Osteoarthritis (OA) of the KneeNCT07436897
Knee Pain and Lumbar Proprioception in Knee Osteoarthritis Patients
An observational study of Osteoarthritis (OA) of the Knee, run by Cairo University at 1 site in Egypt.
Trial summary
Knee osteoarthritis (KOA), is a chronic degenerative joint pathology with a global prevalence of 22.9% in individuals aged 40 and over. It is a leading cause of disability and poor quality of life worldwide due to musculoskeletal pain and functional limitations. Read more about this study
- Who is it for?
- Ages 40 to 60 years
- Conditions the study is for
- Osteoarthritis (OA) of the Knee
- What is being tested?
- porprioception
- How many people
- 56 participants
- Where
- 1 siteEgypt
- Study dates
- 1 May 2025to 20 Dec 2025
- How long will I take part?
- 4 Weeks
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 60 years
- All sexes
- No healthy volunteers
- Adult
Study population: Between the ages of 40 and 60 years, fifty-six individuals of both sexes were recruited, their BMI ranged from 24.02 to 29.98.
Who may be able to join
- Male and female participants diagnosed with knee osteoarthritis.
- The participants diagnosed with grade one, grade two and grade three knee osteoarthritis.
- Subjects aged form 40-60 years old.
- All the participants complain of knee pain.
- Participants able to understand the commands.
Who cannot join
- 1- Experienced serious trauma leading to fractures and dislocations of the spine.
- 2- They have been diagnosed to have spinal deformities such as scoliosis, lumbar disc herniation and lumbar spondylolisthesis.
- 3- They have infection/malignant spinal conditions. 4- They have cauda equine syndrome. 5- Anyone with psychological disorders (e.g. dementia or drug abuse). 6- Uncooperative participant 7- Anyone with grade four knee osteoarthritis
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Association Between Knee Pain and Lumbar Proprioception in Patients With Knee Osteoarthritis
Knee osteoarthritis (KOA), is a chronic degenerative joint pathology with a global prevalence of 22.9% in individuals aged 40 and over. It is a leading cause of disability and poor quality of life worldwide due to musculoskeletal pain and functional limitations. Musculoskeletal pain is the primary patient-reported outcome in patients with osteoarthritis (OA) and a major cause of disability and functional limitations this study was carried to investigate the correlation between knee pain and lumbar proprioception
Read the detailed description
Purpose of the study:
- To investigate the relationship between knee pain and lumbar proprioception in patient with knee osteoarthritis.
- To investigate the gender effect on the relationship between knee pain and lumbar proprioception in patient with knee osteoarthritis.
- To investigate a difference between different grades of knee osteoarthritis on the relationship between lumbar proprioception and knee pain. fifty-six individuals of both sexes were recruited, their BMI ranged from 24.02 to 29.98. Between the ages of 40 and 60 years Pain was assessd by visual analoge scale and proprioception assessed by The Biodex system
- Conditions
- Osteoarthritis (OA) of the Knee
- Being tested
- porprioception
- Keywords
- knee pain, Osteoarthritis, Lumbar proprioception, Repositioning error.
- Medical subject headings
- Osteoarthritis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
porprioceptionOther
The Biodex system 3 was used to measure joint position error.
| Study group | Role | What they receive |
|---|---|---|
| study group | fifty-six individuals of both sexes between the ages of 40 and 60 years with knee osteoarthritis Receives: Other: porprioception |
What is being measured
The primary outcome is the main question the study is designed to answer.
proprioception
Joint position error was measured using the Biodex system 3. Before every test, the system was calibrated and stabilized.
The patient was placed in a seated compressed posture on the Biodex system chair. Two curved pads on the front of the legs allowed for individual adjustment of the knee blocks, and the patient's feet were supported in a way that they did not touch the floor, both thighs were stabilized by two straps, the pelvic brace was then applied and positioned as far down as possible to press firmly but comfortably against the superior aspect of the proximal thighs. The starting position for each participant was with their spines flexed at a 60° angle. As a "target position" for the individuals to maintain during the testing, the predetermined spinal ROM was set at 60° to 90° lumbar flexion. All subjects. After recording the subjects' absolute error (AE) values relative to the 90-degree target position for all three trials, the mean deviation was calculated
Measured: at the baseline (day 1)
Secondary outcomes (1)
Pain intensity
Pain intensity level was measured by applying the VAS. Each participant was made aware that the VAS as being 100 mm horizontal line with one end defined as (no pain = 0 mm), while the other end (Worst pain = 100 mm). Participant was asked to mark a spot on the line between that relates to their level of pain that on a scale of 0-100 mm where 0 mm means absence of pain and 100 mm worst pain. This procedure was repeated three times and average was recorded.
