Cervical RadiculopathyNCT07426614
McKenzie Exercises Along With Neurodynamic Mobilization Exercises in Patients With Cervical Radiculopathy
A study testing Neural Mobilization exercises:, Standard Treatment and McKenzie Exercises in people with Cervical Radiculopathy, run by Riphah International University at 1 site in Pakistan.
Trial summary
This studt was conducted to determine the effects of McKenzie Exercises along with Neurodynamic Mobilization exercises on Pain, Range of Motion and Functional Disability in patients with Cervical Radiculopathy. Read more about this study
- Who is it for?
- Ages 35 to 50 years
- Conditions the study is for
- Cervical Radiculopathy
- What is being tested?
- Neural Mobilization exercises:, Standard Treatment and McKenzie Exercises
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 46 participants
- Where
- 1 sitePakistan
- Study dates
- 1 Nov 2024to 1 Mar 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 35 to 50 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Age limit 35-50 Years.
- Both male and female participants.
- Median nerve related symptoms.
- Participants presenting with unilateral C5-C7 cervical radiculopathy associated with a posterolateral cervical disc bulge were included in the study.
- Ipsilateral neck rotation, Spurling's test, median nerve neurodynamic testing, and ULNTT were considered positive if they reproduced unilateral C5-C7 radicular arm pain and negative if they did not.
- Pain reported as greater than 4-9/10 on the NPRS, persisting for more than 3 months.
- Neck Disability Index score 20-80.
- Participants demonstrating moderate restriction in cervical range of motion, defined as flexion <40°, extension <50°, lateral flexion <35°, and rotation <70°, were included.
Who cannot join
- A cervical spine fracture.
- Spondylolisthesis, subluxation, and cervical instability
- Radicular symptoms in both upper extremities.
- TB, cancer, heart illness, osteoporosis.
- Prolapsed intervertebral disc, neurological problems, any trauma or localized infection in the neck area.
- Upper motor neuron disease, cervical stenosis, and bone and joint metabolic diseases.
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- Hyperelasticity and Thoracic outlet syndrome
- Hyper lordotic if exceeds than normal angle
- Psychiatric conditions including sadness and phobia/obsession.
- Individuals who have had cervical spine surgery within a year.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of McKenzie Exercises Along With Neurodynamic Mobilization Exercises on Pain, Range of Motion and Functional Disability in Patients With Cervical Radiculopathy
This studt was conducted to determine the effects of McKenzie Exercises along with Neurodynamic Mobilization exercises on Pain, Range of Motion and Functional Disability in patients with Cervical Radiculopathy.
- Conditions
- Cervical Radiculopathy
- Being tested
- Neural Mobilization exercises:, Standard Treatment, McKenzie Exercises
- Keywords
- Functional disability, Mobility, McKenzie exercises, Neurodynamic mobilization, Pain
- Medical subject headings
- Radiculopathy, Pain
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Neural Mobilization exercises:Other
The neural mobilization approach used in this group involved moving the median nerve for ten repetitions, each held for three seconds.
Standard TreatmentOther
Hot pack for 10 minutes. TENS for 10 minutes. Cervical traction for 15 minutes 7% of body weight with 4 seconds hold to progression to 7 seconds hold and 5 second rest.
Superficial neck muscles (upper trapezius, Levator scapulae, Pect. Major) stretching for 3 times with 30 seconds hold and Neck isometrics 10 times with 6 seconds hold .
McKenzie ExercisesOther
First Week: The patient is lying supine with their head retracted or their chin tucked. For a little flexion, place a little pillow beneath the occiput. Patient pulls head and neck posteriorly, maintaining end position for 1 second, then relaxes.
Second Week: Patient in sitting position. Progression with neck extension and chin tuck. Therapist applies overpressure at end of motion.
Third Week: Patient in supine, head extended beyond couch edge. Therapist performs retraction and extension exercises with traction, maintaining traction through full range of motion.
Fourth Week: Patient in sitting. Progression with combined movements: retraction with lateral flexion, neck rotation, and final combination of retraction and neck flexion with overpressure. 3-4 sets and 10-15 repititions.
| Study group | Role | What they receive |
|---|---|---|
| Neurodynamic Mobilization exercises with Standardized Physiotherapy treatment | Active comparator | Not described Receives: Other: Neural Mobilization exercises:; Other: Standard Treatment |
| McKenzie exercises along with Neurodynamic Mobilization exercises with Standardi | Experimental | Not described Receives: Other: Neural Mobilization exercises:; Other: Standard Treatment; Other: McKenzie Exercises |
What is being measured
The primary outcome is the main question the study is designed to answer.
