StrokeNCT07428161
Investigation of the Effects of Task-Oriented Circuit Training on Upper Extremity Motor Function in Stroke Patients
A study testing Exercise-TOCT and Exercise- standard in people with Stroke, run by Gazi University at 1 site in Turkey (Türkiye).
Trial summary
Stroke is a disease characterized by symptoms such as weakness on one side of the body, speech impairment or inability to understand spoken language, vision problems, and loss of balance, walking, and coordination, resulting from a disruption in cerebral circulation that prevents oxygenation and nourishment of brain… Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Stroke
- What is being tested?
- Exercise-TOCT and Exercise- standard
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 24 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 13 Jan 2026to 13 May 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Having received a stroke diagnosis for the first time
- Having received a stroke diagnosis at least 1 month ago
- Being between 18-65 years of age
Who cannot join
- Having the following degree of active joint movement in the wrist and fingers (These conditions are necessary for patients to have the minimum hand dexterity to perform TOCT exercises)
- At least 20° extension starting from full flexion in the wrist
- At least 10° extension or abduction in the thumb
- At least 10° extension in the metacarpophalangeal and interphalangeal joints of the other fingers
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Sefa Eldemir
Sivas, Sivas/Center
Sefa Eldemir, +903462981916, sefa.eldemir@gmail.com
About this study
Stroke is a disease characterized by symptoms such as weakness on one side of the body, speech impairment or inability to understand spoken language, vision problems, and loss of balance, walking, and coordination, resulting from a disruption in cerebral circulation that prevents oxygenation and nourishment of brain tissue. Currently, treatment approaches that adopt motor learning principles after stroke are fundamentally based on motor learning, neural plasticity, biomechanics, and the systems model of motor control. Task-Oriented Training (TOT), one of these treatment approaches, is used in the physiotherapy process for neurological diseases, and there is significant clinical evidence regarding the benefits of TOT. While the effects of TOT in physiotherapy have been primarily studied on balance and walking, there are a limited number of studies examining its effects on upper extremity function. Task-Oriented Circuit Training (TOCT) is a task-oriented training program consisting of 15 exercise stations where task-oriented training is applied in the form of exercise stations. TOCT improved upper extremity skills in Parkinson's patients. However, no study examines its effects on stroke. Therefore, this study aims to examine the effects of TOCT on upper extremity motor functions and dual-task performance in stroke patients.
Read the detailed description
This study is a randomized controlled study. The patients will be randomly divided into two groups exercise and control. Both groups will receive standard physiotherapy and rehabilitation exercises aimed at improving balance, gait, mobility, and upper extremity function, as well as standard occupational therapy exercises for the upper extremities. Additionally, the TOCT group will receive 18 one-on-one TOCT training sessions, 3 days a week, for 6 weeks. TOCT will be formed from daily life activities such as reaching out, grasping, writing, and manual skills, which are frequently used in daily life. As the outcome measures, disease severity, disability, and manual dexterity will be evaluated.
- Conditions
- Stroke
- Being tested
- Exercise-TOCT, Exercise- standard
- Keywords
- Stroke, Task Oriented Circuit Training, Manual dexterity
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Exercise-TOCTOther
Both groups will receive exercise-based training
Exercise- standardOther
Standard occupational therapy exercises
| Study group | Role | What they receive |
|---|---|---|
| Test Group | Experimental | The group that will receive task-oriented training Receives: Other: Exercise-TOCT |
| Control Group | Experimental | The control group will receive standard occupational therapy exercises for the upper extremities. Receives: Other: Exercise- standard |
What is being measured
The primary outcome is the main question the study is designed to answer.
