Free Gingival GraftPhase 2FGGNCT07439068

A-PRF and CGF in Palatal Donor Site Healing

A Phase 2 study testing Advanced platelet-rich fibrin, Concentrated growth factor and Sterile gelatin sponge in people with Free Gingival Graft, run by Ordu University at 1 site in Turkey (Türkiye).

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

The objective of this study was to compare and evaluate the effects of concentrated growth factor (CGF) and advanced platelet-rich fibrin (A-PRF) clot membranes on palatal epithelial wound healing and postoperative discomfort following free gingival graft (FGG) harvesting. Read more about this study

Who is it for?: Ages 18 to 55 years
Conditions the study is for: Free Gingival Graft
What is being tested?: Advanced platelet-rich fibrin, Concentrated growth factor and Sterile gelatin sponge
Type of treatment: Surgery or procedure
Could I receive a placebo?: Yes, some participants may receive a placebo
How many people: 45 participants
Where: 1 siteTurkey (Türkiye)
Study dates: 1 Nov 2020to 31 May 2022
Phase: Phase 2
Are there results?: None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 to 55 years
All sexes
No healthy volunteers
Adult

Who may be able to join

at least 18 years old,
without systemic or periodontal diseases,
without medical contraindications to periodontal surgery
with full-mouth plaque control scores ≤ 20%
Gingival index scores ≤ 1

Who cannot join

smoking habits,
diabetes mellitus,
pregnancy or lactation,
removable upper denture,
regular medication that could interpose the healing process, undergoing bisphosphonate therapy, history of radiation therapy of the jaws, and follow-up consults

Trial locations and contacts

1 site in 1 country.

Turkey (Türkiye)1 site

Ordu University
Ordu, 52100

Other trials in Turkey (Türkiye)

About this study

Official title: Effects on Patients' Postoperative Morbidity and Donor Site Wound Healing of A-PRF and CGF Application After Free Gingival Graft Harvesting: A Comparative Randomized Clinical Trial

Read the detailed description

Fourty-five patients who underwent FGG harvesting were randomly assigned to three groups: (1) control group (n=15), receiving only a sterile gelatin sponge; (2) A-PRF group (n=15), receiving A-PRF clot membranes; and (3) CGF group (n=15), receiving CGF clot membranes at the donor site. The epithelization rate, color match, and sensation scores of the palatal wound were assessed at 1, 2, 3, and 4 weeks postoperatively. Pain levels, analgesic consumption, and bleeding time were self-reported by patients for the first 7 days of healing.

Conditions: Free Gingival Graft
Being tested: Advanced platelet-rich fibrin, Concentrated growth factor, Sterile gelatin sponge
Keywords: Concentrated Growth Factor, Advanced Platelet-Rich Fibrin

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Advanced platelet-rich fibrinProcedure or surgery
Advanced platelet-rich fibrin membranes and free gingival graft
Concentrated growth factorProcedure or surgery
Concentrated growth factor membranes and free gingival graft
Sterile gelatin spongeProcedure or surgery
Sterile gelatin sponge and free gingival graft

Study groups in NCT07439068
Study group	Role	What they receive
Advanced platelet-rich fibrin	Active comparator	Advanced platelet-rich fibrin clot membranes on palatal epithelial wound after harvesting free gingival graft Receives: Procedure: Advanced platelet-rich fibrin
Concentrated growth factor	Active comparator	Concentrated growth factor clot membranes on palatal epithelial wound after harvesting free gingival graft Receives: Procedure: Concentrated growth factor
Sterile gelatin sponge	Placebo comparator	Sterile gelatin sponge on palatal epithelial wound after harvesting free gingival graft Receives: Procedure: Sterile gelatin sponge

What is being measured

The primary outcome is the main question the study is designed to answer.

Epithelialization
Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface
Measured: Baseline
Epithelialization
Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface
Measured: 1 week post-surgery
Epithelialization
Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface
Measured: 2 week post-surgery
Epithelialization
Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface
Measured: 3 week post-surgery
Epithelialization
Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface
Measured: 4 week post-surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Measured: Baseline
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Measured: 1st day after surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Measured: 2nd day after surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Measured: 3th day after surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Measured: 4th day after surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Measured: 5th day after surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Measured: 6th day after surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Measured: 7th day after surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Measured: 14th day after surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Measured: 21st day after surgery
Pain perception
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Measured: 28th day after surgery

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

1 Nov 202031 May 2022

First posted27 Feb 2026
Study start1 Nov 2020
Primary completion30 May 2022
Study completion31 May 2022

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Other trials for Free Gingival GraftStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase 2
Primary purpose: Treatment
Allocation: Randomised
Intervention model: Parallel groups
Masking: Single blind
Who is masked: Participant
Enrolment: 45 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT07439068
Sponsor's protocol ID: 2020\159
Acronym: FGG
Status last verified: Feb 2026
First submitted: 10 Feb 2026
Last updated: 27 Feb 2026
Results posted: No
Data monitoring committee: Yes
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: No

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See locations

Not yet recruiting
Free Soft Tissue Grafts (FSTG) Using Autograft Palatal Donor Tissue vs. Xenograft Collagen Matrix (Zderm™)
Gingival Recession Localized Moderate, Dental Implant
Recruiting
Palatal Wound Healing After Free Gingival Graft Harvest in Diabetic Patients: A Clinical Trial
Diabetes Mellitus, Gingival Recession, Generalized
Not yet recruiting
Keratinized Tissue Augmentation Using Augmented Gingival Matrix Compared to Free Gingival Graft Around Implants
Keratinized Tissue Augmentation Around Dental Implants
Recruiting
Effects of Low-Level Laser Therapy and Hyaluronic Acid After Free Gingival Graft
Gingival Recession, Mucogingival Surgery
Not yet recruiting
Comparison of the Keratinized Tissue Gain in Frenal Relocation Alone to Frenal Relocation Combined With the Application of Free Gingival Graft in High Frenum Attachment in Adults
Keratinized Tissue Gain

