Cervical RadiculopathyNCT07447271
Ultrasound Guided Cervical Selective Nerve Root Block Versus Fluoroscopic Guided Cervical Transforaminal Epidural Block
A study testing ultrasound guided cervical selective nerve root block and fluoroscopy-guided cervical transforaminal epidural block in people with Cervical Radiculopathy, run by Pusan National University Yangsan Hospital at 1 site in South Korea.
Trial summary
This study retrospectively analyzed medical records and imaging records (ultrasound images, fluoroscopy-guided images) of US-CSNRB and FL-CTFEB procedures performed at the Yangsan Pusan National University Hospital Pain Clinic outpatient department from May 1, 2019, to April 30, 2024. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cervical Radiculopathy
- What is being tested?
- ultrasound guided cervical selective nerve root block and fluoroscopy-guided cervical transforaminal epidural block
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 330 participants
- Where
- 1 siteSouth Korea
- Study dates
- 22 Dec 2025to 4 May 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adult male and female patients aged 18 years or older.
- Patients diagnosed with cervical radiculopathy who underwent US-guided or FL-guided procedures.
- Patients with clearly documented pain scale (VAS) assessments in medical records at the following time points: 1st visit (before the procedure), 2nd visit, 3rd visit, and at least 3 months post-procedure.
- Patients who underwent procedures for lesions in a single or adjacent two segments.
Who cannot join
- Patients who underwent surgical treatment within one month after the procedure due to progressive neurological deficits.
- Patients with severe systemic diseases (e.g., cancer, severe immunosuppressive disorders) that may affect pain assessment.
- Patients with severe systemic diseases (e.g., cancer, severe immunosuppressive disorders) that may affect pain assessment.
Trial locations and contacts
1 site in 1 country.
South Korea1 site
Pusan National University Yangsan Hospital
Yangsan, Gyeongsangnam-do, 50612
About this study
Official title: Comparison of the Therapeutic Efficacy and Safety of Ultrasound-guided Cervical Selective Nerve Root Block and Fluoroscopic Guided Cervical Transforaminal Epidural Block in Patients With Cervical Radiculopathy: A Retrospective Study
This study retrospectively analyzed medical records and imaging records (ultrasound images, fluoroscopy-guided images) of US-CSNRB and FL-CTFEB procedures performed at the Yangsan Pusan National University Hospital Pain Clinic outpatient department from May 1, 2019, to April 30, 2024. It compared the therapeutic effects (pain reduction), procedure-related indicators (comparison of contrast agent spread), safety (incidence of complications), and changes in analgesic usage.
The primary outcome of this study is the difference in pain chage (Visual Analogue Scale, VAS) between patients undergoing US-CSNRB and FL-CTFEB. The secondary outcomes are comparison of contrast agent spread and comparison of procedure-related complication rates.
Read the detailed description
The following information is retrospectively collected and observed for comparison based on the electronic medical records of selected patients.
- Patient characteristics: Age, height, weight, gender, lesion segment (e.g., C6/C7), comorbidities
- Procedure-related indicators:
- Procedure method (US-CSNRB or FL-CTFEB) 2) Procedure site, procedure level, adverse events during the procedure 3) Contrast agent distribution pattern: Extent of contrast agent spread into the epidural space and into the nerve roots during the procedure 3. Treatment efficacy indicators: VAS (based on arm pain) at the first visit -baseline, the second visit - 1 month after procedure, the third visit - 2 month after procedure, and 4th visit - 3 months post-procedure; treatment success rate (VAS score reduction of 30% or more) 4. Safety indicators: Presence and type of procedure-related complications documented in medical records (e.g., intravascular injection, nerve injury, local anesthetic toxicity symptoms, transient motor paralysis, etc.).
