Rehabilitation ExerciseNCT07440433
Home-Based Physiotherapy in Oncology
A study testing Home-based cycling + resistance training with physiotherapist supervision in people with Rehabilitation Exercise and Oncologic Diseases, run by University Hospital, Geneva at 1 site in Switzerland.
Trial summary
The goal of this clinical trial is to assess the feasibility, acceptability, and safety of a supervised home-based physiotherapy programme for adult oncology patients. The programme combines aerobic cycling exercise, resistance training, and mental preparation strategies, delivered at home with regular professional… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Rehabilitation Exercise, Oncologic Diseases
- What is being tested?
- Home-based cycling + resistance training with physiotherapist supervision
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 21 participants
- Where
- 1 siteSwitzerland
- Study dates
- Mar 2026to Mar 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age ≥ 18 years
- Diagnosis of solid cancer, undergoing or recently completed treatment.
- Overall survival greater than 12 months, as judged by the treating oncologist
- Clinically stable and deemed fit for moderate exercise by the treating oncologist
- Able to use an exercise bike
- Home environment suitable for delivery and installation of the exercise bike
- Able to understand the study language and follow study instructions
- Able to give a written informed consent
Who cannot join
- Medical contraindication to moderate exercise (e.g. uncontrolled cardiac or pulmonary disease, recent myocardial infarction, severe anemia or acute infection, unstable bone metastases or high fracture risk)
- Cognitive impairment preventing active participation
- Physical inability to perform the prescribed exercise programme, including cycling and resistance exercises.
- Participation in another intensive rehabilitation program
- Any other condition that, in the opinion of the treating oncologist or investigator, makes participation unsafe or not feasible
- Pregnant or lactating women.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Home-Based Physiotherapy for Oncology Patients: Feasibility and Acceptability of a Supervised Exercise Programme
The goal of this clinical trial is to assess the feasibility, acceptability, and safety of a supervised home-based physiotherapy programme for adult oncology patients. The programme combines aerobic cycling exercise, resistance training, and mental preparation strategies, delivered at home with regular professional supervision.
The main questions this study aims to answer are:
Read more
Is a 6-month supervised home-based physiotherapy programme feasible in terms of recruitment, adherence, and retention?
Is the programme safe for oncology patients undergoing or having recently completed cancer treatment?
Is the programme acceptable and satisfactory from the patient's perspective?
How do physical function and health-related quality of life change over the course of the programme?
This is a single-arm feasibility study with no comparison group.
Participants will:
Receive a stationary exercise bike delivered and installed at their home
Follow a 6-month individualized physiotherapy programme including:
Three weekly sessions combining moderate-intensity cycling and resistance exercises
Wear a connected activity watch during exercise sessions to monitor heart rate and exercise duration
Receive weekly supervision from oncology-trained physiotherapists through alternating in-person hospital visits and structured phone calls
Complete physical function assessments and questionnaires on quality of life, fatigue, and programme satisfaction at baseline, mid-program, and study completion
The results of this study will inform the design of a future larger controlled trial and contribute to the development of accessible home-based rehabilitation programmes for oncology patients.
Read the detailed description
This study is a prospective, single-centre, single-arm feasibility clinical trial conducted at the Geneva University Hospitals (HUG). It evaluates the implementation of a long-duration supervised home-based physiotherapy programme for adult oncology patients.
A total of 21 participants will be enrolled in three sequential cohorts of approximately seven participants each. Each participant will follow a single 6-month intervention period; cohorts are implemented sequentially for logistical and organisational reasons but follow identical study procedures.
The intervention consists of a 6-month home-based physiotherapy programme combining aerobic cycling exercise, resistance training, and mental preparation strategies. At study initiation, a stationary exercise bike is delivered and installed in the participant's home. An individualized exercise prescription is developed by oncology-trained physiotherapists based on baseline functional assessments and clinical status.
