AmblyopiaNCT07437807
Vision Therapy Outcomes in Amblyopia: Linking Brain Plasticity With Visual Perceptual Skills
An observational study of Amblyopia, run by Okan University at 1 site in Turkey (Türkiye).
Trial summary
The primary objective of this study is to evaluate the effects of a personalized vision therapy programme tailored to baseline visual-cognitive abilities in treatment-resistant amblyopia. Read more about this study
- Who is it for?
- Ages 4 to 18 years
- Conditions the study is for
- Amblyopia
- What is being tested?
- Motor Free Perception Vision Test
- How many people
- 38 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 12 Jun 2024to 30 Sep 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 4 to 18 years
- All sexes
- No healthy volunteers
- Child, Adult
Study population: 38 amblyopia patients who are admitted to the Dr.Semrin Timlioğlu İper Clinic and Okan University. During the time period: June 2024-June 2025. Patients are unresponsive to traditional treatments such as: strabismus surgery, occlusion therapy and atropinization. They recieved personalized vision therapy programme based on their visual-cognitive and perceptual skills.
Who may be able to join
- Ambylopia patient
- Minimal response to traditional treatments
- Ages between 4-18
- Receiving personalized vision therapy
- Taking the TVPS-3 at least 2 times
Who cannot join
- Responsive to treatment
- Discontinued vision therapy
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Correlation of Vision Therapy With Visual-Cognitive Skills and Therapeutic Outcomes in Amblyopia: Linking Brain Plasticity With Visual Perceptual Skills
The primary objective of this study is to evaluate the effects of a personalized vision therapy programme tailored to baseline visual-cognitive abilities in treatment-resistant amblyopia. In addition to testing the hypothesis that rehabilitation protocols targeting amblyopia related visual-perceptual and visual-cognitive skills. Spesific aims of this study are:
- to identify which visual perceptual skills are most significantly impaired sen patients with amblyopia.
- to evaluate whether interventions are targeting fundamental visual perceptual skills are associated with improvements in higher-order visual perceptual skills.
- to determine whether vision therapy tailored to individual neuro-visual impairments associated with improvements in binocular function, including streopsis and overall visual perceptual performance.
- to ases whether baseline neuro-visual perceptual performance predicts the response to vision therapy in patients with amblyopia.
- Conditions
- Amblyopia
- Being tested
- Motor Free Perception Vision Test
- Keywords
- Amblyopia, Vision Therapy, Visual Perceptual Skills, Visual-Cognitive Skills, Neuroplasticity
- Medical subject headings
- Amblyopia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Motor Free Perception Vision TestDiagnostic test
The Motor-Free Visual Perception Test-3 (MVPT-3) represents a significant methodological iteration in the assessment of non-motor visual processing, specifically validated for individuals ranging from 4 to 95 years of age. In pediatric and adolescent contexts (under 18), the MVPT-3 is utilized to isolate cognitive visual-perceptual skills-such as spatial relationships, visual discrimination, figure-ground, and visual closure-from fine motor coordination, which may still be developing or impaired. The test consists of 65 items arranged in a horizontal format to accommodate individuals with hemispatial neglect or limited field of vision. For younger examinees, the assessment is particularly vital for identifying perceptual deficits that may impede academic performance, such as reading fluency or mathematical reasoning, without the results being skewed by the child's handwriting or drawing abilities. By providing age-adjusted normative data, the MVPT-3 allows clinicians to derive standard
| Study group | Role | What they receive |
|---|---|---|
| Amblyopia patients enrolled in vision therapy | Amblyopia patients who are unresponsive to treatmens ( occlusion therapy, atropinization, strabismus surgery) and enrolled in vision therapy Receives: Diagnostic Test: Motor Free Perception Vision Test |
What is being measured
The primary outcome is the main question the study is designed to answer.