- Conditions
- Cervical Radiculopathy
- Being tested
- ultrasound guided cervical selective nerve root block, fluoroscopy-guided cervical transforaminal epidural block
- Keywords
- ultrasound, fluoroscopy, nerve block, cervical radiculopathy
- Medical subject headings
- Radiculopathy
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ultrasound guided cervical selective nerve root blockProcedure or surgery
Also called fluoroscopic guided cervical transforaminal epidural block
A patient presenting to the pain clinic with cervical neck pain and upper extremity radicular pain, whose symptoms did not improve with medication, demonstrated a positive Spurling test on physical examination, and showed cervical radiculopathy at the C3/4 to C7/T1 level on imaging studies (CT or MRI), underwent an ultrasound-guided cervical selective nerve root block
fluoroscopy-guided cervical transforaminal epidural blockProcedure or surgery
A patient presenting to the pain clinic with cervical neck pain and upper extremity radicular pain, whose symptoms did not improve with medication, demonstrated a positive Spurling test on physical examination, and showed cervical radiculopathy at the C3/4 to C7/T1 level on imaging studies (CT or MRI), underwent a fluoroscopy-guided cervical transforaminal epidural block
| Study group | Role | What they receive |
|---|---|---|
| group U | Experimental | Not described Receives: Procedure: ultrasound guided cervical selective nerve root block |
| group F | Active comparator | Not described Receives: Procedure: fluoroscopy-guided cervical transforaminal epidural block |
What is being measured
The primary outcome is the main question the study is designed to answer.
The difference in pain change
the difference in pain change, assessed using the visual analogue scale (VAS), between patients who underwent US-CSNRB and those who underwent FL-CTFEB
Measured: baseline, 1 month, 2 month, 3 month
Secondary outcomes (2)
The pattern of contrast spread
The pattern of contrast spread during the procedure were evaluated, specifically focusing on the extent of contrast dispersion into the epidural space and along the targeted nerve root. The incidence of contrast spread into the epidural space and the targeted nerve root area was recorded.
Measured: periprocedural
The incidence of procedure-related complications
The incidence of procedure-related complications were assessed by reviewing the medical records for the occurrence and specific types of procedure-related complications, encompassing adverse events such as inadvertent intravascular injection, nerve injury, symptoms of local anesthetic systemic toxicity (LAST), and transient motor weakness.
Measured: Periprocedural
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Mar 2026
- Study start22 Dec 2025
- Primary completion4 May 2026 (estimated)
- Study completion4 May 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cervical RadiculopathyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 330 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Pusan National University Yangsan Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Gyeong-Jo Byeon, MD, PhD, Pusan National University Yangsan Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07447271
- Sponsor's protocol ID
- US-CSNRB vs FL-CTFEB
- Status last verified
- Feb 2026
- First submitted
- 21 Feb 2026
- Last updated
- 3 Mar 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of the Therapeutic Efficacy and Safety of Ultrasound-guided Cervical Selective Nerve Root Block and Fluoroscopic Guided Cervical Transforaminal Epidural Block in Patients With Cervical Radiculopathy: A Retrospective Study
- ClinicalTrials.gov ID
- NCT07447271
- Acronym / sponsor ID
- US-CSNRB vs FL-CTFEB
- Conditions
- Cervical Radiculopathy
- Keywords
- ultrasound, fluoroscopy, nerve block, cervical radiculopathy
- Study type
- Interventional
- Recruitment status
- Active, not recruiting
- Enrolment
- 330 participants (estimated)
- Lead sponsor
- Pusan National University Yangsan HospitalUniversity, hospital or other
- Study start
- 22 Dec 2025 (actual)
- Primary completion
- 4 May 2026 (estimated)
- Study completion
- 4 May 2026 (estimated)
- First posted
- 3 Mar 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study retrospectively analyzed medical records and imaging records (ultrasound images, fluoroscopy-guided images) of US-CSNRB and FL-CTFEB procedures performed at the Yangsan Pusan National University Hospital Pain Clinic outpatient department from May 1, 2019, to April 30, 2024. It compared the therapeutic effects (pain reduction), procedure-related indicators (comparison of contrast agent spread), safety (incidence of complications), and changes in analgesic usage.
