Metabolic HealthNCT07435857
Effects of Exercise During Pregnancy on the Long-term Metabolic Health of Mothers and Their Offspring
An observational study of Metabolic Health, run by Peking University First Hospital at 1 site in China.
Trial summary
The aim of this study was to assess the long-term metabolic effects of gestational exercise on overweight and obese women and their offspring 8-10 years post-intervention. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Metabolic Health
- What is being tested?
- exercise
- Type of treatment
- Lifestyle or therapy programme
- How many people
- 221 participants
- Where
- 1 siteChina
- Study dates
- 1 Jun 2024to 15 Nov 2024
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Study population: This follow-up of a randomized trial included 300 overweight/obese pregnant women (prepregnancy BMI ≥24, <12⁺⁶ weeks gestation) from Peking University First Hospital (Dec 2014-Apr 2017). They were randomized to an exercise group (n=150, cycling three times/week, ≥30 min/session) or control group (n=150, usual activities). After excluding those who missed the OGTT (18 exercise, 17 control), 132 and 133 mother-offspring pairs, respectively, were included.
Who may be able to join
- 132 mothers in the exercise group and 133 mothers in the control group in the previous RCT trial who had OGTT results and their offsprings were eligible for follow-up
Who cannot join
- The criteria for exclusion from the follow-up study included loss to follow-up, refusal to participate, or major illness (acute lymphoblastic leukemia) of the mother or the child.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Long-Term Effects of Exercise During Pregnancy on the Metabolic Health of Mothers and Their Offspring: An 8- to 10-year Follow-Up Study
The aim of this study was to assess the long-term metabolic effects of gestational exercise on overweight and obese women and their offspring 8-10 years post-intervention.
Read the detailed description
We conducted a follow-up study of a randomized controlled trial (RCT) in which the impact of prenatal exercise on the incidence of gestational diabetes mellitus (GDM) was investigated. Mother-offspring pairs underwent comprehensive metabolic evaluations, including anthropometric measurements (weight, skinfold thickness, and body composition), blood pressure assessment, oral glucose tolerance tests (OGTTs), insulin release tests (IRTs), and lipid profiling.
- Conditions
- Metabolic Health
- Being tested
- exercise
- Keywords
- Exercise, Obesity, Follow-up, Metabolism, Maternal-offspring
- Medical subject headings
- Motor Activity, Obesity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
exerciseBehavioural
The present study is a prospective follow-up of a randomized controlled trial (RCT) that was conducted in the Department of Obstetrics and Gynecology, Peking University First Hospital, from December 2014 to April 2017. In this RCT, 300 obese/overweight pregnant women (prepregnancy BMI ≥24 kg/m²) at <12+6 weeks of gestation were randomized to exercise (n=150) and control groups (n=150), and the efficacy of regular exercise in early pregnancy to prevent GDM among overweight/obese pregnant Chinese women was investigated. The patients allocated to the exercise group were assigned to a cycling program (3 times per week, at least 30 min/session, rating of perceived exertion 12-14); the program was initiated within 3 days of randomization and continued until 37 weeks of gestation. The patients in the control group maintained their usual daily activities. The original RCT has been reported previously （Wang, C.Am. J. Obstet. Gynecol. 2017, 216 (4), 340-351.)
| Study group | Role | What they receive |
|---|---|---|
| exercise group | We conduct a follow-up study of a randomized controlled trial (RCT) in which the impact of prenatal exercise on the incidence of gestational diabetes mellitus (GDM) was investigated. Mother-offspring pairs underwent follow up Receives: Behavioral: exercise | |
| control group | We conduct a follow-up study of a randomized controlled trial (RCT) in which the impact of prenatal exercise on the incidence of gestational diabetes mellitus (GDM) was investigated. Mother-offspring pairs underwent follow up |
What is being measured
The primary outcome is the main question the study is designed to answer.
OGTT
75-g oral glucose tolerance test （0h，2h，mmol/L）
Measured: 8-10 years
Secondary outcomes (4)
BMI
weight in kilograms, height in meters, and weight and height will be combined to report BMI in kg/m2
Measured: 8-10 years
anthropometric measures
anthropometric measurements include waist circumference and skinfold thickness (centimeters) using skinfold caliper. Additionally，And use a body composition analyzer to measure body fat content and distribution （ The fat mass [kg]； fat percentage [%]； visceral fat area [cm2]； and lean mass [kg] were determined using bioimpedance analysis）.
Measured: 8-10 years
insulin resistance
plasma insulin levels were measured using electrochemiluminescence, and insulin resistance was calculated via the HOMA equation (fasting plasma insulin concentration (μIU/mL) × fasting glucose concentration (mmol/L)/22.5).
Measured: 8-10 years
lipid profile
fasting lipid profiles, including total cholesterol (TCHO), triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured via the cholesterol oxidase method (mmol/L)
Measured: 8-10 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Feb 2026
- Study start1 Jun 2024
- Primary completion15 Nov 2024
- Study completion15 Nov 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Metabolic HealthStudies of the same condition, open and under way.