All Free Gingival Graft trials

Study at a glance

From the registry record, last updated by the sponsor on 27 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Effects on Patients' Postoperative Morbidity and Donor Site Wound Healing of A-PRF and CGF Application After Free Gingival Graft Harvesting: A Comparative Randomized Clinical Trial
ClinicalTrials.gov ID: NCT07439068
Acronym / sponsor ID: FGG / 2020\159
Conditions: Free Gingival Graft
Keywords: Concentrated Growth Factor, Advanced Platelet-Rich Fibrin
Phase: Phase 2
Study type: Interventional
Recruitment status: Completed
Enrolment: 45 participants (actual)
Lead sponsor: Ordu UniversityUniversity, hospital or other
Study start: 1 Nov 2020 (actual)
Primary completion: 30 May 2022 (actual)
Study completion: 31 May 2022 (actual)
First posted: 27 Feb 2026 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Detailed description

Study design

Primary purpose: Treatment
Allocation: Randomised
Intervention model: Parallel groups
Masking: Single blind (participant)
Number of arms: 3

Arm	Type	Receives
Advanced platelet-rich fibrin	Active comparator	Procedure: Advanced platelet-rich fibrinAdvanced platelet-rich fibrin clot membranes on palatal epithelial wound after harvesting free gingival graft
Concentrated growth factor	Active comparator	Procedure: Concentrated growth factorConcentrated growth factor clot membranes on palatal epithelial wound after harvesting free gingival graft
Sterile gelatin sponge	Placebo comparator	Procedure: Sterile gelatin spongeSterile gelatin sponge on palatal epithelial wound after harvesting free gingival graft

Who may qualify

Ages: 18 to 55 years
Sex: All
Healthy volunteers: Not accepted
Age groups: Adult

Key inclusion criteria (5 listed)

at least 18 years old,
without systemic or periodontal diseases,
without medical contraindications to periodontal surgery
with full-mouth plaque control scores ≤ 20%
Gingival index scores ≤ 1

Key exclusion criteria (5 listed)

smoking habits,
diabetes mellitus,
pregnancy or lactation,
removable upper denture,
regular medication that could interpose the healing process, undergoing bisphosphonate therapy, history of radiation therapy of the jaws, and follow-up consults

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Advanced platelet-rich fibrinAdvanced platelet-rich fibrin membranes and free gingival graft	Procedure or surgery	Advanced platelet-rich fibrin
Concentrated growth factorConcentrated growth factor membranes and free gingival graft	Procedure or surgery	Concentrated growth factor
Sterile gelatin spongeSterile gelatin sponge and free gingival graft	Procedure or surgery	Sterile gelatin sponge

Primary outcome

Epithelialization
Time frame: Baseline
Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface
Epithelialization
Time frame: 1 week post-surgery
Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface
Epithelialization
Time frame: 2 week post-surgery
Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface
Epithelialization
Time frame: 3 week post-surgery
Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface
Epithelialization
Time frame: 4 week post-surgery
Rate of re-epithelialization with re-total, partial, or none by dropping hydrogen peroxide (3%) on the wound surface
Pain perception
Time frame: Baseline
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Pain perception
Time frame: 1st day after surgery
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Pain perception
Time frame: 2nd day after surgery
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Pain perception
Time frame: 3th day after surgery
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Pain perception
Time frame: 4th day after surgery
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Pain perception
Time frame: 5th day after surgery
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Pain perception
Time frame: 6th day after surgery
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Pain perception
Time frame: 7th day after surgery
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Pain perception
Time frame: 14th day after surgery
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Pain perception
Time frame: 21st day after surgery
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)
Pain perception
Time frame: 28th day after surgery
Presence of pain perception on the Visual Analog Scale (VAS) pain scores (0: no pain, 1: minimal pain, 10: severe pain)

Results and safety

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 27 Feb 2026.
Individual participant dataSharing planned: No

Related trials for Free Gingival Graft

Not yet recruiting
Free Soft Tissue Grafts (FSTG) Using Autograft Palatal Donor Tissue vs. Xenograft Collagen Matrix (Zderm™)
Gingival Recession Localized Moderate, Dental Implant
Recruiting
Palatal Wound Healing After Free Gingival Graft Harvest in Diabetic Patients: A Clinical Trial
Diabetes Mellitus, Gingival Recession, Generalized
Not yet recruiting
Keratinized Tissue Augmentation Using Augmented Gingival Matrix Compared to Free Gingival Graft Around Implants
Keratinized Tissue Augmentation Around Dental Implants
Recruiting
Effects of Low-Level Laser Therapy and Hyaluronic Acid After Free Gingival Graft
Gingival Recession, Mucogingival Surgery
Not yet recruiting
Comparison of the Keratinized Tissue Gain in Frenal Relocation Alone to Frenal Relocation Combined With the Application of Free Gingival Graft in High Frenum Attachment in Adults
Keratinized Tissue Gain

Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

Figen Öngöz Dede, Prof principal investigator

Ordu Universitesi

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

A Phase 2 study testing Advanced platelet-rich fibrin, Concentrated growth factor and Sterile gelatin sponge in people with Free Gingival Graft, run by Ordu University at 1 site in Turkey (Türkiye).

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 27 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Epithelialization (time frame: Baseline). The study lists 16 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07439068.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Feb 2026.