The Correlation Between Vision Therapy and Visual Cognitive Skills and It's Therapeutic Results in Amblyopia: Associating with Brain Plasticity and Visual Perceptual Skills
Measured: From June 2024 to June 2025
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Feb 2026
- Study start12 Jun 2024
- Primary completion12 Jun 2025
- Study completion30 Sep 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AmblyopiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 38 participants (actual)
Sponsor and investigators
- Lead sponsor
- Okan University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Hatice Semrin Timlioglu İper, Okan University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07437807
- Sponsor's protocol ID
- 56664061-050.01.04-E.2309
- Status last verified
- Mar 2026
- First submitted
- 23 Feb 2026
- Last updated
- 10 Mar 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: All IPD that underlie results in publication
Study at a glance
From the registry record, last updated by the sponsor on 10 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Correlation of Vision Therapy With Visual-Cognitive Skills and Therapeutic Outcomes in Amblyopia: Linking Brain Plasticity With Visual Perceptual Skills
- ClinicalTrials.gov ID
- NCT07437807
- Acronym / sponsor ID
- 56664061-050.01.04-E.2309
- Conditions
- Amblyopia
- Keywords
- Amblyopia, Vision Therapy, Visual Perceptual Skills, Visual-Cognitive Skills, Neuroplasticity
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 38 participants (actual)
- Lead sponsor
- Okan UniversityUniversity, hospital or other
- Study start
- 12 Jun 2024 (actual)
- Primary completion
- 12 Jun 2025 (actual)
- Study completion
- 30 Sep 2025 (actual)
- First posted
- 27 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The primary objective of this study is to evaluate the effects of a personalized vision therapy programme tailored to baseline visual-cognitive abilities in treatment-resistant amblyopia. In addition to testing the hypothesis that rehabilitation protocols targeting amblyopia related visual-perceptual and visual-cognitive skills. Spesific aims of this study are:
- to identify which visual perceptual skills are most significantly impaired sen patients with amblyopia.
- to evaluate whether interventions are targeting fundamental visual perceptual skills are associated with improvements in higher-order visual perceptual skills.
- to determine whether vision therapy tailored to individual neuro-visual impairments associated with improvements in binocular function, including streopsis and overall visual perceptual performance.
- to ases whether baseline neuro-visual perceptual performance predicts the response to vision therapy in patients with amblyopia.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Amblyopia patients enrolled in vision therapy | – | Diagnostic Test: Motor Free Perception Vision TestAmblyopia patients who are unresponsive to treatmens ( occlusion therapy, atropinization, strabismus surgery) and enrolled in vision therapy |
Who may qualify
- Ages
- 4 to 18 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult
- Study population
- 38 amblyopia patients who are admitted to the Dr.Semrin Timlioğlu İper Clinic and Okan University. During the time period: June 2024-June 2025. Patients are unresponsive to traditional treatments such as: strabismus surgery, occlusion therapy and atropinization. They recieved personalized vision therapy programme based on their visual-cognitive and perceptual skills.
Key inclusion criteria (5 listed)
- Ambylopia patient
- Minimal response to traditional treatments
- Ages between 4-18
- Receiving personalized vision therapy
- Taking the TVPS-3 at least 2 times
Key exclusion criteria (2 listed)
- Responsive to treatment
- Discontinued vision therapy
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Motor Free Perception Vision TestThe Motor-Free Visual Perception Test-3 (MVPT-3) represents a significant methodological iteration in the assessment of non-motor visual processing, specifically validated for individuals ranging from 4 to 95 years of age. In pediatric and adolescent contexts (under 18), the MVPT-3 is utilized to isolate cognitive visual-perceptual skills-such as spatial relationships, visual discrimination, figure-ground, and visual closure-from fine motor coordination, which may still be developing or impaired. The test consists of 65 items arranged in a horizontal format to accommodate individuals with hemispatial neglect or limited field of vision. For younger examinees, the assessment is particularly vital for identifying perceptual deficits that may impede academic performance, such as reading fluency or mathematical reasoning, without the results being skewed by the child's handwriting or drawing abilities. By providing age-adjusted normative data, the MVPT-3 allows clinicians to derive standard | Diagnostic test | Amblyopia patients enrolled in vision therapy |
Primary outcome
The Correlation Between Vision Therapy and Visual Cognitive Skills and It's Therapeutic Results in Amblyopia: Associating with Brain Plasticity and Visual Perceptual Skills
Time frame: From June 2024 to June 2025
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Mar 2026.
- Comparison between binocular therapy and patching for treatment of amblyopia: a meta-analysis of randomised controlled trialsLink provided by the sponsor.
- Comparison of a novel gamified binocular therapy and standard monocular patching therapy in treating unilateral amblyopia in young children: a prospective, multicenter, randomized controlled trialLink provided by the sponsor.
- Randomized clinical trial of streaming dichoptic movies versus patching for treatment of amblyopia in children aged 3 to 7 yearsLink provided by the sponsor.
- New advances in amblyopia therapy I: binocular therapies and pharmacologic augmentationLink provided by the sponsor.
- Randomised controlled trial of video clips and interactive games to improve vision in children with amblyopia using the I-BiT systemLink provided by the sponsor.
- Effect of vision-based treatments on visual acuity and motor function in children with amblyopiaLink provided by the sponsor.
- Individual participant dataSharing planned: Yes. All IPD that underlie results in publication
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Amblyopia, run by Okan University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 10 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The Correlation Between Vision Therapy and Visual Cognitive Skills and It's Therapeutic Results in Amblyopia: Associating with Brain Plasticity and Visual Perceptual Skills (time frame: From June 2024 to June 2025). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Mar 2026.