ExercisePhase 4NCT07434752
A Study to See if an Energy Drink With Caffeine and Green Tea Increases Fat Burning When Exercising
A Phase 4 study testing Active (Green tea and caffeine) in people with Exercise, run by RDC Clinical Pty Ltd at 1 site in Australia.
Trial summary
The goal of this study is to evaluate the influence of consuming a drink containing a combination of caffeine and green tea extracts on fat oxidation responses at rest, during and after a period of endurance type exercise. Read more about this study
- Who is it for?
- Ages 18 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Exercise
- What is being tested?
- Active (Green tea and caffeine)
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 36 participants
- Where
- 1 siteAustralia
- Study dates
- 26 Mar 2026to Oct 2026
- Phase
- Phase 4
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Passing the Exercise and Sport Science Australia adult pre-exercise screening system (APSS) stage 1 \& 2 (see appendix 4).
- Between the ages of 18 and 45,
- Not sedentary, and not completing more than 150 minutes of low and/or moderate and/or or vigorous intensity endurance exercise a week,
- Ability to commit to in principle fulfilment of all 3 trial visits,
- No history of coagulopathy e.g., DVT, stroke,
- No known heart disease,
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- No known pancreatic insufficiency,
- No known inflammatory bowel disease, or prior bowel resection or bypass surgery (excluding gastric banding and sleeve),
- BMI of 22.0 to 34.9 kg/m2,
- No known allergies to caffeine or green tea extract,
- No known type I or II diabetes,
- No uncontrolled concurrent illness,
- No known current pregnancy or breastfeeding women
- No current regular consumption of supplements (>2 times a week) or foods and drinks containing caffeine and/or green tea extracts (>2 times per day, weekly).
- Agree not to consume caffeine for 12-hours prior to the clinic visit.
Who cannot join
- Triggering any of the exclusion screening criteria as outlined below, and in compliment with the Exercise and Sport Science Australia adult pre-exercise screening system (APSS).
- Under the age of 18 or over the age of 45,
- Sedentary, or completing over 150 minutes of low and/or moderate and/or or vigorous intensity endurance exercise a week,
- Inability to commit to in principle fulfilment of all 3 trial visits,
- History of coagulopathy e.g., DVT, stroke,
- Known heart disease,
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- Known pancreatic insufficiency,
- Known inflammatory bowel disease, or prior bowel resection or bypass surgery (excluding gastric banding and sleeve),
- BMI < 22.0 or > 34.9 kg/m2,
- Known allergies to caffeine or green tea extract,
- Known type I or II diabetes,
- Uncontrolled concurrent illness,
- Taking GLP-1 agonists, caffeine, or any other medication known to affect metabolism.
- Known current pregnancy or breastfeeding women.
- Currently regularly consuming supplements, foods or drinks containing a caffeine and green tea extract blend, or not willing to abstain for the study
Trial locations and contacts
1 site in 1 country.
Australia1 site
Griffith University, Gold Coast Campus
Southport, Queensland, 4222
About this study
Official title: Influence of Caffeine and Green Tea Extracts Consumption on Basal, Peri- and Post-exercise Fat Oxidation
The goal of this study is to evaluate the influence of consuming a drink containing a combination of caffeine and green tea extracts on fat oxidation responses at rest, during and after a period of endurance type exercise.
Read the detailed description
This study investigates whether consuming an energy drink containing caffeine and green tea extract before exercise increases fat burning (oxidation) compared with a placebo drink. Healthy, moderately active adults will attend three visits at clinic over 3-5 weeks. The first visit determines each participant's individual exercise intensity that maximises fat use during cycling. At two subsequent visits, participants will consume either the active drink or a placebo before completing a 30-minute cycling session at their personalised intensity. Fat and carbohydrate use, heart rate, blood pressure, and subjective responses will be measured at rest, during exercise, and after exercise using a double-blind, crossover design.
- Conditions
- Exercise
- Being tested
- Active (Green tea and caffeine), Placebo
- Keywords
- metabolism
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Active (Green tea and caffeine)Dietary supplement
Also called XS Energy + BURN
Two 355 mL cans of "XS Energy + BURN" drink containing caffeine and green tea extract.
PlaceboOther
Two 355 mL cans of placebo drink but without the active ingredients (caffeine and green tea extract).
| Study group | Role | What they receive |
|---|---|---|
| Active | Experimental | Two 355 mL cans of "XS Energy + BURN" drink containing caffeine and green tea extract. Receives: Dietary Supplement: Active (Green tea and caffeine) |
| Placebo | Other | Two 355 mL cans of placebo drink but without the active ingredients (caffeine and green tea extract). Receives: Other: Placebo |
What is being measured
The primary outcome is the main question the study is designed to answer.
Fat oxidation as measured by indirect calorimetry
Change from baseline to the end of the study period in Fat oxidation as measured by indirect calorimetry (metabolic cart); baseline (pre-drink), post-drink (pre-exercise), time sequence e.g., every 5-min during exercise, 10, 20 and 30-min post-exercise. Change from baseline \& total. Fat oxidation will be measured continuously throughout the exercise and the 30-min post-exercise window, to facilitate total, and any other temporal fat oxidation timepoints.
Measured: Baseline to 30 mins post exercise
Secondary outcomes (3)
Carbohydrate oxidation; indirect calorimetry
Change from baseline to the end of the study period in Carbohydrate oxidation; indirect calorimetry; same timing as fat oxidation (baseline (pre-drink), post-drink (pre-exercise), time sequence e.g., every 5-min during exercise, 10, 20 and 30-min post-exercise.). Change from baseline \& total.