Neck Disability Index
The Neck Disability Index (NDI) is a self-administered tool that is employed to evaluate the functional impairment in people with neck pains. The instrument consists of ten questions which refer to daily activities; every question will be rated out of 0-5 scale, and finally there will be a total mark out of 0 -50. High scores indicate an increased amount of disability hence making NDI useful in assessing the impact of neck discomfort on the quality of life of patients and guide therapeutic decision making. When used in measuring functional disability in cervical radiculopathy, the NDI demonstrates strong levels of reliability. The psychometric integrity of the instrument is also supported by internal consistency where a Cronbach alpha of between approximately 0.80 and 0.90 is shown. 0-4: Minimal Disability, 5-14: Mild Disability, 15-24: Moderate Disability, 25-34: Severe Disability, 35-50: Complete Disability
Measured: From enrollment to the end of treatment at 4 weeks
Numeric Pain Rating Scale
The Numerical Pain Rating Scale (NPRS) is used to assess a patient's level of pain, ranging from 0 to 10, whereas 0 denotes "no pain" and 10 represents the "worst imaginable pain." It is widely used tool in both clinical and research settings. The National Pain Research Scale (NPRS) has good test-retest reliability as revealed by the correlation coefficients of 0.95 to 0.96 and thus validates the reliability and consistency of the pain intensity measures.
Measured: From enrollment to the end of treatment at 4 weeks
ROM Cervical Spine (Flexion)
Changes in cervical spine flexion ROM at baseline and 4th week of intervention was measured using goniometer
Measured: From enrollment to the end of treatment at 4 weeks
ROM Cervical Spine (Extension)
Changes in cervical spine flexion ROM at baseline and 4th week of intervention was measured using goniometer.
Measured: From enrollment to the end of treatment at 4 weeks.
ROM Cervical Spine (Lateral Flexion)
Changes in cervical spine flexion ROM at baseline and 4th week of intervention was measured using goniometer.
Measured: From enrollment to the end of treatment at 4 weeks
ROM Cervical Spine (Rotations)
Changes in cervical spine flexion ROM at baseline and 4th week of intervention was measured using goniometer.
Measured: From enrollment to the end of treatment at 4 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Feb 2026
- Study start1 Nov 2024
- Primary completion1 Feb 2025
- Study completion1 Mar 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cervical RadiculopathyStudies of the same condition, open and under way.
- More trials run by Riphah International UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 46 participants (actual)
Sponsor and investigators
- Lead sponsor
- Riphah International University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Naila Kanwal, Study chair, Riphah International University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07426614
- Sponsor's protocol ID
- REC/RCR&AHS/24/0178
- Status last verified
- Feb 2026
- First submitted
- 17 Feb 2026
- Last updated
- 23 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 23 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of McKenzie Exercises Along With Neurodynamic Mobilization Exercises on Pain, Range of Motion and Functional Disability in Patients With Cervical Radiculopathy
- ClinicalTrials.gov ID
- NCT07426614
- Acronym / sponsor ID
- REC/RCR&AHS/24/0178
- Conditions
- Cervical Radiculopathy
- Keywords
- Functional disability, Mobility, McKenzie exercises, Neurodynamic mobilization, Pain
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 46 participants (actual)
- Lead sponsor
- Riphah International UniversityUniversity, hospital or other
- Study start
- 1 Nov 2024 (actual)
- Primary completion
- 1 Feb 2025 (actual)
- Study completion
- 1 Mar 2025 (actual)
- First posted
- 23 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This studt was conducted to determine the effects of McKenzie Exercises along with Neurodynamic Mobilization exercises on Pain, Range of Motion and Functional Disability in patients with Cervical Radiculopathy.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Neurodynamic Mobilization exercises with Standardized Physiotherapy treatment | Active comparator | Other: Neural Mobilization exercises:, Other: Standard Treatment |
| McKenzie exercises along with Neurodynamic Mobilization exercises with Standardi | Experimental | Other: Neural Mobilization exercises:, Other: Standard Treatment, Other: McKenzie Exercises |
Who may qualify
- Ages
- 35 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (8 listed)
- Age limit 35-50 Years.
- Both male and female participants.
- Median nerve related symptoms.
- Participants presenting with unilateral C5-C7 cervical radiculopathy associated with a posterolateral cervical disc bulge were included in the study.
- Ipsilateral neck rotation, Spurling's test, median nerve neurodynamic testing, and ULNTT were considered positive if they reproduced unilateral C5-C7 radicular arm pain and negative if they did not.