Participants are asked to complete three supervised exercise sessions per week. Each session includes approximately 20 minutes of moderate-intensity aerobic cycling followed by 20 minutes of resistance training. Exercise intensity is prescribed and monitored using perceived exertion and heart rate criteria consistent with current oncology exercise guidelines. A connected activity watch is provided to each participant and worn only during exercise sessions to record heart rate and exercise duration.
Supervision is ensured through weekly contact with oncology physiotherapists, alternating between in-person hospital visits and structured telephone calls. In-person visits include functional reassessments, programme adjustments, symptom review, safety monitoring, and mental preparation sessions. Mental preparation integrates motivational interviewing techniques, goal setting, routine development, and basic mindfulness and imagery strategies aimed at supporting adherence and self-management.
The primary focus of the study is feasibility, assessed through recruitment capability, adherence to prescribed exercise sessions, participant retention over the 6-month period, and successful delivery and use of the home-based equipment. Safety is assessed through systematic monitoring and reporting of adverse events related to the intervention.
Secondary outcomes include changes in physical function and patient-reported outcomes. Functional performance is assessed using standardized physical tests at baseline and at the end of the intervention. Patient-reported outcomes, including health-related quality of life, fatigue, and programme acceptability, are collected at baseline, mid-program (3 months), and study completion (6 months).
All analyses are descriptive and aim to provide feasibility indicators and operational insights to inform the design of a future controlled trial and potential integration of supervised home-based physiotherapy into routine oncology care.
- Conditions
- Rehabilitation Exercise, Oncologic Diseases
- Being tested
- Home-based cycling + resistance training with physiotherapist supervision
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Home-based cycling + resistance training with physiotherapist supervisionBehavioural
Participants complete a 6-month supervised home-based physiotherapy programme. The intervention includes three weekly exercise sessions consisting of approximately 20 minutes of moderate-intensity aerobic cycling followed by 20 minutes of resistance training. Exercise intensity is prescribed and monitored using perceived exertion and heart rate.
A stationary exercise bike is delivered and installed at the participant's home. Participants receive weekly supervision by oncology-trained physiotherapists through alternating in-person hospital visits and structured telephone calls. Mental preparation strategies, including motivational support and goal setting, are integrated during in-person visits to support adherence and self-management.
| Study group | Role | What they receive |
|---|---|---|
| Home-based supervised physiotherapy programme | Other | Participants enrolled in this single-arm study receive a 6-month supervised home-based physiotherapy programme combining aerobic cycling, resistance training, and mental preparation, delivered and monitored by oncology-trained physiotherapists. Receives: Behavioral: Home-based cycling + resistance training with physiotherapist supervision |
What is being measured
The primary outcome is the main question the study is designed to answer.
Retention rate
Percentage of participants completing the 6-month intervention and final assessments.
Measured: 6 months
Adherence to prescribed exercise sessions
Percentage of planned home-based exercise sessions completed over 6 months.
Measured: 6 months
Equipment installation and usability
Percentage of participants with successful delivery, installation, and safe use of the home-based exercise equipment.
Measured: 6 months
Safety of the intervention
Number and type of adverse events and serious adverse events related to the programme.
Measured: 6 months
Secondary outcomes (6)
6-minute walk test
Distance walked during the 6-minute walk test (meters).
Measured: Baseline and 6 months
Peak oxygen uptake (VO₂peak)
Peak oxygen uptake measured during cardiopulmonary exercise testing (CPET), expressed in mL/kg/min.
Measured: Baseline and 6 months
5 Times Sit-to-Stand Test (5xSST)
Time to complete five sit-to-stand repetitions (seconds).
Measured: Baseline and 6 months
Handgrip strength
Maximal grip strength measured with a dynamometer (kilograms).
Measured: Baseline and 6 months
Health-related quality of life (EORTC QLQ-C30 global health status score)
Quality of life assessed using the EORTC QLQ-C30 questionnaire. Scores range from 0 to 100. Higher scores on the global health status scale indicate better quality of life.