- More trials run by Peking University First HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Other
- Enrolment
- 221 participants (actual)
Sponsor and investigators
- Lead sponsor
- Peking University First Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Wang Chen, Peking University First Hospital
- Investigators
- Chen Wang, Principal investigator, Peking University Frist hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07435857
- Sponsor's protocol ID
- 2021YFC2700700
- Status last verified
- Feb 2026
- First submitted
- 17 Feb 2026
- Last updated
- 27 Feb 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Guo J, Zhang Q, Deng Y, Sun T, Ning J, He Y, Pang Q, Wang S, Wen X, Han B, Wang T, Kang X, Han X, Lin X, Hou X, Gao D, Wei Y, Wang C, Yang H. Long-Term Effects of Exercise During Pregnancy on the Metabolic Health of Mothers with Overweight/Obesity and Their Offspring: An 8- to 10-Year Follow-Up Study. Adv Ther. 2026 Jun 12. doi: 10.1007/s12325-026-03649-6. Online ahead of print.
PubMed 42283957
Study at a glance
From the registry record, last updated by the sponsor on 27 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Long-Term Effects of Exercise During Pregnancy on the Metabolic Health of Mothers and Their Offspring: An 8- to 10-year Follow-Up Study
- ClinicalTrials.gov ID
- NCT07435857
- Acronym / sponsor ID
- 2021YFC2700700
- Conditions
- Metabolic Health
- Keywords
- Exercise, Obesity, Follow-up, Metabolism, Maternal-offspring
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 221 participants (actual)
- Lead sponsor
- Peking University First HospitalUniversity, hospital or other
- Study start
- 1 Jun 2024 (actual)
- Primary completion
- 15 Nov 2024 (actual)
- Study completion
- 15 Nov 2024 (actual)
- First posted
- 27 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study was to assess the long-term metabolic effects of gestational exercise on overweight and obese women and their offspring 8-10 years post-intervention.
Detailed description
We conducted a follow-up study of a randomized controlled trial (RCT) in which the impact of prenatal exercise on the incidence of gestational diabetes mellitus (GDM) was investigated. Mother-offspring pairs underwent comprehensive metabolic evaluations, including anthropometric measurements (weight, skinfold thickness, and body composition), blood pressure assessment, oral glucose tolerance tests (OGTTs), insulin release tests (IRTs), and lipid profiling.
Study design
- Observational model
- Other
- Time perspective
- Other
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| exercise group | – | Behavioral: exerciseWe conduct a follow-up study of a randomized controlled trial (RCT) in which the impact of prenatal exercise on the incidence of gestational diabetes mellitus (GDM) was investigated. Mother-offspring pairs underwent follow up |
| control group | – | –We conduct a follow-up study of a randomized controlled trial (RCT) in which the impact of prenatal exercise on the incidence of gestational diabetes mellitus (GDM) was investigated. Mother-offspring pairs underwent follow up |
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- This follow-up of a randomized trial included 300 overweight/obese pregnant women (prepregnancy BMI ≥24, <12⁺⁶ weeks gestation) from Peking University First Hospital (Dec 2014-Apr 2017). They were randomized to an exercise group (n=150, cycling three times/week, ≥30 min/session) or control group (n=150, usual activities). After excluding those who missed the OGTT (18 exercise, 17 control), 132 and 133 mother-offspring pairs, respectively, were included.
Key inclusion criteria (1 listed)
- 132 mothers in the exercise group and 133 mothers in the control group in the previous RCT trial who had OGTT results and their offsprings were eligible for follow-up
Key exclusion criteria (1 listed)
- The criteria for exclusion from the follow-up study included loss to follow-up, refusal to participate, or major illness (acute lymphoblastic leukemia) of the mother or the child.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| exerciseThe present study is a prospective follow-up of a randomized controlled trial (RCT) that was conducted in the Department of Obstetrics and Gynecology, Peking University First Hospital, from December 2014 to April 2017. In this RCT, 300 obese/overweight pregnant women (prepregnancy BMI ≥24 kg/m²) at <12+6 weeks of gestation were randomized to exercise (n=150) and control groups (n=150), and the efficacy of regular exercise in early pregnancy to prevent GDM among overweight/obese pregnant Chinese women was investigated. The patients allocated to the exercise group were assigned to a cycling program (3 times per week, at least 30 min/session, rating of perceived exertion 12-14); the program was initiated within 3 days of randomization and continued until 37 weeks of gestation. The patients in the control group maintained their usual daily activities. The original RCT has been reported previously （Wang, C.Am. J. Obstet. Gynecol. 2017, 216 (4), 340-351.) | Behavioural | exercise group |
Primary outcome
OGTT
Time frame: 8-10 years
75-g oral glucose tolerance test （0h，2h，mmol/L）
4 secondary outcomes
BMI
Time frame: 8-10 years
anthropometric measures
Time frame: 8-10 years
insulin resistance
Time frame: 8-10 years
lipid profile
Time frame: 8-10 years
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Feb 2026.
- Derived from this study: PubMed 42283957Guo J, Zhang Q, Deng Y, Sun T, Ning J, He Y, Pang Q, Wang S, Wen X, Han B, Wang T, Kang X, Han X, Lin X, Hou X, Gao D, Wei Y, Wang C, Yang H. Long-Term Effects of Exercise During Pregnancy on the Metabolic Health of Mothers with Overweight/Obesity and Their Offspring: An 8- to 10-Year Follow-Up Study. Adv Ther. 2026 Jun 12. doi: 10.1007/s12325-026-03649-6. Online ahead of print.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Chen Wang principal investigator
Peking University Frist hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Metabolic Health, run by Peking University First Hospital at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
OGTT (time frame: 8-10 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07435857, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Feb 2026.