Measured: Baseline to 30 mins post exercise
Respiratory exchange ratio; indirect calorimetry
Change from baseline to the end of the study period in Respiratory exchange ratio; indirect calorimetry; same timing as fat oxidation (baseline (pre-drink), post-drink (pre-exercise), time sequence e.g., every 5-min during exercise, 10, 20 and 30-min post-exercise). Change from baseline \& total
Measured: Baseline to 30 mins post exercise
Exercise efficiency; indirect calorimetry
Change from baseline to the end of the study period in Exercise efficiency; indirect calorimetry; time sequence during exercise e.g., every 5-min. Change from the beginning of exercise \& average
Measured: Baseline to 30 mins post exercise
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Feb 2026
- Study start26 Mar 2026
- Primary completionOct 2026 (estimated)
- Study completionOct 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for ExerciseStudies of the same condition, open and under way.
- More trials run by RDC Clinical Pty LtdThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 4
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 36 participants (actual)
Sponsor and investigators
- Lead sponsor
- RDC Clinical Pty Ltd
- Sponsor type
- Industry (pharma, biotech, devices)
- Collaborators
- Amway Corp
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07434752
- Sponsor's protocol ID
- GRIFEX
- Status last verified
- Jan 2026
- First submitted
- 5 Jan 2026
- Last updated
- 27 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 27 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Influence of Caffeine and Green Tea Extracts Consumption on Basal, Peri- and Post-exercise Fat Oxidation
- ClinicalTrials.gov ID
- NCT07434752
- Acronym / sponsor ID
- GRIFEX
- Conditions
- Exercise
- Keywords
- metabolism
- Phase
- Phase 4
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 36 participants (actual)
- Lead sponsor
- RDC Clinical Pty LtdIndustry (pharma, biotech, devices)
- Collaborators
- Amway Corp
- Study start
- 26 Mar 2026 (actual)
- Primary completion
- Oct 2026 (estimated)
- Study completion
- Oct 2026 (estimated)
- First posted
- 27 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this study is to evaluate the influence of consuming a drink containing a combination of caffeine and green tea extracts on fat oxidation responses at rest, during and after a period of endurance type exercise.
Detailed description
This study investigates whether consuming an energy drink containing caffeine and green tea extract before exercise increases fat burning (oxidation) compared with a placebo drink. Healthy, moderately active adults will attend three visits at clinic over 3-5 weeks. The first visit determines each participant's individual exercise intensity that maximises fat use during cycling. At two subsequent visits, participants will consume either the active drink or a placebo before completing a 30-minute cycling session at their personalised intensity. Fat and carbohydrate use, heart rate, blood pressure, and subjective responses will be measured at rest, during exercise, and after exercise using a double-blind, crossover design.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Active | Experimental | Dietary Supplement: Active (Green tea and caffeine)Two 355 mL cans of "XS Energy + BURN" drink containing caffeine and green tea extract. |
| Placebo | Other | Other: PlaceboTwo 355 mL cans of placebo drink but without the active ingredients (caffeine and green tea extract). |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (15 listed)
- Passing the Exercise and Sport Science Australia adult pre-exercise screening system (APSS) stage 1 \& 2 (see appendix 4).
- Between the ages of 18 and 45,
- Not sedentary, and not completing more than 150 minutes of low and/or moderate and/or or vigorous intensity endurance exercise a week,
- Ability to commit to in principle fulfilment of all 3 trial visits,
- No history of coagulopathy e.g., DVT, stroke,
Key exclusion criteria (15 listed)
- Triggering any of the exclusion screening criteria as outlined below, and in compliment with the Exercise and Sport Science Australia adult pre-exercise screening system (APSS).
- Under the age of 18 or over the age of 45,
- Sedentary, or completing over 150 minutes of low and/or moderate and/or or vigorous intensity endurance exercise a week,
- Inability to commit to in principle fulfilment of all 3 trial visits,
- History of coagulopathy e.g., DVT, stroke,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Active (Green tea and caffeine)Also: XS Energy + BURNTwo 355 mL cans of "XS Energy + BURN" drink containing caffeine and green tea extract. | Dietary supplement | Active |
| PlaceboTwo 355 mL cans of placebo drink but without the active ingredients (caffeine and green tea extract). | Other | Placebo |
Primary outcome
Fat oxidation as measured by indirect calorimetry
Time frame: Baseline to 30 mins post exercise
Change from baseline to the end of the study period in Fat oxidation as measured by indirect calorimetry (metabolic cart); baseline (pre-drink), post-drink (pre-exercise), time sequence e.g., every 5-min during exercise, 10, 20 and 30-min post-exercise. Change from baseline \& total. Fat oxidation will be measured continuously throughout the exercise and the 30-min post-exercise window, to facilitate total, and any other temporal fat oxidation timepoints.
3 secondary outcomes
Carbohydrate oxidation; indirect calorimetry
Time frame: Baseline to 30 mins post exercise
Respiratory exchange ratio; indirect calorimetry
Time frame: Baseline to 30 mins post exercise
Exercise efficiency; indirect calorimetry
Time frame: Baseline to 30 mins post exercise
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Oct 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 4 study testing Active (Green tea and caffeine) in people with Exercise, run by RDC Clinical Pty Ltd at 1 site in Australia.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 15 inclusion and 15 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 27 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Australia. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 4 studies take place after a treatment is approved, to learn more about its long-term benefits and risks in everyday use.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Fat oxidation as measured by indirect calorimetry (time frame: Baseline to 30 mins post exercise). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Oct 2026.