Manual dexterity performance - Baseline
Nine Hole Peg test (9-HPT)
Measured: Assessment will be conducted before the intervention
Manual dexterity performance - Post intervention
Nine Hole Peg test (9-HPT)
Measured: Assessment will be conducted immediately after the intervention
Finger and hand function - Baseline
Jebsen-Taylor Hand Function Test (JTHFT)
Measured: Assessment will be conducted before the intervention
Finger and hand function - Post intervention
Jebsen-Taylor Hand Function Test (JTHFT)
Measured: Assessment will be conducted immediately after the intervention
Upper extremity performance (coordination, dexterity and functioning) - Baseline
Action Research Arm Test (ARAT)
Measured: Assessment will be conducted before the intervention
Upper extremity performance (coordination, dexterity and functioning) - Post intervention
Action Research Arm Test (ARAT)
Measured: Assessment will be conducted immediately after the intervention
Grip muscle strength
Hand dynamometer
Measured: Assessment will be conducted before the intervention
Grip muscle strength
Hand dynamometer
Measured: Assessment will be conducted immediately after the intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Feb 2026
- Study start13 Jan 2026
- Primary completion13 Apr 2026 (estimated)
- Study completion13 May 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for StrokeStudies of the same condition, open and under way.
- More trials run by Gazi UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Two groups as exercise group and control group
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 24 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Gazi University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Sefa Eldemir, Cumhuriyet University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07428161
- Sponsor's protocol ID
- 8- STROKE-UE-TOCT
- Status last verified
- Feb 2026
- First submitted
- 17 Feb 2026
- Last updated
- 25 Feb 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: There is not a plan to make data but when the statistical analysis of all data is made, all results will be shared.
Publications
Eldemir S, Guclu-Gunduz A, Eldemir K, Saygili F, Yilmaz R, Akbostanci MC. The effect of task-oriented circuit training-based telerehabilitation on upper extremity motor functions in patients with Parkinson's disease: A randomized controlled trial. Parkinsonism Relat Disord. 2023 Apr;109:105334. doi: 10.1016/j.parkreldis.2023.105334. Epub 2023 Feb 28.
PubMed 36917914
Study at a glance
From the registry record, last updated by the sponsor on 25 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Investigation of the Effects of Task-Oriented Circuit Training on Upper Extremity Motor Function in Stroke Patients
- ClinicalTrials.gov ID
- NCT07428161
- Acronym / sponsor ID
- 8- STROKE-UE-TOCT
- Conditions
- Stroke
- Keywords
- Stroke, Task Oriented Circuit Training, Manual dexterity
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 24 participants (estimated)
- Lead sponsor
- Gazi UniversityUniversity, hospital or other
- Study start
- 13 Jan 2026 (actual)
- Primary completion
- 13 Apr 2026 (estimated)
- Study completion
- 13 May 2026 (estimated)
- First posted
- 23 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Stroke is a disease characterized by symptoms such as weakness on one side of the body, speech impairment or inability to understand spoken language, vision problems, and loss of balance, walking, and coordination, resulting from a disruption in cerebral circulation that prevents oxygenation and nourishment of brain tissue. Currently, treatment approaches that adopt motor learning principles after stroke are fundamentally based on motor learning, neural plasticity, biomechanics, and the systems model of motor control. Task-Oriented Training (TOT), one of these treatment approaches, is used in the physiotherapy process for neurological diseases, and there is significant clinical evidence regarding the benefits of TOT. While the effects of TOT in physiotherapy have been primarily studied on balance and walking, there are a limited number of studies examining its effects on upper extremity function. Task-Oriented Circuit Training (TOCT) is a task-oriented training program consisting of 15 exercise stations where task-oriented training is applied in the form of exercise stations. TOCT improved upper extremity skills in Parkinson's patients. However, no study examines its effects on stroke. Therefore, this study aims to examine the effects of TOCT on upper extremity motor functions and dual-task performance in stroke patients.