The primary outcome of this study is the difference in pain chage (Visual Analogue Scale, VAS) between patients undergoing US-CSNRB and FL-CTFEB. The secondary outcomes are comparison of contrast agent spread and comparison of procedure-related complication rates.
Detailed description
The following information is retrospectively collected and observed for comparison based on the electronic medical records of selected patients.
- Patient characteristics: Age, height, weight, gender, lesion segment (e.g., C6/C7), comorbidities
- Procedure-related indicators:
- Procedure method (US-CSNRB or FL-CTFEB) 2) Procedure site, procedure level, adverse events during the procedure 3) Contrast agent distribution pattern: Extent of contrast agent spread into the epidural space and into the nerve roots during the procedure 3. Treatment efficacy indicators: VAS (based on arm pain) at the first visit -baseline, the second visit - 1 month after procedure, the third visit - 2 month after procedure, and 4th visit - 3 months post-procedure; treatment success rate (VAS score reduction of 30% or more) 4. Safety indicators: Presence and type of procedure-related complications documented in medical records (e.g., intravascular injection, nerve injury, local anesthetic toxicity symptoms, transient motor paralysis, etc.).
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| group U | Experimental | Procedure: ultrasound guided cervical selective nerve root block |
| group F | Active comparator | Procedure: fluoroscopy-guided cervical transforaminal epidural block |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Adult male and female patients aged 18 years or older.
- Patients diagnosed with cervical radiculopathy who underwent US-guided or FL-guided procedures.
- Patients with clearly documented pain scale (VAS) assessments in medical records at the following time points: 1st visit (before the procedure), 2nd visit, 3rd visit, and at least 3 months post-procedure.
- Patients who underwent procedures for lesions in a single or adjacent two segments.
Key exclusion criteria (3 listed)
- Patients who underwent surgical treatment within one month after the procedure due to progressive neurological deficits.
- Patients with severe systemic diseases (e.g., cancer, severe immunosuppressive disorders) that may affect pain assessment.
- Patients with severe systemic diseases (e.g., cancer, severe immunosuppressive disorders) that may affect pain assessment.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ultrasound guided cervical selective nerve root blockAlso: fluoroscopic guided cervical transforaminal epidural blockA patient presenting to the pain clinic with cervical neck pain and upper extremity radicular pain, whose symptoms did not improve with medication, demonstrated a positive Spurling test on physical examination, and showed cervical radiculopathy at the C3/4 to C7/T1 level on imaging studies (CT or MRI), underwent an ultrasound-guided cervical selective nerve root block | Procedure or surgery | group U |
| fluoroscopy-guided cervical transforaminal epidural blockA patient presenting to the pain clinic with cervical neck pain and upper extremity radicular pain, whose symptoms did not improve with medication, demonstrated a positive Spurling test on physical examination, and showed cervical radiculopathy at the C3/4 to C7/T1 level on imaging studies (CT or MRI), underwent a fluoroscopy-guided cervical transforaminal epidural block | Procedure or surgery | group F |
Primary outcome
The difference in pain change
Time frame: baseline, 1 month, 2 month, 3 month
the difference in pain change, assessed using the visual analogue scale (VAS), between patients who underwent US-CSNRB and those who underwent FL-CTFEB
2 secondary outcomes
The pattern of contrast spread
Time frame: periprocedural
The incidence of procedure-related complications
Time frame: Periprocedural
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Mar 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing ultrasound guided cervical selective nerve root block and fluoroscopy-guided cervical transforaminal epidural block in people with Cervical Radiculopathy, run by Pusan National University Yangsan Hospital at 1 site in South Korea.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: under way, not looking for participants, as of the sponsor's last update on 3 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in South Korea. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The difference in pain change (time frame: baseline, 1 month, 2 month, 3 month). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Mar 2026; AzTrials last refreshed its copy on 31 Oct 2026.