Inactivity, PhysicalNCT07429370
The Effects of One Day of Activity on the Next Day's Exercise Response
A study testing Decreased step count in people with Inactivity, Physical, run by Concordia University Wisconsin at 1 site in United States.
Trial summary
Exercise can reduce the risk of several chronic diseases. However, recent studies have suggested sitting for too long before exercising can decrease exercise benefits. This study will help determine why this may occur. Read more about this study
- Who is it for?
- Ages 18 to 30 yearsHealthy volunteers can take part
- Conditions the study is for
- Inactivity, Physical
- What is being tested?
- Decreased step count
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 6 participants
- Where
- 1 siteUnited States
- Study dates
- 1 Jan 2026to 31 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 30 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- • between the ages of 18-30 years old
Who cannot join
- • free from acute or chronic illness (cardiac, pulmonary, liver, or kidney abnormalities, cancer, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other known metabolic disorders)
- do not take medications related to metabolism (i.e., statins, metformin, GLP-1 agonists)
- free from orthopedic limitations (including any artificial joints)
- currently smoke or participate in other forms of tobacco use.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
Concordia University of Wisconsin
Mequon, Wisconsin, 53093
Kevin J Gries, PhD, 2622434293, kevin.gries@cuw.edu
About this study
Official title: A Single Day of Inactivity on the Systemic Metabolic and Inflammatory Exercise Response
Exercise can reduce the risk of several chronic diseases. However, recent studies have suggested sitting for too long before exercising can decrease exercise benefits. This study will help determine why this may occur.
Read the detailed description
Previous work demonstrated a greater utilization of carbohydrates (CHO) at the end of aerobic exercise with a day of reduced activity (<5,000 steps). Additionally, there are differences in the RNA profile at rest and during exercise in pathways related to inflammation, metabolism, and innate immunity that warrant further research. Together, these data highlight that a single day of reduced activity alters systemic homeostasis that affects the exercise response. Given the potency of exercise to ameliorate risk of cardiovascular disease, more research is needed to find factors to augment the exercise response. Therefore, this study has two goals: 1) Analyze circulating metabolomics, and 2) metabolomics and proteomics in response to exercise after a day of reduced activity.
- Conditions
- Inactivity, Physical
- Being tested
- Decreased step count
- Keywords
- Exercise, Metabolism
- Medical subject headings
- Sedentary Behavior, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Decreased step countBehavioural
Subjects will walk less than 5,000 steps
| Study group | Role | What they receive |
|---|---|---|
| >8,500 steps the day prior to exericse | Active comparator | Not described Receives: Behavioral: Decreased step count |
| <5,000 steps the day prior to exercise | Experimental | Not described Receives: Behavioral: Decreased step count |
What is being measured
The primary outcome is the main question the study is designed to answer.
Concentration of metabolites within the plasma
We will collect blood before and immediately after exercise. Plasma will be separated and sent for untargeted metabolomic analysis.
Measured: Participants will complete the study within 6 weeks of enrollment.
Concentration of proteins within the plasma
We will collect blood before and immediately after exercise. Plasma will be separated and sent for untargeted proteomic analysis.
Measured: Participants will complete the study within 6 weeks of enrollment.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Feb 2026
- Study start1 Jan 2026
- Primary completion31 Dec 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Inactivity, PhysicalStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 6 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Concordia University Wisconsin
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07429370
- Sponsor's protocol ID
- https://pubmed.ncbi.nlm.nih.go
- Other IDs
- 26BAIREA1560979
- Status last verified
- Feb 2026
- First submitted
- 17 Feb 2026
- Last updated
- 24 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 24 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Single Day of Inactivity on the Systemic Metabolic and Inflammatory Exercise Response
- ClinicalTrials.gov ID
- NCT07429370
- Acronym / sponsor ID
- https://pubmed.ncbi.nlm.nih.go
- Conditions
- Inactivity, Physical
- Keywords
- Exercise, Metabolism
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 6 participants (estimated)
- Lead sponsor
- Concordia University WisconsinUniversity, hospital or other
- Study start
- 1 Jan 2026 (actual)
- Primary completion
- 31 Dec 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 24 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Exercise can reduce the risk of several chronic diseases. However, recent studies have suggested sitting for too long before exercising can decrease exercise benefits. This study will help determine why this may occur.
Detailed description
Previous work demonstrated a greater utilization of carbohydrates (CHO) at the end of aerobic exercise with a day of reduced activity (<5,000 steps). Additionally, there are differences in the RNA profile at rest and during exercise in pathways related to inflammation, metabolism, and innate immunity that warrant further research. Together, these data highlight that a single day of reduced activity alters systemic homeostasis that affects the exercise response. Given the potency of exercise to ameliorate risk of cardiovascular disease, more research is needed to find factors to augment the exercise response. Therefore, this study has two goals: 1) Analyze circulating metabolomics, and 2) metabolomics and proteomics in response to exercise after a day of reduced activity.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| >8,500 steps the day prior to exericse | Active comparator | Behavioral: Decreased step count |
| <5,000 steps the day prior to exercise | Experimental | Behavioral: Decreased step count |
Who may qualify
- Ages
- 18 to 30 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- • between the ages of 18-30 years old
Key exclusion criteria (4 listed)
- • free from acute or chronic illness (cardiac, pulmonary, liver, or kidney abnormalities, cancer, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other known metabolic disorders)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Decreased step countSubjects will walk less than 5,000 steps | Behavioural | <5,000 steps the day prior to exercise, >8,500 steps the day prior to exericse |
Primary outcome
Concentration of metabolites within the plasma
Time frame: Participants will complete the study within 6 weeks of enrollment.
We will collect blood before and immediately after exercise. Plasma will be separated and sent for untargeted metabolomic analysis.
Concentration of proteins within the plasma
Time frame: Participants will complete the study within 6 weeks of enrollment.
We will collect blood before and immediately after exercise. Plasma will be separated and sent for untargeted proteomic analysis.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Feb 2026.
- Individual participant dataSharing planned: Yes
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Decreased step count in people with Inactivity, Physical, run by Concordia University Wisconsin at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 24 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Kevin J Gries, PhD (2622434293, kevin.gries@cuw.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Concentration of metabolites within the plasma (time frame: Participants will complete the study within 6 weeks of enrollment.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Feb 2026.