AzTrials
AzTrials

Asthma AcuteCHERISHNCT07431021

Children's Health, Respiratory Inflammation and Short-term Air Pollution

A study testing science lesson and PE Lesson in people with Asthma Acute and Respiratory, run by Queen Mary University of London at 1 site in United Kingdom.

Recruiting

Looking for participants now. Contact the study team or a site below to ask about taking part.

Sites and contacts
Official record

Search all trials

Trial summary

The goal of this study is to see if physical activity in high air pollution is worse than rest in high air pollution. Read more about this study

Who is it for?
Ages 7 to 11 yearsHealthy volunteers can take part
Conditions the study is for
Asthma Acute, Respiratory
What is being tested?
science lesson and PE Lesson
Could I receive a placebo?
No, everyone receives an active treatment
How many people
330 participants
Where
1 siteUnited Kingdom
Study dates
20 Oct 2025to 1 Jul 2027
Phase
Interventional

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 7 to 11 years
  • All sexes
  • Healthy volunteers accepted
  • Child

Who may be able to join

  • Attending schools in Central and East London that have been recruited to the study

Who cannot join

  • Not able to engage with PE lessons on safety grounds, reported by their parents.
  • Children with learning or physical disabilities sufficient for them to be unable to give informed assent to the study, or to carry out study procedures

Trial locations and contacts

1 site in 1 country. Contact the study team or a site near you to ask about taking part.

James Scales, PhD contact

+447533897264

j.scales@qmul.ac.uk

Abigail Whitehouse, MD,PhD contact

a.whitehouse@qmul.ac.uk

United Kingdom1 site, 1 recruiting
  • Faculty of Medicine and Dentistry

    London, E1 2AB

    James Scales, 07533897264, j.scales@qmul.ac.uk

    Recruiting

Other trials in United Kingdom

About this study

The goal of this study is to see if physical activity in high air pollution is worse than rest in high air pollution.

Read the detailed description

The study will recruit a total of 330 children from 10 primary schools split into two groups: "higher pollution" and "lower pollution" schools. The team shall invite children in years 3 to 6 to take part in the study and consent will be provided by parents following information sheets sent home in school bags and parent evening presentations.

After the team have received written permission from parents. The study team will visit the school on two days. On the first day the study team will perform lung health assessment in a dedicated classroom. The assessment will involve, measuring children's height and weight, a breathing test (photo and a snot sample collected by squirting a small bit of saline water up one nostril and catching the snot in a cup.

Children will then take part in a PE lesson or a sedentary science lesson in a random order in their school playground while wearing activity monitors - like a Fitbit- to track their physical activity. The session is designed to be just like a typical outdoor science or PE lesson and will be exactly the same at all schools. Air pollution levels in the playground will be monitored during this time.

Once the PE lesson has finished the children will perform the same health assessment immediately after the lesson and again on a second day. The team shall compare the change in these scores between higher and lower pollution schools. The breathing tests will tell us if the has been any change in lung health and the snot samples will tell us about the pollution the children have breathed and how their bodies try to fight it. Participating will take about 4 hours total.

Being tested
science lesson, PE Lesson
Keywords
air pollution, physical activity, children, exercise, no2, Public health, air quality, pollution, paediatric, exposure, environment
Medical subject headings
Motor Activity

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • science lessonBehavioural

    children have a 90 minute science lesson outdoors

  • PE LessonBehavioural

    CHildren have a 90 minute PE lesson outdoors

Study groups in NCT07431021
Study groupRoleWhat they receive
Physical activityExperimentalPE Lesson
Receives: Behavioral: PE Lesson
SedenaryActive comparatorScience lesson
Receives: Behavioral: science lesson

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. "Airway resistance" measured by Oscillometry at R5

    measured as oscillometery R5

    Measured: Pre-24 hour post exposure

Secondary outcomes (2)
  1. "Small airway resistance" measured by Oscillometry at R5-20

    Measured by oscillometry R5-20

    Measured: pre- 24 hour post exposure

  2. Immune responses as measured by Il6 in nasal lavage

    Immune response as measured by Il6 in nasal lavage

    Measured: pre-24 hour post exposure

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted24 Feb 2026
  2. Study start20 Oct 2025
  3. Primary completion1 Jul 2027 (estimated)
  4. Study completion1 Jul 2027 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Prevention
Allocation
Randomised
Intervention model
Single group
Model description
mixed methods. crossover of conditions (physical activity (PE) Vs Sedentary (science)
Masking
None (open label)
Enrolment
330 participants (estimated)
IDs, dates and publications
ClinicalTrials.gov ID
NCT07431021
Sponsor's protocol ID
QME25.1220
Other IDs
G-002887
Acronym
CHERISH
Status last verified
Jun 2026
First submitted
3 Feb 2026
Last updated
15 Jun 2026
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Free account

Keep searching with a free account

You’ve used your 3 free searches for this session. Log in or create a free AzTrials account to keep searching clinical trials and save the ones you want to follow.

Create a free accountLog in