Detailed description
This study is a randomized controlled study. The patients will be randomly divided into two groups exercise and control. Both groups will receive standard physiotherapy and rehabilitation exercises aimed at improving balance, gait, mobility, and upper extremity function, as well as standard occupational therapy exercises for the upper extremities. Additionally, the TOCT group will receive 18 one-on-one TOCT training sessions, 3 days a week, for 6 weeks. TOCT will be formed from daily life activities such as reaching out, grasping, writing, and manual skills, which are frequently used in daily life. As the outcome measures, disease severity, disability, and manual dexterity will be evaluated.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- Two groups as exercise group and control group
| Arm | Type | Receives |
|---|---|---|
| Test Group | Experimental | Other: Exercise-TOCTThe group that will receive task-oriented training |
| Control Group | Experimental | Other: Exercise- standardThe control group will receive standard occupational therapy exercises for the upper extremities. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- Having received a stroke diagnosis for the first time
- Having received a stroke diagnosis at least 1 month ago
- Being between 18-65 years of age
Key exclusion criteria (4 listed)
- Having the following degree of active joint movement in the wrist and fingers (These conditions are necessary for patients to have the minimum hand dexterity to perform TOCT exercises)
- At least 20° extension starting from full flexion in the wrist
- At least 10° extension or abduction in the thumb
- At least 10° extension in the metacarpophalangeal and interphalangeal joints of the other fingers
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Exercise-TOCTBoth groups will receive exercise-based training | Other | Test Group |
| Exercise- standardStandard occupational therapy exercises | Other | Control Group |
Primary outcome
Manual dexterity performance - Baseline
Time frame: Assessment will be conducted before the intervention
Nine Hole Peg test (9-HPT)
Manual dexterity performance - Post intervention
Time frame: Assessment will be conducted immediately after the intervention
Nine Hole Peg test (9-HPT)
Finger and hand function - Baseline
Time frame: Assessment will be conducted before the intervention
Jebsen-Taylor Hand Function Test (JTHFT)
Finger and hand function - Post intervention
Time frame: Assessment will be conducted immediately after the intervention
Jebsen-Taylor Hand Function Test (JTHFT)
Upper extremity performance (coordination, dexterity and functioning) - Baseline
Time frame: Assessment will be conducted before the intervention
Action Research Arm Test (ARAT)
Upper extremity performance (coordination, dexterity and functioning) - Post intervention
Time frame: Assessment will be conducted immediately after the intervention
Action Research Arm Test (ARAT)
Grip muscle strength
Time frame: Assessment will be conducted before the intervention
Hand dynamometer
Grip muscle strength
Time frame: Assessment will be conducted immediately after the intervention
Hand dynamometer
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Feb 2026.
- Results publication: PubMed 36917914Eldemir S, Guclu-Gunduz A, Eldemir K, Saygili F, Yilmaz R, Akbostanci MC. The effect of task-oriented circuit training-based telerehabilitation on upper extremity motor functions in patients with Parkinson's disease: A randomized controlled trial. Parkinsonism Relat Disord. 2023 Apr;109:105334. doi: 10.1016/j.parkreldis.2023.105334. Epub 2023 Feb 28.
- Individual participant dataSharing planned: No. There is not a plan to make data but when the statistical analysis of all data is made, all results will be shared.
Related trials for Stroke
Not yet recruiting
Temporal Interference Stimulation for Upper-Limb Motor Recovery in Early Subacute Stroke
Acute Ischemic Stroke
RecruitingObservational study
ELATE Study: Evaluating Large-vessel Acute Thrombectomy in Extended Time Window
Acute Ichemic Stroke
Recruiting
Web-Based Tele-Rehabilitation Using Action Observation and Mirror Therapy for Subacute Stroke: A Randomized Controlled Trial
Stroke, Upper Extremity Paresis
Recruiting
Early Motor-Cognitive Integrative Training on Cognitive and Motor Performance in Patients With Aneurysmal Subarachnoid Hemorrhage
Subarachnoid Aneurysm Hemorrhage
Not yet recruiting
Selective Intra-Arterial Hypothermia After Endovascular Treatment for Acute Basilar Artery Occlusion
Acute Ischemic Stroke, Basilar Artery Occlusion
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Exercise-TOCT and Exercise- standard in people with Stroke, run by Gazi University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 25 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Sefa Eldemir (+903462981916, sefa.eldemir@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Manual dexterity performance - Baseline (time frame: Assessment will be conducted before the intervention). The study lists 8 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07428161, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Feb 2026.