Key exclusion criteria (10 listed)
- A cervical spine fracture.
- Spondylolisthesis, subluxation, and cervical instability
- Radicular symptoms in both upper extremities.
- TB, cancer, heart illness, osteoporosis.
- Prolapsed intervertebral disc, neurological problems, any trauma or localized infection in the neck area.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Neural Mobilization exercises:The neural mobilization approach used in this group involved moving the median nerve for ten repetitions, each held for three seconds. | Other | McKenzie exercises along with Neurodynamic Mobilization exercises with Standardi, Neurodynamic Mobilization exercises with Standardized Physiotherapy treatment |
| Standard TreatmentHot pack for 10 minutes. TENS for 10 minutes. Cervical traction for 15 minutes 7% of body weight with 4 seconds hold to progression to 7 seconds hold and 5 second rest. Superficial neck muscles (upper trapezius, Levator scapulae, Pect. Major) stretching for 3 times with 30 seconds hold and Neck isometrics 10 times with 6 seconds hold . | Other | McKenzie exercises along with Neurodynamic Mobilization exercises with Standardi, Neurodynamic Mobilization exercises with Standardized Physiotherapy treatment |
| McKenzie ExercisesFirst Week: The patient is lying supine with their head retracted or their chin tucked. For a little flexion, place a little pillow beneath the occiput. Patient pulls head and neck posteriorly, maintaining end position for 1 second, then relaxes. Second Week: Patient in sitting position. Progression with neck extension and chin tuck. Therapist applies overpressure at end of motion. Third Week: Patient in supine, head extended beyond couch edge. Therapist performs retraction and extension exercises with traction, maintaining traction through full range of motion. Fourth Week: Patient in sitting. Progression with combined movements: retraction with lateral flexion, neck rotation, and final combination of retraction and neck flexion with overpressure. 3-4 sets and 10-15 repititions. | Other | McKenzie exercises along with Neurodynamic Mobilization exercises with Standardi |
Primary outcome
Neck Disability Index
Time frame: From enrollment to the end of treatment at 4 weeks
The Neck Disability Index (NDI) is a self-administered tool that is employed to evaluate the functional impairment in people with neck pains. The instrument consists of ten questions which refer to daily activities; every question will be rated out of 0-5 scale, and finally there will be a total mark out of 0 -50. High scores indicate an increased amount of disability hence making NDI useful in assessing the impact of neck discomfort on the quality of life of patients and guide therapeutic decision making. When used in measuring functional disability in cervical radiculopathy, the NDI demonstrates strong levels of reliability. The psychometric integrity of the instrument is also supported by internal consistency where a Cronbach alpha of between approximately 0.80 and 0.90 is shown. 0-4: Minimal Disability, 5-14: Mild Disability, 15-24: Moderate Disability, 25-34: Severe Disability, 35-50: Complete Disability
Numeric Pain Rating Scale
Time frame: From enrollment to the end of treatment at 4 weeks
The Numerical Pain Rating Scale (NPRS) is used to assess a patient's level of pain, ranging from 0 to 10, whereas 0 denotes "no pain" and 10 represents the "worst imaginable pain." It is widely used tool in both clinical and research settings. The National Pain Research Scale (NPRS) has good test-retest reliability as revealed by the correlation coefficients of 0.95 to 0.96 and thus validates the reliability and consistency of the pain intensity measures.
ROM Cervical Spine (Flexion)
Time frame: From enrollment to the end of treatment at 4 weeks
Changes in cervical spine flexion ROM at baseline and 4th week of intervention was measured using goniometer
ROM Cervical Spine (Extension)
Time frame: From enrollment to the end of treatment at 4 weeks.
Changes in cervical spine flexion ROM at baseline and 4th week of intervention was measured using goniometer.
ROM Cervical Spine (Lateral Flexion)
Time frame: From enrollment to the end of treatment at 4 weeks
Changes in cervical spine flexion ROM at baseline and 4th week of intervention was measured using goniometer.
ROM Cervical Spine (Rotations)
Time frame: From enrollment to the end of treatment at 4 weeks
Changes in cervical spine flexion ROM at baseline and 4th week of intervention was measured using goniometer.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Feb 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Naila Kanwal study chair
Riphah International University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Neural Mobilization exercises:, Standard Treatment and McKenzie Exercises in people with Cervical Radiculopathy, run by Riphah International University at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 23 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Neck Disability Index (time frame: From enrollment to the end of treatment at 4 weeks). The study lists 6 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Feb 2026.