StrokeNCT07446062
Telerehab Exerbrain: Bridging Physical and Cognitive Therapy in Stroke
A study testing Web-Based Physical-Cognitive Telerehabilitation Exergaming in people with Stroke and Tele-rehabilitation, run by Chiang Mai University.
Trial summary
The goal of this clinical trial is to learn if a web-based exercise and cognitive training (physical-cognitive) program works to improve movements and brain function in adults with long-term stroke. It will also learn whether the program is safe and enjoyable. Read more about this study
- Who is it for?
- Ages 20 to 80 years
- Conditions the study is for
- Stroke, Tele-rehabilitation, Exercise
- What is being tested?
- Web-Based Physical-Cognitive Telerehabilitation Exergaming
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 52 participants
- Where
- No sites listed yet
- Study dates
- Feb 2026to Mar 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- diagnosed with ischemic or hemorrhagic stroke at least 6 months before enrollment
- aged between 20 and 80 years
- able to walk at least 10 meters with or without assistive devices
- able to perform sit-to-stand safely with or without assistive devices
- can see the screen of a tablet or notebook computer at a distance of at least 60 cm
- have a stable medical condition and can follow study instructions
- frequent users of a mobile phone, tablet, or notebook computers
Who cannot join
- have medical conditions or complications that would be unsafe to exercise
- have neglect, impaired communication, or uncorrected visual problems [30], or - have severe spasticity of the upper or lower extremities (Modified Ashworth Scale ≥ 3)
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Effects of Web-Based Physical-Cognitive Telerehabilitation Exergaming on Physical and Cognitive Performance in Chronic Stroke Survivors: Protocol for a Randomized Controlled Trial
The goal of this clinical trial is to learn if a web-based exercise and cognitive training (physical-cognitive) program works to improve movements and brain function in adults with long-term stroke. It will also learn whether the program is safe and enjoyable.
The main questions it aims to answer are:
Read more
Does the program improve walking, balance, strength, and reduce fall risk? Does the program improve cognitive skills such as memory, attention, and problem-solving? Researchers will compare the online exercise-and-cognitive training program to usual care to see if the program leads to greater improvements.
Participants will:
- Be randomly assigned to either the online training group or the usual care group
- If in the training group, complete the home-based program for 12 weeks.
- Take part in physical and cognitive tests before and after the program
Read the detailed description
The goal of this clinical trial is to evaluate whether a 12-week, web-based exercise and cognitive (physical-cognitive) training program can improve both physical abilities and brain function in adults with long-term stroke. The study will also examine whether the program is safe, practical to use at home, and enjoyable.
Many people who have had a stroke continue to experience problems with movement (such as walking, balance, weakness, and risk of falling) as well as problems with cognition (such as memory, attention, and problem-solving). Traditional rehabilitation often focuses mainly on physical recovery. This study tests a program that combines physical exercises and cognitive training at the same time using interactive online "exergames" delivered through telerehabilitation.
The main questions this study aims to answer are:
Does the program improve motor function, walking speed, balance, muscle power, and reduce fall risk? Does the program improve cognitive abilities, including global cognitive ability, executive function, memory, and attention? Is the program enjoyable and feasible for people with chronic stroke to use at home? In this study, 52 participants will be randomly assigned to one of two groups. One group will complete the 12-week web-based physical-cognitive training program at home. Another group will continue receiving their usual care. The researchers will compare changes in physical and cognitive performance between the two groups.
Participants in the training group will follow guided exercise sessions delivered online. All participants will complete physical and cognitive assessments before and after the 12-week period. The results of this study may help determine whether web-based physical-cognitive training is an effective and accessible rehabilitation option for people living with chronic stroke.
- Conditions
- Stroke, Tele-rehabilitation, Exercise, Motor Abilities, Cognitive Abilities
- Being tested
- Web-Based Physical-Cognitive Telerehabilitation Exergaming
- Medical subject headings
- Stroke, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Web-Based Physical-Cognitive Telerehabilitation ExergamingBehavioural
Perform a physical-cognitive exergame via ExerbrainCMU web-based platform at home setting for 60 min/session, 3 sessions/week for 12 weeks.
| Study group | Role | What they receive |
|---|---|---|
| Web-Based Physical-Cognitive Telerehabilitation Exergaming | Experimental | Physical-cognitive exergame via web-based platform at home setting for 60 min/session, 3 sessions/week for 12 weeks. Receives: Behavioral: Web-Based Physical-Cognitive Telerehabilitation Exergaming |
| Control | No intervention | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
Executive function
Trail Making Test (TMT) part B-A will be evaluated at baseline and 3 months.
