 Dec 2027 (estimated)
- First posted
- 23 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
the current study is a Blinded Randomised Controlled Trial investing the effectiveness of Combining Transcutaneous Vagus Nerve Stimulation with Peripheral Nerve Stimulation on Upper Limb Motor Function in People with Stroke
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| taVNS + TENS | Experimental | Device: transcutaneous auricular vagus nerve stimulation, Device: transcutaneous electrical nerve stimulation, Other: task-oriented trainingparticipate will received taVNS cominged with TENS |
| sham-taVNS + TENS | Sham comparator | Device: sham transcutaneous auricular vagus nerve stimulation, Device: transcutaneous electrical nerve stimulation, Other: task-oriented trainingparticipate will received sham-taVNS cominged with TENS |
| taVNS + sham-TENS | Sham comparator | Device: transcutaneous auricular vagus nerve stimulation, Device: sham transcutaneous electrical nerve stimulation, Other: task-oriented trainingparticipate will received taVNS cominged with sham-TENS |
| control training group | Active comparator | Other: task-oriented trainingparticipate will receive exercise training only |
Who may qualify
- Ages
- 50 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- aged 55 - 75 years old;
- diagnosed with stroke confirmed by magnetic resonance imaging or computed tomography for more than 6 months;
- had volitional control of the non-paretic arm and at least minimal antigravity movement in the paretic shoulder;
- had at least 5 degrees of wrist extension in the antigravity position;
- be able to communicate
Key exclusion criteria (3 listed)
- had neurological disease other than stroke, e.g., Parkinson's disease or dementia;
- ongoing healthy condition, e.g., angina pectoris, pain, or arthritis;
- had any contraindications of taVNS (metal implants in the brain, history of seizure)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| transcutaneous auricular vagus nerve stimulationThe left cymba conchae was selected as taVNS stimulation side. The taVNS was delivered by earphone-shaped stimulators for 30 minutes with the stimulation parameters as follows: 0.3-ms square pulses at 20 Hz for 30 seconds with a duty cycle of 1:1; and the intensity of the stimulation was individually adjusted according to the tolerance of participants | Device | taVNS + TENS, taVNS + sham-TENS |
| sham transcutaneous auricular vagus nerve stimulationThe sham stimulation will be delivered with a shame model of the same device that used in the taVNS intervention. The interference of the device will display that the device is working normally while no electrical current output. | Device | sham-taVNS + TENS |
| transcutaneous electrical nerve stimulationTENS will be delivered with commercial TENS machine. The stimulation parameters were as follows: continuous 0.2-ms square pulses at 100 Hz with the intensity adjusted according to the tolerance of each patient. Disposable surface electrodes of 5X5 cm2 were applied to stimulate the median nerve and the superficial radial nerve of both the affected and non-affected upper limbs. The placebo stimulation was delivered with a device that looked identical but had its internal electrical circuit disconnected. | Device | sham-taVNS + TENS, taVNS + TENS |
| sham transcutaneous electrical nerve stimulationThe sham stimulation will be administered using a device that looks identical to the TENS device used in the TENS intervention. However, the internal electrical circuit of this device will be disconnected. | Device | taVNS + sham-TENS |
| task-oriented trainingA physiotherapist supervised the intervention and monitored individual progress. The task-oriented training aims to improve the motor recovery of the upper limbs through the systematic and repetitive movement of shoulder, elbow, forearm, wrist and fingers. The task-oriented training will be conducted in seating position with a table in front. Each training task will be repeated for 10 repetitions per set with 1 minute of rest between sets.The progressions are repositioning from gravity eliminate to against position, improve movement quality, increasing number of sets and shortening rest period. | Other | control training group, sham-taVNS + TENS, taVNS + TENS, taVNS + sham-TENS |
Primary outcome
Fugl-Meyer assessment of upper extremity (FMA-UE)
Time frame: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
The FMA-UE was used to assess motor impairment. It includes 33 items assessing movement, coordination, and reflex actions of the shoulder, elbow, forearm, wrist, and hand joints of the paretic arm. Each item consists of a 3-point scale (0, 1, and 2), with a total maximum score of 66.
Chinese version of brief memory and executive test (BMET)
Time frame: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
The Chinese version of BMET will be used to assess cognitive function. It incorporates tests divided into two main categories: i) executive functioning and processing speed; and ii) orientation and memory. The initial performance of each item is converted to item score (0-2) and the total score (0-16) was used for statistical analysis, where a higher score indicates better general cognitive function.
