Asthma AcuteCHERISHNCT07431021
Children's Health, Respiratory Inflammation and Short-term Air Pollution
A study testing science lesson and PE Lesson in people with Asthma Acute and Respiratory, run by Queen Mary University of London at 1 site in United Kingdom.
Trial summary
The goal of this study is to see if physical activity in high air pollution is worse than rest in high air pollution. Read more about this study
- Who is it for?
- Ages 7 to 11 yearsHealthy volunteers can take part
- Conditions the study is for
- Asthma Acute, Respiratory
- What is being tested?
- science lesson and PE Lesson
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 330 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 20 Oct 2025to 1 Jul 2027
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 7 to 11 years
- All sexes
- Healthy volunteers accepted
- Child
Who may be able to join
- Attending schools in Central and East London that have been recruited to the study
Who cannot join
- Not able to engage with PE lessons on safety grounds, reported by their parents.
- Children with learning or physical disabilities sufficient for them to be unable to give informed assent to the study, or to carry out study procedures
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Abigail Whitehouse, MD,PhD contact
United Kingdom1 site, 1 recruiting
- Recruiting
Faculty of Medicine and Dentistry
London, E1 2AB
James Scales, 07533897264, j.scales@qmul.ac.uk
About this study
The goal of this study is to see if physical activity in high air pollution is worse than rest in high air pollution.
Read the detailed description
The study will recruit a total of 330 children from 10 primary schools split into two groups: "higher pollution" and "lower pollution" schools. The team shall invite children in years 3 to 6 to take part in the study and consent will be provided by parents following information sheets sent home in school bags and parent evening presentations.
After the team have received written permission from parents. The study team will visit the school on two days. On the first day the study team will perform lung health assessment in a dedicated classroom. The assessment will involve, measuring children's height and weight, a breathing test (photo and a snot sample collected by squirting a small bit of saline water up one nostril and catching the snot in a cup.
Children will then take part in a PE lesson or a sedentary science lesson in a random order in their school playground while wearing activity monitors - like a Fitbit- to track their physical activity. The session is designed to be just like a typical outdoor science or PE lesson and will be exactly the same at all schools. Air pollution levels in the playground will be monitored during this time.
Once the PE lesson has finished the children will perform the same health assessment immediately after the lesson and again on a second day. The team shall compare the change in these scores between higher and lower pollution schools. The breathing tests will tell us if the has been any change in lung health and the snot samples will tell us about the pollution the children have breathed and how their bodies try to fight it. Participating will take about 4 hours total.
- Conditions
- Asthma Acute, Respiratory
- Being tested
- science lesson, PE Lesson
- Keywords
- air pollution, physical activity, children, exercise, no2, Public health, air quality, pollution, paediatric, exposure, environment
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
science lessonBehavioural
children have a 90 minute science lesson outdoors
PE LessonBehavioural
CHildren have a 90 minute PE lesson outdoors
| Study group | Role | What they receive |
|---|---|---|
| Physical activity | Experimental | PE Lesson Receives: Behavioral: PE Lesson |
| Sedenary | Active comparator | Science lesson Receives: Behavioral: science lesson |
What is being measured
The primary outcome is the main question the study is designed to answer.
"Airway resistance" measured by Oscillometry at R5
measured as oscillometery R5
Measured: Pre-24 hour post exposure
Secondary outcomes (2)
"Small airway resistance" measured by Oscillometry at R5-20
Measured by oscillometry R5-20
Measured: pre- 24 hour post exposure
Immune responses as measured by Il6 in nasal lavage
Immune response as measured by Il6 in nasal lavage
Measured: pre-24 hour post exposure
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Feb 2026
- Study start20 Oct 2025
- Primary completion1 Jul 2027 (estimated)
- Study completion1 Jul 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Asthma AcuteStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Single group
- Model description
- mixed methods. crossover of conditions (physical activity (PE) Vs Sedentary (science)
- Masking
- None (open label)
- Enrolment
- 330 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Queen Mary University of London
- Sponsor type
- University, hospital or other
- Collaborators
- Imperial College London
- Responsible party
- Sponsor
- Investigators
- James Scales, PhD, Principal investigator, Queen Mary University LondonAbigail Whitehouse, PhD, MD, Principal investigator, QMUL
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07431021
- Sponsor's protocol ID
- QME25.1220
- Other IDs
- G-002887
- Acronym
- CHERISH
- Status last verified
- Jun 2026
- First submitted
- 3 Feb 2026
- Last updated
- 15 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No