AgingNCT07440017
Older Age and Generalization
A study testing Memory decision type in people with Aging, run by Caitlin Bowman at 1 site in United States.
Trial summary
The goal of this clinical is to learn how the brain supports different kinds of memory decisions in healthy young and older adults. The main question it seeks to answer is: Do older adults make memory decisions by integrating across experiences? Young (aged 18-30 years) and older (aged 65-80 years) participants will… Read more about this study
- Who is it for?
- Ages 18 to 80 yearsHealthy volunteers can take part
- Conditions the study is for
- Aging
- What is being tested?
- Memory decision type
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 360 participants
- Where
- 1 siteUnited States
- Study dates
- 15 Jun 2026to 31 Dec 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Either aged 18-30 years (young adults) or aged 65-80 years (older adults) (self-report)
- Fluent in English (self-report)
- Right-handed (self-report)
- Cognitively healthy (self report verified by score > 24 on Montreal Cognitive Assessment)
- Self-reported normal or corrected-to-normal vision
Who cannot join
- Self-reported neurological disorder (e.g., Alzheimer's or Parkinson's disease)
- Self-reported uncontrolled hypertension, diabetes, or thyroid disorder
- Having conditions or devices that are unsafe for MRI (assessed via imaging center's MRI safety screening form)
- Self-reported difficulty lying still on one's back for 1-2 hours
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
United States1 site, 1 recruiting
- Recruiting
University of Wisconsin-Milwaukee
Milwaukee, Wisconsin, 53211
Caitlin Bowman, PhD, 414-251-5010, bowman2@uwm.edu
About this study
Official title: Effects of Older Age on the Neural Basis of Memory Generalization
The goal of this clinical is to learn how the brain supports different kinds of memory decisions in healthy young and older adults. The main question it seeks to answer is: Do older adults make memory decisions by integrating across experiences?
Young (aged 18-30 years) and older (aged 65-80 years) participants will complete a memory task while undergoing functional MRI to measure their brain responses.
Researchers will compare brain measures of integration in older adults to those of young adults to see if integration increases in older age.
- Conditions
- Aging
- Being tested
- Memory decision type
- Keywords
- cognitive aging, episodic memory, fMRI, generalization, hippocampus, prefrontal cortex
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Memory decision typeBehavioural
Subjects will be probed to either remember an association they saw directly during the study phase or to make an inference across indirectly associated items.
| Study group | Role | What they receive |
|---|---|---|
| Experimental Arm | Experimental | This is a within-subject design with a single experimental arm Receives: Behavioral: Memory decision type |
What is being measured
The primary outcome is the main question the study is designed to answer.
Behavioral memory responses
Participants will complete the study and test phases of a memory-based inference task designed by the investigators. The investigators will focus on the accuracy of decisions (0-100% scale with higher scores meaning better memory) and how long it takes to make correct decisions (in seconds, faster responses mean less cognitive processing needed).
Measured: Session 2 (experimental session)
Neural memory responses
Investigators will measure the neural underpinnings of direct memory and the ability to make inferences.
Measured: Session 2 (experimental session)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Feb 2026
- Study start15 Jun 2026
- Primary completion1 Dec 2029 (estimated)
- Study completion31 Dec 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AgingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 360 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Caitlin Bowman
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute on Aging (NIA)
- Responsible party
- Sponsor-investigator, Caitlin Bowman, University of Wisconsin, Milwaukee
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07440017
- Sponsor's protocol ID
- 23.108
- Other IDs
- R01AG098263
- Status last verified
- Jun 2026
- First submitted
- 23 Feb 2026
- Last updated
- 17 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Shared data will include structural and function MRI images, behavioral data from experimental tasks, behavioral data from the pre-experimental cognitive assessment, behavioral data from any post-experimental debriefing questionnaires, and participant demographic information.
Study at a glance
From the registry record, last updated by the sponsor on 17 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Older Age on the Neural Basis of Memory Generalization
- ClinicalTrials.gov ID
- NCT07440017
- Acronym / sponsor ID
- 23.108
- Conditions
- Aging
- Keywords
- cognitive aging, episodic memory, fMRI, generalization, hippocampus, prefrontal cortex
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 360 participants (estimated)
- Lead sponsor
- Caitlin BowmanUniversity, hospital or other
- Collaborators
- National Institute on Aging (NIA)
- Study start
- 15 Jun 2026 (actual)
- Primary completion
- 1 Dec 2029 (estimated)
- Study completion
- 31 Dec 2029 (estimated)
- First posted
- 27 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical is to learn how the brain supports different kinds of memory decisions in healthy young and older adults. The main question it seeks to answer is: Do older adults make memory decisions by integrating across experiences?
Young (aged 18-30 years) and older (aged 65-80 years) participants will complete a memory task while undergoing functional MRI to measure their brain responses.
Researchers will compare brain measures of integration in older adults to those of young adults to see if integration increases in older age.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Experimental Arm | Experimental | Behavioral: Memory decision typeThis is a within-subject design with a single experimental arm |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Either aged 18-30 years (young adults) or aged 65-80 years (older adults) (self-report)
- Fluent in English (self-report)
- Right-handed (self-report)
- Cognitively healthy (self report verified by score > 24 on Montreal Cognitive Assessment)
- Self-reported normal or corrected-to-normal vision
Key exclusion criteria (4 listed)
- Self-reported neurological disorder (e.g., Alzheimer's or Parkinson's disease)
- Self-reported uncontrolled hypertension, diabetes, or thyroid disorder
- Having conditions or devices that are unsafe for MRI (assessed via imaging center's MRI safety screening form)
- Self-reported difficulty lying still on one's back for 1-2 hours
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Memory decision typeSubjects will be probed to either remember an association they saw directly during the study phase or to make an inference across indirectly associated items. | Behavioural | Experimental Arm |
Primary outcome
Behavioral memory responses
Time frame: Session 2 (experimental session)
Participants will complete the study and test phases of a memory-based inference task designed by the investigators. The investigators will focus on the accuracy of decisions (0-100% scale with higher scores meaning better memory) and how long it takes to make correct decisions (in seconds, faster responses mean less cognitive processing needed).
Neural memory responses
Time frame: Session 2 (experimental session)
Investigators will measure the neural underpinnings of direct memory and the ability to make inferences.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Jun 2026.
- Individual participant dataSharing planned: Yes. Shared data will include structural and function MRI images, behavioral data from experimental tasks, behavioral data from the pre-experimental cognitive assessment, behavioral data from any post-experimental debriefing questionnaires, and participant demographic information.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Memory decision type in people with Aging, run by Caitlin Bowman at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 17 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Caitlin Bowman, PhD (414-251-5010, bowman2@uwm.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Behavioral memory responses (time frame: Session 2 (experimental session)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Jun 2026.