Measured: Baseline, 3 months, and 6 months
Participant satisfaction score
Participant satisfaction assessed using a study-specific questionnaire (score range 0-10, higher scores indicate greater satisfaction).
Measured: 3 months and 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Feb 2026
- Study startMar 2026 (estimated)
- Primary completionMar 2028 (estimated)
- Study completionMar 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Rehabilitation ExerciseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 21 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Geneva
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Floryane Kim, University Hospital, Geneva
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07440433
- Sponsor's protocol ID
- PRADA-HUG
- Status last verified
- Feb 2026
- First submitted
- 12 Jan 2026
- Last updated
- 27 Feb 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Home-Based Physiotherapy for Oncology Patients: Feasibility and Acceptability of a Supervised Exercise Programme
- ClinicalTrials.gov ID
- NCT07440433
- Acronym / sponsor ID
- PRADA-HUG
- Conditions
- Rehabilitation Exercise, Oncologic Diseases
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 21 participants (estimated)
- Lead sponsor
- University Hospital, GenevaUniversity, hospital or other
- Study start
- Mar 2026 (estimated)
- Primary completion
- Mar 2028 (estimated)
- Study completion
- Mar 2028 (estimated)
- First posted
- 27 Feb 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to assess the feasibility, acceptability, and safety of a supervised home-based physiotherapy programme for adult oncology patients. The programme combines aerobic cycling exercise, resistance training, and mental preparation strategies, delivered at home with regular professional supervision.
The main questions this study aims to answer are:
Is a 6-month supervised home-based physiotherapy programme feasible in terms of recruitment, adherence, and retention?
Is the programme safe for oncology patients undergoing or having recently completed cancer treatment?
Is the programme acceptable and satisfactory from the patient's perspective?
How do physical function and health-related quality of life change over the course of the programme?
This is a single-arm feasibility study with no comparison group.
Participants will:
Receive a stationary exercise bike delivered and installed at their home
Follow a 6-month individualized physiotherapy programme including:
Three weekly sessions combining moderate-intensity cycling and resistance exercises
Wear a connected activity watch during exercise sessions to monitor heart rate and exercise duration
Receive weekly supervision from oncology-trained physiotherapists through alternating in-person hospital visits and structured phone calls
Complete physical function assessments and questionnaires on quality of life, fatigue, and programme satisfaction at baseline, mid-program, and study completion
The results of this study will inform the design of a future larger controlled trial and contribute to the development of accessible home-based rehabilitation programmes for oncology patients.
Detailed description
This study is a prospective, single-centre, single-arm feasibility clinical trial conducted at the Geneva University Hospitals (HUG). It evaluates the implementation of a long-duration supervised home-based physiotherapy programme for adult oncology patients.
A total of 21 participants will be enrolled in three sequential cohorts of approximately seven participants each. Each participant will follow a single 6-month intervention period; cohorts are implemented sequentially for logistical and organisational reasons but follow identical study procedures.
The intervention consists of a 6-month home-based physiotherapy programme combining aerobic cycling exercise, resistance training, and mental preparation strategies. At study initiation, a stationary exercise bike is delivered and installed in the participant's home. An individualized exercise prescription is developed by oncology-trained physiotherapists based on baseline functional assessments and clinical status.
Participants are asked to complete three supervised exercise sessions per week. Each session includes approximately 20 minutes of moderate-intensity aerobic cycling followed by 20 minutes of resistance training. Exercise intensity is prescribed and monitored using perceived exertion and heart rate criteria consistent with current oncology exercise guidelines. A connected activity watch is provided to each participant and worn only during exercise sessions to record heart rate and exercise duration.
Supervision is ensured through weekly contact with oncology physiotherapists, alternating between in-person hospital visits and structured telephone calls. In-person visits include functional reassessments, programme adjustments, symptom review, safety monitoring, and mental preparation sessions. Mental preparation integrates motivational interviewing techniques, goal setting, routine development, and basic mindfulness and imagery strategies aimed at supporting adherence and self-management.