8 secondary outcomes
Jacket test
Time frame: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
Motor Activity Log (MAL)
Time frame: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
Capabilities of upper extremity test (CUE-T)
Time frame: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
Hand grip strength
Time frame: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
Pinch grip strength
Time frame: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
Capabilities of upper extremity-questionnaire (CUE-Q)
Time frame: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
Stroke impact scale (SIS)
Time frame: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
Community integration measure(CIM)
Time frame: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Feb 2026.
- Background: PubMed 24995317Liu TW, Ng SS, Ng GY. Translation and initial validation of the Chinese (Cantonese) version of community integration measure for use in patients with chronic stroke. Biomed Res Int. 2014;2014:623836. doi: 10.1155/2014/623836. Epub 2014 Jun 4.
- Background: PubMed 24695074Vellone E, Savini S, Fida R, Dickson VV, Melkus GD, Carod-Artal FJ, Rocco G, Alvaro R. Psychometric evaluation of the Stroke Impact Scale 3.0. J Cardiovasc Nurs. 2015 May-Jun;30(3):229-41. doi: 10.1097/JCN.0000000000000145.
- Background: PubMed 24891011Oleson CV, Marino RJ. Responsiveness and concurrent validity of the revised capabilities of upper extremity-questionnaire (CUE-Q) in patients with acute tetraplegia. Spinal Cord. 2014 Aug;52(8):625-8. doi: 10.1038/sc.2014.77. Epub 2014 Jun 3.
- Background: PubMed 25297342Marino RJ, Kern SB, Leiby B, Schmidt-Read M, Mulcahey MJ. Reliability and validity of the capabilities of upper extremity test (CUE-T) in subjects with chronic spinal cord injury. J Spinal Cord Med. 2015 Jul;38(4):498-504. doi: 10.1179/2045772314Y.0000000272. Epub 2014 Oct 9.
- Background: PubMed 17030751Uswatte G, Taub E, Morris D, Light K, Thompson PA. The Motor Activity Log-28: assessing daily use of the hemiparetic arm after stroke. Neurology. 2006 Oct 10;67(7):1189-94. doi: 10.1212/01.wnl.0000238164.90657.c2.
- Background: PubMed 27793076Chen P, Lai CKY, Chung RCK, Ng SSM. The Jacket Test for assessing people with chronic stroke. Disabil Rehabil. 2017 Dec;39(25):2577-2583. doi: 10.1080/09638288.2016.1236413. Epub 2016 Oct 28.
- Background: PubMed 11441212Wolf SL, Catlin PA, Ellis M, Archer AL, Morgan B, Piacentino A. Assessing Wolf motor function test as outcome measure for research in patients after stroke. Stroke. 2001 Jul;32(7):1635-9. doi: 10.1161/01.str.32.7.1635.
- Background: PubMed 40358471Ren L, Wong T, Lai C, Ng S. Psychometric assessment of the translated and culturally adapted Chinese (Cantonese) of the brief memory and executive test in people with stroke. Eur J Phys Rehabil Med. 2025 Jun;61(3):401-410. doi: 10.23736/S1973-9087.25.08873-2. Epub 2025 May 13.
- Background: PubMed 1135616Fugl-Meyer AR, Jaasko L, Leyman I, Olsson S, Steglind S. The post-stroke hemiplegic patient. 1. a method for evaluation of physical performance. Scand J Rehabil Med. 1975;7(1):13-31.
- Individual participant dataSharing planned: No. Data can be requested based on reasonable request
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Shamay Ng, Professor principal investigator
The Hong Kong Polytechnic University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing transcutaneous auricular vagus nerve stimulation, transcutaneous electrical nerve stimulation and task-oriented training in people with Stroke, run by The Hong Kong Polytechnic University at 1 site in Hong Kong.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 23 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Hong Kong. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Shamay NG, PhD (+852 27664889, shamay.ng@polyu.edu.hk), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Fugl-Meyer assessment of upper extremity (FMA-UE) (time frame: Baseline (A0) , 3 weeks from baseline (A1), immediately after the interventions (A2), 4 weeks follow-up (A3) and 8 weeks follow-up (A4).). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07425756, which also lists 9 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Feb 2026.