Measured: 3 months
Fall risk
Fall risk will be assessed using the Timed Up and Go (TUG) test at baseline and 3 months. The time taken to complete TUG will be recorded in Sec.
Measured: 3 months
Gait speed
10-Meter Walk test (10MWT) will be used to assessed gait speed at baseline and 3 months.
Measured: 3 months.
Secondary outcomes (7)
Global cognitive function
Montreal Cognitive Assessment (MoCA) test will used to measured global cognitive function at baseline and 3 months.The total scores range from 0-30 points with higher scores indicating better global cognitive function.
Measured: 3 months
Attention
Digit Span test will be used to assess memory and attention at baseline and 3 months.
Measured: 3 months
Motor function
Motor Assessment Scale (MAS) will be used to evaluate motor function at baseline and 3 months.
Measured: 3 months
Balance
Modified Functional Reach Test (MFRT) will be used to assessed balance at baseline and 3 months.
Measured: 3 months
Muscle strength
Five-Time Sit to Stand will be used to evaluate lower limb muscle strength at baseline and 3 months.
Measured: 3 months
Weight distribution
Stance Symmetry Test (SST) will be used to assess weight distribution at baseline and 3 months.
Measured: 3 months
Enjoyment
Physical Activity Enjoyment Scale (PACES) will be used to assess enjoyment.
Measured: 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Mar 2026
- Study startFeb 2026 (estimated)
- Primary completionNov 2026 (estimated)
- Study completionMar 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- A two-arm, assessor blind, and randomized controlled trial
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 52 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Chiang Mai University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Somporn Sungkarat, Chiang Mai University
- Investigators
- Puntarik Keawtep, Principal investigator, Chiang Mai Uiversity
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07446062
- Sponsor's protocol ID
- N42A680192
- Status last verified
- Feb 2026
- First submitted
- 18 Feb 2026
- Last updated
- 3 Mar 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual Participant Data (IPD) will not be shared because the informed consent obtained from participants did not include permission for public data sharing. Additionally, due to the sensitive nature of the clinical data and the potential risk of participant re-identification, data sharing is not planned.
Study at a glance
From the registry record, last updated by the sponsor on 3 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Web-Based Physical-Cognitive Telerehabilitation Exergaming on Physical and Cognitive Performance in Chronic Stroke Survivors: Protocol for a Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07446062
- Acronym / sponsor ID
- N42A680192
- Conditions
- Stroke, Tele-rehabilitation, Exercise, Motor Abilities, Cognitive Abilities
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 52 participants (estimated)
- Lead sponsor
- Chiang Mai UniversityUniversity, hospital or other
- Study start
- Feb 2026 (estimated)
- Primary completion
- Nov 2026 (estimated)
- Study completion
- Mar 2027 (estimated)
- First posted
- 3 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn if a web-based exercise and cognitive training (physical-cognitive) program works to improve movements and brain function in adults with long-term stroke. It will also learn whether the program is safe and enjoyable.
The main questions it aims to answer are:
Does the program improve walking, balance, strength, and reduce fall risk? Does the program improve cognitive skills such as memory, attention, and problem-solving? Researchers will compare the online exercise-and-cognitive training program to usual care to see if the program leads to greater improvements.
Participants will:
- Be randomly assigned to either the online training group or the usual care group
- If in the training group, complete the home-based program for 12 weeks.
- Take part in physical and cognitive tests before and after the program
Detailed description
The goal of this clinical trial is to evaluate whether a 12-week, web-based exercise and cognitive (physical-cognitive) training program can improve both physical abilities and brain function in adults with long-term stroke. The study will also examine whether the program is safe, practical to use at home, and enjoyable.
Many people who have had a stroke continue to experience problems with movement (such as walking, balance, weakness, and risk of falling) as well as problems with cognition (such as memory, attention, and problem-solving). Traditional rehabilitation often focuses mainly on physical recovery. This study tests a program that combines physical exercises and cognitive training at the same time using interactive online "exergames" delivered through telerehabilitation.