The primary focus of the study is feasibility, assessed through recruitment capability, adherence to prescribed exercise sessions, participant retention over the 6-month period, and successful delivery and use of the home-based equipment. Safety is assessed through systematic monitoring and reporting of adverse events related to the intervention.
Secondary outcomes include changes in physical function and patient-reported outcomes. Functional performance is assessed using standardized physical tests at baseline and at the end of the intervention. Patient-reported outcomes, including health-related quality of life, fatigue, and programme acceptability, are collected at baseline, mid-program (3 months), and study completion (6 months).
All analyses are descriptive and aim to provide feasibility indicators and operational insights to inform the design of a future controlled trial and potential integration of supervised home-based physiotherapy into routine oncology care.
Study design
- Primary purpose
- Supportive care
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Home-based supervised physiotherapy programme | Other | Behavioral: Home-based cycling + resistance training with physiotherapist supervisionParticipants enrolled in this single-arm study receive a 6-month supervised home-based physiotherapy programme combining aerobic cycling, resistance training, and mental preparation, delivered and monitored by oncology-trained physiotherapists. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Age ≥ 18 years
- Diagnosis of solid cancer, undergoing or recently completed treatment.
- Overall survival greater than 12 months, as judged by the treating oncologist
- Clinically stable and deemed fit for moderate exercise by the treating oncologist
- Able to use an exercise bike
Key exclusion criteria (6 listed)
- Medical contraindication to moderate exercise (e.g. uncontrolled cardiac or pulmonary disease, recent myocardial infarction, severe anemia or acute infection, unstable bone metastases or high fracture risk)
- Cognitive impairment preventing active participation
- Physical inability to perform the prescribed exercise programme, including cycling and resistance exercises.
- Participation in another intensive rehabilitation program
- Any other condition that, in the opinion of the treating oncologist or investigator, makes participation unsafe or not feasible
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Home-based cycling + resistance training with physiotherapist supervisionParticipants complete a 6-month supervised home-based physiotherapy programme. The intervention includes three weekly exercise sessions consisting of approximately 20 minutes of moderate-intensity aerobic cycling followed by 20 minutes of resistance training. Exercise intensity is prescribed and monitored using perceived exertion and heart rate. A stationary exercise bike is delivered and installed at the participant's home. Participants receive weekly supervision by oncology-trained physiotherapists through alternating in-person hospital visits and structured telephone calls. Mental preparation strategies, including motivational support and goal setting, are integrated during in-person visits to support adherence and self-management. | Behavioural | Home-based supervised physiotherapy programme |
Primary outcome
Retention rate
Time frame: 6 months
Percentage of participants completing the 6-month intervention and final assessments.
Adherence to prescribed exercise sessions
Time frame: 6 months
Percentage of planned home-based exercise sessions completed over 6 months.
Equipment installation and usability
Time frame: 6 months
Percentage of participants with successful delivery, installation, and safe use of the home-based exercise equipment.
Safety of the intervention
Time frame: 6 months
Number and type of adverse events and serious adverse events related to the programme.
6 secondary outcomes
6-minute walk test
Time frame: Baseline and 6 months
Peak oxygen uptake (VO₂peak)
Time frame: Baseline and 6 months
5 Times Sit-to-Stand Test (5xSST)
Time frame: Baseline and 6 months
Handgrip strength
Time frame: Baseline and 6 months
Health-related quality of life (EORTC QLQ-C30 global health status score)
Time frame: Baseline, 3 months, and 6 months
Participant satisfaction score
Time frame: 3 months and 6 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Feb 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Home-based cycling + resistance training with physiotherapist supervision in people with Rehabilitation Exercise and Oncologic Diseases, run by University Hospital, Geneva at 1 site in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 27 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Floryane Dr Kim (+41 22 372 98 62, floryane.kim@hug.ch), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Retention rate (time frame: 6 months). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Feb 2026.