Orthodontic ExtractionPremolarNCT07445321

Comparison of Rate and Amount of Orthodontic Space Closure

A study testing Space Closure in people with Orthodontic Extraction, run by Dow University of Health Sciences at 1 site in Pakistan.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

The goal of this clinical trial is to compare rate and amount of space closure among fresh vs healed extraction sites during fixed orthodontic treatment in patients with all first premolar's extraction Primary outcome measure is to calculate rate and amount of space closure between fresh vs healed as well as maxilla… Read more about this study

Who is it for?: Ages 18 to 35 yearsHealthy volunteers can take part
Conditions the study is for: Orthodontic Extraction
What is being tested?: Space Closure
Type of treatment: Surgery or procedure
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 34 participants
Where: 1 sitePakistan
Study dates: 15 Feb 2023to 9 Feb 2024
Phase: Interventional

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 to 35 years
All sexes
Healthy volunteers accepted
Adult

Who may be able to join

Patients aged 18-35 years.
Patients undergoing fixed appliance treatment.
Good oral hygiene and periodontal support.
Patients with all first premolar's extraction treatment plan.
Atraumatic extraction.

Who cannot join

History of previous orthodontic treatment
Systemic diseases like diabetes, hypertension etc
Any bone pathology or taking medicines like bisphosphonates
Patients with clefts or any syndromic condition.
Patients with old extraction socket.

Trial locations and contacts

1 site in 1 country.

Pakistan1 site

Dr Ishrat ul Ebad Khan Institute of Oral Health Sciences
Karachi, Sindh, 75300

Other trials in Pakistan

About this study

Official title: Comparison of Rate and Amount of Orthodontic Space Closure After All First Premolars Extraction in Healed vs Fresh Extraction Sites. A Randomized Clinical Trial.

Read the detailed description

The mandibular and maxillary arches of 34 patients will be included whose treatment plan decision was the extraction of all first premolars. Due to the split mouth approach, patients' maxillary and mandibular arches are randomly subdivided into two groups (right and left sides). First premolar extraction spaces in Group 1 will be closed once they have healed (6 week), while first premolar extraction spaces in Group 2 will be closed immediately after extraction. Both the upper and lower extraction spaces will be closed using coil springs (magnitude of force 30g per side). We'll specify the following time intervals: T1: Immediately prior to space closure; T2: 1 month after initial space closure; T3: 2 months after initial space closure T3: 3 months after initial space closure. Records will include measuring the rate and amount of space closure through Vernier calipers on dental cast as well as intraorally and will be evaluated at each time point.

Conditions: Orthodontic Extraction
Being tested: Space Closure
Keywords: Fixed Orthodontic Treatment, Fresh extraction socket, Healed extraction socket, premolar
Medical subject headings: Bicuspid Aortic Valve Disease

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Space ClosureProcedure or surgery
Also called Extraction
Space Closure in fresh vs healed extraction socket

Study groups in NCT07445321
Study group	Role	What they receive
fresh vs healed extraction socket	Experimental	Comparison of rate and amount of space closure in fresh vs healed extraction socket Receives: Procedure: Space Closure

What is being measured

The primary outcome is the main question the study is designed to answer.

To compare rate of space closure among fresh vs healed extraction sites during fixed orthodontic treatment in patients with all first premolar's extraction.
This study will be useful in making the timely decision for extraction of premolars and estimation of orthodontic treatment duration as well.
Measured: four time points are taken. T0: Baseline, T1: One month, T2: Two months, T3: Three months

Secondary outcomes (1)

To compare amount of space closure among fresh vs healed extraction sites during fixed orthodontic treatment in patients with all first premolar's extraction.
Total space closure
Measured: Space closure at T3 is subtracted from T0

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

15 Feb 20239 Feb 2024

First posted3 Mar 2026
Study start15 Feb 2023
Primary completion20 Dec 2023
Study completion9 Feb 2024

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Other trials for Orthodontic ExtractionStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Treatment
Allocation: Not applicable
Intervention model: Single group
Model description: Each patients mouth is splitted into four quadrants.Intervention is done either on left or right side randomly allocated
Masking: None (open label)
Enrolment: 34 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT07445321
Sponsor's protocol ID: BAnis
Acronym: Premolar
Status last verified: Feb 2026
First submitted: 29 Jan 2026
Last updated: 3 Mar 2026
Results posted: No
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: No: There is no need to share individual participants data

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See locations

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