The main questions this study aims to answer are:
Does the program improve motor function, walking speed, balance, muscle power, and reduce fall risk? Does the program improve cognitive abilities, including global cognitive ability, executive function, memory, and attention? Is the program enjoyable and feasible for people with chronic stroke to use at home? In this study, 52 participants will be randomly assigned to one of two groups. One group will complete the 12-week web-based physical-cognitive training program at home. Another group will continue receiving their usual care. The researchers will compare changes in physical and cognitive performance between the two groups.
Participants in the training group will follow guided exercise sessions delivered online. All participants will complete physical and cognitive assessments before and after the 12-week period. The results of this study may help determine whether web-based physical-cognitive training is an effective and accessible rehabilitation option for people living with chronic stroke.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- A two-arm, assessor blind, and randomized controlled trial
| Arm | Type | Receives |
|---|---|---|
| Web-Based Physical-Cognitive Telerehabilitation Exergaming | Experimental | Behavioral: Web-Based Physical-Cognitive Telerehabilitation ExergamingPhysical-cognitive exergame via web-based platform at home setting for 60 min/session, 3 sessions/week for 12 weeks. |
| Control | No intervention | – |
Who may qualify
- Ages
- 20 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- diagnosed with ischemic or hemorrhagic stroke at least 6 months before enrollment
- aged between 20 and 80 years
- able to walk at least 10 meters with or without assistive devices
- able to perform sit-to-stand safely with or without assistive devices
- can see the screen of a tablet or notebook computer at a distance of at least 60 cm
Key exclusion criteria (2 listed)
- have medical conditions or complications that would be unsafe to exercise
- have neglect, impaired communication, or uncorrected visual problems [30], or - have severe spasticity of the upper or lower extremities (Modified Ashworth Scale ≥ 3)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Web-Based Physical-Cognitive Telerehabilitation ExergamingPerform a physical-cognitive exergame via ExerbrainCMU web-based platform at home setting for 60 min/session, 3 sessions/week for 12 weeks. | Behavioural | Web-Based Physical-Cognitive Telerehabilitation Exergaming |
Primary outcome
Executive function
Time frame: 3 months
Trail Making Test (TMT) part B-A will be evaluated at baseline and 3 months.
Fall risk
Time frame: 3 months
Fall risk will be assessed using the Timed Up and Go (TUG) test at baseline and 3 months. The time taken to complete TUG will be recorded in Sec.
Gait speed
Time frame: 3 months.
10-Meter Walk test (10MWT) will be used to assessed gait speed at baseline and 3 months.
7 secondary outcomes
Global cognitive function
Time frame: 3 months
Attention
Time frame: 3 months
Motor function
Time frame: 3 months
Balance
Time frame: 3 months
Muscle strength
Time frame: 3 months
Weight distribution
Time frame: 3 months
Enjoyment
Time frame: 3 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Mar 2026.
- Individual participant dataSharing planned: No. Individual Participant Data (IPD) will not be shared because the informed consent obtained from participants did not include permission for public data sharing. Additionally, due to the sensitive nature of the clinical data and the potential risk of participant re-identification, data sharing is not planned.
Related trials for Stroke
Not yet recruiting
Temporal Interference Stimulation for Upper-Limb Motor Recovery in Early Subacute Stroke
Acute Ischemic Stroke
RecruitingObservational study
ELATE Study: Evaluating Large-vessel Acute Thrombectomy in Extended Time Window
Acute Ichemic Stroke
Recruiting
Web-Based Tele-Rehabilitation Using Action Observation and Mirror Therapy for Subacute Stroke: A Randomized Controlled Trial
Stroke, Upper Extremity Paresis
Recruiting
Early Motor-Cognitive Integrative Training on Cognitive and Motor Performance in Patients With Aneurysmal Subarachnoid Hemorrhage
Subarachnoid Aneurysm Hemorrhage
Not yet recruiting
Selective Intra-Arterial Hypothermia After Endovascular Treatment for Acute Basilar Artery Occlusion
Acute Ischemic Stroke, Basilar Artery Occlusion
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Puntarik Keawtep principal investigator
Chiang Mai Uiversity
Questions about this trial
What is this clinical trial studying?
A study testing Web-Based Physical-Cognitive Telerehabilitation Exergaming in people with Stroke and Tele-rehabilitation, run by Chiang Mai University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 3 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Puntarik Keawtep, Ph.D., Primary investigator (66 861822590, puntarik.k@cmu.ac.th), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Executive function (time frame: 3 months). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Mar 2026.