Measured: at the baseline (day 1)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Feb 2026
- Study start1 May 2025
- Primary completion1 Nov 2025
- Study completion20 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Osteoarthritis (OA) of the KneeStudies of the same condition, open and under way.
- More trials run by Cairo UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 56 participants (actual)
- Target duration
- 4 Weeks
Sponsor and investigators
- Lead sponsor
- Cairo University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Doaa Rafat, Cairo University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07436897
- Sponsor's protocol ID
- Physical Therapy 25055
- Status last verified
- Feb 2026
- First submitted
- 28 Jan 2026
- Last updated
- 27 Feb 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Association Between Knee Pain and Lumbar Proprioception in Patients With Knee Osteoarthritis
- ClinicalTrials.gov ID
- NCT07436897
- Acronym / sponsor ID
- Physical Therapy 25055
- Conditions
- Osteoarthritis (OA) of the Knee
- Keywords
- knee pain, Osteoarthritis, Lumbar proprioception, Repositioning error.
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 56 participants (actual)
- Lead sponsor
- Cairo UniversityUniversity, hospital or other
- Study start
- 1 May 2025 (actual)
- Primary completion
- 1 Nov 2025 (actual)
- Study completion
- 20 Dec 2025 (actual)
- First posted
- 27 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Knee osteoarthritis (KOA), is a chronic degenerative joint pathology with a global prevalence of 22.9% in individuals aged 40 and over. It is a leading cause of disability and poor quality of life worldwide due to musculoskeletal pain and functional limitations. Musculoskeletal pain is the primary patient-reported outcome in patients with osteoarthritis (OA) and a major cause of disability and functional limitations this study was carried to investigate the correlation between knee pain and lumbar proprioception
Detailed description
Purpose of the study:
- To investigate the relationship between knee pain and lumbar proprioception in patient with knee osteoarthritis.
- To investigate the gender effect on the relationship between knee pain and lumbar proprioception in patient with knee osteoarthritis.
- To investigate a difference between different grades of knee osteoarthritis on the relationship between lumbar proprioception and knee pain. fifty-six individuals of both sexes were recruited, their BMI ranged from 24.02 to 29.98. Between the ages of 40 and 60 years Pain was assessd by visual analoge scale and proprioception assessed by The Biodex system
Study design
- Observational model
- Other
- Time perspective
- Prospective
- Target follow-up
- 4 Weeks
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| study group | – | Other: porprioceptionfifty-six individuals of both sexes between the ages of 40 and 60 years with knee osteoarthritis |
Who may qualify
- Ages
- 40 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
- Study population
- Between the ages of 40 and 60 years, fifty-six individuals of both sexes were recruited, their BMI ranged from 24.02 to 29.98.
Key inclusion criteria (5 listed)
- Male and female participants diagnosed with knee osteoarthritis.
- The participants diagnosed with grade one, grade two and grade three knee osteoarthritis.
- Subjects aged form 40-60 years old.
- All the participants complain of knee pain.
- Participants able to understand the commands.
Key exclusion criteria (3 listed)
- 1- Experienced serious trauma leading to fractures and dislocations of the spine.
- 2- They have been diagnosed to have spinal deformities such as scoliosis, lumbar disc herniation and lumbar spondylolisthesis.
- 3- They have infection/malignant spinal conditions. 4- They have cauda equine syndrome. 5- Anyone with psychological disorders (e.g. dementia or drug abuse). 6- Uncooperative participant 7- Anyone with grade four knee osteoarthritis
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| porprioceptionThe Biodex system 3 was used to measure joint position error. | Other | study group |
Primary outcome
proprioception
Time frame: at the baseline (day 1)
Joint position error was measured using the Biodex system 3. Before every test, the system was calibrated and stabilized. The patient was placed in a seated compressed posture on the Biodex system chair. Two curved pads on the front of the legs allowed for individual adjustment of the knee blocks, and the patient's feet were supported in a way that they did not touch the floor, both thighs were stabilized by two straps, the pelvic brace was then applied and positioned as far down as possible to press firmly but comfortably against the superior aspect of the proximal thighs. The starting position for each participant was with their spines flexed at a 60° angle. As a "target position" for the individuals to maintain during the testing, the predetermined spinal ROM was set at 60° to 90° lumbar flexion. All subjects. After recording the subjects' absolute error (AE) values relative to the 90-degree target position for all three trials, the mean deviation was calculated
1 secondary outcome
Pain intensity
Time frame: at the baseline (day 1)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Feb 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Osteoarthritis (OA) of the Knee, run by Cairo University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
proprioception (time frame: at the baseline (day 1)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Feb 2026.